A Togawa

Summary

Affiliation: Hamamatsu University School of Medicine
Country: Japan

Publications

  1. ncbi request reprint Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    FEBS Lett 579:2557-63. 2005
  2. ncbi request reprint Catastrophic exacerbation of antiphospholipid syndrome after lung adenocarcinoma biopsy
    T Yamamoto
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    J Rheumatol 27:2035-7. 2000
  3. ncbi request reprint Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease
    Tatsuo Yamamoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, Japan
    J Am Soc Nephrol 18:1558-65. 2007
  4. pmc Ubiquitin-dependent degradation of Smad2 is increased in the glomeruli of rats with anti-thymocyte serum nephritis
    Akashi Togawa
    First Department of Medicine and the Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Am J Pathol 163:1645-52. 2003
  5. ncbi request reprint Plasma protein extravasation and vascular endothelial growth factor expression with endothelial nitric oxide synthase induction in gentamicin-induced acute renal failure in rats
    Tetsuo Goto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192 Hamamatsu, Japan
    Virchows Arch 444:362-74. 2004
  6. doi request reprint Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Physiol Renal Physiol 295:F1512-8. 2008
  7. ncbi request reprint Transforming growth factor-beta receptors in self-limited vs. chronic progressive nephritis in rats
    Takuya Watanabe
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Shizuoka 431 3192, Japan
    J Pathol 198:397-406. 2002
  8. pmc Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice
    Sayuri Suzuki
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Japan
    Am J Pathol 171:473-83. 2007
  9. ncbi request reprint Potential therapeutic effect of simvastatin on progressive renal failure and nephrotic-range proteinuria caused by renal cholesterol embolism
    K Yonemura
    Hemodialysis Unit, Hamamatsu University School of Medicine, Japan
    Am J Med Sci 322:50-2. 2001
  10. pmc Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
    Hirotaka Fukasawa
    First Department of Medicine and Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Proc Natl Acad Sci U S A 101:8687-92. 2004

Detail Information

Publications39

  1. ncbi request reprint Transcriptional induction of Smurf2 ubiquitin ligase by TGF-beta
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    FEBS Lett 579:2557-63. 2005
    ..These results suggest that TGF-beta stimulates Smurf2 expression by Smad-independent pathway such as PI3K/Akt pathway via TGF-beta receptor...
  2. ncbi request reprint Catastrophic exacerbation of antiphospholipid syndrome after lung adenocarcinoma biopsy
    T Yamamoto
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    J Rheumatol 27:2035-7. 2000
    ..This case emphasizes the need for great caution for catastrophic exacerbation of malignancy associated APS following biopsy of the underlying malignancy...
  3. ncbi request reprint Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease
    Tatsuo Yamamoto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, Japan
    J Am Soc Nephrol 18:1558-65. 2007
    ..These data suggest that urinary angiotensinogen is a potentially suitable marker of intrarenal AngII activity associated with increased risk for deterioration of renal function in patients with CKD...
  4. pmc Ubiquitin-dependent degradation of Smad2 is increased in the glomeruli of rats with anti-thymocyte serum nephritis
    Akashi Togawa
    First Department of Medicine and the Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Am J Pathol 163:1645-52. 2003
    ..These data suggest that the decrease in Smad2 resulted from enhanced ubiquitin-dependent degradation of Smad2 mediated by Smurf2, and is involved in the regulation of Smad2-mediated TGF-beta signaling in nephritic glomeruli...
  5. ncbi request reprint Plasma protein extravasation and vascular endothelial growth factor expression with endothelial nitric oxide synthase induction in gentamicin-induced acute renal failure in rats
    Tetsuo Goto
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192 Hamamatsu, Japan
    Virchows Arch 444:362-74. 2004
    ..Since VEGF-induced vascular hyperpermeability may depend on NO production, VEGF/VEGF receptor system with eNOS induction might be responsible for this process...
  6. doi request reprint Intrarenal RAS activity and urinary angiotensinogen excretion in anti-thymocyte serum nephritis rats
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Physiol Renal Physiol 295:F1512-8. 2008
    ..These data suggest that an increase in kidney-specific RAS activity, which parallels urinary AGT excretion, plays an important role in the development of ATS nephritis...
  7. ncbi request reprint Transforming growth factor-beta receptors in self-limited vs. chronic progressive nephritis in rats
    Takuya Watanabe
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Shizuoka 431 3192, Japan
    J Pathol 198:397-406. 2002
    ....
  8. pmc Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice
    Sayuri Suzuki
    Department of Biochemistry 1, Hamamatsu University School of Medicine, Japan
    Am J Pathol 171:473-83. 2007
    ..These findings suggest that p27 accumulation, which results from SCF-Skp2 ubiquitin ligase deficiency in Skp2(-/-) mice, is involved in the amelioration of renal damage induced by obstructive nephropathy...
  9. ncbi request reprint Potential therapeutic effect of simvastatin on progressive renal failure and nephrotic-range proteinuria caused by renal cholesterol embolism
    K Yonemura
    Hemodialysis Unit, Hamamatsu University School of Medicine, Japan
    Am J Med Sci 322:50-2. 2001
    ..Progressive renal failure and nephrotic-range proteinuria were halted just after treatment with simvastatin. Thus, simvastatin can exert a beneficial therapeutic effect on renal cholesterol embolism...
  10. pmc Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
    Hirotaka Fukasawa
    First Department of Medicine and Department of Biochemistry 1, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Proc Natl Acad Sci U S A 101:8687-92. 2004
    ..Our results suggest that the reduction of Smad7 protein resulting from enhanced ubiquitin-dependent degradation plays a pathogenic role in progression of tubulointerstitial fibrosis...
  11. ncbi request reprint A mechanism for the development of subepithelial deposits in a patient with type III membranoproliferative glomerulonephritis
    Yoshihide Fujigaki
    The First Department of Medicine, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan
    Nephrology (Carlton) 8:280-4. 2003
    ....
  12. ncbi request reprint Rapid improvement of acute pulmonary edema with angiotensin converting enzyme inhibitor under hemodialysis in a patient with renovascular disease
    Yoshihide Fujigaki
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Ther Apher Dial 8:148-52. 2004
    ..Blocking of angiotensin II should be considered in such patients even after introduction of hemodialysis...
  13. ncbi request reprint Transient myofibroblast differentiation of interstitial fibroblastic cells relevant to tubular dilatation in uranyl acetate-induced acute renal failure in rats
    Yoshihide Fujigaki
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192, Hamamatsu, Japan
    Virchows Arch 446:164-76. 2005
    ....
  14. ncbi request reprint Kinetics and characterization of initially regenerating proximal tubules in S3 segment in response to various degrees of acute tubular injury
    Yoshihide Fujigaki
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192 Hamamatsu, Japan
    Nephrol Dial Transplant 21:41-50. 2006
    ..We examined kinetics and characterization of regenerating proximal tubule (PT) cells after various degrees of tubular injury in S3 segments of PT and assessed label-retaining slow cycling cells in S3...
  15. ncbi request reprint Giant coronary aneurysm in a patient with systemic lupus erythematosus
    Hiroyuki Suzuki
    The First Department of Medicine, Hamamatsu University School of Medicine
    Intern Med 48:1407-12. 2009
    ..The aneurysm may have developed during the long course of inactive stage of SLE, emphasizing the need for screening of coronary lesions in the management of SLE...
  16. pmc Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats
    Taro Misaki
    Department of Health and Nutritional Sciences, Faculty of Health Promotional Sciences, Hamamatsu University, Hamamatsu, Japan
    Am J Pathol 175:74-83. 2009
    ....
  17. ncbi request reprint Association of serum adiponectin levels with all-cause mortality in hemodialysis patients
    Naro Ohashi
    The First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu
    Intern Med 47:485-91. 2008
    ..1%), hypertensive nephrosclerosis in 10 (11.8%), and others in 10 (11.8%)] who survived for more than 3 months after the start of HD. We first measured serum ADPN levels and prospectively followed patients for the next 3 years...
  18. ncbi request reprint Immunohistochemical study on caveolin-1alpha in regenerating process of tubular cells in gentamicin-induced acute tubular injury in rats
    Yoshihide Fujigaki
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, 431 3192 Hamamatsu, Japan
    Virchows Arch 450:671-81. 2007
    ..Our results suggest that transient expression of caveolin-1alpha in early regenerating PTs might contribute to the regenerating process of PTs through modulating growth factor receptors...
  19. ncbi request reprint Treatment with anti-TGF-beta antibody ameliorates chronic progressive nephritis by inhibiting Smad/TGF-beta signaling
    Hirotaka Fukasawa
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Kidney Int 65:63-74. 2004
    ....
  20. ncbi request reprint Withdrawal of interferon-alpha results in prompt resolution of thrombocytopenia and hemolysis but not renal failure in hemolytic uremic syndrome caused by interferon-alpha
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, and Seirei Hamamatsu General Hospital, Hamamatsu, Japan
    Am J Kidney Dis 41:E10. 2003
    ....
  21. doi request reprint Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma
    Hirotaka Fukasawa
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Int J Cancer 127:1517-25. 2010
    ..Our results suggest that the low TbetaR-II protein level is due to augmented ubiquitin-dependent degradation via Smurf2 and might be involved in the attenuation of TGF-beta signaling pathway in RCC...
  22. ncbi request reprint A case of thrombotic microangiopathy complicated with systemic lupus erythematosus
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Am J Med Sci 326:102-4. 2003
    ..The data suggest that prompt induction of plasmapheresis in addition to immunosuppressive therapy is necessary in SLE patients having symptoms suspicious of TMA even before they fulfill the 5 symptoms typical of TMA...
  23. ncbi request reprint Anti-glomerular basement membrane antibody-induced glomerulonephritis with periglomerular granulomatous reaction and massive renal eosinophilic infiltration
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Am J Kidney Dis 42:E28-35. 2003
    ..He was discharged from our hospital 65 days after admission. Three months later, his anti-GBM antibody level was less than 10 EU, and the number of peripheral eosinophils stayed with the normal range...
  24. ncbi request reprint Longterm complete remission of AL-amyloid-related nephrotic syndrome
    Yoshihide Fujigaki
    The First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    Clin Exp Nephrol 7:250-3. 2003
    ....
  25. ncbi request reprint Dietary salt intake modulates progression of antithymocyte serum nephritis through alteration of glomerular angiotensin II receptor expression
    Hiroyuki Suzuki
    First Department of Medicine, Hamamatsu Univ School of Medicine, 1 20 1, Handayama, Hamamatsu 431 3192, Japan
    Am J Physiol Renal Physiol 286:F267-77. 2004
    ..Our results suggest that dietary salt intake influences progression of ATS nephritis by modulating glomerular TGF-beta1 and TbetaR expression resulting, at least in part, from altered glomerular AT1R and AT2R expression...
  26. ncbi request reprint Influence of body composition on 5 year mortality in patients on regular haemodialysis
    Akihiko Kato
    First Department of Medicine and Dialysis Unit, Hamamatsu University School of Medicine, Nagaizumi, Shizuoka 411 8777, Japan
    Nephrol Dial Transplant 18:333-40. 2003
    ..Reduction of body mass index (BMI) significantly affects mortality in haemodialysis (HD) patients, but it remains to be determined which of the body components influences mortality...
  27. doi request reprint A distinct population of tubular cells in the distal S3 segment contributes to S3 segment regeneration in rats following acute renal failure induced by uranyl acetate
    Masanori Sakakima
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Nephron Exp Nephrol 109:e57-70. 2008
    ..We also discriminated target cells from bromodeoxyuridine (BrdU)-label-retaining cells labeled under normal conditions and examined their capacity to proliferate following a second insult and their resistance to 5-fluorouracil (5-FU)...
  28. ncbi request reprint Inhibition of p21 modifies the response of cortical proximal tubules to cisplatin in rats
    Hua Zhou
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, and Division of Nephrology, Endocrinology and Metabolism, Shizuoka Cancer Center Hospital, Japan
    Am J Physiol Renal Physiol 291:F225-35. 2006
    ..Because antisense may not adequately be taken up and/or function in PTs in the OSOM, the role of p21 in PTs in the OSOM in CDDP-induced ARF remains to be clarified...
  29. ncbi request reprint Urinary marker for oxidative stress in kidneys in cisplatin-induced acute renal failure in rats
    Hua Zhou
    First Department of Medicine, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka, 431 3192, Japan
    Nephrol Dial Transplant 21:616-23. 2006
    ..We evaluated whether urinary oxidative stress markers reflect intrarenal oxidative stress in cisplatin (CDDP)-induced ARF, and whether these markers can be used for the prediction of future ARF...
  30. doi request reprint Effects of relaxin on development of mesangial proliferative nephritis
    Naoki Ikegaya
    Medical Care Center, Shizuoka University, Shizuoka, Japan
    Ann N Y Acad Sci 1160:300-3. 2009
    ..These results suggest that RLX is a promising therapeutic tool for nephritic diseases...
  31. ncbi request reprint Membranous glomerulonephritis associated with renal cell carcinoma: failure to detect a nephritogenic tumor antigen
    Akashi Togawa
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Nephron 90:219-21. 2002
    ..Further studies are necessary to establish the pathogenic mechanism of MGN associated with malignancy...
  32. ncbi request reprint Measurement of des-gamma-carboxy prothrombin levels in hemodialysis patients positive for anti-hepatitis virus C antibody
    A Kato
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Clin Nephrol 58:296-300. 2002
    ..In this study, we measured blood PIVKA-II in HD patients positive for anti-HCV antibody or hepatitis B virus surface (HBs) antigen to examine if HD therapy may affect the measurement of PIVKA-II...
  33. ncbi request reprint Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury
    H Fukasawa
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Kidney Int 69:1733-40. 2006
    ..Our results suggest that the reduction of SnoN/Ski proteins resulting from increased ubiquitin-dependent degradation is involved in the progression of tubulointerstitial fibrosis...
  34. ncbi request reprint A patient with sarcoidosis presenting with acute renal failure: implication for granulomatous interstitial nephritis and hypercalcemia
    Naro Ohashi
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu
    Intern Med 41:1171-4. 2002
    ..Serum intact osteocalcin concentration was markedly suppressed and urinary deoxypyridinoline excretion increased. It is possible suppressed bone resorption may be associated with overproduction of 1,25-(OH)2D3...
  35. ncbi request reprint Recovery from hemodialysis therapy in a patient with renal cholesterol crystal embolism
    Akihiko Kato
    First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Nephron 92:240-3. 2002
    ..This case suggested that the surgical amputation promptly recovered renal function. Reversal of inflammation may be more effective than lipid-lowering therapy for renal failure in our patient...
  36. ncbi request reprint Thrombotic thrombocytopenic purpura associated with mixed connective tissue disease
    Akihiko Kato
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Rheumatol Int 22:122-5. 2002
    ..Neuropsychiatric symptoms due to thrombotic microangiopathy could be some of the fatal complications in MCTD patients...
  37. ncbi request reprint The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure
    Hua Zhou
    First Department of Medicine, Hamamatsu University School of Medicine, Shizuoka, Japan
    Toxicol Appl Pharmacol 200:111-20. 2004
    ....
  38. ncbi request reprint [Nephrotic syndrome: pathophysiology, classification and diagnostic criteria]
    Akashi Togawa
    First Department of Medicine, Hamamatsu University School of Medicine
    Nihon Rinsho 62:1777-83. 2004
    ..Abnormality of coagulation factors is also associated with nephrotic syndrome. Nephrotic syndrome may be primary or secondary to systemic disorders. Once diagnosed, the cause for the nephrotic syndrome must be examined...
  39. ncbi request reprint High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein
    Masanori Sakakima
    First Department of Medicine, Hamamatsu University School of Medicine, Japan
    Intern Med 44:970-4. 2005
    ..Immunophenotypic analysis of marrow cells facilitates clinical decision making regarding the use of HDC/PBSCT for LHCDD patients without monoclonal protein...