Affiliation: Hamamatsu University School of Medicine
- Tubulin tyrosination navigates the kinesin-1 motor domain to axonsYoshiyuki Konishi
Department of Molecular Anatomy, Hamamatsu University School of Medicine, Handayama, Shizuoka, Japan
Nat Neurosci 12:559-67. 2009..Our study identifies a molecular mechanism that discriminates the axonal microtubules from somatodendritic microtubules, as well as a previously unknown linkage between tubulin modification and polarized trafficking in neurons...
- Developments and applications of mass microscopyMitsutoshi Setou
Department of Molecular Anatomy, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka, 431 3192, Japan
Med Mol Morphol 43:1-5. 2010..In this Award Lecture Review, we focus on some of the recent developments in clinical applications to show how mass microscopy can be employed to assess medical molecular morphology...
- Axonal gradient of arachidonic acid-containing phosphatidylcholine and its dependence on actin dynamicsHyun Jeong Yang
Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1 20 1, Handayama, Hamamatsu 431 3192, Japan
J Biol Chem 287:5290-300. 2012..Inhibitors of actin dynamics (cytochalasin D and phallacidin) disrupted this gradient. This is the first report of the gradual distribution of AA-PC along the axon and its association with actin dynamics...
- Ttll9-/- mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beatingAlu Konno
Department of Cellular and Molecular Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 4313192, Japan Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 4313192, Japan
J Cell Sci 129:2757-66. 2016..These results indicate that mammalian Ttll9 plays essential roles in maintaining the normal structure and beating pattern of sperm flagella by establishing normal heterogeneous polyglutamylation patterns...
- Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs)Yoshishige Kimura
Department of Molecular Anatomy, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
J Biol Chem 285:22936-41. 2010..Together, these data from two evolutionarily divergent systems identify C. elegans CCPP-6 and its mammalian ortholog CCP5 as a tubulin deglutamylase...