Noriko Takahashi

Summary

Affiliation: Hoshi University
Country: Japan

Publications

  1. doi request reprint Retinoylation (covalent modification by retinoic acid) of Rho-GDIβ in the human myeloid leukemia cell line HL60 and its functional significance
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan Electronic address
    Biochim Biophys Acta 1861:2011-2019. 2016
  2. doi request reprint Inhibitory effects of p-alkylaminophenol on melanogenesis
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan Electronic address
    Bioorg Med Chem 22:4677-83. 2014
  3. doi request reprint Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Bioorg Med Chem 21:6015-21. 2013
  4. ncbi request reprint Anticancer and superoxide scavenging activities of p-alkylaminophenols having various length alkyl chains
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Bioorg Med Chem 14:409-17. 2006
  5. ncbi request reprint Demonstration of basic proteins that bind retinoic acid in the human myeloid leukemia cell line HL60
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Biol Pharm Bull 32:1943-6. 2009
  6. ncbi request reprint Antioxidant and anticancer activities of novel p-alkylaminophenols and p-acylaminophenols (aminophenol analogues)
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Tokyo 142 8501, Japan
    Bioorg Med Chem 14:6089-96. 2006
  7. ncbi request reprint p-Dodecylaminophenol derived from the synthetic retinoid, fenretinide: antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Int J Cancer 122:689-98. 2008
  8. doi request reprint Cytokeratins 16 and 10 bind to retinoic acid covalently in skin tissue of mice
    N Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo, 142 8501 Japan
    Br J Dermatol 162:974-9. 2010
  9. doi request reprint Effects of the aminophenol analogue p-Dodecylaminophenol on mouse skin
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo, Japan
    J Invest Dermatol 130:1258-67. 2010
  10. doi request reprint The anti-tumor agent, p-DDAP potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cells
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Cancer Lett 297:252-8. 2010

Collaborators

Detail Information

Publications54

  1. doi request reprint Retinoylation (covalent modification by retinoic acid) of Rho-GDIβ in the human myeloid leukemia cell line HL60 and its functional significance
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan Electronic address
    Biochim Biophys Acta 1861:2011-2019. 2016
    ..RA did not induce caspase-3 activity or Rho-GDIβ mRNA expression. It is likely that retinoylation of Rho-GDIβ increases its metabolic stability...
  2. doi request reprint Inhibitory effects of p-alkylaminophenol on melanogenesis
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan Electronic address
    Bioorg Med Chem 22:4677-83. 2014
    ..This results in the reduction of melanin in B16 cells. Compound 3 might be an alternative to RA as a potent inhibitor of melanogenesis. ..
  3. doi request reprint Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Bioorg Med Chem 21:6015-21. 2013
    ..Compound 1 might be useful clinically as a new and potent anticancer agent that could overcome adverse side effects of the retinoids. ..
  4. ncbi request reprint Anticancer and superoxide scavenging activities of p-alkylaminophenols having various length alkyl chains
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Bioorg Med Chem 14:409-17. 2006
    ..These results indicate that anticancer activity of p-alkylaminophenols correlated with the inhibitory activity of lipid peroxidation, but not with the superoxide scavenging activity...
  5. ncbi request reprint Demonstration of basic proteins that bind retinoic acid in the human myeloid leukemia cell line HL60
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Biol Pharm Bull 32:1943-6. 2009
    ..These results indicate that basic proteins, including histones, may be bound to RA covalently in HL60 cells and that RA-binding histones may play significant roles in the transcriptional regulation of genes by RA...
  6. ncbi request reprint Antioxidant and anticancer activities of novel p-alkylaminophenols and p-acylaminophenols (aminophenol analogues)
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Tokyo 142 8501, Japan
    Bioorg Med Chem 14:6089-96. 2006
    ....
  7. ncbi request reprint p-Dodecylaminophenol derived from the synthetic retinoid, fenretinide: antitumor efficacy in vitro and in vivo against human prostate cancer and mechanism of action
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Int J Cancer 122:689-98. 2008
    ....
  8. doi request reprint Cytokeratins 16 and 10 bind to retinoic acid covalently in skin tissue of mice
    N Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo, 142 8501 Japan
    Br J Dermatol 162:974-9. 2010
    ..The molecular mechanisms underlying the effects of RA on epidermal cells and other cell types are mediated by RA nuclear receptors and retinoylation (acylation by RA) of proteins...
  9. doi request reprint Effects of the aminophenol analogue p-Dodecylaminophenol on mouse skin
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo, Japan
    J Invest Dermatol 130:1258-67. 2010
    ..An increase in cytokeratin 16 expression might be essential for the effects of both p-DDAP and RA in skin healing and maintenance...
  10. doi request reprint The anti-tumor agent, p-DDAP potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cells
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Cancer Lett 297:252-8. 2010
    ..Neuronal differentiation was not detected in p-DDAP-treated cells. Since p-DDAP is not toxic and does not reduce blood retinol levels, p-DDAP might be a useful anti-neuroblastoma drug having reduced side-effects...
  11. doi request reprint A close relationship between type 1 diabetes and vitamin A-deficiency and matrix metalloproteinase and hyaluronidase activities in skin tissues
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo, Japan
    Exp Dermatol 20:899-904. 2011
    ..Vitamin A-derived RA might be a significant regulator of ECM-degrading enzyme expression and diabetic symptoms...
  12. ncbi request reprint Effects on M5076-hepatic metastasis of retinoic acid and N-(4-hydroxyphenyl) retinamide, fenretinide entrapped in SG-liposomes
    Noriko Takahashi
    Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Biol Pharm Bull 26:1060-3. 2003
    ..In contrast, free RA and 4-HPR were inactive. These results indicate that RA and 4-HPR in SG-liposomes exhibit anticancer efficacy on metastatic cancers, and may have great potential for clinical use in the treatment of various cancers...
  13. ncbi request reprint Induction of differentiation in human promyelocytic leukemia cell line HL60 by a new type of polyenes, falconensone A and its derivatives
    N Takahashi
    Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo, 142 8501, Japan
    Arch Biochem Biophys 360:113-20. 1998
    ..Based on these results, falconensone A and its derivatives may have clinical utility in the treatment of leukemia...
  14. ncbi request reprint Biological activity of p-methylaminophenol, an essential structural component of N-(4-hydroxyphenyl)retinamide, fenretinide
    Noriko Takahashi
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo 142 8501
    J Biochem 132:767-74. 2002
    ..The retinoyl residue or long alkyl chain substituent attached to an aminophenol may be significant for anticancer properties...
  15. ncbi request reprint Induction of differentiation and apoptosis in human promyelocytic leukemia HL60 cell line by a new type of steroids
    N Takahashi
    Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo, 142 8501, Japan
    Exp Cell Res 245:313-20. 1998
    ..In addition, Mer-NF8054X enhanced the differentiation of HL60 cells induced by RA. Based on these results, Mer-NF8054X may have utility in the clinic in combination with RA for leukemia patients...
  16. ncbi request reprint Enhancement of antioxidant activity of p-alkylaminophenols by alkyl chain elongation
    Noriko Takahashi
    Faculty of Pharmaceutical Sciences, Hoshi University, 4 41 Ebara 2 chome, Shinagawa ku, 142 8501 Tokyo, Japan
    Bioorg Med Chem 11:3255-60. 2003
    ..These results indicate that elongation of alkyl chains in p-alkylaminophenols may increase antioxidative activity, and that p-alkylaminophenols may potentially be useful in the development of antioxidants...
  17. ncbi request reprint Tunicamycin in combination with retinoic acid synergistically inhibits cell growth while decreasing palmitoylation and enhancing retinoylation of proteins in the human breast cancer cell line MCF-7
    N Takahashi
    Department of Health Chemistry, Hoshi University, Tokyo, Japan
    Oncol Res 9:527-33. 1997
    ..Furthermore, our results suggest that combinations of TM and RA may have clinical utility...
  18. ncbi request reprint Potent anticancer activities of novel aminophenol analogues against various cancer cell lines
    Toshihiro Ohba
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Bioorg Med Chem 15:847-53. 2007
    ..Compound 1, a potent anticancer agent with potency strikingly greater than 5, may potentially be useful in clinic...
  19. ncbi request reprint Stability and antitumor effects of all-trans retinoic acid-loaded liposomes contained sterylglucoside mixture
    Kazuyuki Shimizu
    Department of Pharmaceutics, Hoshi University, Ebara 2 4 41, Shinagawa ku, 142, Tokyo, Japan
    Int J Pharm 258:45-53. 2003
    ..1 days) (P<0.001) without change of mean body weight. It is concluded that the current ATRA-loaded SG liposomes are potentially applicable for hepatic metastasis of M5076 tumor...
  20. doi request reprint Proteins in human myeloid leukemia cell line HL60 reacting with retinoic acid monoclonal antibodies
    Yoshinori Kubo
    Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo, 142 8501, Japan
    J Biochem 144:349-55. 2008
    ....
  21. ncbi request reprint Expression of acetoacetyl-CoA synthetase, a novel cytosolic ketone body-utilizing enzyme, in human brain
    Masahiro Ohgami
    Department of Health Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Biochem Pharmacol 65:989-94. 2003
    ..The expression level of the AACS mRNA was high in kidney, heart and brain, but low in liver, and the expression profile of AACS in the human brain was quite similar to that of 3-hydroxy-3-methylglutaryl-CoA reductase...
  22. doi request reprint Transcriptional regulation of ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, by C/EBPalpha during adipocyte differentiation
    Shinya Hasegawa
    Department of Health Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Biochim Biophys Acta 1779:414-9. 2008
    ..Moreover, we found that AACS promoter activity was controlled mainly by C/EBPalpha during adipogenesis...
  23. ncbi request reprint Antioxidative collagen-derived peptides in human-placenta extract
    Shin ichi Togashi
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Placenta 23:497-502. 2002
    ..These results suggest that peptides produced from collagen are also antioxidative components of PLx...
  24. ncbi request reprint Different localization in rat brain of the novel cytosolic ketone body-utilizing enzyme, acetoacetyl-CoA synthetase, as compared to succinyl-CoA:3-oxoacid CoA-transferase
    Mizuomi Ohnuki
    Department of Health Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 4 41, Ebara 2 Chome, Shinagawa ku, Tokyo 142 8501, Japan
    Biochim Biophys Acta 1729:147-53. 2005
    ..These results suggest that the physiological role of AACS is different from that of SCOT and varies depending upon its localization in the brain...
  25. doi request reprint Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma
    Masahiko Imai
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Bioorg Med Chem 20:2520-6. 2012
    ..Compound 1 may represent a potent and useful anti-cancer drug for use against pancreatic cancer and cholangiocarcinoma that lacks their key side-effects...
  26. doi request reprint Acetoacetyl-CoA synthetase is essential for normal neuronal development
    Shinya Hasegawa
    Department of Health Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142 8501, Japan
    Biochem Biophys Res Commun 427:398-403. 2012
    ..These results suggest that AACS is regulated by SREBP-2 and involves in the normal development of neurons...
  27. ncbi request reprint Formation of retinoylated proteins from retinoyl-CoA in rat tissues
    Yoshinori Kubo
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501
    J Biochem 138:493-500. 2005
    ..These results demonstrate that retinoylation in rat tissues occurs via retinoyl-CoA formed from RA. This process may play a significant physiological role in cells...
  28. ncbi request reprint [Induction of cell differentiation and development of new anticancer drugs]
    Noriko Takahashi
    Department of Health Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Yakugaku Zasshi 122:547-63. 2002
    ..Both derivatives have exhibited more potent biological activity than the parent falconensone A in vitro and in vivo...
  29. doi request reprint Protein kinase A activation by retinoic acid in the nuclei of HL60 cells
    Asako Sakai
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41, Ebara, Shinagawa, Tokyo 142 8501, Japan
    Biochim Biophys Acta 1861:276-285. 2016
    ..We have investigated the effects of RA on PKA during cell differentiation in order to understand the potential significance of this process in the retinoylation of RIIα subunits...
  30. doi request reprint Site-specific cleavage of acetoacetyl-CoA synthetase by legumain
    Shinya Hasegawa
    Department of Health Chemistry, Hoshi University, Shinagawa, Tokyo, Japan
    FEBS Lett 590:1592-601. 2016
    ..These results suggest that cleavage of AACS by legumain is critical for the regulation of enzymatic activity and results in gain-of-function changes. ..
  31. ncbi request reprint [Regulation of cytodifferentiation by retinoylation]
    Noriko Takahashi
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Seikagaku 77:527-36. 2005
  32. doi request reprint Growth inhibition of refractory human gallbladder cancer cells by retinol, and its mechanism of action
    Chuan Li
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University
    Biol Pharm Bull . 2017
    ..This suggests that retinol might be useful for anticancer prevention and therapy in the clinic...
  33. doi request reprint High-fat diet-induced obesity stimulates ketone body utilization in osteoclasts of the mouse bone
    Masahiro Yamasaki
    Department of Health Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan Electronic address
    Biochem Biophys Res Commun 473:654-61. 2016
    ..Because the abnormal activation of osteoclasts by IL-6 induces bone resorption, our data suggest that AACS and ketone bodies are important factors in the relationship between obesity and osteoporosis. ..
  34. doi request reprint Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells
    Chuan Li
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University
    Biol Pharm Bull 39:636-40. 2016
    ..These results indicate that Rol is a potent suppressor of cancer cell growth and adhesion, which are both linked to metastasis and tumor progression. Rol might be useful for the clinical treatment of cancer. ..
  35. doi request reprint Effect of p-aminophenols on tyrosinase activity
    Yu Komori
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Bioorg Med Chem 22:3994-4000. 2014
    ..These results suggest that 3 might be a useful alternative to kojic acid as a tyrosinase inhibitor. ..
  36. doi request reprint Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels
    Eiko Kato
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    Bioorg Med Chem 20:3837-42. 2012
    ..These results suggest that 1 could be an excellent agent for improving skin moisture-retention by enhancing ceramide synthesis through the induction of differentiation...
  37. ncbi request reprint Down-regulation of Bcl-2-interacting protein BAG-1 confers resistance to anti-cancer drugs
    Noriko Takahashi
    Department of Bioengineering, Faculty of Engineering, Soka University, Hachioji, Tokyo, Japan
    Biochem Biophys Res Commun 301:798-803. 2003
    ..Taken together resistance against anti-cancer drugs acquired by BAG-1 down-regulated cells may well be accounted for by the retardation of cell cycle progression, implicating the importance of BAG-1 in cell growth regulation...
  38. doi request reprint Effects of pre- and post-administration of vitamin A on the growth of refractory cancers in xenograft mice
    Chuan Li
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University
    Biol Pharm Bull . 2017
    ..The regulation of vitamin A concentration in the body, which is critical biomarker of health, could be beneficial for cancer prevention and therapy...
  39. ncbi request reprint L-tryptophan as an antioxidant in human placenta extract
    Satoshi Watanabe
    Department of Health Chemistry, Hoshi University, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:36-9. 2002
    ..These results suggest that L-Trp is a main antioxidant of HPE of which the effect is based on the suppression of lipid peroxidation in the oxidative stress status...
  40. doi request reprint Stromal cells in bone marrow play important roles in pro-inflammatory cytokine secretion causing fever following bortezomib administration in patients with multiple myeloma
    Dai Maruyama
    Hematology and Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan
    Int J Hematol 88:396-402. 2008
    ..Although this investigation was a preliminary study with a small number of patients, our results suggested that pro-inflammatory cytokines causing bortezomib-associated fever were secreted from BMSCs rather than MM cells...
  41. doi request reprint Molecular mechanism of 9-cis-retinoic acid inhibition of adipogenesis in 3T3-L1 cells
    Chiaki Sagara
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Biochem Biophys Res Commun 433:102-7. 2013
    ..These results suggest that 9-cis-RA could inhibit adipogenesis by activating RXR, and decrease both RXR and PPARγs levels in a RXR activation-independent manner...
  42. doi request reprint Carcinoma of donor origin after allogeneic peripheral blood stem cell transplantation
    Wataru Munakata
    Departments of Hematology and Hematopoietic Stem Cell Transplantation, Division of Thoracic Surgery, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Am J Surg Pathol 36:1376-84. 2012
    ..Our observations suggest that transfused peripheral blood cells may be involved in the development of cancers after allogeneic peripheral blood stem cell transplantation...
  43. ncbi request reprint Effects of streptozotocin-induced diabetes on acetoacetyl-CoA synthetase activity in rats
    Hiroki Sato
    Department of Health Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Biochem Pharmacol 63:1851-5. 2002
    ....
  44. doi request reprint Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants
    Eiko Kato
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Bioorg Med Chem 19:6348-55. 2011
    ..These results suggest that 1 is a highly potent protective when compared among the examined commercial human skin care products, and that it might be useful for therapeutic and preventive medicine...
  45. doi request reprint Regular dose of gemcitabine induces an increase in CD14+ monocytes and CD11c+ dendritic cells in patients with advanced pancreatic cancer
    Atsuko Soeda
    Department of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 39:797-806. 2009
    ..This study was designed to evaluate the immunological reaction by gemcitabine for future clinical trial of combination therapy with gemcitabine and cancer vaccines...
  46. ncbi request reprint The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation
    Kenji Fukui
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita Osaka 565 0871, Japan
    Cell Metab 2:373-84. 2005
    ..Therefore, collectrin is a regulator of SNARE complex function, which thereby controls insulin exocytosis...
  47. ncbi request reprint [Screening of DNA topoisomerase inhibitors]
    Toshiwo Andoh
    Department of Bioinformatics, Faculty of Engineering, Soka University, 1 236 Tangi cho, Hachioji, Tokyo 192 8577, Japan
    Gan To Kagaku Ryoho 31:495-500. 2004
    ..Thus, many candidate anticancer drugs targeting topos are being screened, and preclinical and clinical studies thereof are being conducted world-wide and in Japan...
  48. ncbi request reprint Psathyrella velutina lectin as a specific probe for N-acetylneuraminic acid in glycoconjugates
    Haruko Ueda
    Graduate School of Humanities and Sciences, Ochanomizu University, 2 1 1 Otsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Methods Enzymol 363:77-90. 2003
  49. ncbi request reprint Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of N-phenyl-N'-{4-(4-quinolyloxy)phenyl}ureas
    Kazuo Kubo
    Pharmaceutical Research and Development Laboratories, Kirin Brewery Co Ltd, 3 Miyahara cho, Takasaki shi, Gunma 370 1295, Japan
    J Med Chem 48:1359-66. 2005
    ....
  50. ncbi request reprint Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription
    Mitsuhiko Noda
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Japan
    J Biol Chem 277:41817-26. 2002
    ..This is the first report to demonstrate the connection between metabolic alteration of electron transport system and that of tricarboxylic acid cycle and its impact on insulin secretion...
  51. ncbi request reprint Development of structural analysis of sulfated N-glycans by multidimensional high performance liquid chromatography mapping methods
    Hirokazu Yagi
    Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya 467 8603, Japan
    Glycobiology 15:1051-60. 2005
    ....
  52. ncbi request reprint Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells
    Atsuko Miura
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:5246-57. 2006
    ..Because the K(ATP) channel is important for proper insulin secretion in beta-cells, altered K(ATP) channel activity could be related to the impaired insulin secretion in the betaHNF-4alphaKO mice...
  53. ncbi request reprint Interaction of N-linked glycans, having multivalent GlcNAc termini, with GM3 ganglioside
    Seon Joo Yoon
    Division of Biomembrane Research, Pacific Northwest Research Institute, and Department of Pathobiology, University of Washington, Seattle, WA, USA
    Glycoconj J 23:639-49. 2006
    ..Natural occurrence of such interaction to define cell biological phenomena is under investigation...
  54. ncbi request reprint 920 MHz ultra-high field NMR approaches to structural glycobiology
    Koichi Kato
    Institute for Molecular Science, National Institutes of Natural Sciences, 5 1 Higashiyama Myodaiji, Okazaki 444 8787, Japan
    Biochim Biophys Acta 1780:619-25. 2008
    ..6 T magnetic field (corresponding to 920 MHz (1)H observation frequency). The ultra-high field NMR spectroscopy combined with sugar library and stable-isotope labeling approaches will open new horizons in structural glycobiology...