Hirofumi Sawa

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. pmc The human polyoma JC virus agnoprotein acts as a viroporin
    Tadaki Suzuki
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan
    PLoS Pathog 6:e1000801. 2010
  2. pmc Population genetic analysis and sub-structuring of Theileria parva in the northern and eastern parts of Zambia
    Walter Muleya
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, n20, W10, Kita ku, Sapporo 001 0020, Japan
    Parasit Vectors 5:255. 2012
  3. pmc Evidence of Yersinia pestis DNA from fleas in an endemic plague area of Zambia
    Bernard M Hang'ombe
    School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
    BMC Res Notes 5:72. 2012
  4. ncbi request reprint [Recent research on the JC virus]
    Hirofumi Sawa
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Nishi 9, Kita 18, Kita ku, Sapporo, Japan
    Brain Nerve 59:101-8. 2007
  5. pmc Cysteine residues in the major capsid protein, Vp1, of the JC virus are important for protein stability and oligomer formation
    Shintaro Kobayashi
    Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Kita ku, Sapporo, Japan Global COE Program for Zoonosis Control, Hokkaido University, Sapporo, Japan
    PLoS ONE 8:e76668. 2013
  6. ncbi request reprint Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation
    Tadaki Suzuki
    Laboratory of Molecular and Cellular Pathology, School of Medicine, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sapporo, Japan
    J Biol Chem 280:24948-56. 2005
  7. ncbi request reprint DDX1 promotes proliferation of the JC virus through transactivation of its promoter
    Yuji Sunden
    Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo, Hokkaido, Japan
    Microbiol Immunol 51:339-47. 2007
  8. doi request reprint Role of JC virus agnoprotein in virion formation
    Tadaki Suzuki
    Division of Molecular Pathobiology, Hokkaido University, Research Center for Zoonosis Control, n20, W10, Kita ku, Sapporo, 001 0020, Japan
    Microbiol Immunol 56:639-46. 2012
  9. pmc Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling
    Yasuko Orba
    Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, n20, W10, Kita ku, Sapporo 001 0020, Japan
    J Biol Chem 285:1544-54. 2010
  10. ncbi request reprint Identification of DDX1 as a JC virus transcriptional control region-binding protein
    Yuji Sunden
    Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo, Hokkaido, Japan
    Microbiol Immunol 51:327-37. 2007

Collaborators

Detail Information

Publications57

  1. pmc The human polyoma JC virus agnoprotein acts as a viroporin
    Tadaki Suzuki
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan
    PLoS Pathog 6:e1000801. 2010
    ..The viroporin-like properties of agnoprotein result in increased membrane permeability and alterations in intracellular Ca(2+) homeostasis leading to membrane dysfunction and enhancement of virus release...
  2. pmc Population genetic analysis and sub-structuring of Theileria parva in the northern and eastern parts of Zambia
    Walter Muleya
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, n20, W10, Kita ku, Sapporo 001 0020, Japan
    Parasit Vectors 5:255. 2012
    ..It is a major constraint to the development of the livestock industry in some parts of eastern, central and southern Africa. In Zambia, theileriosis causes losses of up to 10,000 cattle annually...
  3. pmc Evidence of Yersinia pestis DNA from fleas in an endemic plague area of Zambia
    Bernard M Hang'ombe
    School of Veterinary Medicine, University of Zambia, Lusaka, Zambia
    BMC Res Notes 5:72. 2012
    ..abstract:..
  4. ncbi request reprint [Recent research on the JC virus]
    Hirofumi Sawa
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Nishi 9, Kita 18, Kita ku, Sapporo, Japan
    Brain Nerve 59:101-8. 2007
    ..Thus, siRNA directed against JCV encoding genes may provide a useful tool for suppression of JCV infection...
  5. pmc Cysteine residues in the major capsid protein, Vp1, of the JC virus are important for protein stability and oligomer formation
    Shintaro Kobayashi
    Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Kita ku, Sapporo, Japan Global COE Program for Zoonosis Control, Hokkaido University, Sapporo, Japan
    PLoS ONE 8:e76668. 2013
    ..These findings suggest that C80 of JCV Vp1 is required for Vp1 stability and pentamer formation, and C247 is involved in capsid assembly in the nucleus. ..
  6. ncbi request reprint Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation
    Tadaki Suzuki
    Laboratory of Molecular and Cellular Pathology, School of Medicine, Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sapporo, Japan
    J Biol Chem 280:24948-56. 2005
    ..These results suggest that FEZ1 promotes neurite extension through its interaction with microtubules, and that agnoprotein facilitates JCV propagation by inducing the dissociation of FEZ1 from microtubules...
  7. ncbi request reprint DDX1 promotes proliferation of the JC virus through transactivation of its promoter
    Yuji Sunden
    Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo, Hokkaido, Japan
    Microbiol Immunol 51:339-47. 2007
    ..Our results clearly demonstrate that DDX1 regulates proliferation of JCV in vitro through transcriptional activation...
  8. doi request reprint Role of JC virus agnoprotein in virion formation
    Tadaki Suzuki
    Division of Molecular Pathobiology, Hokkaido University, Research Center for Zoonosis Control, n20, W10, Kita ku, Sapporo, 001 0020, Japan
    Microbiol Immunol 56:639-46. 2012
    ..The present findings suggest that JCV agnoprotein plays a role, similar to that of SV40 agnoprotein, in facilitating virion assembly...
  9. pmc Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling
    Yasuko Orba
    Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, n20, W10, Kita ku, Sapporo 001 0020, Japan
    J Biol Chem 285:1544-54. 2010
    ..The observation that oligodendrocytes productively infected with JCV in vivo also undergo G(2) arrest suggests that G(2) checkpoint inhibitors such as caffeine are potential therapeutic agents for JCV infection...
  10. ncbi request reprint Identification of DDX1 as a JC virus transcriptional control region-binding protein
    Yuji Sunden
    Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine, Sapporo, Hokkaido, Japan
    Microbiol Immunol 51:327-37. 2007
    ..Our findings indicate that an association between DDX1 and the JCV-TCR may play a significant role in JCV infection in IMR-32 cells...
  11. ncbi request reprint [Recent research on the JC virus]
    Hirofumi Sawa
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Nishi 9, Kita 18, Kita ku, Sapporo 060 0818, Japan
    No To Shinkei 59:101-8. 2007
    ..Thus, siRNA directed against JCV encoding genes may provide a useful tool for suppression of JCV infection...
  12. doi request reprint An siRNA against JC virus (JCV) agnoprotein inhibits JCV infection in JCV-producing cells inoculated in nude mice
    Tomoko Matoba
    Laboratory of Molecular and Cellular Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuropathology 28:286-94. 2008
    ..Thus, the combination of siRNA and atelocollagen might be a candidate therapeutic agent for the treatment of JCV infection...
  13. doi request reprint Characterization of influenza A viruses isolated from wild waterfowl in Zambia
    Edgar Simulundu
    Hokkaido University Research Center for Zoonosis Control, Kita ku, Sapporo, Japan
    J Gen Virol 92:1416-27. 2011
    ..This study stresses the need for continued monitoring of AIVs in wild and domestic birds in southern Africa to gain a better understanding of the emergence of strains with the potential to infect mammals...
  14. ncbi request reprint JC virus agnoprotein colocalizes with tubulin
    Shuichi Endo
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, and CREST, Japan Science and Technology, Sapporo, Japan
    J Neurovirol 9:10-4. 2003
    ..The results suggest that JCV agnoprotein may play a role in the stability of microtubules and the preservation of JCV infected cells via an interaction with tubulin...
  15. pmc Single amino acid residue in the A2 domain of major histocompatibility complex class I is involved in the efficiency of equine herpesvirus-1 entry
    Michihito Sasaki
    Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001 0020, Japan
    J Biol Chem 286:39370-8. 2011
    ..4 to mediate EHV-1 entry into cells. These results suggest that the amino acid residue at position 173 of the MHC class I molecule is involved in the efficiency of EHV-1 entry...
  16. ncbi request reprint Characterization and application of polyclonal antibodies that specifically recognize JC virus large T antigen
    Yuji Sunden
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, N15, W7, 060 8638, Sapporo, Japan
    Acta Neuropathol 111:379-87. 2006
    ..In conclusion, the newly generated JCV-specific TAg antibodies may be useful both in the investigation of the pathophysiological function of JCV TAg and in discriminating between Polyomavirus-related clinical samples...
  17. ncbi request reprint Natalizumab has no direct biological effect on JC virus infectivity in permissive human neural cell lines
    Tadaki Suzuki
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Kita ku, Sapporo, Japan
    J Med Virol 82:1229-35. 2010
    ..These results suggest that there is no direct effect of Natalizumab on JCV infectivity in IMR-32 cells in vitro...
  18. ncbi request reprint Cross-reactivity of secondary antibodies against African rodents and application for sero-surveillance
    Ichiro Nakamura
    Hokkaido University Research Center for Zoonosis Control, N20W10, Kita ku, Sapporo, Hokkaido 001 0020, Japan
    J Vet Med Sci 75:819-25. 2013
    ..Thus, anti-mouse IgG would be a useful detection tool in serological examination of the Zambian rodent population. Preliminary sero-surveillance for plague, leptospirosis and hantavirus infection was performed by ELISA. ..
  19. doi request reprint Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration
    Taichi Kimura
    Laboratory of Molecular and Cellular Pathology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Lab Invest 89:645-56. 2009
    ....
  20. ncbi request reprint Inhibitory effects of an M2-specific monoclonal antibody on different strains of influenza A virus
    Nilton Akio Muto
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Jpn J Vet Res 60:71-83. 2012
    ..These results suggest that rM2ss23 prevents virus release from infected cells and further suggest that the mechanisms underlying the virus budding mediates by HA and M2 proteins might differ between the Aichi and PR8 strains...
  21. ncbi request reprint Oligodendrocyte lineage transcription factor 2 inhibits the motility of a human glial tumor cell line by activating RhoA
    Kouichi Tabu
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan
    Mol Cancer Res 5:1099-109. 2007
    ..In contrast, in OLIG2-expressing cells, it lined almost the entire plasma membrane. Thus, OLIG2 suppresses the motile phenotype of glioblastoma cells by activating RhoA...
  22. ncbi request reprint Pharmacological cdk inhibitor R-Roscovitine suppresses JC virus proliferation
    Yasuko Orba
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, N18, W9, Kita ku, 060 0818, Sapporo, Japan
    Virology 370:173-83. 2008
    ..That Roscovitine exhibited antiviral activity in JCV-infected cells suggests that Roscovitine might have therapeutic utility in the treatment of progressive multifocal leukoencephalopathy (PML)...
  23. doi request reprint Molecular surveillance and phylogenetic analysis of Old World arenaviruses in Zambia
    Akihiro Ishii
    Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido, Japan
    J Gen Virol 93:2247-51. 2012
    ..Amino acid sequences of the GP, NP, Z and L proteins showed poor similarity among the three Zambian arenavirus strains, i.e. Luna, Lunk and Lujo virus...
  24. ncbi request reprint [Etiological agent and pathogenicity mechanism of PML]
    Tadaki Suzuki
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control
    Nihon Rinsho 65:1495-500. 2007
    ....
  25. pmc Molecular detection of a novel paramyxovirus in fruit bats from Indonesia
    Michihito Sasaki
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Virol J 9:240. 2012
    ..Fruit bats are known to harbor zoonotic paramyxoviruses including Nipah, Hendra, and Menangle viruses. The aim of this study was to detect the presence of paramyxovirus RNA in fruit bats from Indonesia...
  26. doi request reprint Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice
    Akira Kawaguchi
    Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Hokkaido, Japan
    Blood 114:2961-8. 2009
    ..These results demonstrate the involvement of the SDF-1alpha/CXCR4 interaction as one mechanism of leukemic cell migration and this may provide a novel target as part of combination therapy for ATL...
  27. ncbi request reprint Application of laser capture microdissection to cytologic specimens for the detection of immunoglobulin heavy chain gene rearrangement in patients with malignant lymphoma
    Yasuko Orba
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Cancer 99:198-204. 2003
    ..However, to the authors' knowledge the applicability of LCM to cytologic specimens has not yet been well established...
  28. ncbi request reprint Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines
    Takuya Watanabe
    Laboratory of Molecular and Cellular Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Cancer Res 4:499-510. 2006
    ....
  29. doi request reprint Molecular epidemiology and a loop-mediated isothermal amplification method for diagnosis of infection with rabies virus in Zambia
    Walter Muleya
    Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001 0021, Japan
    Virus Res 163:160-8. 2012
    ..The specificity and reproducibility of the RT-LAMP assay was confirmed with actual clinical specimens. Therefore, the RT-LAMP assay presented in this study may prove to be useful for routine diagnosis of rabies in Zambia...
  30. ncbi request reprint Pathological examination of lung tissues in influenza a virus-infected mice
    Nilton Akio Muto
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Jpn J Infect Dis 65:383-91. 2012
    ..These findings provide detailed insights into the age-specific course of infection in young and aged populations with associated differences in lung pathology...
  31. ncbi request reprint Characterization of Japanese encephalitis virus infection in an immortalized mesencephalic cell line, CSM14.1
    Takashi Kimura
    Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, West 10 North 20, Kita ku, Sapporo, 001 0020, Japan
    Microbiol Immunol 57:723-31. 2013
    ..1 cells. Because CSM14.1 cells became more resistant to JEV infection as they mature, this culture system can be used as an in vitro model for studying age-dependent resistance of neurons to JEV infection. ..
  32. pmc Role of the C-terminal region of vervet monkey polyomavirus 1 VP1 in virion formation
    Hiroki Yamaguchi
    Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Hokkaido 001 0020, Japan
    J Vet Med Sci 76:637-44. 2014
    ..These results suggest that the length of VP1 is unrelated to virion morphology; however, the C-terminal region of VmPyV VP1 affects the efficiency of its VLP formation. ..
  33. pmc Equine major histocompatibility complex class I molecules act as entry receptors that bind to equine herpesvirus-1 glycoprotein D
    Michihito Sasaki
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001 0020, Japan
    Genes Cells 16:343-57. 2011
    ..Derm cells drastically reduced their susceptibility to EHV-1 infection. These results suggest that equine MHC class I is a functional gD receptor that plays a pivotal role in EHV-1 entry into equine cells...
  34. doi request reprint Characterization of H3N6 avian influenza virus isolated from a wild white pelican in Zambia
    Edgar Simulundu
    Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Kita 20, Nishi 10, Kita ku, Sapporo, 001 0020, Japan
    Arch Virol 154:1517-22. 2009
    ..The present study underscores the need for continued monitoring of avian influenza viruses in Eurasia and Africa...
  35. ncbi request reprint Lamprey TLRs with properties distinct from those of the variable lymphocyte receptors
    Akihiro Ishii
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 178:397-406. 2007
    ..Thus, the jawless vertebrate lamprey possesses two LRR-based recognition systems, the variable lymphocyte receptor and TLR, and the M-type TLRs are conserved across humans, fish, and lampreys...
  36. pmc Transcellular transport of West Nile virus-like particles across human endothelial cells depends on residues 156 and 159 of envelope protein
    Rie Hasebe
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Kita 20, Nishi 10, Kita ku, Sapporo 001 0020, Japan
    BMC Microbiol 10:165. 2010
    ..Here, we analyzed the capacity of virus-like particles (VLPs) of the highly virulent NY99 6-LP strain (6-LP VLPs) and the low virulence Eg101 strain (Eg VLPs) to cross cultured human endothelial cells...
  37. ncbi request reprint DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines
    Hiroshi Nishihara
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Blood 100:3968-74. 2002
    ..Finally, the stable expression of DOCK2-dCS mutant in Jurkat cells was shown to reduce cell attachment. These data suggest the presence of a novel protein complex of CrkL, DOCK2, and Vav to regulate Rac1 in leukemia cell lines...
  38. ncbi request reprint Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas
    Akiko Ohnishi
    Laboratory of Molecular and Cellular Pathology, Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuropathol Exp Neurol 62:1052-9. 2003
    ..In conclusion, combining Olig mRNA expression and immunohistochemistry of OLIG2 enables oligodendrogliomas to be distinguished from glioblastomas and other astrocytic glial tumors...
  39. pmc Novel arenavirus, Zambia
    Akihiro Ishii
    Hokkaido University, Sapporo, Japan
    Emerg Infect Dis 17:1921-4. 2011
    ..Full-genome sequences of the viruses suggested that they were new strains similar to Lassa virus-related arenaviruses. Analyzing samples from additional rodents and other species can elucidate epizootiologic aspects of arenaviruses...
  40. ncbi request reprint Investigation of simian virus 40 large T antigen in 18 autopsied malignant mesothelioma patients in Japan
    Mulan Jin
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    J Med Virol 74:668-76. 2004
    ..This study shows that SV40 genome was present in a subset of Japanese malignant mesothelioma patients who were unlikely to have received a contaminated polio vaccine based on their age...
  41. ncbi request reprint Clinico-pathological features of pilomyxoid astrocytoma of the optic pathway
    Kanako Chikai
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Kita 15, Nishi 7, 060 8638, Kita ku, Sapporo, Japan
    Acta Neuropathol 108:109-14. 2004
    ..Hence, we conclude that PmA might be an infantile form of PA and speculate that a subset of PmA in the optic pathway/hypothalamus originates from the optic chiasm, possibly derived from radial glia existing in the embryonic optic chiasm...
  42. doi request reprint Accumulation of ubiquitinated proteins is related to West Nile virus-induced neuronal apoptosis
    Shintaro Kobayashi
    Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
    Neuropathology 32:398-405. 2012
    ..Our histopathological and in vitro studies suggest that accumulation of ubiquitinated proteins in neuronal cells might be associated with neuronal apoptosis caused by WNV infection...
  43. doi request reprint Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection
    Eunmi Kim
    Department of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001 0020, Japan
    Biochem Biophys Res Commun 409:717-22. 2011
    ....
  44. doi request reprint Detection of KI polyomavirus and WU polyomavirus DNA by real-time polymerase chain reaction in nasopharyngeal swabs and in normal lung and lung adenocarcinoma tissues
    Shinobu Teramoto
    Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Microbiol Immunol 55:525-30. 2011
    ..KIPyV was detected in one of 30 specimens of lung tissue (3.3%). Neither of the viruses was detected in 30 samples of lung adenocarcinoma tissue...
  45. doi request reprint Gold nanoparticle arrangement on viral particles through carbohydrate recognition: a non-cross-linking approach to optical virus detection
    Kenichi Niikura
    Graduate School of Science and Research Institute for Electronic Science, Hokkaido University, Sapporo, Japan
    Bioconjug Chem 20:1848-52. 2009
    ....
  46. doi request reprint De novo sequence analysis of cytochrome P450 1-3 genes expressed in ostrich liver with highest expression of CYP2G19
    Yusuke K Kawai
    Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
    Comp Biochem Physiol Part D Genomics Proteomics 8:201-8. 2013
    ..The other CYP genes displayed similar expression levels. Our results suggest that CYP2G19, which has not been a focus of previous bird studies, has an important role in ostrich xenobiotic metabolism. ..
  47. ncbi request reprint Dysferlinopathy associated with rigid spine syndrome
    Toshiko Nagashima
    Department of Neurology, Seiwa Memorial Hospital, Sapporo, Japan
    Neuropathology 24:341-6. 2004
    ..This study might propose some clues to resolve the combination of musular dystrophies and rigid spine syndrome...
  48. doi request reprint Detection and characterization of a novel polyomavirus in wild rodents
    Yasuko Orba
    Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, n20, W10, Kita ku, Sapporo 001 0020, Japan
    J Gen Virol 92:789-95. 2011
    ....
  49. doi request reprint Functional analysis of an alpha-helical antimicrobial peptide derived from a novel mouse defensin-like gene
    Akira Kawaguchi
    Department of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 001 0020, Japan
    Biochem Biophys Res Commun 398:778-84. 2010
    ..These results suggested that K17 may be a candidate therapeutic for the treatment of bacterial infection...
  50. ncbi request reprint Survival of rabid rabbits after intrathecal immunization
    Sawang Kesdangsakonwut
    Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Neuropathology 34:277-83. 2014
    ..We report here a possible, although still incomplete, therapy for rabies using IT immunization. Our protocol may rescue the life of rabid patients and prompt the future development of novel therapies against rabies. ..
  51. ncbi request reprint Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers
    Hiroshi Nishihara
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, N 15, W7, Kita ku, Sapporo, Japan
    Cancer Lett 180:55-61. 2002
    ..The elevated expression levels of c-Crk-II might be related to the development of human cancers...
  52. ncbi request reprint The JC virus-like particle overlay assay
    Hirofumi Sawa
    Laboratory of Molecular and Cellular Pathology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    Methods Mol Biol 292:175-86. 2005
    ..In this section, detailed procedures for the synthesis of VLP from E. coli and VLP overlay assay are described...
  53. ncbi request reprint Anti-Hu paraneoplastic syndrome presenting with brainstem-cerebellar symptoms and Lambert-Eaton myasthenic syndrome
    Toshiko Nagashima
    Seiwa Memorial Hospital, Sapporo, Japan
    Neuropathology 23:230-8. 2003
    ....
  54. ncbi request reprint Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Circulation 106:1269-74. 2002
    ..Recent studies have identified genetic variants of the cardiac K+ channel genes predisposing affected individuals to acquired LQTS. We have identified a novel Na+ channel mutation in an individual who exhibited drug-induced LQTS...
  55. ncbi request reprint Advanced glycation end products induce angiogenesis in vivo
    Tamami Okamoto
    Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, N 15, W7, Kita ku, Sapporo, 060 8638, Japan
    Microvasc Res 63:186-95. 2002
    ....
  56. ncbi request reprint Desmoplastic malignant mesothelioma of the pleura: autopsy reveals asbestos exposure
    Ryoichi Ishikawa
    Laboratory of Molecular and Cellular Pathology and Department of Surgical Pathology, Hokkaido University School of Medicine, Sapporo, Japan
    Pathol Int 53:401-6. 2003
    ..Thus, autopsy analyses of fibrous pleurisy are necessary to detect a desmoplastic variant of mesothelioma of the pleura and its association with asbestos exposure...