K Kamata

Summary

Affiliation: Hoshi University
Country: Japan

Publications

  1. ncbi request reprint Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo, 142 8501, Japan
    Eur J Pharmacol 428:241-9. 2001
  2. ncbi request reprint Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 42:171-87. 2006
  3. ncbi request reprint Endothelin-1-induced impairment of endothelium-dependent relaxation in aortas isolated from controls and diabetic rats
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Japan
    J Cardiovasc Pharmacol 44:S186-90. 2004
  4. ncbi request reprint Acetylcholine-induced vasodilation in the perfused kidney of the streptozotocin-induced diabetic rat: role of prostacyclin
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 42:159-70. 2006
  5. ncbi request reprint Enhancement of methoxamine-induced contractile responses of rat ventricular muscle in streptozotocin-induced diabetes is associated with alpha1A adrenoceptor upregulation
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Acta Physiol (Oxf) 188:173-83. 2006
  6. ncbi request reprint Effect of long-term streptozotocin-induced diabetes on coronary vasoconstriction in isolated perfused rat heart
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 44:177-88. 2008
  7. ncbi request reprint Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 45:125-37. 2009
  8. ncbi request reprint Effects of chronic administration of fruit extract (Citrus unshiu Marc) on endothelial dysfunction in streptozotocin-induced diabetic rats
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Biol Pharm Bull 28:267-70. 2005
  9. ncbi request reprint Changes in angiotensin converting enzyme activity in the renal vascular bed of streptozotocin-induced diabetic rat
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry Hoshi University, Tokyo, Japan
    Res Commun Mol Pathol Pharmacol 104:181-92. 1999
  10. ncbi request reprint Insulin resistance and impaired endothelium-dependent renal vasodilatation in fructose-fed hypertensive rats
    K Kamata
    Department of Physiology and Morphology, Hoshi University, Tokyo, Japan
    Res Commun Mol Pathol Pharmacol 103:195-210. 1999

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Mechanisms underlying attenuated contractile response of aortic rings to noradrenaline in fructose-fed mice
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo, 142 8501, Japan
    Eur J Pharmacol 428:241-9. 2001
    ....
  2. ncbi request reprint Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 42:171-87. 2006
    ..These results suggest that in the STZ-induced diabetic perfused kidney, vasorelaxant metabolites derived from AA (probably COX and/or CYP450 metabolites) are increased, and may serve to regulate vascular tone...
  3. ncbi request reprint Endothelin-1-induced impairment of endothelium-dependent relaxation in aortas isolated from controls and diabetic rats
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Japan
    J Cardiovasc Pharmacol 44:S186-90. 2004
    ..These results indicate that endothelin-1 can induce endothelial dysfunction, and that this may be related to superoxide generation and to PI3-kinase activity...
  4. ncbi request reprint Acetylcholine-induced vasodilation in the perfused kidney of the streptozotocin-induced diabetic rat: role of prostacyclin
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 42:159-70. 2006
    ..Increased prostacyclin-signaling may occur to help compensate for the impaired endothelial function seen in the kidney in long-term diabetic states...
  5. ncbi request reprint Enhancement of methoxamine-induced contractile responses of rat ventricular muscle in streptozotocin-induced diabetes is associated with alpha1A adrenoceptor upregulation
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Acta Physiol (Oxf) 188:173-83. 2006
    ....
  6. ncbi request reprint Effect of long-term streptozotocin-induced diabetes on coronary vasoconstriction in isolated perfused rat heart
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 44:177-88. 2008
    ..These changes may be due to alterations in the activity of voltage-gated Ca(2+) channels...
  7. ncbi request reprint Effect of N-epsilon-(carboxymethyl)lysine on coronary vasoconstriction in isolated perfused hearts from control and streptozotocin-induced diabetic rats
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 45:125-37. 2009
    ....
  8. ncbi request reprint Effects of chronic administration of fruit extract (Citrus unshiu Marc) on endothelial dysfunction in streptozotocin-induced diabetic rats
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Biol Pharm Bull 28:267-70. 2005
    ..This beneficial effect may be due to this extract protecting of nitric oxide against inactivation by oxygen free radicals...
  9. ncbi request reprint Changes in angiotensin converting enzyme activity in the renal vascular bed of streptozotocin-induced diabetic rat
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry Hoshi University, Tokyo, Japan
    Res Commun Mol Pathol Pharmacol 104:181-92. 1999
    ..These results suggest that angiotensin I is rapidly converted to angiotensin II in the renal vascular bed, and that converting enzyme activity in the renal vascular bed may be decreased in STZ-induced diabetic rats...
  10. ncbi request reprint Insulin resistance and impaired endothelium-dependent renal vasodilatation in fructose-fed hypertensive rats
    K Kamata
    Department of Physiology and Morphology, Hoshi University, Tokyo, Japan
    Res Commun Mol Pathol Pharmacol 103:195-210. 1999
    ..It is further suggested that hyperinsulinemia is more important than endothelial dysfunction as a cause of hypertension in fructose-fed rats...
  11. ncbi request reprint Effects of superoxide dismutase on the acetylcholine-induced relaxation response in cholesterol-fed and streptozotocin-induced diabetic mice
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 35:33-46. 1999
    ..It is further suggested that impairment of endothelium-dependent relaxation in STZ-diabetic and cholesterol fed mice may be caused by different mechanisms...
  12. ncbi request reprint Effects of chronic treatment with the spontaneous nitric oxide releaser FK409 on vascular responses in established streptozotocin-induced diabetic rat
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Res Commun Mol Pathol Pharmacol 103:275-94. 1999
    ..These results demonstrate that chronic administration of the novel NO releaser FK409 can improve diabetes-impaired endothelium-dependent vasodilatation in the rat aorta and perfused kidney...
  13. ncbi request reprint Altered endothelium-dependent and -independent hyperpolarization and endothelium-dependent relaxation in carotid arteries isolated from streptozotocin-induced diabetic rats
    K Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Naunyn Schmiedebergs Arch Pharmacol 362:52-9. 2000
    ....
  14. ncbi request reprint Effect of chronic insulin treatment on NO production and endothelium-dependent relaxation in aortae from established STZ-induced diabetic rats
    T Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, 142-8501, Tokyo, Japan
    Atherosclerosis 155:313-20. 2001
    ....
  15. pmc Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK
    T Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Br J Pharmacol 155:974-83. 2008
    ..Functions for angiotensin II, endothelin-1 receptor expression and extracellular signal-regulated kinase (ERK) have been investigated...
  16. ncbi request reprint Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Can J Physiol Pharmacol 82:175-82. 2004
    ..The plasma concentration of NOx (NO2- + NO3-) was significantly lower in diabetic rats than in control rats. We conclude that vasomotor activities in conduit arteries are impaired in this type II diabetes model...
  17. doi request reprint Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat
    Takayuki Matsumoto
    Dept of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi Univ, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 296:H1388-97. 2009
    ..These results suggest that upregulation of ET(A), a defect in ET(B)-mediated NO signaling, and activation of the MEK/ERK pathway together represent a likely mechanism mediating the hyperreactivity to ET-1 examined in this study...
  18. doi request reprint Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 297:H1767-75. 2009
    ....
  19. ncbi request reprint Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 283:H1761-8. 2002
    ..These receptors were increased in diabetes, perhaps as result of insulin deficiency...
  20. ncbi request reprint Mechanisms underlying increased release of endothelin-1 from aorta in diabetic rats
    A Makino
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa-ku, 142-8501, Tokyo, Japan
    Peptides 22:639-45. 2001
    ..These results suggest that the increases in the basal and alpha-agonist-induced release of endothelin-1 in the diabetic state may be due to an overexpression of the mRNA for prepro endothelin-1...
  21. pmc Effects of chronic administration of the novel endothelin antagonist J-104132 on endothelial dysfunction in streptozotocin-induced diabetic rat
    Noriyasu Kanie
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Br J Pharmacol 135:1935-42. 2002
    ..7. These results suggest that in STZ-induced diabetic rats, ET-1 may be directly involved in impairing endothelium-dependent relaxation via increased superoxide-anion production...
  22. ncbi request reprint Vascular NAD(P)H oxidase mediates endothelial dysfunction in basilar arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Atherosclerosis 192:15-24. 2007
    ..Possibly, an impairment of NO-dependent relaxation responses and a basal impairment of NO signaling may be responsible for the increased risk of adverse cerebrovascular events in type 2 diabetes...
  23. ncbi request reprint Modulation by hydrogen peroxide of noradrenaline-induced contraction in aorta from streptozotocin-induced diabetic rat
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142 8501, Japan
    Eur J Pharmacol 441:83-9. 2002
    ..Enhanced production of H(2)O(2) in the aorta from diabetic rats may seem contribute to the endothelial generation of nitric oxide and vasoconstrictor prostanoids...
  24. pmc Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat aorta
    T Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Br J Pharmacol 149:931-41. 2006
    ..The effect of lysophosphatidylcholine (LPC) on aortic contractions in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a type 2 diabetic model, was studied...
  25. ncbi request reprint Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Hypertension 44:956-62. 2004
    ..This may be a major cause of endothelial dysfunction (and the resulting hypertension) in type 2 diabetes...
  26. doi request reprint Mechanisms underlying the losartan treatment-induced improvement in the endothelial dysfunction seen in mesenteric arteries from type 2 diabetic rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Pharmacol Res 62:271-81. 2010
    ..Losartan thus normalizes vascular dysfunction in this type 2 diabetic model, and the above effects may contribute to the reduction of adverse cardiovascular events seen in diabetic patients treated with angiotensin II receptor blockers...
  27. ncbi request reprint Possible involvement of Akt activity in endothelial dysfunction in type 2 diabetic mice
    Yasuhiro Takenouchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    J Pharmacol Sci 106:600-8. 2008
    ..These results strongly suggest that simvastatin improves the endothelial dysfunction seen in type 2 diabetic mice via increases in Akt and Akt phosphorylation...
  28. ncbi request reprint Vasodilator effect of Cassiarin A, a novel antiplasmodial alkaloid from Cassia siamea, in rat isolated mesenteric artery
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Biol Pharm Bull 33:844-8. 2010
    ..These results suggest that in the rat mesenteric artery, cassiarin A-induced relaxation may be mediated by endothelial NO and may occur partly via BK(Ca)-channel activation...
  29. ncbi request reprint Effects of anthocyanidin derivative (HK-008) on relaxation in rat perfused mesenterial bed
    Katsuo Kamata
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Ebara 2 4 41, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 42:75-88. 2006
    ..These results suggest that HK-008 increases endothelium-induced relaxation by suppressing oxidative stress or modulating prostanoids signaling. This compound may therefore be useful against certain cardiovascular disorders...
  30. ncbi request reprint Gender differences in endothelial function in aortas from type 2 diabetic model mice
    Yasuhiro Takenouchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Japan
    J Pharmacol Sci 111:91-9. 2009
    ..These results suggest that endothelial functions dependent on the Akt pathway are abrogated by type 2 diabetes only in male mice...
  31. doi request reprint Mechanisms underlying enhanced vasorelaxant response to protease-activated receptor 2-activating peptide in type 2 diabetic Goto-Kakizaki rat mesenteric artery
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Peptides 30:1729-34. 2009
    ....
  32. doi request reprint Mechanisms underlying reduced P2Y(1) -receptor-mediated relaxation in superior mesenteric arteries from long-term streptozotocin-induced diabetic rats
    K Ishida
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Acta Physiol (Oxf) 207:130-41. 2013
    ..We hypothesized that in a model of established type 1 diabetes, long-term streptozotocin (STZ)-induced diabetic rats, the arterial relaxation elicited by a P2Y(1) -receptor agonist would be impaired...
  33. ncbi request reprint Apocynin normalizes hyperreactivity to phenylephrine in mesenteric arteries from cholesterol-fed mice by improving endothelium-derived hyperpolarizing factor response
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Free Radic Biol Med 41:1289-303. 2006
    ....
  34. ncbi request reprint Specific impairment of endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from streptozotocin-induced diabetic mice
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Vascul Pharmacol 44:450-60. 2006
    ....
  35. ncbi request reprint Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 538:132-40. 2006
    ..We conclude that the impairment of EDHF-type relaxation seen in OLETF rats may be attributable not only to a reduction in cAMP/PKA signaling, but also to reduced endothelial K(Ca) channel activities...
  36. ncbi request reprint Differential expression of alpha2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 287:H135-43. 2004
    ....
  37. doi request reprint Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Peptides 31:346-53. 2010
    ....
  38. ncbi request reprint Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 293:H1480-90. 2007
    ..These results suggest that an imbalance between EDRFs and EDCFs may be implicated in the endothelial dysfunction seen in aged OLETF mesenteric arteries, and may be attributable to increased oxidative stress...
  39. ncbi request reprint Modulations of shear stress-induced contractile responses and agonist-induced vasodilation in hypercholesterolemic rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Atherosclerosis 175:31-8. 2004
    ..These abnormal vascular responses may contribute to hypertension in beef tallow-fed hypercholesterolemic model rats...
  40. ncbi request reprint Flow-induced endothelium-dependent vasoreactivity in rat mesenteric arterial bed
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 40:1-14. 2004
    ....
  41. doi request reprint Suppressed G-protein-coupled receptor kinase 2 activity protects female diabetic-mouse aorta against endothelial dysfunction
    K Taguchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Acta Physiol (Oxf) 207:142-55. 2013
    ..The cellular mechanisms underlying these sex differences remain unclear. We aimed to investigate the ways in which GRK2 might modulate vascular functions in male and female diabetic mice (DM)...
  42. doi request reprint Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 295:H1165-H1176. 2008
    ..Our data suggest that within the timescale studied here, metformin improves endothelial function through this direct mechanism, rather than by improving metabolic abnormalities...
  43. ncbi request reprint Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Peptides 25:1985-94. 2004
    ....
  44. ncbi request reprint IGF-I-induced enhancement of contractile response in organ-cultured aortae from diabetic rats is mediated by sustained thromboxane A2 release from endothelial cells
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo 142 8501, Japan
    J Endocrinol 186:367-76. 2005
    ..The observed enhancement of IGF-I receptor expression within endothelial cells may be causally related to the potentiation of vascular contractility and the increase in TXA2 production...
  45. ncbi request reprint ANG II enhances contractile responses via PI3-kinase p110 delta pathway in aortas from diabetic rats with systemic hyperinsulinemia
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 291:H846-53. 2006
    ....
  46. ncbi request reprint Insulin-induced impairment via peroxynitrite production of endothelium-dependent relaxation and sarco/endoplasmic reticulum Ca(2+)-ATPase function in aortas from diabetic rats
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Free Radic Biol Med 43:431-43. 2007
    ....
  47. ncbi request reprint Mechanisms underlying the chronic pioglitazone treatment-induced improvement in the impaired endothelium-dependent relaxation seen in aortas from diabetic rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Free Radic Biol Med 42:993-1007. 2007
    ....
  48. ncbi request reprint Enalapril improves impairment of SERCA-derived relaxation and enhancement of tyrosine nitration in diabetic rat aorta
    Kumiko Taguchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 556:121-8. 2007
    ..Enalapril improved the diabetes-related impairments...
  49. ncbi request reprint Changes in aortic endothelial gene expressions and relaxation responses following chronic short-term insulin treatment in diabetic rats
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Atherosclerosis 185:47-57. 2006
    ..The hyperinsulinemia caused by this treatment may oppose the alterations in some gene expressions and the endothelial proliferation (cell growth-related gene expressions) that occur in established diabetes...
  50. pmc Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Br J Pharmacol 140:285-94. 2003
    ..This may be a major cause of the increased vascular contractility induced by insulin administration and by hyperinsulinemia in established diabetes, resulting in hypertension...
  51. ncbi request reprint Cilostazol improves endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from diabetic rats
    Takayuki Matsumoto
    Dept of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi Univ, Shinagawa ku, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 289:H1933-40. 2005
    ..These results strongly suggest that cilostazol improves EDHF-type relaxations in STZ rats via an increase in cAMP and PKA signaling...
  52. pmc Lysophosphatidylcholine potentiates vascular contractile responses in rat aorta via activation of tyrosine kinase
    Hiroshi Suenaga
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Br J Pharmacol 135:789-99. 2002
    ..This enhancing effect was attenuated by genistein. These results suggest that the LPC-induced augmentation of contractile responses in the rat aorta is due to activation of tyrosine kinase, which in turn regulates Ca(2+) influx...
  53. ncbi request reprint Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats
    Takayuki Matsumoto
    Deparment of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 285:H283-91. 2003
    ..We conclude that the impairment of EDHF-type relaxations in STZ-induced diabetic rats may be attributed to a reduction in the action of cAMP via increased PDE activity...
  54. doi request reprint Relationship among superoxide-related enzyme, PPARs, and endothelium-dependent relaxation in murine aortas previously organ-cultured in high-glucose conditions
    Yasuhiro Takenouchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Can J Physiol Pharmacol 88:760-9. 2010
    ..Moreover, such protein changes in gp91phox and Mn-SOD may be secondary to a decreased expression of PPARgamma protein...
  55. doi request reprint Cilostazol improves endothelial dysfunction by increasing endothelium-derived hyperpolarizing factor response in mesenteric arteries from Type 2 diabetic rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 599:102-9. 2008
    ..On that basis, cilostazol may prove to be a potent drug for the clinical treatment of diabetic vasculopathy...
  56. ncbi request reprint Chronic treatment with losartan (angiotensin II type 1 receptor antagonist) normalizes enhanced acetylcholine-induced coronary vasoconstriction in isolated perfused hearts of type 2 diabetic OLETF rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 45:197-208. 2009
    ....
  57. ncbi request reprint Effects of chronic administration of L-arginine on vasoactive responses induced by endothelin-1 and its plasma level in streptozotocin-induced diabetic rats
    Ayako Makino
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 38:101-15. 2002
    ....
  58. ncbi request reprint Losartan normalizes endothelium-derived hyperpolarizing factor-mediated relaxation by activating Ca2+-activated K+ channels in mesenteric artery from type 2 diabetic GK rat
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Pharmacol Sci 112:299-309. 2010
    ..We conclude that losartan improves EDHF-type relaxation in GK rats at least partly by normalizing SK(Ca)/IK(Ca) activities and increasing BK(Ca) activity...
  59. ncbi request reprint [Possible involvement of IGF-1 receptor and IGF-binding protein in insulin-induced enhancement of noradrenaline response in diabetic rat aorta]
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Nihon Yakurigaku Zasshi 122:40P-42P. 2003
    ..The downside is that such a perturbation of the activity in the IGF-1 system in diabetes could be a key event in the progress of arteriosclerosis and hypertension in syndromes involving hyperinsulinemia...
  60. ncbi request reprint Effects of chronic insulin on endothelial dysfunction of basilar arteries from established streptozotocin-diabetic rats
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 504:119-27. 2004
    ..Furthermore, we directly demonstrated that the expression profile for SOD and NAD(P)H oxidase was altered in the streptozotocin-induced diabetic basilar artery...
  61. ncbi request reprint Effect of phorbol 12,13-dibutyrate on smooth muscle tone in rat stomach fundus
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 41:107-16. 2005
    ..We speculate that a major factor mediating the relaxant action of PDBu in rat stomach fundus smooth muscle is represented by a reduction in Ca2+ influx via an inhibition of Ca2+ channels...
  62. ncbi request reprint Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats
    Takayuki Matsumoto
    Dept of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi Univ, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 289:H2234-43. 2005
    ..These results suggest that AC-mediated relaxation is impaired in the STZ-diabetic rat mesenteric artery, perhaps reflecting a reduction in AC5/6 activity...
  63. doi request reprint Pravastatin normalizes endothelium-derived contracting factor-mediated response via suppression of Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat
    K Ishida
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    Acta Physiol (Oxf) 205:255-65. 2012
    ..We aimed to determine the effects of pravastatin on the production of and responses to EDCF in superior mesenteric arteries isolated from rats at the chronic stage of type 2 diabetes...
  64. ncbi request reprint Enhanced Ca2+ sensitization of the bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats
    Y Chiba
    Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan
    Res Commun Mol Pathol Pharmacol 106:77-85. 1999
    ..These findings suggest that an augmentation of ACh-induced Ca2+ sensitization may occur in bronchial smooth muscle of the rats with antigen-induced AHR...
  65. ncbi request reprint Effects of calmodulin antagonist (W-7) on phorbol ester (PMA)-induced contractile response in isolated rat aorta
    H Suenaga
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 37:1-7. 2001
    ..Higher concentration of W-7 strongly inhibited PMA-induced sustained contraction. These results suggest that PMA-induced biphasic contractile response may be regulated by calmodulin...
  66. ncbi request reprint Diabetes-related changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 287:H1064-71. 2004
    ..Possibly, the decreased PKA activity may result from an imbalance between PKA catalytic and regulatory subunit expressions...
  67. ncbi request reprint Diabetes-related changes in contractile responses of stomach fundus to endothelin-1 in streptozotocin-induced diabetic rats
    Kazuki Endo
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 41:35-47. 2005
    ..These results suggest that the diabetes-related enhancement of the ET-1-induced contraction of the stomach fundus may be due to an increase in the ET(B) receptor population...
  68. doi request reprint Synthesis and structure-activity relationships of cassiarin A as potential antimalarials with vasorelaxant activity
    Hiroshi Morita
    Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo 142 8501, Japan
    Bioorg Med Chem 17:8234-40. 2009
    ..falciparum in vitro. These cassiarin derivatives may be promising candidates as antimalarials with different mode of actions...
  69. pmc Relationship between peroxisome proliferator-activated receptors (PPAR alpha and PPAR gamma) and endothelium-dependent relaxation in streptozotocin-induced diabetic rats
    Noriyasu Kanie
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Br J Pharmacol 140:23-32. 2003
    ..6) These results suggest that downregulations of PPARalpha and PPARgamma may lead to an increased expression of ppET-1 mRNA in diabetic states and this increment may trigger endothelial dysfunction...
  70. doi request reprint Short-term angiotensin-1 receptor antagonism in type 2 diabetic Goto-Kakizaki rats normalizes endothelin-1-induced mesenteric artery contraction
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, 4 41 Ebara 2 chome, Shinagawa ku, Tokyo 142 8501, Japan
    Peptides 31:609-17. 2010
    ..Our data suggest that within the timescale studied here, losartan normalizes ET-1-induced mesenteric artery contraction through a suppression of ERK activities and/or by normalizing endothelial function...
  71. doi request reprint Gender differences in age-related endothelial function in the murine aorta
    Yasuhiro Takenouchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Atherosclerosis 206:397-404. 2009
    ....
  72. pmc Enhancement of mesenteric artery contraction to 5-HT depends on Rho kinase and Src kinase pathways in the ob/ob mouse model of type 2 diabetes
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Br J Pharmacol 160:1092-104. 2010
    ..We have assessed responses to 5-HT shown by mesenteric arteries from type 2 diabetic ob/ob mice (27-32 weeks old) and have identified the molecular mechanisms involved...
  73. ncbi request reprint Relationships among ET-1, PPARgamma, oxidative stress and endothelial dysfunction in diabetic animals
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 44:41-55. 2008
    ..In the present review, we discuss the beneficial effects of PPARgamma agonists on vasomotor activities, focusing in particular on endothelium-dependent relaxation in vessels affected by cardiovascular diseases...
  74. ncbi request reprint The PI3-K/Akt pathway: roles related to alterations in vasomotor responses in diabetic models
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 41:283-302. 2005
    ..This article summarizes the PI3-K/Akt pathway-mediated contraction and relaxation responses induced by various agents in the blood vessels of diabetic animals...
  75. doi request reprint Eicosapentaenoic acid improves imbalance between vasodilator and vasoconstrictor actions of endothelium-derived factors in mesenteric arteries from rats at chronic stage of type 2 diabetes
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Pharmacol Exp Ther 329:324-34. 2009
    ..We propose that EPA ameliorates endothelial dysfunction in OLETF rats by correcting the imbalance between endothelium-derived factors, at least partly, by inhibiting ERK, decreasing NF-kappaB activation, and reducing COX-2 expression...
  76. pmc Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
    H Abe
    Second Department of Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 101:1784-8. 1998
    ..Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance...
  77. ncbi request reprint Pyrrolidine dithiocarbamate reduces vascular prostanoid-induced responses in aged type 2 diabetic rat model
    Takayuki Matsumoto
    Department of Physiology, Institute of Medicinal Chemistry, Hoshi University, Japan
    J Pharmacol Sci 110:326-33. 2009
    ..These results suggest that PDTC has beneficial effects against the abnormal vasoconstrictor prostanoid signaling present in rats at the chronic stage of type 2 diabetes...
  78. ncbi request reprint Effect of chronic insulin on cromakalim-induced relaxation in established streptozotocin-diabetic rat basilar artery
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Eur J Pharmacol 504:129-37. 2004
    ....
  79. ncbi request reprint Lysophosphatidylcholine activates extracellular-signal-regulated protein kinase and potentiates vascular contractile responses in rat aorta
    Hiroshi Suenaga
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Japan
    J Pharmacol Sci 92:348-58. 2003
    ..These results suggest that the LPC-induced augmentation of contractile responses in the rat aorta is due to activation of ERK, which in turn regulates Ca(2+) influx...
  80. ncbi request reprint Relationship between radical intensity and biological activity of cacao husk extracts
    N Motohashi
    Meiji Pharmaceutical University, Tokyo, Japan
    Anticancer Res 19:1125-9. 1999
    ..However, their cytotoxic activity against human leukemic and carcinoma cell lines is not always correlated with their radical intensity. Water-soluble and lipophilic compounds might induce cytotoxic activity by different mechanisms...
  81. doi request reprint Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice
    Kumiko Taguchi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 301:H571-83. 2011
    ....
  82. ncbi request reprint Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats
    Kaoruko Tada Iida
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Am J Physiol Endocrinol Metab 284:E1125-30. 2003
    ..It is also suggested that the thiazolidinediones and metformin improve vascular function in diabetes. These effects may play a role in the prevention of atherosclerosis in diabetic patients...
  83. ncbi request reprint Effects of dual-action genistein derivatives on relaxation in rat aorta
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan
    J Smooth Muscle Res 41:23-33. 2005
    ..These results suggest that each of our newly developed G-II and G-VI compounds has a dual action, as an NO donor and a tyrosine kinase inhibitor. These compounds may be useful against certain cardiovascular diseases...
  84. ncbi request reprint Pathophysiological role of 20-HETE a cytochrome P450 metabolite of arachidonic acid
    Katsuo Kamata
    J Pharmacol Sci 97:303-4. 2005
  85. ncbi request reprint Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury
    Tetsuya Kubota
    Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital 2 17 6 Ohashi, Meguro ku, Tokyo 153 8515, Japan
    Circulation 107:3073-80. 2003
    ..It has been reported that insulin receptor substrate (IRS)-1 deficient (IRS-1-/-) mice showed insulin resistance without type 2 diabetes, whereas the IRS-2 deficient (IRS-2-/-) mice showed insulin resistance with type 2 diabetes...
  86. ncbi request reprint [A therapeutic target for microvascular complications in diabetes]
    Takayuki Matsumoto
    Nihon Yakurigaku Zasshi 131:78-84. 2008
  87. ncbi request reprint Phosphodiesterases in the vascular system
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Smooth Muscle Res 39:67-86. 2003
    ..The development of novel methods to deliver more potent and selective PDE inhibitors to individual cell types and subcellular locations will lead to new therapeutic uses for this class of drugs in diseases of the vascular system...
  88. ncbi request reprint Role of lysophosphatidylcholine (LPC) in atherosclerosis
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Curr Med Chem 14:3209-20. 2007
    ..In this review, we focus in some detail on the entirety of the signal-transduction system for LPC, its pathophysiological implications, and the vascular abnormalities associated with it...
  89. ncbi request reprint Adiponectin gene therapy of streptozotocin-induced diabetic mice using hydrodynamic injection
    Masayoshi Fukushima
    Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    J Gene Med 9:976-85. 2007
    ..However, successful delivery of Adipo to the receptors is difficult due to their peptide characteristics. Receptors for Adipo are abundantly expressed in the liver and skeletal muscle...
  90. ncbi request reprint Mechanism underlying gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, 1796 Yaho, Kunitachi shi, Tokyo 186 8650, Japan
    Eur J Pharmacol 438:107-13. 2002
    ..These results suggest that, in spontaneously hypertensive rats, GABA has an antihypertensive effect due to its inhibition of noradrenaline release from sympathetic nerves in the mesenteric arterial bed via presynaptic GABA(B) receptors...