Akira Kudoh

Summary

Affiliation: Hirosaki University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Lidocaine added to a tracheostomy tube cuff reduces tube discomfort
    W Hirota
    Department of Dentistry and Oral Surgery, University of Hirosaki School of Medicine, Japan
    Can J Anaesth 47:412-4. 2000
  2. ncbi request reprint The relationship between salivary biomarkers and state-trait anxiety inventory score under mental arithmetic stress: a pilot study
    Yuka Noto
    Department of Nursing, Hirosaki University School of Medicine, Hirosaki 036 8563, Japan
    Anesth Analg 101:1873-6. 2005
  3. ncbi request reprint Quantification and comparison of pulmonary emboli formation after pneumatic tourniquet release in patients undergoing reconstruction of anterior cruciate ligament and total knee arthroplasty
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562, Japan
    Anesth Analg 94:1633-8, table of contents. 2002
  4. ncbi request reprint Ketamine and the inhibition of albumin extravasation in chemical peritonitis in rat
    K Hirota
    University of Hirosaki School of Medicine, Department of Anesthesiology, Japan
    Eur J Anaesthesiol 19:173-6. 2002
  5. ncbi request reprint Special cases: ketamine, nitrous oxide and xenon
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Best Pract Res Clin Anaesthesiol 20:69-79. 2006
  6. ncbi request reprint Supraclinical concentrations of dexmedetomidine evoke norepinephrine release from rat cerebrocortical slices possible involvement of the orexin-1 receptor
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, 53 Hon cho, Hirosaki, Aomori 036 8563, Japan
    Neurosci Lett 372:142-5. 2004
  7. ncbi request reprint Orexinergic neurons and barbiturate anesthesia
    T Kushikata
    Department of Anesthesiology, University of Hirosaki School of Medicine, Zaifu cho 5, Hirosaki, Japan 036 8562
    Neuroscience 121:855-63. 2003
  8. ncbi request reprint Tumor necrosis factor-alpha reduces ketamine- and propofol-induced anesthesia time in rats
    Tadanobu Yasuda
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Anesth Analg 95:952-5, table of contents. 2002
  9. doi request reprint A new method to estimate regional pulmonary blood flow using transesophageal echocardiography
    Yuichi Yatsu
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562, Japan
    Anesth Analg 106:530-4, table of contents. 2008
  10. ncbi request reprint Ketamine inhibits endotoxin-induced inositol 1,4,5-triphosphate in rat ventricular cardiomyocytes
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, 1 Tominocho, Hirosaki 036 8545, Aomori, Japan
    Intensive Care Med 29:1812-7. 2003

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Lidocaine added to a tracheostomy tube cuff reduces tube discomfort
    W Hirota
    Department of Dentistry and Oral Surgery, University of Hirosaki School of Medicine, Japan
    Can J Anaesth 47:412-4. 2000
    ..To examine whether lidocaine diffusion across an endotracheal tube cuff affects tracheostomy tube discomfort...
  2. ncbi request reprint The relationship between salivary biomarkers and state-trait anxiety inventory score under mental arithmetic stress: a pilot study
    Yuka Noto
    Department of Nursing, Hirosaki University School of Medicine, Hirosaki 036 8563, Japan
    Anesth Analg 101:1873-6. 2005
    ..The STAI-s was significantly correlated to salivary alpha-amylase (r = 0.589; P < 0.01) but not to salivary chromogranin-A or cortisol. Therefore, salivary alpha-amylase is a useful indicator of psychosocial stress...
  3. ncbi request reprint Quantification and comparison of pulmonary emboli formation after pneumatic tourniquet release in patients undergoing reconstruction of anterior cruciate ligament and total knee arthroplasty
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562, Japan
    Anesth Analg 94:1633-8, table of contents. 2002
    ..An increase in ET(CO(2)) was inversely proportional to peak %Ae (P < 0.01; r = 0.703). Therefore, the present data suggest that the risk of acute pulmonary embolism after tourniquet release may be more frequent during TKA than ACL...
  4. ncbi request reprint Ketamine and the inhibition of albumin extravasation in chemical peritonitis in rat
    K Hirota
    University of Hirosaki School of Medicine, Department of Anesthesiology, Japan
    Eur J Anaesthesiol 19:173-6. 2002
    ..It was previously reported that topical ketamine inhibits albumin extravasation in a rat chemical peritonitis model. Using the same model, the present study investigated whether intravenous ketamine inhibited this extravasation...
  5. ncbi request reprint Special cases: ketamine, nitrous oxide and xenon
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Best Pract Res Clin Anaesthesiol 20:69-79. 2006
    ..Similarly, ketamine and nitrous oxide do not suppress the mid-latency auditory evoked potential whereas xenon does. Thus, anaesthetic depth monitors fail to describe consciousness accurately when ketamine and nitrous oxide are used...
  6. ncbi request reprint Supraclinical concentrations of dexmedetomidine evoke norepinephrine release from rat cerebrocortical slices possible involvement of the orexin-1 receptor
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, 53 Hon cho, Hirosaki, Aomori 036 8563, Japan
    Neurosci Lett 372:142-5. 2004
    ..Thus, supraclinical concentrations of dexmedetomidine increase norepinephrine release from rat cerebrocortical slices, and this release may be mediated via OX(1) but not alpha(2)-adrenoceptors...
  7. ncbi request reprint Orexinergic neurons and barbiturate anesthesia
    T Kushikata
    Department of Anesthesiology, University of Hirosaki School of Medicine, Zaifu cho 5, Hirosaki, Japan 036 8562
    Neuroscience 121:855-63. 2003
    ..Collectively our data suggest that orexinergic neurons may be an important target for barbiturates, and GABAA, OX1 and OX2 receptors may not be involved in this interaction...
  8. ncbi request reprint Tumor necrosis factor-alpha reduces ketamine- and propofol-induced anesthesia time in rats
    Tadanobu Yasuda
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Anesth Analg 95:952-5, table of contents. 2002
    ..These data show that TNFalpha can modulate the anesthesia time of IV anesthetics, suggesting that anesthetic requirements might be altered in the presence of cerebral or systemic inflammation...
  9. doi request reprint A new method to estimate regional pulmonary blood flow using transesophageal echocardiography
    Yuichi Yatsu
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562, Japan
    Anesth Analg 106:530-4, table of contents. 2008
    ..To verify the efficacy of the method, we investigated the ability of this experimental model to detect changes in regional pulmonary blood flow...
  10. ncbi request reprint Ketamine inhibits endotoxin-induced inositol 1,4,5-triphosphate in rat ventricular cardiomyocytes
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, 1 Tominocho, Hirosaki 036 8545, Aomori, Japan
    Intensive Care Med 29:1812-7. 2003
    ..To investigate the effect of ketamine on endotoxin modulation of inositol 1,4,5-triphosphate (IP3) formation in cardiomyocytes...
  11. ncbi request reprint Increased cortisol response to surgery in patients with alcohol problems who developed postoperative confusion
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Alcohol Clin Exp Res 28:1187-93. 2004
    ..However, the relationship between neuroendocrine responses to surgical stress and postoperative confusion remains unclear in patients with alcohol problems...
  12. ncbi request reprint Postoperative confusion increases in elderly long-term benzodiazepine users
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, 1 Tominocho, Hirosaki 036 8545, Aomori, Japan
    Anesth Analg 99:1674-8, table of contents. 2004
    ..In conclusion, the incidence of postoperative confusion was significantly more frequent in long-term benzodiazepine users...
  13. ncbi request reprint Spasmolytic effects of colforsin daropate on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs
    K Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    Acta Anaesthesiol Scand 46:297-302. 2002
    ..In the present study we have simultaneously evaluated the spasmolytic effects of colforsin daropate, a novel forskolin derivative, on serotonin-induced pulmonary hypertension and bronchoconstriction...
  14. ncbi request reprint Use of olprinone, a phosphodiesterase III inhibitor, in an asthmatic patient
    K Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Acta Anaesthesiol Scand 45:510-2. 2001
    ..3 microg x kg(-1) x min(-1), total 5 mg). Olprinone infusion rapidly decreased peak Paw from 30 cmH2O to 24 cmH2O and increased bronchial cross-sectional area by 50%. These findings suggest that olprinone produced bronchodilation...
  15. ncbi request reprint Effects of nociceptinNH2 and [Nphe1]nociceptin(1-13)NH2 on rat brain noradrenaline release in vivo and in vitro
    H Okawa
    Department of Anesthesiology, University of Hirosaki School of Medicine, 5 Zaifu cho 036, Hirosaki, Japan
    Neurosci Lett 303:173-6. 2001
    ..These data demonstrate an inhibition of NA release by NCNH2 in a [Nphe1]NC(1-13)NH2 sensitive manner in both in vivo brain microdialysis and in vitro cerebrocortical slices studies in rats...
  16. ncbi request reprint Effects of isoflurane and ketamine on sleep in rabbits
    S Takahashi
    Department of Anaesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    Psychiatry Clin Neurosci 55:239-40. 2001
    ..In contrast, ketamine anesthesia significantly enhanced NREMS. Both anesthetics did not affect rapid eye movement sleep. These results suggest that isoflurane may contribute to the POSD, but ketamine may decrease the POSD...
  17. ncbi request reprint A comparison of the relaxant effects of olprinone and aminophylline on methacholine-induced bronchoconstriction in dogs
    K Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    Anesth Analg 93:230-3. 2001
    ..Therefore, the relaxant effects of olprinone are independent of plasma epinephrine, whereas aminophylline effects may partially result from increased circulating concentrations of epinephrine...
  18. pmc Orexin A and B evoke noradrenaline release from rat cerebrocortical slices
    K Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Br J Pharmacol 134:1461-6. 2001
    ..38+/-0.04 (42 mM) and 1240+/-50%, 1.47+/-0.02 (34 mM) and 480+/-10% and 1.40+/-0.05 (40 mM) and 560+/-60% respectively. 6. We conclude that the neuropeptides orexin A and B evoke noradrenaline release from rat cerebrocortical slices...
  19. ncbi request reprint Unventilated airway is time-dependently constricted in paralyzed dogs
    K Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Anesthesiology 95:1480-4. 2001
    ..In this study, the authors determined the mechanism of apnea-induced bronchoconstriction...
  20. ncbi request reprint Lack of interaction between orexinergic and alpha2-adrenergic neuronal systems in rat cerebrocortical slices
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Neurosci Lett 387:49-52. 2005
    ..50+/-0.34 (77.6+/-10.9%); orexin A was ineffective. The present data suggest a lack of interaction between orexinergic and alpha2-adrenergic neurons in rat cerebral cortex...
  21. ncbi request reprint Perioperative management for chronic schizophrenic patients
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, 1 Tominocho, Hirosaki 036 8545, Aomori, Japan
    Anesth Analg 101:1867-72. 2005
    ..Thus, anesthesiologists must not only be aware of the perioperative problems of these patients but must also learn how to manage their perioperative course...
  22. ncbi request reprint A comparison of anesthetic quality in propofol-spinal anesthesia and propofol-fentanyl anesthesia for total knee arthroplasty in elderly patients
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Japan
    J Clin Anesth 16:405-10. 2004
    ..To compare propofol plus spinal anesthesia during spontaneous ventilation using the Laryngeal Mask Airway and propofol plus fentanyl anesthesia during mechanical ventilation with an endotracheal tube on quality of recovery after anesthesia...
  23. ncbi request reprint Effects of three different L-type Ca2+ entry blockers on airway constriction induced by muscarinic receptor stimulation
    K Hirota
    Department of Anesthesiology, University of Hirosaki, School of Medicine, Japan
    Br J Anaesth 90:671-5. 2003
    ..In this study, we examined the effects of the dihydropyridines nifedipine and nicardipine, the benzothiazepine diltiazem, and the phenylalkylamine verapamil on airway constriction...
  24. ncbi request reprint Cortisol response to surgery and postoperative confusion in depressed patients under general anesthesia with fentanyl
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, University of Hirosaki School of Medicine, Hirosaki, Japan
    Neuropsychobiology 46:22-6. 2002
    ..The incidence of postoperative confusion in depressed patients with fentanyl was significantly lower than that of depressed patients without fentanyl...
  25. ncbi request reprint Chronic treatment with antipsychotics enhances intraoperative core hypothermia
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, 1 Tominocho, Aomori, Hirosaki 036 0545, Japan
    Anesth Analg 98:111-5, table of contents. 2004
    ..In conclusion, chronic schizophrenic patients were more hypothermic during anesthesia. The incidence of postanesthesia shivering was not significantly increased...
  26. ncbi request reprint Postoperative confusion in schizophrenic patients is affected by interleukin-6
    Akira Kudoh
    Department of Anesthesiology, Hakodate Watanabe Hospital, Hakodate, Japan
    J Clin Anesth 15:455-62. 2003
    ..To investigate whether epidural analgesia with local anesthetics affects postoperative confusion in schizophrenic patients or the relationships between cortisol or interleukin-6 (IL-6) and postoperative confusion...
  27. ncbi request reprint Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Japan
    J Clin Anesth 14:107-10. 2002
    ..To investigate whether total IV anesthesia with ketamine, propofol, and fentanyl affects the frequency of postoperative psychosis emergence or confusion in schizophrenic patients...
  28. ncbi request reprint Endocrine response to surgical stress and postoperative confusion in depressed patients with alcohol abuse
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Neuropsychobiology 50:195-9. 2004
    ..Increased plasma cortisol concentrations after surgery were associated with postoperative confusion in depressed patients with alcohol abuse...
  29. ncbi request reprint Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, 036 8563 Hirosaki, Japan
    Brain Res 981:143-50. 2003
    ..The present data suggest that hypocretinergic neurons may contribute to the regulation of central but not adrenal sympathetic activity. Moreover, sympathetic regulation by hypocretinergic neurones may disappear in middle-age in rats...
  30. ncbi request reprint Chronic treatment with antidepressants decreases intraoperative core hypothermia
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Japan
    Anesth Analg 97:275-9, table of contents. 2003
    ..In conclusion, intraoperative core hypothermia in chronically depressed patients was decreased. However, the incidence of shivering in depressed patients was significantly more frequent...
  31. ncbi request reprint Increased postoperative pain scores in chronic depression patients who take antidepressants
    Akira Kudoh
    Department of Anesthesiology, Hakodate Watanabe Hospital, Hirasaki 036 8545, Aonori, Japan
    J Clin Anesth 14:421-5. 2002
    ..To investigate postoperative pain and current perception thresholds in chronic depression in patients who are treated with antidepressants...
  32. ncbi request reprint Small-dose ketamine improves the postoperative state of depressed patients
    Akira Kudoh
    Department of Anesthesiology, Hakodate Watanabe Hospital, Aomori, Japan
    Anesth Analg 95:114-8, table of contents. 2002
    ..05) lower than 34.3 +/- 12.0 and 31.1 +/- 8.8 in Group B. In conclusion, small-dose ketamine improved the postoperative depressive state and relieved postoperative pain in depressed patients...
  33. ncbi request reprint Schizophrenic patients who develop postoperative confusion have an increased norepinephrine and cortisol response to surgery
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, University of Hirosaki School of Medicine, Hirosaki, Aomori, Japan
    Neuropsychobiology 46:7-12. 2002
    ..3 +/- 5.1 and 13.8 +/- 3.8 microg/dl, respectively). In conclusion, the occurrence of postoperative confusion in schizophrenic patients is associated with an increase in plasma norepinephrine and cortisol levels during and after surgery...
  34. ncbi request reprint A history of aggression is a risk factor for postoperative confusion in elderly male drinkers
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, 1 Tomino cho, Hirosaki, 036 8545, Japan
    J Anesth 21:13-8. 2007
    ..We investigated the relationship between preoperative psychological state and postoperative confusion in elderly drinkers...
  35. ncbi request reprint Norepinephrine-induced inositol 1,4,5-trisphosphate formation in atrial myocytes is regulated by extracellular calcium, protein kinase C, and calmodulin
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Jpn Heart J 44:547-56. 2003
    ..In conclusion, elevation of extracellular Ca2+ concentrations affects NE-induced IP3 formation in atrial myocytes. Protein kinase C and calmodulin may control the IP3 response to NE by a negative feedback mechanism...
  36. ncbi request reprint Postoperative interleukin-6 and cortisol concentrations in elderly patients with postoperative confusion
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Japan
    Neuroimmunomodulation 12:60-6. 2005
    ..To investigate changes in plasma interleukin (IL)-6, cortisol or noradrenaline concentrations after surgery in elderly patients with postoperative confusion...
  37. doi request reprint Interaction between orexinergic neurons and NMDA receptors in the control of locus coeruleus-cerebrocortical noradrenergic activity of the rat
    Ryuji Tose
    Department of Anesthesiology, University of Hirosaki Postgraduate School of Medicine, Hirosaki 036 8562, Japan
    Brain Res 1250:81-7. 2009
    ..These findings strongly indicate that there is a significant interaction between orexinergic neurons and NMDA receptors in the control of LC-cerebrocortical noradrenergic activity...
  38. doi request reprint Orexin A decreases ketamine-induced anesthesia time in the rat: the relevance to brain noradrenergic neuronal activity
    Ryuji Tose
    Department of Anesthesiology, Institute of Brain Science, University of Hirosaki School of Medicine, Hirosaki, Japan
    Anesth Analg 108:491-5. 2009
    ..Ketamine increases NE release from the rat cerebral cortex. We hypothesized that OX would affect ketamine anesthesia's interactions with brain noradrenergic neuronal activity...
  39. ncbi request reprint [A case of severe bradycardia and AV block during administration of propofol]
    Hajime Takase
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki 036 8545
    Masui 52:1000-2. 2003
    ..Postoperative Holter ECG and echocardiography showed no abnormalities. It is likely that stimulation of the trachea triggered vagovagal reflex and propofol prolonged AV conduction, causing the AV block...
  40. ncbi request reprint Sevoflurane increases glucose transport in skeletal muscle cells
    Akira Kudoh
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki National Hospital, 1 Tominocho, Hirosaki 036 8545, Aomori, Japan
    Anesth Analg 95:123-8, table of contents. 2002
    ..h(-1). mg protein(-1). We conclude that sevoflurane increases glucose uptake in skeletal muscle cells and that the sevoflurane-stimulated glucose uptake was associated with tyrosine kinase, protein kinase C, and intracellular Ca(2+)...
  41. ncbi request reprint Insulin potentiates bradykinin-induced inositol 1,4,5-triphosphate in neonatal rat cardiomyocytes
    Akira Kudoh
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki National Hospital, Aomori, Japan
    J Cardiovasc Pharmacol 39:621-7. 2002
    ..Tyrosine kinase appears to play an important role in the cross-talking. Calmodulin controls the IP3 response to bradykinin by a negative feedback mechanism...
  42. ncbi request reprint [Severe hypoxia during right lateral position induced by mediastinal shift]
    Tadanobu Yasuda
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki 036 8545
    Masui 56:1071-4. 2007
    ..After 8 days, the operation was performed using the supine position. We concluded that a downward mediastinal shift induced severe right lung volume reduction in the right lateral position during anesthesia...
  43. ncbi request reprint Antidepressant treatment for chronic depressed patients should not be discontinued prior to anesthesia
    Akira Kudoh
    Departments of Anesthesiology, Hakodate Watanabe Hospital, and Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Can J Anaesth 49:132-6. 2002
    ..To investigate whether antidepressants administered to patients for chronic depression patients should be continued or discontinued before anesthesia...
  44. doi request reprint The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices
    Yoko Kawaguchi
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Anesth Analg 108:1177-81. 2009
    ..We hypothesized that there was some interaction between benzodiazepines and the UII system in the cerebral cortex...
  45. doi request reprint Use of initial distribution volume of glucose to determine fluid volume loading in pulmonary thromboembolism and right ventricular myocardial infarction
    Eiji Hashiba
    Intensive Care Unit, Hirosaki University Hospital, 5 Zaifu cho, Hirosaki, 036 8563, Japan
    J Anesth 22:453-6. 2008
    ..Although the patient died on the subsequent day, this case report could support the usefulness of IDVG as a fluid volume marker in critically ill patients, especially those with right AMI...
  46. ncbi request reprint [Orexinergic neurons and noradrenergic awakening system in general anesthesia]
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562
    Masui 56:9-18. 2007
    ..Moreover, muscimol (GABAA-receptor agonist) did not inhibit the OX-norepinephrine release but inhibited the K+-evoked release. Therefore, GABAA-receptor may also not be involved...
  47. ncbi request reprint Determination of the standard value of circulating blood volume during anesthesia using pulse dye-densitometry: a multicenter study in Japan
    Takehiko Iijima
    Department of Anesthesiology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, 181 8611, Japan
    J Anesth 19:193-8. 2005
    ..The standard value for circulating blood volume (BV) during anesthesia was determined by a multicenter study in Japan. The significance of BV on the reduction of blood pressure after the induction of anesthesia was also examined...
  48. ncbi request reprint Possible overestimation of indocyanine green-derived plasma volume early after induction of anesthesia with propofol/fentanyl
    Wei Dong Mi
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki Shi, Japan
    Anesth Analg 97:1421-7. 2003
    ..Simultaneous measurement of the initial distribution volume of glucose may help investigate the presence of overestimation in indocyanine green derived plasma volume...
  49. ncbi request reprint Ketamine suppresses norepinephrine-induced inositol 1,4,5-trisphosphate formation via pathways involving protein kinase C
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Japan
    Anesth Analg 94:552-7; table of contents. 2002
    ..In conclusion, ketamine suppresses NE-induced IP(3) production, and the inhibition is caused through pathways including protein kinase C and a decrease in intracellular Ca(2+) concentrations...
  50. ncbi request reprint The effects of benzodiazepines on orexinergic systems in rat cerebrocortical slices
    Ying He
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    Anesth Analg 104:338-40. 2007
    ..As orexinergic (OXergic) neurons have been reported to mediate emotional changes, benzodiazepines might interact with OXergic neurons...
  51. ncbi request reprint Does long-term medication with a proton pump inhibitor induce a tolerance to H2 receptor antagonist?
    Hiroshi Hashimoto
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Aomori 036 8563, Japan
    J Gastroenterol 42:275-8. 2007
    ..Therefore, we studied the efficacy of an H2RA, roxatidine, in patients receiving long-term PPI medication...
  52. ncbi request reprint Regular use of H2 blockers reduces the efficacy of roxatidine to control gastric pH and volume
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Can J Anaesth 52:166-71. 2005
    ..However, several reports suggest that long-term medication may produce tolerance. Therefore, we studied the efficacy of a preanesthetic H(2) antagonist (oral roxatidine) in patients on regular H(2) antagonist therapy...
  53. ncbi request reprint Alpha-2 adrenoceptor activity affects propofol-induced sleep time
    Tetsuya Kushikata
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Anesth Analg 94:1201-6, table of contents. 2002
    ..These changes were essentially mirrored in both groups by changes in norepinephrine release in the prefrontal cortex...
  54. ncbi request reprint Atrial natriuretic peptide increases glucose uptake during hypoxia in cardiomyocytes
    Akira Kudoh
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Aomori, Japan
    J Cardiovasc Pharmacol 40:601-10. 2002
    ..It was concluded that the atrial natriuretic peptide-stimulated glucose uptake during hypoxia acts through a phospholipase C-tyrosine kinase pathway...
  55. ncbi request reprint Efficacy of landiolol in attenuating hemodynamic responses to local epinephrine infiltration in patients undergoing vaginal total hysterectomy
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, 53 Honcho, Hirosaki, 036 8563, Japan
    J Anesth 19:17-20. 2005
    ..In this study, we examined the effects of landiolol on the hemodynamic changes resulting from local infiltration of epinephrine...
  56. ncbi request reprint Effects of nociceptin/orphanin FQ receptor ligands on blood pressure, heart rate, and plasma catecholamine concentrations in guinea pigs
    Eiji Hashiba
    Department of Anesthesiology, University of Hirosaki School of Medicine, 036 8562 Hirosaki, Japan
    Naunyn Schmiedebergs Arch Pharmacol 367:342-7. 2003
    ....
  57. ncbi request reprint Flat electroencephalogram caused by carbon dioxide pneumoperitoneum
    Hitoshi Yoshida
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    Anesth Analg 105:1749-52, table of contents. 2007
    ..Termination of the laparoscopic procedure improved ventilation, EEG, and hemodynamics. These EEG changes may result from the narcotic properties of CO2 or hypercapnia-induced neurological abnormalities...
  58. doi request reprint Role of the orexinergic system in acute haemorrhage in the rat
    Kazuyoshi Hirota
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8563, Japan
    Neurosci Lett 432:162-6. 2008
    ..436, p=0.002). There was no correlation with plasma orexin A levels. These data suggest that despite a weak activation the orexinergic system is unlikely to make a major contribution to the response to haemorrhage...
  59. doi request reprint Neuropeptide microdialysis in free-moving animals
    Tetsuya Kushikata
    Department of Anesthesiology, Hirosaki University Hospital, Hirosaki, Japan
    Methods Mol Biol 789:261-9. 2011
    ..These molecules include neuropeptides and hormones. In this chapter, we describe a principle of the microdialysis technique, how to prepare a microdialysis system, and how to obtain samples from the brain of free-moving animals...
  60. doi request reprint Efficacy of a single 24-hour pre-anesthetic dose of proton pump inhibitors
    Kazuyoshi Hirota
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    J Gastroenterol Hepatol 24:1244-7. 2009
    ..In the present study, we have compared the effects of roxatidine, rabeprazole and lansoprazole given singly at night as an alternative to the standard double roxatidine medication...
  61. doi request reprint Nitrous oxide and xenon increase noradrenaline release in the cerebral cortex in vivo and in vitro
    Hitoshi Yoshida
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
    Neurosci Lett 469:199-203. 2010
    ..The nitrous oxide-induced increase in noradrenaline release may be due to both excitation of the locus coeruleus-noradrenergic neuron and direct stimulation of its axon terminals...
  62. doi request reprint Time-consumption risk of real-time ultrasound-guided internal jugular vein cannulation in pediatric patients: comparison with two conventional techniques
    Hitoshi Yoshida
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori, 036 8562, Japan
    J Anesth 24:653-5. 2010
    ..Thus real-time USG leads to the highest success rate for IJV cannulation but with a significant time delay, whereas it was the most useful without time delay for the smaller-body-weight subgroup...
  63. pmc Initial distribution volume of glucose can be approximated using a conventional glucose analyzer in the intensive care unit
    Hironori Ishihara
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki Shi, Japan
    Crit Care 9:R144-9. 2005
    ..The purpose of the present study was to compare approximated IDVG, derived from just two blood samples, versus original IDVG, and to test whether approximated IDVG is an acceptable alternative measure of IDVG in the intensive care unit...
  64. ncbi request reprint Comparison of initial distribution volume of glucose and intrathoracic blood volume during hemodynamically unstable States early after esophagectomy
    Hironori Ishihara
    Department of Anesthesiology, University of Hirosaki School of Medicine, 5 Zaifu cho, Hirosaki Shi, 036 8562, Japan
    Chest 128:1713-9. 2005
    ..We hypothesized that IDVG has a close relationship with intrathoracic blood volume (ITBV). We examined whether IDVG can correlate with ITBV during hemodynamically unstable states early after esophagectomy...
  65. ncbi request reprint The efficacy of preanesthetic proton pump inhibitor treatment for patients on long-term H2 antagonist therapy
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Anesth Analg 101:1038-41, table of contents. 2005
    ..05) were at risk. These data suggest that in patients receiving H2-antagonist therapy for longer than 4 wk, prophylaxis for acid aspiration pneumonia should include preanesthetic PPI medication...
  66. ncbi request reprint Correlation between salivary alpha-amylase activity and pain scale in patients with chronic pain
    Shyuichi Shirasaki
    Department of Anesthesiology, Caress Alliance Tenshi Hospital, Sapporo, Japan
    Reg Anesth Pain Med 32:120-3. 2007
    ..In this study, we have determined the usefulness of a portable salivary alpha-amylase analyzer as an objective biomarker of stress...
  67. doi request reprint Use of bispectral index monitoring for a patient with hepatic encephalopathy requiring living donor liver transplantation: a case report
    Hirobumi Okawa
    Department of Anesthesia, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8216, Japan
    J Anesth 25:117-9. 2011
    ..We believe that, with BIS, we were able to follow preoperative exacerbation of the "pathological" process of hepatic encephalopathy, and predict postoperative emergence from general anesthesia, suggesting normal graft function...
  68. doi request reprint Plasma orexin A increases at emergence from sevoflurane-fentanyl anesthesia in patients undergoing ophthalmologic surgery
    Tetsuya Kushikata
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Aomori, Japan
    Neurosci Lett 482:212-5. 2010
    ..292, p<0.05) but not with norepinephrine. In conclusion we found that plasma OXA significantly increased at emergence from sevoflurane-fentanyl anesthesia and this was probably via activation of the hypothalamic-pituitary-adrenal axis...
  69. ncbi request reprint Lack of an interaction between orexinergic and opioid/nociceptinergic systems in rat cerebrocortical slices
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563, Japan
    Neurosci Lett 340:173-6. 2003
    ..We conclude that opioid receptors (DOP and KOP) are involved in K(+) but not OXA-evoked release. Moreover, we have failed to demonstrate an interaction between orexinergic and opioid/N/OFQ-ergic systems in this system...
  70. ncbi request reprint A new non-invasive continuous cardiac output trend solely utilizing routine cardiovascular monitors
    Hironori Ishihara
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki, Japan
    J Clin Monit Comput 18:313-20. 2004
    ..Using pulmonary artery catheter (CCOpa), we compared this estimated CCO (esCO) with the thermodilution CCO early after cardiac surgery, and tested whether the esCO method has potential of being an alternative measure of CCO...
  71. ncbi request reprint Does indocyanine green accurately measure plasma volume early after cardiac surgery?
    Hironori Ishihara
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki Shi, Japan
    Anesth Analg 94:781-6, table of contents. 2002
    ..Results suggest that most of the PV-ICG measurements are accurate, but inaccuracy of PV-PDD can occur early after cardiac surgery...
  72. doi request reprint A central neuropathic pain model by DSP-4 induced lesion of noradrenergic neurons: preliminary report
    Takashi Kudo
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neurosci Lett 481:102-4. 2010
    ..As response to hot-plate and tail-flick implies supra-spinal process and spinal reflex, respectively, central neuropathic pain may be facilitated by DSP-4 depleting LC-noradrenergic neurons although the present data are preliminary...
  73. ncbi request reprint [Sleep and anesthesia--Part 1, Recent findings in research]
    Tetsuya Kushikata
    Department of Anesthesiology, University of Hirosaki Schoool of Medicine, Hirosaki 036 8563
    Masui 56:1047-52. 2007
    ..In addition, anesthesia-related sleep disturbance must be settled to serve satisfied quality of life of patients and to save economic and medical resources...
  74. ncbi request reprint [Sleep and anesthesia--part 2, on the relationship between sleep and general anesthesia]
    Tetsuya Kushikata
    Department of Anesthesiology, University of Hirosaki, School of Medicine, Hirosaki 036 8563
    Masui 56:1148-54. 2007
    ..Moreover, research to solve anesthesia related-sleep disorder would be useful to improve patient's quality of life and save much medical resource...
  75. ncbi request reprint Inhibitory effects of intravenous anaesthetic agents on K(+)-evoked glutamate release from rat cerebrocortical slices. Involvement of voltage-sensitive Ca(2+) channels and GABA(A) receptors
    Masatou Kitayama
    Department of Anesthesiology, University of Hirosaki, School of Medicine, Hirosaki 036 8563, Japan
    Naunyn Schmiedebergs Arch Pharmacol 366:246-53. 2002
    ....
  76. doi request reprint Urotensin II evokes neurotransmitter release from rat cerebrocortical slices
    Tomoko Ono
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    Neurosci Lett 440:275-9. 2008
    ....
  77. doi request reprint Marked reduction in bispectral index with severe bradycardia without hypotension in a diabetic patient undergoing ophthalmic surgery
    Hiroshi Hashimoto
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Anesth 22:300-3. 2008
    ..Severe bradycardia during anesthesia will cause cerebral hypoperfusion and this may affect cerebral function. We conclude that a BIS monitor may be a useful tool for the detection of bradycardia-related cerebral hypoperfusion...
  78. ncbi request reprint Evaluation of density area in dorsal lung region during prone position using transesophageal echocardiography
    Toshihito Tsubo
    Intensive Care Unit, University of Hirosaki School of Medicine, Aomori ken, Japan
    Crit Care Med 32:83-7. 2004
    ..To evaluate the changes of density area in the dorsal lung regions of acute respiratory distress syndrome patients during prone position using transesophageal echocardiography...
  79. ncbi request reprint [Case of autonomic hyperreflexia treated with intravenous nicardipine]
    Junichi Saito
    Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki 036 8562
    Masui 58:1528-30. 2009
    ..The operation was finished with no evidence of any complications. Nicardipine may be preferable in a patient with upper spinal cord injury undergoing operation in the paralyzed area...
  80. ncbi request reprint [Effectiveness of continuous central venous oxymetry in living-donor liver transplantation with massive bleeding]
    Yoko Kawaguchi
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562
    Masui 59:242-5. 2010
    ..The use of the oxymetry to evaluate oxygen demand and supply balance in a living relative liver transplantation especially in a case of massive bleeding was very effective...
  81. ncbi request reprint [Laryngeal mask application for a case of unpredictable adult tracheal stenosis]
    Tetsuya Kushikata
    Department of Anesthesiology, University of Hirosaki Schoool of Medicine, Hirosaki 036 8563
    Masui 55:89-91. 2006
    ..The patient complained no respiratory distress after the surgery. In such unpredictable tracheal stenosis with easy mask ventilation, LMA is a considerable option for respiratory management...
  82. ncbi request reprint [Case of hemoglobinuria following glycerin enema]
    Shoko Murakami
    Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki 036 8562
    Masui 56:689-91. 2007
    ..Although it is well-known that glycerin enema could cause hemolysis, renal failure and rectal ulcer, the increase of CPK and myoglobin in serum made the diagnosis difficult from other conditions leading to rhabdomyolysis in this case...
  83. ncbi request reprint Measurement of [3H]PN200-110 and [125I]omega-conotoxin MVIIA binding
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Methods Mol Biol 312:147-59. 2006
  84. ncbi request reprint [A case of pulmonary edema due to excess absorption of perfusion fluid during transcervical resection using saline solution]
    Norikazu Takada
    Department of Anesthesiology, Hirosaki University Hospital, Hirosaki 036 8563
    Masui 59:1004-6. 2010
    ..And the patient recovered without any subsequent complications. It should be noted that in case of TCR, unpredicted excess fluid load could develop, and careful observation and management are required by anesthesiologist in charge...
  85. ncbi request reprint [A case of successful tracheal tube exchange with Airway Scope for tube damage during maxillo-mandibular osteotomy]
    Kishiko Nakai
    Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki 036 8563
    Masui 59:1315-7. 2010
    ..The extubated tracheal tube had serious cut on cuff inflation line made by surgical maneuver. In the case of suspected laryngeal edema or tracheal tube injury, use of Airway Scope for tube exchange may be a safe and reliable method...
  86. ncbi request reprint [Case in which landiolol hydrochloride improved left ventricular outflow tract obstruction with systolic anterior motion of the mitral valve following mitral valve plasty]
    Tetsuya Kushikata
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562
    Masui 55:96-9. 2006
    ..We conclude that acute LVOT obstruction with SAM could develop following MVP. TEE was a much useful tool for early diagnosis and landiolol hydrochloride would be a notable agent for nonsurgical treatment of LVOT obstruction with SAM...
  87. ncbi request reprint [Anesthetic management for patients with Brugada syndrome]
    Yoko Kawaguchi
    Department of Anesthesiology, University of Hirosaki, School of Medicine, Hirosaki 036 8562
    Masui 55:142-9. 2006
    ..We review current concept of anesthetic management for patients with Brugada syndrome including fourteen cases in our institution, two out of which developed VF during operation...
  88. ncbi request reprint [Obstruction of an reinforced endotracheal tube due to dissection of internal tube wall during total intravenous anesthesia]
    Ryuji Tose
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562
    Masui 52:1218-20. 2003
    ..We should bear in mind that repeated use of reinforced endotracheal tube could induce a critical airway obstruction...
  89. ncbi request reprint The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors
    Kazuyoshi Hirota
    Department of Anesthesiology, University of Hirosaki School of Medicine, Japan
    Anesth Analg 96:1656-60, table of contents. 2003
    ..In conclusion, the present data suggest that local but not IV general anesthetics interact with recombinant rat VR1 receptors with the former anesthetics having antagonistic activity...
  90. ncbi request reprint [Case of unexpected epiglottic cyst found during endotracheal intubation by an emergency medical technician trainee]
    Kishiko Nakai
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8563
    Masui 56:1217-9. 2007
    ..The video-laryngoscope was useful in such a case to prevent fatal complication developing on endotracheal intubation by a trainee, and also it is a good tool to show the trainee how severe the cyst related-airway trouble would be...
  91. ncbi request reprint Anaphylactoid shock in a patient following 5% human serum albumin infusion during off-pump coronary artery bypass grafting
    Ayaka Fujita
    Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki 036 8563, Japan
    J Anesth 21:396-8. 2007
    ..However, the present case suggests that severe allergic reactions should be kept in mind with the use of any colloids...
  92. ncbi request reprint [Safe management of anesthesia with total intravenous anesthesia using propofol, fentanyl and ketamine for a patient treated with intraoperative radiotherapy]
    Hitoshi Yoshida
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562
    Masui 55:614-6. 2006
    ..This discontinuation, however, may cause the cardiovascular instability. It seems that total intravenous anesthesia has advantages over inhalation anesthesia for patients who undergo intraoperative radiation therapy...
  93. ncbi request reprint [Does a high inspired oxygen concentration consistently play a key role in developing combustion in the airway during fiberoptic bronchoscopy guided laser treatment?--A case of firing in the airway under total intravenous anesthesia]
    Hironori Ishihara
    Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036 8562
    Masui 51:1359-62. 2002
    ....
  94. ncbi request reprint Rapid improvement of respiratory symptoms associated with fat embolism by high-dose methylpredonisolone: a case report
    Takeshi Kubota
    Department of Anesthesiology, University of Hirosaki School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Anesth 17:186-9. 2003
  95. ncbi request reprint [Accidental use of suxamethonium for general anesthesia in a patient with hereditary hypocholinesterasemia that was not recognized preoperatively]
    Hiroshi Hashimoto
    Department of Anesthesiology, Hirosaki University School of Medicine, Hirosaki 036 8562
    Masui 55:1014-7. 2006
    ..However, this case strongly suggests us that preoperative screening should be done without any omission. In addition, if serum ChE activity is not examined, use of suxamethonium should be avoided...
  96. ncbi request reprint [A clinical study of total intravenous anesthesia by using mainly propofol, fentanyl and ketamine--with special reference to its safety based on 26,079 cases]
    Akitomo Matsuki
    Department of Anesthesiology, University of Hirosaki Hospital, Hirosaki 036 8563
    Masui 51:1336-42. 2002
    ..These data suggest that total intravenous anesthesia with propofol, fentanyl and ketamine has a very wide margin of safety...
  97. ncbi request reprint Initial distribution volume of glucose early after cardiac surgery
    Hironori Ishihara
    Anesth Analg 102:1904. 2006