M Kasahara

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. pmc Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus
    M F Flajnik
    Department of Microbiology and Immunology, University of Miami, FL 33101
    Proc Natl Acad Sci U S A 88:537-41. 1991
  2. ncbi request reprint Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1)
    M Hayashi
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Genomics 32:367-74. 1996
  3. pmc Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex
    M Kasahara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Proc Natl Acad Sci U S A 93:9096-101. 1996
  4. ncbi request reprint New insights into the genomic organization and origin of the major histocompatibility complex: role of chromosomal (genome) duplication in the emergence of the adaptive immune system
    M Kasahara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Hereditas 127:59-65. 1997
  5. ncbi request reprint Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit
    K Kohda
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 47:77-87. 1997
  6. ncbi request reprint Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes
    K Kohda
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 160:4923-35. 1998
  7. ncbi request reprint PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 46:337-44. 1997
  8. ncbi request reprint The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter
    M Hayashi
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 159:2760-70. 1997
  9. ncbi request reprint The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Cytogenet Cell Genet 73:97-8. 1996
  10. ncbi request reprint Isolation of the Xenopus complement factor B complementary DNA and linkage of the gene to the frog MHC
    Y Kato
    Department of Biochemistry, Nagoya City University Medical School, Japan
    J Immunol 153:4546-54. 1994

Collaborators

Detail Information

Publications36

  1. pmc Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus
    M F Flajnik
    Department of Microbiology and Immunology, University of Miami, FL 33101
    Proc Natl Acad Sci U S A 88:537-41. 1991
    ....
  2. ncbi request reprint Characterization of a human glycoprotein with a potential role in sperm-egg fusion: cDNA cloning, immunohistochemical localization, and chromosomal assignment of the gene (AEGL1)
    M Hayashi
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Genomics 32:367-74. 1996
    ..The gene encoding ARP (AEGL1) was mapped by fluorescence in situ hybridization to 6p21.1-p21.2. This result indicates that AEGL1 and the mouse gene for AEG are located in the chromosomal segments with conserved syntenies...
  3. pmc Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex
    M Kasahara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Proc Natl Acad Sci U S A 93:9096-101. 1996
    ..3 and 9q33-q34). These observations have implications in understanding the genomic organization of the present-day MHC and offer insights into the origin of the MHC...
  4. ncbi request reprint New insights into the genomic organization and origin of the major histocompatibility complex: role of chromosomal (genome) duplication in the emergence of the adaptive immune system
    M Kasahara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Hereditas 127:59-65. 1997
    ....
  5. ncbi request reprint Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit
    K Kohda
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 47:77-87. 1997
    ..These results were confirmed by fluorescent in situ hybridization analysis that localized Psmb5 to band C2 to proximal D1 of chromosome 14 and Psmb5-ps to band D of chromosome 11...
  6. ncbi request reprint Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes
    K Kohda
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 160:4923-35. 1998
    ..The Psme1 and Psme2 genes are located approximately 6 kb apart with their 3'-ends pointing toward each other on bands C2 to D1 of mouse chromosome 14, supporting the idea that they emerged by tandem duplication...
  7. ncbi request reprint PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo 060, Japan
    Immunogenetics 46:337-44. 1997
    ..It appears that the IFN-gamma-inducible alpha- and beta-subunits emerged by gene duplication from a gamma-subunit-like precursor...
  8. ncbi request reprint The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter
    M Hayashi
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 159:2760-70. 1997
    ..Besides the Psmb7 gene previously mapped to chromosome 2, a truncated processed pseudogene, designated Psmb7-ps, was identified and mapped to chromosome X...
  9. ncbi request reprint The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Cytogenet Cell Genet 73:97-8. 1996
    ..3. Thus, like its mouse counterpart, the human FCGRT gene is located outside the major histocompatibility complex...
  10. ncbi request reprint Isolation of the Xenopus complement factor B complementary DNA and linkage of the gene to the frog MHC
    Y Kato
    Department of Biochemistry, Nagoya City University Medical School, Japan
    J Immunol 153:4546-54. 1994
    ....
  11. ncbi request reprint The MHC class I-like Zn-alpha 2-glycoprotein gene maps to mouse chromosome 5
    M Noguchi
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Immunogenetics 42:72-4. 1995
  12. ncbi request reprint Mapping of acidic epididymal glycoprotein (Aeg) genes to mouse chromosome 17
    M Kasahara
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Mamm Genome 6:52-4. 1995
  13. ncbi request reprint Existence of human DAZLA protein in the cytoplasm of human oocytes
    S Nishi
    Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan
    Mol Hum Reprod 5:495-7. 1999
    ..Immunohistochemical analyses with the human DAZLA antiserum showed that the DAZLA protein is expressed at a cytoplasmic location in female germ cells. Available evidence suggests that the DAZLA gene is a participant in human oogenesis...
  14. ncbi request reprint Exon-intron organization of Xenopus MHC class II beta chain genes
    F Kobari
    Department of Biochemistry, Hokkaido University School of Medicine, N 15, W 7, Sapporo 060, Japan
    Immunogenetics 42:376-85. 1995
    ..laevis is diploidized at the genomic level and contains three class II beta chain genes per haplotype that cross-hybridize to one another under reduced stringency conditions...
  15. ncbi request reprint Structural and phylogenetic analysis of the MHC class I-like Fc receptor gene
    E Kandil
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    J Immunol 154:5907-18. 1995
    ..The fact that Fcrn is a single copy gene indicates that it is expressed in both the neonatal intestine and the fetal yolk sac...
  16. ncbi request reprint Microheterogeneity and intrahepatic localization of human and rat liver cytosolic alanine aminotransferase
    T Matsuzawa
    Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    Biochim Biophys Acta 1340:115-22. 1997
    ..In human hepatocytes the plasma membrane was intensely stained, implicating an intracellular localization near the plasma membrane...
  17. pmc Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta
    S Murata
    Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, and CREST, Japan Science and Technology Corporation, Tokyo 113 8613, Japan
    EMBO J 20:5898-907. 2001
    ..Hence, PA28alpha/beta is not a prerequisite for antigen presentation in general, but plays an essential role for the processing of certain antigens...
  18. ncbi request reprint Growth retardation in mice lacking the proteasome activator PA28gamma
    S Murata
    Department of Allergy, Graduate School of Medicine, Japan
    J Biol Chem 274:38211-5. 1999
    ..These results indicate that PA28gamma functions as a regulator of cell proliferation and body growth in mice and suggest that neither PA28alpha nor PA28beta compensates for the PA28gamma deficiency...
  19. ncbi request reprint Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes
    M Yawata
    CREST, Japan Science and Technology Corporation JST, Hayama 240 0193, Japan
    Immunogenetics 53:119-29. 2001
    ....
  20. pmc Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes
    H Kawahara
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    EMBO J 19:4144-53. 2000
    ..While the former is thought to perform proteolysis constitutively in a wide variety of cells, the latter may play a specialized role in early embryonic development...
  21. ncbi request reprint A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2
    A Kobayashi
    Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Biochem 128:711-8. 2000
    ..3. Furthermore, the transcription of TAPL gene is not responsive to interferon-gamma, in contrast to TAP1 and TAP2. These results indicate that the gene regulation of TAPL is different from those of TAP1 and TAP2...
  22. ncbi request reprint Overexpression of brain natriuretic peptide in mice ameliorates immune-mediated renal injury
    T Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Am Soc Nephrol 12:2652-63. 2001
    ..The present study opens a possibility of a novel therapeutic potential of natriuretic peptides for treating immune-mediated renal injury...
  23. ncbi request reprint Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene
    E Seboun
    Genethon, Evry, France
    Genomics 41:227-35. 1997
    ..Familial cases of male infertility in humans show an autosomal recessive mode of inheritance. It is possible that some of these families may carry mutations in the DAZLA gene...
  24. ncbi request reprint Mouse submandibular glands express an androgen-regulated transcript encoding an acidic epididymal glycoprotein-like molecule
    N Mizuki
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    Mol Cell Endocrinol 89:25-32. 1992
    ....
  25. ncbi request reprint The evolutionary origin of the HLA-DR3 haplotype
    V Vincek
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    Immunogenetics 35:263-71. 1992
    ..In the human and the gorilla haplotype, the DRB2 pseudogene is flanked on each side by what appear to be related genes. Apparently, the DR3 haplotype has existed in its present form for more than six myr...
  26. ncbi request reprint Genetic mapping of a male germ cell-expressed gene Tpx-2 to mouse chromosome 17
    M Kasahara
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    Immunogenetics 34:132-5. 1991
  27. ncbi request reprint Mapping of class alpha glutathione S-transferase 2 (GST-2) genes to the vicinity of the d locus on mouse chromosome 9
    M Kasahara
    Department of Microbiology and Immunology, University of Miami School of Medicine, Florida 33101
    Genomics 8:90-6. 1990
    ..The fact that the syntenic group extends across the centromere of human chromosome 6 can best be explained by a pericentric inversion postulated to have taken place in the primate lineage leading to Catarhini...
  28. ncbi request reprint Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria
    K Kita
    Department of Parasitology, Juntendo University, School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 166:101-8. 1990
    ..8%). Striking sequence conservation was found around the three cysteine-rich clusters which have been thought to comprise the iron-sulfur centers of the enzyme. This is the first report on the cDNA sequence of mitochondrial complex II...
  29. ncbi request reprint A testis-specific gene Tpx-1 maps between Pgk-2 and Mep-1 on mouse chromosome 17
    M Kasahara
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101
    Immunogenetics 29:61-3. 1989
  30. ncbi request reprint Linkage map of mouse chromosome 17: localization of 27 new DNA markers
    V Vincek
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany
    Genomics 5:773-86. 1989
    ..The distal region of MMU17, on the other hand, is populated by only a few, rather imprecisely mapped markers. Molecular maps are available for most of the H-2 complex and for parts of the t complex...
  31. ncbi request reprint Mapping of the Sod-2 locus into the t complex on mouse chromosome 17
    F Figueroa
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany
    Immunogenetics 28:260-4. 1988
    ....
  32. ncbi request reprint Molecular cloning of a testis-specific gene from mouse chromosome 17
    M Kasahara
    Department of Immunogenetics, Max Planck Institute for Biology, Tubingen, FRG
    Transplant Proc 19:815-6. 1987
  33. pmc Random cloning of genes from mouse chromosome 17
    M Kasahara
    Proc Natl Acad Sci U S A 84:3325-8. 1987
    ..The randomly isolated mouse-derived cosmid clones can also be screened for the presence of functional genes. Using testicular cDNA as a probe, a testis-specific gene was cloned from mouse chromosome 17...
  34. ncbi request reprint Nucleotide sequence analysis of class II genes borne by mouse t chromosomes
    M Golubic
    Genet Res 50:137-46. 1987
  35. pmc A novel type of class I gene organization in vertebrates: a large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus
    M F Flajnik
    Department of Microbiology and Immunology, University of Miami, FL 33101
    EMBO J 12:4385-96. 1993
    ..We hypothesize that this class Ib gene family is under very different selection pressures from the classical MHC genes, and that each subfamily may have evolved for a particular function...
  36. ncbi request reprint Altered behavioural adaptation in mice with neural corticotrophin-releasing factor overexpression
    M Kasahara
    Department of Pharmacology, University of Cambridge, Cambridge, United Kingdom
    Genes Brain Behav 6:598-607. 2007
    ..This may be related to individual differences in stress reactivity. These findings have implications for our understanding of the role of CRF overproduction in behavioural maladaptation and stress-related psychiatric disorders...