Keiko Sasaki

Summary

Affiliation: Health Sciences University of Hokkaido
Country: Japan

Publications

  1. ncbi request reprint Effects of bilobalide, a sesquiterpene in Ginkgo biloba leaves, on population spikes in rat hippocampal slices
    K Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:315-21. 1999
  2. ncbi request reprint Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver
    Keiko Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Life Sci 70:1657-67. 2002
  3. ncbi request reprint Effects of chronic administration of bilobalide on amino acid levels in mouse brain
    Keiko Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, lshikari Tobetsu, Japan
    Cell Mol Biol (Noisy-le-grand) 48:681-4. 2002
  4. ncbi request reprint Bilobalide prevents reduction of gamma-aminobutyric acid levels and glutamic acid decarboxylase activity induced by 4-O-methylpyridoxine in mouse hippocampus
    K Sasaki
    Department of Pharmacology, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Life Sci 67:709-15. 2000
  5. ncbi request reprint Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver
    Keiko Sasaki
    Laboratory for Molecular Cellular Biology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi shi, Chiba, Japan
    J Med Food 8:184-9. 2005
  6. doi request reprint Decrease in pyridoxal-5'-phosphate concentration and increase in pyridoxal concentration in rat plasma by 4'-O-methylpyridoxine administration
    Daisuke Kobayashi
    Department of Food and Chemical Toxicology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan
    Nutr Res 35:637-42. 2015
  7. ncbi request reprint Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, NSW 2006, Sydney, Australia
    Eur J Pharmacol 464:1-8. 2003
  8. ncbi request reprint Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:159-69. 2004
  9. ncbi request reprint Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 494:131-8. 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Effects of bilobalide, a sesquiterpene in Ginkgo biloba leaves, on population spikes in rat hippocampal slices
    K Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 124:315-21. 1999
    ..These results suggest that bilobalide induces an enhancement of excitability of CA1 pyramidal neurons, which involves, at least in part, a reduction in GABAergic inhibition in rat hippocampus...
  2. ncbi request reprint Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver
    Keiko Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Life Sci 70:1657-67. 2002
    ....
  3. ncbi request reprint Effects of chronic administration of bilobalide on amino acid levels in mouse brain
    Keiko Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, lshikari Tobetsu, Japan
    Cell Mol Biol (Noisy-le-grand) 48:681-4. 2002
    ..These changes in the levels of various amino acids may be involved in the broad spectrum of pharmacological activities of the extract of Ginkgo biloba on the central nervous system...
  4. ncbi request reprint Bilobalide prevents reduction of gamma-aminobutyric acid levels and glutamic acid decarboxylase activity induced by 4-O-methylpyridoxine in mouse hippocampus
    K Sasaki
    Department of Pharmacology, School of Medicine, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Life Sci 67:709-15. 2000
    ....
  5. ncbi request reprint Thyme (Thymus vulgaris L.) leaves and its constituents increase the activities of xenobiotic-metabolizing enzymes in mouse liver
    Keiko Sasaki
    Laboratory for Molecular Cellular Biology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi shi, Chiba, Japan
    J Med Food 8:184-9. 2005
    ..These results imply that thyme contains bifunctional inducers (i.e., substances capable of inducing both phase I and phase II enzymes) and that thymol and carvacrol may account for the effects of thyme...
  6. doi request reprint Decrease in pyridoxal-5'-phosphate concentration and increase in pyridoxal concentration in rat plasma by 4'-O-methylpyridoxine administration
    Daisuke Kobayashi
    Department of Food and Chemical Toxicology, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Hokkaido, Japan
    Nutr Res 35:637-42. 2015
    ..The present study is the first in vivo study showing relatively rapid elimination of MPN in rats and a decrease in plasma PLP concentration caused by MPN. ..
  7. ncbi request reprint Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, University of Sydney, NSW 2006, Sydney, Australia
    Eur J Pharmacol 464:1-8. 2003
    ..While bilobalide and picrotoxinin were clearly noncompetitive antagonists, the potency of bilobalide decreased at high GABA concentrations suggesting a component of competitive antagonism...
  8. ncbi request reprint Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:159-69. 2004
    ..These findings might suggest possible chemopreventive ability of EGb or bilobalide, through alterations in cryptal cell proliferation activity and drug metabolizing enzymes' activities, in colon tumorigenesis...
  9. ncbi request reprint Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors
    Shelley H Huang
    Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology, Faculty of Medicine, The University of Sydney, Sydney, NSW 2006, Australia
    Eur J Pharmacol 494:131-8. 2004
    ..Antagonism by these ginkgolides at alpha(1)beta(2)gamma(2L) GABA(A) receptors appears to be noncompetitive as indicated by the nonparallel right shift and reduced maximal GABA response in their GABA concentration-effect curves...