Hiroyuki Tsutsui

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. pmc Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Clin Biochem Nutr 48:68-71. 2011
  2. ncbi request reprint Oxidative stress and mitochondrial DNA damage in heart failure
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 72:A31-7. 2008
  3. doi request reprint Mitochondrial oxidative stress and dysfunction in myocardial remodelling
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Cardiovasc Res 81:449-56. 2009
  4. ncbi request reprint Clinical characteristics and outcome of hospitalized patients with heart failure in Japan
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 70:1617-23. 2006
  5. ncbi request reprint Novel pathophysiological insight and treatment strategies for heart failure--lessons from mice and patients--
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
    Circ J 68:1095-103. 2004
  6. doi request reprint Clinical characteristics and outcomes of heart failure with preserved ejection fraction: lessons from epidemiological studies
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Cardiol 55:13-22. 2010
  7. ncbi request reprint Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertens Res 30:439-49. 2007
  8. ncbi request reprint Characteristics and outcomes of patients with heart failure in general practices and hospitals
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Circ J 71:449-54. 2007
  9. doi request reprint Oxidative stress and heart failure
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 301:H2181-90. 2011
  10. ncbi request reprint Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload
    Hidenori Matsusaka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertension 47:711-7. 2006

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. pmc Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Clin Biochem Nutr 48:68-71. 2011
    ..Based on the findings in animal models, this review discusses the role of oxidative stress that may be involved in the development and progression of cardiac and skeletal dysfunction associated with diabetes...
  2. ncbi request reprint Oxidative stress and mitochondrial DNA damage in heart failure
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 72:A31-7. 2008
    ..Inhibition of oxidative stress and mtDNA damage could be novel and potentially effective treatment strategies for heart failure...
  3. doi request reprint Mitochondrial oxidative stress and dysfunction in myocardial remodelling
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Cardiovasc Res 81:449-56. 2009
    ..Inhibition of oxidative stress and mtDNA damage could be novel and effective treatment strategies for heart failure...
  4. ncbi request reprint Clinical characteristics and outcome of hospitalized patients with heart failure in Japan
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 70:1617-23. 2006
    ..Very little information is available on this issue in Japan...
  5. ncbi request reprint Novel pathophysiological insight and treatment strategies for heart failure--lessons from mice and patients--
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
    Circ J 68:1095-103. 2004
    ..These basic and clinical approaches are needed to establish new and effective treatment strategies for Japanese patients with HF...
  6. doi request reprint Clinical characteristics and outcomes of heart failure with preserved ejection fraction: lessons from epidemiological studies
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Cardiol 55:13-22. 2010
    ....
  7. ncbi request reprint Angiotensin II type 1 receptor blocker attenuates myocardial remodeling and preserves diastolic function in diabetic heart
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertens Res 30:439-49. 2007
    ..Moreover, candesartan directly inhibited Ang II-mediated induction of CTGF in cultured cardiac fibroblasts. ARB might be beneficial to prevent cardiac abnormalities in DM...
  8. ncbi request reprint Characteristics and outcomes of patients with heart failure in general practices and hospitals
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Circ J 71:449-54. 2007
    ..However, very little information is available on this issue in general practice in Japan...
  9. doi request reprint Oxidative stress and heart failure
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 301:H2181-90. 2011
    ..A better understanding of these mechanisms may enable the development of novel and effective therapeutic strategies against HF...
  10. ncbi request reprint Targeted deletion of matrix metalloproteinase 2 ameliorates myocardial remodeling in mice with chronic pressure overload
    Hidenori Matsusaka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertension 47:711-7. 2006
    ..2+/-1.0%; P<0.01) than WT+TAC mice. MMP 2 plays an important role in PO-induced LV hypertrophy and dysfunction. The inhibition of MMP 2 activation may, therefore, be a useful therapeutic strategy to manage hypertensive heart disease...
  11. ncbi request reprint Mitochondrial oxidative stress, DNA damage, and heart failure
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Antioxid Redox Signal 8:1737-44. 2006
    ..Inhibition of mitochondrial oxidative stress and mtDNA damage could be novel and potentially very effective treatment strategies for heart failure...
  12. ncbi request reprint Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction
    Tetsuya Shiomi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 106:3126-32. 2002
    ..Because proinflammatory cytokines play a critical role in left ventricular (LV) remodeling after myocardial infarction (MI), we examined the effects of pioglitazone treatment in an experimental model of chronic heart failure...
  13. ncbi request reprint Anti-monocyte chemoattractant protein-1 gene therapy attenuates left ventricular remodeling and failure after experimental myocardial infarction
    Shunji Hayashidani
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Circulation 108:2134-40. 2003
    ..We thus determined whether MCP-1 is increased in post-myocardial infarction (MI) hearts and its blockade can attenuate the development of left ventricular (LV) remodeling and failure...
  14. ncbi request reprint Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice
    Tetsuya Shiomi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 109:544-9. 2004
    ..We determined whether the overexpression of glutathione peroxidase (GSHPx) could attenuate left ventricular (LV) remodeling and failure after myocardial infarction (MI)...
  15. ncbi request reprint Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis
    Yoh Takekuma
    Laboratory of Pharmcotherapeutic Information, Department of Biopharmaceutical Sciences and Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 jo, Nishi 6 chome, Kita ku, Sapporo 060 0812, Japan
    Biol Pharm Bull 30:537-42. 2007
    ..It was estimated that UGT2B7*3 decreased the clearance of carvedilol by 37%, but UGT2B7*2 did not show any effect. Clearance in the patients who have intermediate activity of CYP2D6 was decreased by 39%...
  16. ncbi request reprint Disruption of inducible nitric oxide synthase improves beta-adrenergic inotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy
    Hajime Funakoshi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circ Res 90:959-65. 2002
    ....
  17. ncbi request reprint Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction
    Takaki Tsutsumi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cardiovasc Res 77:713-21. 2008
    ..Since vagal nerve stimulation (VNS) is known to improve survival and attenuate cardiac remodelling, we hypothesized that VNS may modulate the myocardial redox state...
  18. doi request reprint Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes
    Shouji Matsushima
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 297:H409-16. 2009
    ..Type 2 diabetes was associated with the exacerbation of LV failure after MI via increasing NAD(P)H oxidase-derived O(2)(-), which may be a novel important therapeutic target in advanced heart failure with diabetes...
  19. ncbi request reprint Overexpression of mitochondrial transcription factor a ameliorates mitochondrial deficiencies and cardiac failure after myocardial infarction
    Masaki Ikeuchi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 112:683-90. 2005
    ..Myocardial mtDNA copy number and TFAM expression both decreased in cardiac failure. However, the functional significance of TFAM has not been established in this disease state...
  20. doi request reprint Myocardial beta-adrenergic receptor density assessed by 11C-CGP12177 PET predicts improvement of cardiac function after carvedilol treatment in patients with idiopathic dilated cardiomyopathy
    Masanao Naya
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Nucl Med 50:220-5. 2009
    ....
  21. doi request reprint Time-dependent changes of myocardial and systemic oxidative stress are dissociated after myocardial infarction
    Takahiro Inoue
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Free Radic Res 43:37-46. 2009
    ....
  22. ncbi request reprint Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling after experimental myocardial infarction
    Shunji Hayashidani
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 285:H1229-35. 2003
    ..The inhibition of MMP-2 activation may therefore be a potentially useful therapeutic strategy to manage post-MI hearts...
  23. ncbi request reprint Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy
    Hidenori Matsusaka
    Dept of Cardiovascular Medicine, Kyushu Imoversotu Graduate School of Medical Sciences, Fukuoka, Japan
    Am J Physiol Heart Circ Physiol 289:H1858-64. 2005
    ..MMP-2 may play a cardioprotective role in the pathogenesis of cytokine-induced cardiomyopathy...
  24. ncbi request reprint Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart
    Shouji Matsushima
    Dept of Cardiovascular Medicine, Hokkaido Univ Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Am J Physiol Heart Circ Physiol 291:H2237-45. 2006
    ..Overexpression of GSHPx gene ameliorated LV remodeling and diastolic dysfunction in DM. Therapies designed to interfere with oxidative stress might be beneficial to prevent cardiac abnormalities in DM...
  25. ncbi request reprint Olmesartan, but not amlodipine, improves endothelium-dependent coronary dilation in hypertensive patients
    Masanao Naya
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Am Coll Cardiol 50:1144-9. 2007
    ..We aimed to compare the effects of the angiotensin II receptor blocker (ARB) olmesartan versus the calcium channel blocker (CCB) amlodipine on coronary endothelial dysfunction in patients with hypertension...
  26. doi request reprint Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
    Yoshinori Hayashi
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 28:8624-34. 2008
    ..Together, an overexpression of TFAM is therefore considered to ameliorate age-dependent impairment of the brain functions through the prevention of oxidative stress and mitochondrial dysfunctions in microglia...
  27. ncbi request reprint Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice
    Hidenori Matsusaka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cardiovasc Res 70:457-65. 2006
    ..p53 is a well-known proapoptotic factor. However, its pathophysiological significance in these conditions remains unclear. We thus examined the effects of target deletion of the p53 gene on post-MI hearts...
  28. doi request reprint Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice
    Tadashi Suga
    Departments of Cardiovascular Medicine T S, S K, S Tak, T K, A F, T H, Y M, T F, M T, M A S, T O, K H, T Y, H T and Cancer Pathology S Tan, Hokkaido University Graduate School of Medicine, Hokkaido 060 8638, Japan Faculty of Sport and Health Science T S, Ritsumeikan University, Kusatsu, Shiga 525 8577, Japan Research Fellow of the Japan Society for the Promotion of Science S Tak and Graduate School of Program in Lifelong Learning Studies K O, Hokusho University, Hokkaido 069 8511, Japan
    Endocrinology 155:68-80. 2014
    ..In conclusion, a comprehensive lifestyle therapy of exercise and diet normalizes the limited exercise capacity and impaired muscle function in diabetes mellitus. ..
  29. doi request reprint Conduction and refractory disorders in the diabetic atrium
    Masaya Watanabe
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 303:H86-95. 2012
    ....
  30. ncbi request reprint Elevated plasma plasminogen activator inhibitor type-1 is an independent predictor of coronary microvascular dysfunction in hypertension
    Masanao Naya
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 71:348-53. 2007
    ..Thus, in the present study it was investigated whether elevated plasma PAI-1 activity is associated with coronary microvascular dysfunction in hypertensive patients...
  31. ncbi request reprint Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction
    Hidenori Matsusaka
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Cardiovasc Pharmacol 48:95-102. 2006
    ..Post-MI LV remodeling and failure in diabetes were ameliorated by ARB, providing further evidence that angiotensin II plays a pivotal role in the exacerbated heart failure after diabetic MI...
  32. ncbi request reprint Soluble TNF receptors prevent apoptosis in infiltrating cells and promote ventricular rupture and remodeling after myocardial infarction
    Yoshiya Monden
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cardiovasc Res 73:794-805. 2007
    ..The present study aimed to evaluate the effects of soluble TNF receptor treatment on myocardial infarction (MI)...
  33. ncbi request reprint Plasma interleukin-6 and tumor necrosis factor-alpha can predict coronary endothelial dysfunction in hypertensive patients
    Masanao Naya
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hypertens Res 30:541-8. 2007
    ....
  34. ncbi request reprint Blockade of NF-kappaB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II
    Shunichi Kawano
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cardiovasc Res 67:689-98. 2005
    ..In the present study, we assessed the hypothesis that blockade of NF-kappaB may ameliorate ventricular hypertrophy in response to chronic infusion of angiotensin II...
  35. ncbi request reprint Streptozotocin-induced hyperglycemia exacerbates left ventricular remodeling and failure after experimental myocardial infarction
    Tetsuya Shiomi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582 Fukuoka, Japan
    J Am Coll Cardiol 42:165-72. 2003
    ..The aim of the present study was to determine whether streptozotocin (STZ)-induced hyperglycemia exacerbates progressive left ventricular (LV) dilation and dysfunction after myocardial infarction (MI)...
  36. ncbi request reprint Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice
    Tsuyoshi Hattori
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Circulation 109:2234-9. 2004
    ..Because proinflammatory cytokines play a critical role in left ventricular (LV) remodeling after myocardial infarction (MI), we examined whether long-term blockade of Rho-kinase suppresses LV remodeling in a mouse model of MI in vivo...
  37. doi request reprint Effects of surgical ventricular reconstruction and mitral complex reconstruction on cardiac oxidative metabolism and efficiency in nonischemic and ischemic dilated cardiomyopathy
    Takashi Sugiki
    Department of Cardiovascular Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    JACC Cardiovasc Imaging 4:762-70. 2011
    ..The aim of this study was to investigate the effects of surgical ventricular reconstruction (SVR) on cardiac efficiency as a surrogate marker for cardiac function and oxidative metabolism in patients with severe heart failure...
  38. doi request reprint Quantification of regional myocardial blood flow estimation with three-dimensional dynamic rubidium-82 PET and modified spillover correction model
    Chietsugu Katoh
    Department of Health Sciences, Hokkaido University Graduate School of Medicine, Kita12 Nishi5, Kita ku, Sapporo, Hokkaido 060 0812, Japan
    J Nucl Cardiol 19:763-74. 2012
    ..We sought to develop a new algorithm to reduce the spillover in image-derived blood activity curves, using non-uniform weighted least-squares fitting...
  39. ncbi request reprint Predictors of long-term adverse outcomes in elderly patients over 80 years hospitalized with heart failure. - A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)-
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 75:2403-10. 2011
    ..The predictors of these adverse outcomes were also identified...
  40. ncbi request reprint Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction
    Shunji Hayashidani
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 105:868-73. 2002
    ..However, the effects of long-term administration of statins on left ventricular (LV) remodeling and failure after myocardial infarction remain unknown...
  41. ncbi request reprint Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy
    Takahiro Tsukamoto
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Nucl Med 48:1777-82. 2007
    ....
  42. ncbi request reprint Anemia is an independent predictor of long-term adverse outcomes in patients hospitalized with heart failure in Japan. A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 73:1901-8. 2009
    ..The impact of anemia on long-term outcomes including mortality and rehospitalization among patients hospitalized with HF was thus assessed...
  43. doi request reprint Characteristics, management, and outcomes for patients during hospitalization due to worsening heart failure-A report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Cardiol 62:95-101. 2013
    ..We thus clarified the characteristics and clinical status as well as in-hospital management and outcomes among patients hospitalized with worsening HF in Japan and compared them with those reported in previous studies...
  44. doi request reprint Angiotensin II-induced reduction in exercise capacity is associated with increased oxidative stress in skeletal muscle
    Naoki Inoue
    Departments of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 302:H1202-10. 2012
    ..ANG II-induced oxidative stress can impair mitochondrial respiration in skeletal muscle and limit exercise capacity...
  45. ncbi request reprint Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction
    Masaki Ikeuchi
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi, Fukuoka 812 8582, Japan
    Cardiovasc Res 64:526-35. 2004
    ..However, its pathophysiological significance remains obscure in post-MI hearts...
  46. doi request reprint Discharge use of angiotensin receptor blockers provides comparable effects with angiotensin-converting enzyme inhibitors on outcomes in patients hospitalized for heart failure
    Miyuki Tsuchihashi-Makaya
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Hypertens Res 33:197-202. 2010
    ..These findings provide further support for guideline recommendations that ARBs can be used in patients with HF and LVSD as an alternative of ACE inhibitors...
  47. ncbi request reprint Oxidative stress mediates tumor necrosis factor-alpha-induced mitochondrial DNA damage and dysfunction in cardiac myocytes
    Nobuhiro Suematsu
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 107:1418-23. 2003
    ..We thus investigated whether the direct exposure of cardiac myocytes to TNF-alpha and Ang II in vitro could induce mtDNA damage via production of ROS...
  48. ncbi request reprint Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction
    Yoshiya Monden
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 293:H743-53. 2007
    ..TNF-alpha is toxic via R1 and protective via R2 in a murine model of MI. Selective blockade of R1 may be a candidate therapeutic intervention for MI...
  49. doi request reprint Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction
    Yutaka Matsui
    Department of Matrix Medicine, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Circ Res 108:1328-39. 2011
    ..Syndecan-4 (Syn4), a cell-surface heparan sulfate proteoglycan, has been detected in the infarct region after myocardial infarction (MI), but its functional significance has not been elucidated...
  50. doi request reprint Impact of statins on modulation by insulin of expression of plasminogen activator inhibitor type-1
    Yuki Sato
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Coron Artery Dis 19:355-61. 2008
    ..This study was designed to determine whether insulin stimulation of PAI-1 expression is attenuated by statins, and if so to explore mechanisms that are responsible for the attenuation...
  51. doi request reprint Oxidative stress impairs insulin signal in skeletal muscle and causes insulin resistance in postinfarct heart failure
    Yukihiro Ohta
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Physiol Heart Circ Physiol 300:H1637-44. 2011
    ..Insulin resistance was induced by the direct impairment of insulin signaling in the skeletal muscle from postinfarct heart failure, which was associated with the enhanced oxidative stress via NAD(P)H oxidase...
  52. ncbi request reprint Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice
    Shouji Matsushima
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 113:1779-86. 2006
    ..We hypothesized that overexpression of the mitochondrial antioxidant, peroxiredoxin-3 (Prx-3), could attenuate this deleterious process...
  53. ncbi request reprint Blockade of NF-kappaB improves cardiac function and survival after myocardial infarction
    Shunichi Kawano
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 291:H1337-44. 2006
    ..Blockade of NF-kappaB might be a new therapeutic strategy to attenuate cardiac remodeling and failure after MI...
  54. doi request reprint Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice
    Shingo Takada
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Appl Physiol (1985) 114:844-57. 2013
    ..These data may have a clinical impact on exercise capacity in the medical treatment of diabetes mellitus...
  55. doi request reprint Interrelation between myocardial oxidative metabolism and diastolic function in patients undergoing surgical ventricular reconstruction
    Satoru Chiba
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo, 060 8638, Japan
    Eur J Nucl Med Mol Imaging 40:349-55. 2013
    ..We hypothesized that cardiac oxidative metabolism and diastolic dysfunction might improve in parallel to the reduction of left ventricular chamber size after SVR...
  56. doi request reprint Decreased glomerular filtration rate is a significant and independent risk for in-hospital mortality in Japanese patients with acute myocardial infarction: report from the Hokkaido acute myocardial infarction registry
    Hiroki Satoh
    Department of Clinical Management and Bioinformatics, Hokkaido Information University, 59 2 Nishi Nopporo, Ebetsu, Hokkaido, Japan
    Hypertens Res 35:463-9. 2012
    ..47 (95% CI: 1.51-19.80) for eGFR 15-29 ml min(-1) per 1.73 m(2). In conclusion, the eGFR of <30 ml min(-1) per 1.73 m(2) was a significant and independent risk for in-hospital mortality in abroad cohort of Japanese patients with AMI...
  57. ncbi request reprint Mode of death in patients with heart failure and reduced vs. preserved ejection fraction: report from the registry of hospitalized heart failure patients
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 76:1662-9. 2012
    ..preserved ejection fraction (HFPEF). The aim of the present study was therefore to carry out this comparison...
  58. doi request reprint Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinal myocardial relaxation
    Kazunori Okada
    Division of Health Sciences, Hokkaido University Graduate School of Health Sciences, Kita 12, Nishi 5, Kita ku, Sapporo 060 0812, Japan
    Eur J Echocardiogr 12:917-23. 2011
    ....
  59. doi request reprint Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice
    Takashi Yokota
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Am J Physiol Heart Circ Physiol 297:H1069-77. 2009
    ..Therapies designed to regulate oxidative stress and maintain mitochondrial function could be beneficial to improve the exercise capacity in type 2 diabetes...
  60. ncbi request reprint Beta-blocker use at discharge in patients hospitalized for heart failure is associated with improved survival
    Miyuki Tsuchihashi-Makaya
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 74:1364-71. 2010
    ..We thus examined the long-term effects of beta-blocker use at discharge on outcomes in patients hospitalized for HF and left ventricular systolic dysfunction (LVSD) (ejection fraction <40%)...
  61. doi request reprint Pravastatin attenuates left ventricular remodeling and diastolic dysfunction in angiotensin II-induced hypertensive mice
    Zhujie Xu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Cardiovasc Pharmacol 51:62-70. 2008
    ..However, the exact mechanisms of statins possibly explaining the decreased cardiovascular morbidity and mortality in patients with DHF have not been elucidated...
  62. ncbi request reprint Body mass index is an independent predictor of long-term outcomes in patients hospitalized with heart failure in Japan
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 74:2605-11. 2010
    ..However, in heart failure (HF), elevated body mass index (BMI) has been shown to be associated with better prognosis, but it is unknown whether this is the case in unselected HF patients encountered in routine clinical practice in Japan...
  63. doi request reprint Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice
    Kazue Ohmura
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Arterioscler Thromb Vasc Biol 30:193-9. 2010
    ..Natural killer T (NKT) cells, which integrate proinflammatory cytokines, have been demonstrated in the atherosclerotic lesions and in visceral adipose tissue...
  64. ncbi request reprint Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients
    Naotsugu Oyama
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 70:362-3. 2006
    ..There are few biological markers, which strictly show the severity of congestive heart failure (CHF)...
  65. pmc Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with metabolic syndrome
    Takashi Yokota
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Diabetes Care 36:1341-6. 2013
    ..Systemic oxidative stress is associated with insulin resistance and obesity. We tested the hypothesis that systemic oxidative stress is linked to lower aerobic capacity and skeletal muscle dysfunction in metabolic syndrome (MetS)...
  66. ncbi request reprint Loop diuretic use at discharge is associated with adverse outcomes in hospitalized patients with heart failure: a report from the Japanese cardiac registry of heart failure in cardiology (JCARE-CARD)
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 76:1920-7. 2012
    ..We thus determined the effects of loop diuretic use at discharge on long-term mortality and rehospitalization among patients hospitalized with HF...
  67. doi request reprint Blood flow restriction exercise in sprinters and endurance runners
    Shingo Takada
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
    Med Sci Sports Exerc 44:413-9. 2012
    ..We investigated intramuscular metabolic responses during low-intensity resistance exercise with BFR between two different types of track athletes...
  68. doi request reprint Hyperuricemia predicts adverse outcomes in patients with heart failure
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Int J Cardiol 151:143-7. 2011
    ..We thus assessed the impact of hyperuricemia on long-term outcomes including mortality and rehospitalization among patients hospitalized with worsening HF...
  69. ncbi request reprint Risk factors and the incidence of coronary artery disease in young middle-aged Japanese men: results from a 10-year cohort study
    Hiroki Satoh
    Department of Cardiovasucular Medicine, Hokkaido University Graduate School of Medicine, Nishi, Sapporo
    Intern Med 45:235-9. 2006
    ..The objective of this study was to elucidate the relationship between risk factors and the coronary artery disease (CAD) in young middle-aged Japanese men...
  70. ncbi request reprint Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium
    Yoji Machida
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 284:H449-55. 2003
    ..Damaged myocytes, but not infiltrating inflammatory cells, may be the source of ROS in TG...
  71. ncbi request reprint Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy
    Natsumi Kawamura
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Higashi ku, Fukuoka, Japan
    Cardiovasc Res 66:520-9. 2005
    ..In the present study, we assessed the hypothesis that cardiotoxic effects of proinflammatory cytokines are mediated by the activation of NF-kappaB...
  72. doi request reprint Dose effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction
    Tadashi Suga
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Appl Physiol (1985) 108:1563-7. 2010
    ..Intramuscular metabolic stress during BFR exercise might be susceptible to increasing exercise intensity. To replace high-intensity resistance exercise, the BFR protocol might require an intensity of >or=30% 1 RM...
  73. ncbi request reprint Mitochondrial oxidative stress and heart failure
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 45:809-13. 2006
    ..Inhibition of mitochondrial oxidative stress and DNA damage could be the most effective and novel treatment strategies for heart failure...
  74. doi request reprint Long-term smoking causes more advanced coronary endothelial dysfunction in middle-aged smokers compared to young smokers
    Masanao Naya
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Eur J Nucl Med Mol Imaging 38:491-8. 2011
    ..Therefore, we compared the effects of smoking cessation on coronary vasomotor response between both young and middle-aged smokers and identified the predictor for its improvement...
  75. doi request reprint Lower aerobic capacity was associated with abnormal intramuscular energetics in patients with metabolic syndrome
    Takashi Yokota
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Hypertens Res 34:1029-34. 2011
    ..64). These results suggested that lean-body aerobic capacity in MetS patients was lower compared with activity-matched healthy subjects, which might be due to the reduced intramuscular fatty acid oxidative metabolism...
  76. doi request reprint Effects of oral single-dose administration of sarpogrelate hydrochloride on saturation O(2) of calf muscle during plantar flexion exercise
    Masahiro Horiuchi
    Department of Human Care Studies, Hokkaido University of Education, Sapporo, Japan
    Adv Exp Med Biol 662:531-6. 2010
    ..These results indicated that an oral single-dose administration of SH might improve peripheral circulation independent of any changes in BP and HR...
  77. ncbi request reprint Induction of c-fos mRNA expression by pure pressure overload in cultured cardiac myocytes
    Hidetsugu Sakai
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Hokkaido
    Int Heart J 48:359-67. 2007
    ..Pressures greater than 80 mmHg enhanced c-fos mRNA after 30 minutes. These results suggest that pure atmospheric pressure overload can also induce early hypertrophic responses in cardiac myocytes...
  78. ncbi request reprint Volume-outcome relation for hospitals performing angioplasty for acute myocardial infarction: results from the Nationwide Japanese Registry
    Miyuki Tsuchihashi
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ J 68:887-91. 2004
    ..An inverse relation exists between the number of PCIs and short-term outcome, but PCI practice has been changing with the availability of new devices such as stents...
  79. ncbi request reprint Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan. Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 73:1442-7. 2009
    ....
  80. ncbi request reprint Angiotensin II receptor blocker, valsartan, increases myocardial blood volume and regresses hypertrophy in hypertensive patients
    Hiroshi Komatsu
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circ J 73:2098-103. 2009
    ....
  81. ncbi request reprint Effects of atrial fibrillation on long-term outcomes in patients hospitalized for heart failure in Japan: a report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)
    Sanae Hamaguchi
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine
    Circ J 73:2084-90. 2009
    ..The effect of AF on long-term outcomes, including mortality and rehospitalization, among unselected HF patients hospitalized with HF in routine clinical practice in Japan was assessed in the present study...
  82. ncbi request reprint Probucol attenuates left ventricular dysfunction and remodeling in tachycardia-induced heart failure: roles of oxidative stress and inflammation
    Ryo Nakamura
    Department of Cardiovascular Medicine, School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circulation 106:362-7. 2002
    ....
  83. ncbi request reprint Smoking cessation normalizes coronary endothelial vasomotor response assessed with 15O-water and PET in healthy young smokers
    Koichi Morita
    Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Nucl Med 47:1914-20. 2006
    ..Therefore, the aim of this study was to assess the effect of smoking cessation on coronary vasomotor response by quantitative myocardial blood flow (MBF) measurement using (15)O-water and PET...
  84. ncbi request reprint Coronary revascularization in Japan. Part 4: coronary artery bypass surgery during 1997
    Hideaki Shigematsu
    Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ J 66:20-9. 2002
    ..8%. In Japan, CABG was performed in patients with multivessel coronary artery disease with extensive risk factors. Angiographically determined success was achieved in 93% and the need for subsequent revascularization was relatively low...
  85. ncbi request reprint Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha
    Hajime Funakoshi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan 812 8582
    Am J Physiol Heart Circ Physiol 282:H2159-66. 2002
    ..These results indicate that induction of iNOS may play an important role in the pathogenesis of cardiac dysfunction in this mouse model of cytokine-induced cardiomyopathy...
  86. ncbi request reprint [Role of oxidative stress in heart failure]
    Hiroyuki Tsutsui
    Department of Cardiovascular Medicine, Kyushu University
    Nihon Rinsho 61:756-60. 2003
    ..These cellular events might play an important role in the development and progression of myocardial remodeling and failure...
  87. pmc The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Clin Invest 118:2219-29. 2008
    ....
  88. ncbi request reprint Post-beta-receptor impairment in the regulation of myofibrillar Ca2+ sensitivity in tachypacing-induced canine failing heart
    Shinji Satoh
    Department of Bioclimatology and Medicine, Medical Institute of Bioregulation, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Cardiovasc Pharmacol 39:88-97. 2002
    ..These results suggest that abnormalities of the beta-adrenergic signaling system exist not only at the receptor level but also at downstream steps after cAMP production...
  89. ncbi request reprint Contribution of polymorphisms in UDP-glucuronosyltransferase and CYP2D6 to the individual variation in disposition of carvedilol
    Yoh Takekuma
    Department of Clinical Pharmaceutics and Therapeutics, Graduate School of Pharmaceutical Science, Hokkaido University, Sapporo, Japan
    J Pharm Pharm Sci 9:101-12. 2006
    ....
  90. doi request reprint Single-slice epicardial fat area measurement: do we need to measure the total epicardial fat volume?
    Noriko Oyama
    Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita ku, Sapporo, Japan
    Jpn J Radiol 29:104-9. 2011
    ..The aim of this study was to assess a method for measuring epicardial fat volume (EFV) by means of a single-slice area measurement. We investigated the relation between a single-slice fat area measurement and total EFV...
  91. ncbi request reprint Nonreentrant atrioventricular nodal tachycardia due to triple nodal pathways manifested by radiofrequency ablation at coronary sinus ostium
    Hisashi Yokoshiki
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Electrocardiol 39:395-9. 2006
    ....
  92. ncbi request reprint Novel SCN5A mutation (Q55X) associated with age-dependent expression of Brugada syndrome presenting as neurally mediated syncope
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Heart Rhythm 4:516-9. 2007
    ..Although mutations in SCN5A have been identified in Brugada syndrome, the genetic link between Brugada syndrome and neurally mediated syncope has not been determined...
  93. ncbi request reprint Congenital atrial standstill associated with coinheritance of a novel SCN5A mutation and connexin 40 polymorphisms
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Heart Rhythm 2:1128-34. 2005
    ..Incomplete penetrance observed in atrial standstill has been attributed in part to the digenic inheritance of polymorphisms in the atrial-specific gap junction connexin 40 (Cx40) in conjunction with an SCN5A mutation...
  94. ncbi request reprint Prevalence and clinical importance of spontaneous echo contrast within the carotid artery in patients with ischemic cerebrovascular disease
    Hisao Onozuka
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Ultrasound Med 26:169-77. 2007
    ..This study aimed to clarify the clinical importance of SEC in the carotid artery (CA) in patients with ischemic cerebrovascular disease (ICVD)...
  95. ncbi request reprint Genetic polymorphisms and arrhythmia susceptibility
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo 060 8638, Japan
    Circ J 71:A54-60. 2007
    ..This paper reviews the current understanding of the contribution of genetic polymorphisms to the pathophysiology of cardiac arrhythmias...
  96. doi request reprint Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization
    Masahiro Ikesue
    Department of Matrix Medicine, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo, 060 0815, Japan
    Arterioscler Thromb Vasc Biol 31:1066-74. 2011
    ..Syndecan-4 (Syn4) is a heparan sulfate proteoglycan and works as a coreceptor for various growth factors. We examined whether Syn4 could be involved in the development of neointimal formation in vivo...
  97. doi request reprint Pleomorphic ventricular tachycardia originating from Purkinje fiber network of left anterior fascicle
    Hisashi Yokoshiki
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    J Electrocardiol 43:452-8. 2010
    ..Delivery of radiofrequency current targeting the delayed potentials abolished all the VTs. Different exits from relatively large area of slow conduction in the left anterior fascicle might have produced the pleomorphic VTs...
  98. ncbi request reprint Fatty acids increase the circulating levels of oxidative stress factors in mice with diet-induced obesity via redox changes of albumin
    Mayumi Yamato
    Department REDOX Medicinal Science, Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    FEBS J 274:3855-63. 2007
    ..These results indicate that the increased plasma fatty acids in the high-fat diet group resulted in the activated redox cycling of the copper-albumin complex and excessive lipid peroxidation...
  99. doi request reprint Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice
    Masaaki Hokari
    Department of Neurosurgery and Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuropathology 30:401-7. 2010
    ..001). Our data strongly suggest that TFAM overexpression can reduce mitochondrial permeability transition and ameliorate delayed neuronal death in the hippocampus after transient forebrain ischemia...
  100. ncbi request reprint Absence of a trafficking defect in R1232W/T1620M, a double SCN5A mutant responsible for Brugada syndrome
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Circ J 72:1018-9. 2008
    ..Although R1232W polymorphism and T1620M mutation by themselves have little effect on Na-channel function, their combination has been reported to disrupt membrane trafficking, resulting in a non-functioning Na channel...
  101. doi request reprint 64-Slice MDCT imaging of endocardial cushion defect associated with other cardiac and extracardiac abnormalities
    Noriko Oyama
    Department of Radiology, Hokkaido University Hospital, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    J Cardiovasc Comput Tomogr 4:218-20. 2010
    ..This patient also had heterotaxy syndrome with polysplenia and azygos continuation. MDCT proved to be a good noninvasive imaging method for the evaluation of ECD associated with cardiac as well as extracardiac abnormalities...