Seiichi Hirota

Summary

Affiliation: Hyogo College of Medicine
Country: Japan

Publications

  1. pmc An inflammatory myofibroblastic tumor exhibiting immunoreactivity to KIT: a case report focusing on a diagnostic pitfall
    Tatsuki R Kataoka
    Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    World J Surg Oncol 12:186. 2014
  2. ncbi request reprint Pathology of gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Pathol Int 56:1-9. 2006
  3. pmc Metastatic lobular carcinoma of the breast masquerading as a primary rectal cancer
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    World J Surg Oncol 10:231. 2012
  4. doi request reprint Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503
    Ning Ning Liu
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 93:502-7. 2013
  5. doi request reprint Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis
    Hirokuni Akahori
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Eur Heart J 32:888-96. 2011
  6. doi request reprint Association of body mass index with risk of luminal A but not luminal B estrogen receptor-positive and HER2-negative breast cancer for postmenopausal Japanese women
    Yoshimasa Miyagawa
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Breast Cancer 22:399-405. 2015
  7. doi request reprint Prognostic significance of geminin expression levels in Ki67-high subset of estrogen receptor-positive and HER2-negative breast cancers
    Tomoko Yagi
    Department of Surgery, Division of Breast and Endocrine, Hyogo College of Medicine, Mukogawa 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Breast Cancer 23:224-30. 2016
  8. doi request reprint Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors
    Mayumi Nakai
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 92:451-7. 2012
  9. doi request reprint Ex vivo comparison of angioscopy and histopathology for the evaluation of coronary plaque characteristics
    Masahiko Shibuya
    Cardiovascular Division Division of Coronary Heart Disease, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 6638501, Japan
    Int J Cardiovasc Imaging 32:863-9. 2016
  10. doi request reprint Activation of mTOR/S6K But Not MAPK Pathways Might Be Associated With High Ki-67, ER(+), and HER2(-) Breast Cancer
    Ayako Yanai
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Clin Breast Cancer 15:197-203. 2015

Detail Information

Publications71

  1. pmc An inflammatory myofibroblastic tumor exhibiting immunoreactivity to KIT: a case report focusing on a diagnostic pitfall
    Tatsuki R Kataoka
    Department of Diagnostic Pathology, Kyoto University Hospital, Sakyo ku, Kyoto 606 8507, Japan
    World J Surg Oncol 12:186. 2014
    ..Therefore, IMTs should be included in the differential diagnosis of spindle cell tumors, even those that are KIT-positive. ..
  2. ncbi request reprint Pathology of gastrointestinal stromal tumors
    Seiichi Hirota
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Pathol Int 56:1-9. 2006
    ..Mutational analyses of c-kit and PDGFRA genes are also significant for prediction of effectiveness of drugs including newly developed agents...
  3. pmc Metastatic lobular carcinoma of the breast masquerading as a primary rectal cancer
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    World J Surg Oncol 10:231. 2012
    ..In some cases, the interval between the primary breast cancer and metastatic colorectal lesions is so long that the critical records for diagnosis including history might be lost or missed...
  4. doi request reprint Extracellular domain c-kit mutation with duplication of Ser501Ala502 found in gastrointestinal stromal tumors is more imatinib- and nilotinib-sensitive than that with duplication of Ala502Tyr503
    Ning Ning Liu
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 93:502-7. 2013
    ..Although mutation sites of KIT-Dup-Ser501Ala502 and KIT-Dup-Ala502Tyr503 are closely located, imatinib- and nilotinib-sensitive KIT-Dup-Ser501Ala502 are distinguishable from KIT-Dup-Ala502Tyr503...
  5. doi request reprint Intraleaflet haemorrhage is associated with rapid progression of degenerative aortic valve stenosis
    Hirokuni Akahori
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Eur Heart J 32:888-96. 2011
    ..The purpose of this study is to clarify whether the haemorrhage in the aortic valve leaflet (intraleaflet haemorrhage) accelerates the progression of aortic valve stenosis (AS)...
  6. doi request reprint Association of body mass index with risk of luminal A but not luminal B estrogen receptor-positive and HER2-negative breast cancer for postmenopausal Japanese women
    Yoshimasa Miyagawa
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Breast Cancer 22:399-405. 2015
    ..However, the mechanism for the impact of BMI on the etiology of luminal A and luminal B subtypes has not yet been identified...
  7. doi request reprint Prognostic significance of geminin expression levels in Ki67-high subset of estrogen receptor-positive and HER2-negative breast cancers
    Tomoko Yagi
    Department of Surgery, Division of Breast and Endocrine, Hyogo College of Medicine, Mukogawa 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Breast Cancer 23:224-30. 2016
    ..However, since Ki67-high cancers are not necessarily sensitive to chemotherapy, identification of such patients who do not need chemotherapy is an important issue...
  8. doi request reprint Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors
    Mayumi Nakai
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 92:451-7. 2012
    ....
  9. doi request reprint Ex vivo comparison of angioscopy and histopathology for the evaluation of coronary plaque characteristics
    Masahiko Shibuya
    Cardiovascular Division Division of Coronary Heart Disease, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 6638501, Japan
    Int J Cardiovasc Imaging 32:863-9. 2016
    ..Not only fibroatheroma but also various types of plaques and their components, such as immature lipidic components and superficial calcium plates, appeared yellow on coronary angioscopy. ..
  10. doi request reprint Activation of mTOR/S6K But Not MAPK Pathways Might Be Associated With High Ki-67, ER(+), and HER2(-) Breast Cancer
    Ayako Yanai
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Clin Breast Cancer 15:197-203. 2015
    ..pS6 positivity, but not pMAPK positivity, was significantly associated with the high Ki-67 expression subset...
  11. pmc Gastrointestinal stromal tumors with exon 8 c-kit gene mutation might occur at extragastric sites and have metastasis-prone nature
    Takashi Ito
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan Department of Pathology, Sanda Municipal Hospital Hyogo, Japan
    Int J Clin Exp Pathol 7:8024-31. 2014
    ....
  12. doi request reprint In vivo effect of imatinib on progression of cecal GIST-like tumors in exon 17-type c-kit knock-in mice
    Takashi Ishikawa
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Lab Invest 89:1161-8. 2009
    ....
  13. doi request reprint Correlation of the SUVmax of FDG-PET and ADC values of diffusion-weighted MR imaging with pathologic prognostic factors in breast carcinoma
    Kazuhiro Kitajima
    Department of Nuclear Medicine and PET Center, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan Electronic address
    Eur J Radiol 85:943-9. 2016
    ....
  14. doi request reprint Ex vivo assessment of neointimal characteristics after drug-eluting stent implantation: Optical coherence tomography and histopathology validation study
    Takahiro Imanaka
    Division of Cardiovascular Medicine and Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Japan
    Int J Cardiol 221:1043-7. 2016
    ..This study evaluated the diagnostic accuracy of OCT for characterization of lipid-atherosclerotic neointima following drug-eluting stent (DES) implantation...
  15. ncbi request reprint Histopathological validation of optical frequency domain imaging to quantify various types of coronary calcifications
    Ten Saita
    Cardiovascular Division, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 6638501, Japan
    Eur Heart J Cardiovasc Imaging . 2016
    ..This study evaluated whether optical frequency domain imaging (OFDI) could identify various coronary calcifications and accurately measure calcification thickness in comparison with histopathology...
  16. doi request reprint C4.4A highly expressed in HER2-positive human breast cancers may indicate a good prognosis
    Tomohiro Miyake
    Division of Breast and Endocrine Surgery, Department of Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Breast Cancer 22:366-73. 2015
    ..The aim of our study was to investigate the association of C4.4A expression in breast tumors with both patients' clinicopathological characteristics and outcomes in order to clarify the significance of C4.4A in breast cancer...
  17. doi request reprint Aortic iron overload with oxidative stress and inflammation in human and murine abdominal aortic aneurysm
    Hisashi Sawada
    From the Cardiovascular Division, Department of Internal Medicine H S, Y N, M O, S Hirotani, T M, Department of Surgical Pathology H H, S Hirota, and Department of Cardiovascular Surgery M M, Y M, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Arterioscler Thromb Vasc Biol 35:1507-14. 2015
    ..We, therefore, examined whether iron is involved in the pathophysiology of AAA formation using human AAA walls and murine AAA models...
  18. doi request reprint Influence of body mass index on clinicopathological factors including estrogen receptor, progesterone receptor, and Ki67 expression levels in breast cancers
    Ayako Yanai
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Int J Clin Oncol 19:467-72. 2014
    ..It is speculated that both enhanced production of estrogens and other factors associated with obesity are involved in these associations, but the biological characteristics associated with high BMI have yet to be thoroughly identified...
  19. doi request reprint Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: report of a very rare case
    Masataka Zozumi
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 209:124-7. 2013
    ..Genetic analysis elucidated that the tumor had a chromosomal translocation, type 3 DDIT3-FUS chimeric gene. The tumor was definitely diagnosed as myxoid/round cell liposarcoma of the paratesticular region...
  20. pmc Characterization of various types of mast cells derived from model mice of familial gastrointestinal stromal tumors with KIT-Asp818Tyr mutation
    Noriko Kajimoto
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 8:11970-82. 2015
    ..IMC-G4 cells might be a useful mast cell line to investigate mast cell biology. ..
  21. doi request reprint Rare form of extraovarian primary peritoneal papillary serous carcinoma with solitary cystic lesion mimicking a liver tumor; report of a case
    Yuji Iimuro
    Department of Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Clin J Gastroenterol 6:145-9. 2013
    ..The present case is very rare form of EOPPC without any ascites or peritoneal dissemination. ..
  22. doi request reprint Impact of biomarker changes during neoadjuvant chemotherapy for clinical response in patients with residual breast cancers
    Yukie Enomoto
    Division of Breast and Endocrine Surgery, Department of Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Int J Clin Oncol 21:254-61. 2016
    ..However, the significance of Ki67 reduction for clinical response during chemotherapy in each subtype or menopausal status is yet to be determined...
  23. ncbi request reprint Expression of Hedgehog Signals and Growth Inhibition by Itraconazole in Endometrial Cancer
    Kayo Inoue
    Department of Obstetrics and Gynecology, Hyogo College of Medicine, Mukogawa, Nishinomiya, Hyogo, Japan
    Anticancer Res 36:149-53. 2016
    ..Herein, we evaluated the efficacy of itraconazole in treating EC...
  24. ncbi request reprint Gremlin 2 is Repressed in Invasive Endometrial Cancer and Inhibits Cell Growth In Vitro
    Hiroshi Tsubamoto
    Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Anticancer Res 36:199-203. 2016
    ..There exist limited therapeutic opportunities regarding the treatment of endometrial cancer (EC), and novel therapies based on the molecular profiling of EC cells are required...
  25. pmc Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type with malakoplakia in the urinary bladder: a case report
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 7:5280-4. 2014
    ....
  26. doi request reprint Small gastrointestinal stromal tumor of the stomach showing rapid growth and early metastasis to the liver
    Junji Tanaka
    Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Dig Endosc 22:354-6. 2010
    ..Liver metastasis was found 6 months postoperatively, and molecular target therapy was carried out. However, the patient died 2 years after the finding of liver metastasis...
  27. ncbi request reprint [Small-molecule inhibitors against KIT and PDGFRs especially in GISTs]
    Kazuhiro Shiba
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Gan To Kagaku Ryoho 36:1080-5. 2009
    ..Secondary mutations of the c-kit gene in addition to primary c-kit gene mutation are a major cause of secondary resistance to imatinib. Now, we can use sunitinib for patients with imatinib-resistant GIST...
  28. doi request reprint Diagnostic and prognostic value of (18)F-FDG PET/CT for axillary lymph node staging in patients with breast cancer
    Kazuhiro Kitajima
    Department of Nuclear Medicine and PET Center, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Jpn J Radiol 34:220-8. 2016
    ..To investigate the diagnostic and prognostic value of (18)F-FDG-PET/CT for axillary lymph node (LN) staging in breast cancer patients, employing histologic evaluation as the reference...
  29. doi request reprint Development of hepatocellular carcinoma in cardiac congestive liver fibrosis: report of a case
    Koichiro Ohashi
    Department of Surgery, Hyogo College of Medicine, 1 1 Mukogawacho, Nishinomiya, Hyogo, 663 8501, Japan
    Clin J Gastroenterol 8:143-7. 2015
    ..Nine months later, multiple recurrent HCCs were detected in segment 6, and transcatheter arterial chemoembolization was employed thereafter. The patient died 40 months after surgery due to advanced recurrence. ..
  30. pmc Occurrence of colon tumors in a 16-year-old Japanese boy after hematopoietic stem cell transplantation for Diamond Blackfan anemia at age of 4: a case report
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 8:5938-43. 2015
    ..To our knowledge, this is the first case report of colon tumors associated with DBA. ..
  31. doi request reprint Accuracy of OCT, grayscale IVUS, and their combination for the diagnosis of coronary TCFA: an ex vivo validation study
    Kenichi Fujii
    Cardiovascular Division, Hyogo College of Medicine, Nishinomiya, Japan Electronic address
    JACC Cardiovasc Imaging 8:451-60. 2015
    ..This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA)...
  32. doi request reprint Distribution of myofibroblast and tenascin-C in cystic adventitial disease: comparison with ganglion
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Pathol Int 63:591-8. 2013
    ..These results suggest that CAD may arise as capsular synovial structures, similar to ganglion cysts. ..
  33. doi request reprint Solid-pseudopapillary neoplasm of the pancreas with massive central calcification in an old man
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 206:372-5. 2010
    ..Nuclear accumulation of beta-catenin protein and a point mutation of the beta-catenin gene by genomic DNA sequencing confirmed that the tumor was SPN. This is a very rare case of pancreatic SPN with massive calcification in an old man...
  34. doi request reprint Impact of dietary iron restriction on the development of monocrotaline-induced pulmonary vascular remodeling and right ventricular failure in rats
    Yoshiro Naito
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Biochem Biophys Res Commun 436:145-51. 2013
    ..Iron restriction attenuated the development of monocrotaline-induced pulmonary vascular remodeling and RV failure. Cellular iron transport might be involved in the pathophysiology of PH and PH induced RV failure. ..
  35. doi request reprint Primary carcinoid tumor of the urinary bladder with prominent subnuclear eosinophilic granules
    Masataka Zozumi
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 208:109-12. 2012
    ..The lower part of the mass showed the findings of glandular cystitis, as its coexistence with carcinoid tumors of the bladder has often been described in previous reports...
  36. doi request reprint New double embedding technique for specimens of endoscopic submucosal dissection using agarose: comparison with other media
    Masataka Zozumi
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    J Clin Pathol 63:904-9. 2010
    ..Therefore, easy and reliable tissue-processing method for multiple cut specimens is needed. The authors report here a new double embedding technique for specimens of ESD...
  37. doi request reprint Increase in tissue and circulating pentraxin3 levels in patients with aortic valve stenosis
    Yoshiro Naito
    Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Am Heart J 160:685-91. 2010
    ..Inflammation is involved in the pathogenesis of nonrheumatic aortic valve stenosis (AS). Pentraxin3 (PTX3) is produced at the inflammatory site; however, tissue and circulating PTX3 levels in patients with AS remain largely unknown...
  38. doi request reprint Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma
    Yoshikazu Togo
    Department of Urology, Hyogo College of Medicine, Hyogo 663 8501, Japan
    Int J Oncol 48:1571-80. 2016
    ..Surprisingly, nuclear staining of BAP1 was negative in 10 out of 31 tumors (32.3%) with hemizygous normal BAP1, suggesting that haploinsufficiency may relate to RCC development...
  39. doi request reprint Penile pseudomyogenic hemangioendothelioma/epithelioid sarcoma-like hemangioendothelioma with a novel pattern of SERPINE1-FOSB fusion detected by RT-PCR--report of a case
    Yoshi hiro Ide
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pathol Res Pract 211:415-20. 2015
    ..Thus, this is the third case of PHE/ES-HE with SERPINE1-FOSB fusion proved by RT-PCR. ..
  40. pmc Spontaneous regression of primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) colliding with invasive ductal carcinoma of the breast: a case report
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 7:7020-7. 2014
    ..However, the lymphoma disappeared, while the carcinoma remained, in the resected mass. To our knowledge, this is the first case report of spontaneous regression of MALT lymphoma of the breast colliding with breast cancer. ..
  41. ncbi request reprint Expression of chemokine ligand 18 in stage IA low-grade endometrial cancer
    Riya Sakane
    Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Anticancer Res 34:5331-6. 2014
    ..The identification of novel molecules associated with endometrial cancer (EC) development might offer less invasive surgery, better fertility preservation, and avoidance of unnecessary adjuvant therapy...
  42. ncbi request reprint Drug-eluting stent: importance of clinico-pathological correlations
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan
    Circ J 75:1548-58. 2011
    ..Ex vivo imaging using angioscopy, intravascular ultrasound, and optical coherency tomography of SES implantation is presented and the images are compared with the corresponding pathological section...
  43. doi request reprint Correlation of thin fibrous cap possessing adipophilin-positive macrophages and intraplaque hemorrhage with high clinical risk for carotid endarterectomy
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Neurosurg 114:1080-7. 2011
    ..Furthermore, the authors examined whether the plaque with high embolic potential after CA intervention, particularly CAS, could be predicted based on clinical risks for CEA...
  44. ncbi request reprint Familial adenomatous polyposis complicated by chronic myelogenous leukemia: response to imatinib mesylate
    Takeyoshi Itsukuma
    Division of Hematology Oncology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    J Gastroenterol 42:402-5. 2007
    ..Eighteen months later, however, the polyps were enlarged. In this patient, imatinib administration led to the remission of CML and might also have been responsible for the temporary regression of adenomatous polyps of FAP...
  45. ncbi request reprint Spontaneous regression of pulmonary involvement after smoking reduction and removal of and radiation therapy for Langerhans cell histiocytosis of the sphenoid bone: which comes first, the chicken or the egg?
    Hiroya Tamaki
    Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Japan
    Intern Med 51:497-501. 2012
    ..Here, we present a 37-year-old man with spontaneous regression of pulmonary lesions in multisystem LCH, achieved solely by smoking reduction following local treatment of bone lesions...
  46. doi request reprint Combined small cell carcinoma of the hypopharynx
    Nobuhiro Uwa
    Department of Otolaryngology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Auris Nasus Larynx 40:106-9. 2013
    ..Combined SmCC is a disease with a poor prognosis. Although biopsy sometimes fails to detect the SmCC component, intensive diagnosis and treatment are necessary...
  47. ncbi request reprint Juxtamembrane-type c-kit gene mutation found in aggressive systemic mastocytosis induces imatinib-resistant constitutive KIT activation
    Nami Nakagomi
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Lab Invest 87:365-71. 2007
    ....
  48. doi request reprint Genetic instability, CpG island methylator phenotype and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum
    Yoshiki Nando
    Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan
    Hum Pathol . 2016
    ....
  49. doi request reprint Association between ¹⁸F-FDG uptake and molecular subtype of breast cancer
    Kazuhiro Kitajima
    Department of Nuclear Medicine and PET Center, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Eur J Nucl Med Mol Imaging 42:1371-7. 2015
    ..To determine whether (18)F-FDG uptake in breast cancer correlates with immunohistochemically defined subtype and is able to predict molecular subtypes...
  50. doi request reprint HER2 expression in locally advanced gastric cancer with extensive lymph node (bulky N2 or paraaortic) metastasis (JCOG1005-A trial)
    Tomohiro Matsumoto
    Department of Upper Gastrointestinal Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Gastric Cancer 18:467-75. 2015
    ..This study evaluated the frequency of HER2 overexpression and amplification in The Japanese Gastric Cancer Association (JGCA)-N3 and JGCA-bulky N2 tumors and the correlation between HER2 status and survival...
  51. pmc Follicular lymphoma mimicking marginal zone lymphoma in lymph node: a case report
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 7:7076-81. 2014
    ..Our case illustrates and reconfirms the importance of clinicopathological correlation which leads to a correct diagnosis. ..
  52. doi request reprint Fatal case of multiple recurrences of endometrial stromal sarcoma after fertility-sparing management
    Atsushi Morimoto
    Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Obstet Gynaecol Res 41:162-6. 2015
    ..We report the first fatal case of ESS 10 years after fertility-sparing management. A specimen obtained from the last operation showed loss of estrogen receptor status and expression of c-kit without c-kit or PDGFR-α gene mutations...
  53. doi request reprint A rare case of clear cell sarcoma with 4 types of EWSR1-ATF1 fusions detected not in primary site but in metastatic site
    Yoshitane Tsukamoto
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan Electronic address
    Pathol Res Pract 209:803-7. 2013
    ..In our case, increased splicing activity in the EWSR1-ATF1 fusion might be acquired at the metastatic site. There is another possibility that metastasis might develop through the increased splicing activity in the fusion...
  54. pmc Primary follicular lymphoma of the spleen incidentally found in a patient with alcohol- and hepatitis C-related liver cirrhosis
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Nishinomiya, Hyogo, Japan
    Int J Clin Exp Pathol 7:4484-8. 2014
    ..Our case illustrates the importance to recognize a possibility of co-occurrence of chronic liver disease and extrahepatic lymphoma. ..
  55. pmc Diffuse alveolar damage in a patient with Epstein Barr virus (EBV)-positive diffuse large B-cell lymphoma,severely low serum folate, and megaloblastic anemia: a case report of autopsy
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 7:1742-7. 2014
    ..We considered that low serum folate in this case was not by the low intake but by increased consumption of folate by rapid progression of the lymphoma. ..
  56. doi request reprint ¹⁸F-Fluorodeoxyglucose uptake and clinicopathological features of recurrent or metastatic endometrial stromal sarcoma
    Kayo Inoue
    Department of Obstetrics and Gynecology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan Department of Obstetrics and Gynecology, Meiwa General Hospital, Nishinomiya, Hyogo, Japan
    J Obstet Gynaecol Res 40:576-82. 2014
    ..Maximum standardized uptake value on (18) F-fluorodeoxyglucose positron emission tomography was evaluated as a predictive surrogate marker in developing treatment strategies for recurrent or metastatic endometrial stromal sarcoma...
  57. ncbi request reprint Distinct global DNA methylation status in B-cell lymphomas: immunohistochemical study of 5-methylcytosine and 5-hydroxymethylcytosine
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine
    J Clin Exp Hematop 54:67-73. 2014
    ....
  58. pmc A case of synchronous bilateral lung cancers: EML4-ALK positive adenocarcinoma in the right lung and adenocarcinoma in situ (the former bronchioloalveolar carcinoma) in the left lung
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, Hyogo 663 8501, Japan
    BMC Pulm Med 13:25. 2013
    ..On the other hand, echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene in a subset of lung adenocarcinoma is related to mucinous cribriform histology...
  59. doi request reprint Pancreatic desmoid-type fibromatosis with beta-catenin gene mutation-Report of a case and review of the literature
    Yoshitane Tsukamoto
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Hyogo, Japan Electronic address
    Pathol Res Pract 212:484-9. 2016
    ..Thus, our case is the 19th pancreatic DTF and the second case with confirmed beta-catenin gene mutation. ..
  60. pmc Bone marrow infiltration of CD20-negative follicular lymphoma after rituximab therapy: a histological mimicker of hematogones and B-cell acute lymphoblastic leukemia/lymphoma
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 8:9737-41. 2015
    ..In this paper, we report a case where bone marrow infiltration of follicular lymphoma histopathologically mimicked hematogones or B-ALL/LBL when CD20 expression was downregulated in follicular lymphoma after R-CHOP therapy...
  61. doi request reprint Epithelioid pleural mesothelioma concurrently associated with miliary pulmonary metastases and minimal change nephrotic syndrome - A hitherto undescribed case
    Yoshitane Tsukamoto
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan Electronic address
    Pathol Res Pract 211:1014-9. 2015
    ..The patient died because of the worsening of the general condition. To our knowledge, this is the first case of MPM concurrently associated with multiple miliary pulmonary metastases and nephrotic syndrome. ..
  62. doi request reprint Overexpression of Ephrin A2 receptors in cancer stromal cells is a prognostic factor for the relapse of gastric cancer
    Shojiro Kikuchi
    Department of Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    Gastric Cancer 18:485-94. 2015
    ..Microenvironments control cancer growth and progression. We explored the prognostic impact of stromal reaction and cancer stromal cells on relapse risk and survival after curative gastrectomy in gastric cancer patients...
  63. pmc A case of immunohistochemical false positive staining caused by incompatibility between a CD4 antibody and an autostainer
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine Hyogo, Japan
    Int J Clin Exp Pathol 8:1019-24. 2015
    ..This case illustrates the importance of using compatible combinations of antibodies and autostainers in diagnostic immunohistochemistry. ..
  64. doi request reprint Upregulation of interleukin-33 in the epidermis of two Japanese patients with Netherton syndrome
    Tomoko Konishi
    Department of Dermatology, Hyogo College of Medicine, Nishinomiya, Japan
    J Dermatol 41:258-61. 2014
    ..The upregulation of interleukin-33 (IL-33) was evident in basal and thickened lower spinous layers of the epidermis in those cases. This suggests that IL-33 may be involved in the pathophysiology of NS as well as in atopic dermatitis. ..
  65. doi request reprint STAT6-positive intraorbital papillary tumor: a rare variant of solitary fibrous tumor?
    Yoshitane Tsukamoto
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan Electronic address
    Pathol Res Pract 210:450-3. 2014
    ....
  66. doi request reprint Biological characteristics of luminal subtypes in pre- and postmenopausal estrogen receptor-positive and HER2-negative breast cancers
    Keiko Murase
    Division of Breast and Endocrine, Department of Surgery, Hyogo College of Medicine, Mukogawa cho 1 1, Nishinomiya, Hyogo, 663 8501, Japan
    Breast Cancer 21:52-7. 2014
    ..However, the biological differences in ER and progesterone receptor (PR) expression levels between these luminal subtypes are not clear...
  67. pmc Primary squamous cell carcinoma of the liver: an uncommon finding in contrast-enhanced ultrasonography imaging
    Yuji Iimuro
    Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Case Rep Gastroenterol 5:628-35. 2011
    ..From the review, it could be proposed that a combination of radiation therapy, systemic chemotherapy (5-FU and CDDP) and surgical resection, if possible, is appropriate for advanced primary SCC of the liver...
  68. ncbi request reprint Expression of cyclooxygenase-2 and DNA topoisomerase II alpha in precancerous and cancerous lesions of the oral mucosa
    Emi Segawa
    Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Oral Oncol 44:664-71. 2008
    ..The patients with high expression of both COX-2 and DNA-Topo II alpha showed poor prognosis. Our results suggested that COX-2 expression become a possible indicator in oral carcinogenesis and may reflect the outcome of the patients...
  69. doi request reprint Global histone modification profiles are well conserved between normal B lymphocytes and neoplastic counterparts
    Ikuo Matsuda
    Department of Surgical Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Pathol Oncol Res 16:447-51. 2010
    ....
  70. doi request reprint Immunohistochemical phenotype of the urinary bladder endocervicosis: comparison with normal endocervix and well-differentiated mucinous adenocarcinoma of uterine cervix
    Hiroyuki Hao
    Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    Pathol Int 60:528-32. 2010
    ..Furthermore, diffuse distribution of estrogen and progesterone receptors, lack of human gastric mucin and low proliferative activity were distinct features for endocervicosis compared to well-differentiated mucinous adenocarcinoma...
  71. doi request reprint Sustained improvement in cardiac function with persistent amyloid deposition in a patient with multiple myeloma-associated cardiac amyloidosis treated with bortezomib
    Hiroya Tamaki
    Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Int J Hematol 92:655-8. 2010
    ....