Hiroyuki Shimizu

Summary

Affiliation: Gunma University
Country: Japan

Publications

  1. ncbi request reprint Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy
    Hiroyuki Shimizu
    First Department of Internal Medicine, Gunma University School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    Nutrition 18:309-12. 2002
  2. ncbi request reprint Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes
    Mitsuhiko Umahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 149:40-9. 2008
  3. doi request reprint CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
    Shuichi Okada
    Department of Medicine, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 0034, Japan
    J Biol Chem 283:35455-63. 2008
  4. pmc Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Protein Pept Lett 19:997-1004. 2012
  5. doi request reprint Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene
    Masanobu Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 151:2494-503. 2010
  6. pmc Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
    Eijiro Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371 8511, Japan
    J Cell Biol 168:921-8. 2005
  7. doi request reprint Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor
    Satoshi Yoshino
    Departments of Medicine and Molecular Science S Y, T Sat, M Y, K H, T To, A K T, S K, S O, H S, A O, T Tu, Ma Mori and Human Pathology H I, Y N, Gunma University Graduate School of Medicine, Maebashi, 371 8511 Japan Laboratory of Biosignal Sciences Mu Mori, T Ma and Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation T Sas, T K, Gunma University, Maebashi, 371 8512 Japan and Kitakanto Molecular Novel Research Institute for Obesity and Metabolism Ma Mori, Midori, 379 2311 Japan
    Endocrinology 155:3459-72. 2014
  8. doi request reprint THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation
    Akiko Katano-Toki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Mol Endocrinol 27:769-80. 2013
  9. pmc Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 7:e50918. 2012
  10. ncbi request reprint Synip phosphorylation is required for insulin-stimulated Glut4 translocation
    Shuichi Okada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 356:102-6. 2007

Detail Information

Publications76

  1. ncbi request reprint Circulating concentrations of soluble leptin receptor: influence of menstrual cycle and diet therapy
    Hiroyuki Shimizu
    First Department of Internal Medicine, Gunma University School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan
    Nutrition 18:309-12. 2002
    ....
  2. ncbi request reprint Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes
    Mitsuhiko Umahara
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 149:40-9. 2008
    ..Together, these data demonstrate that one mechanism accounting for the PDGF induction of Glut4 translocation is the suppression of the Munc18c negative regulation of Syntaxin 4 function...
  3. doi request reprint CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation
    Shuichi Okada
    Department of Medicine, Gunma University Graduate School of Medicine, Showa machi, Maebashi, Gunma 371 0034, Japan
    J Biol Chem 283:35455-63. 2008
    ..Because cortical actin reorganization is required for insulin-stimulated GLUT4 translocation, these data are consistent with a CDK5-dependent TC10alpha cycling between lipid raft and non-lipid raft compartments...
  4. pmc Secreted nucleobindin-2 inhibits 3T3-L1 adipocyte differentiation
    Yuko Tagaya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Protein Pept Lett 19:997-1004. 2012
    ..Taken together, these data indicate that secreted Nucleobindin-2 is a suppressor of adipocyte differentiation through inhibition of cAMP production and insulin signal...
  5. doi request reprint Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene
    Masanobu Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma 371 8511, Japan
    Endocrinology 151:2494-503. 2010
    ....
  6. pmc Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles
    Eijiro Yamada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371 8511, Japan
    J Cell Biol 168:921-8. 2005
    ..These data demonstrate that insulin activation of Akt2 specifically regulates the docking/fusion step of GLUT4-containing vesicles at the plasma membrane through the regulation of Synip phosphorylation and Synip-Syntaxin4 interaction...
  7. doi request reprint Protection against high-fat diet-induced obesity in Helz2-deficient male mice due to enhanced expression of hepatic leptin receptor
    Satoshi Yoshino
    Departments of Medicine and Molecular Science S Y, T Sat, M Y, K H, T To, A K T, S K, S O, H S, A O, T Tu, Ma Mori and Human Pathology H I, Y N, Gunma University Graduate School of Medicine, Maebashi, 371 8511 Japan Laboratory of Biosignal Sciences Mu Mori, T Ma and Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation T Sas, T K, Gunma University, Maebashi, 371 8512 Japan and Kitakanto Molecular Novel Research Institute for Obesity and Metabolism Ma Mori, Midori, 379 2311 Japan
    Endocrinology 155:3459-72. 2014
    ..Hepatic HELZ2 might be a novel target molecule for the treatment of obesity with hepatosteatosis. ..
  8. doi request reprint THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation
    Akiko Katano-Toki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Mol Endocrinol 27:769-80. 2013
    ..These findings collectively suggest that Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARĪ³-mediated gene activation cooperatively with Helz2...
  9. pmc Nesfatin-1 induces the phosphorylation levels of cAMP response element-binding protein for intracellular signaling in a neural cell line
    Emi Ishida
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    PLoS ONE 7:e50918. 2012
    ..Our study highlights that Nesfatin-1, via its receptor, induces the phosphorylation of CREB, thus activating the intracellular signaling cascade in neurons...
  10. ncbi request reprint Synip phosphorylation is required for insulin-stimulated Glut4 translocation
    Shuichi Okada
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Biochem Biophys Res Commun 356:102-6. 2007
    ..These data are consistent with Synip serine 99 phosphorylation required for insulin-stimulated Glut4 translocation...
  11. doi request reprint The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis
    Yasuyo Ariyama
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Metabolism 57:1625-35. 2008
    ..The present studies showed that CHOP should be important in pancreatic beta-cell injury by oxidative stress and indicate that CHOP may play a role in the development of pancreatic beta-cell damage on the onset of diabetes mellitus...
  12. ncbi request reprint Nesfatin-1: an overview and future clinical application
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 56:537-43. 2009
    ..We summarize recent observations about nesfatin-1, and attempt to present future direction of nesfatin-1 research for developing a new anti-obesity treatment...
  13. ncbi request reprint Fenofibrate, troglitazone, and 15-deoxy-Delta12,14-prostaglandin J2 close KATP channels and induce insulin secretion
    Kenju Shimomura
    Department of Medicine and Molecular Science, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511 Japan
    J Pharmacol Exp Ther 310:1273-80. 2004
    ..Our data suggest that PPAR-alpha and -gamma ligands interact directly with the beta-cell membrane and stimulate insulin secretion...
  14. ncbi request reprint Contribution of fasting and postprandial hyperglycemia to hemoglobin A1c in insulin-treated Japanese diabetic patients
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 55:753-6. 2008
    ..Postprandial hyperglycemia after breakfast and dinner should be regarded as most important for improving HbA(1c) levels in insulin treated diabetic patients...
  15. ncbi request reprint Leptin resistance and obesity
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Endocr J 54:17-26. 2007
  16. ncbi request reprint 9HODE stimulates cell proliferation and extracellular matrix synthesis in human mesangial cells via PPARgamma
    Mayumi Negishi
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 22 Showamachi, Maebashi, Gunma 371 8511, Japan E mail
    Exp Biol Med (Maywood) 229:1053-60. 2004
    ..In addition, the stimulatory effects are, at least in part, mediated by PPARgamma, which may exist in downstream of ERK1/2 pathway...
  17. doi request reprint Enhanced expression of nesfatin/nucleobindin-2 in white adipose tissue of ventromedial hypothalamus-lesioned rats
    Aya Osaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Neurosci Lett 521:46-51. 2012
    ..Further, this action may be mediated via inhibition of the sympathetic nerve activity...
  18. ncbi request reprint Is leptin a key factor which develops obesity by ovariectomy?
    Kenju Shimomura
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Endocr J 49:417-23. 2002
    ....
  19. ncbi request reprint A new anorexigenic protein, nesfatin-1
    Hiroyuki Shimizu
    aDepartment of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Japan
    Peptides 30:995-8. 2009
    ..In this review, we summarized recent progress in the research about the possible mechanism of nesfatin-1-induced anorexia...
  20. ncbi request reprint Troglitazone inhibits isolated cell proliferation, and induces apoptosis in isolated rat mesangial cells
    Takahumi Tsuchiya
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Gunma, Japan
    Am J Nephrol 23:222-8. 2003
    ..There have been few reports about direct effect of thiazolidinedione derivatives on mesangial cell function. We determined the effect of troglitazone on isolated rat mesangial cell proliferation...
  21. ncbi request reprint Cumulative effects of genetic risk variants on the development of common atherosclerosis
    Takafumi Tsuchiya
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa, Maebashi, Gunma 371 8511, Japan
    Expert Rev Cardiovasc Ther 9:295-8. 2011
    ..The findings of this study may indicate a new biochemical pathway involved in the development of atherosclerosis...
  22. ncbi request reprint Activation of peroxisome proliferator-activated receptor-gamma stimulates the growth arrest and DNA-damage inducible 153 gene in non-small cell lung carcinoma cells
    Teturou Satoh
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi 371 8511, Japan
    Oncogene 21:2171-80. 2002
    ..These findings collectively indicated that activation of PPAR-gamma by TZDs could cause growth inhibition and apoptosis of NSCLC cells and that GADD153 might be a candidate factor implicated in these processes...
  23. ncbi request reprint Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma 371 8511, Japan
    Endocrinology 145:4232-43. 2004
    ..The increased Erk activation by BTC associated with antiapoptotic function...
  24. ncbi request reprint The brain-adipose axis: a review of involvement of molecules
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma 371 8511, Japan
    Nutr Neurosci 8:7-20. 2005
    ..Analysis of the disturbance and dysregulation of this axis might promote the development of new anti-obesity drugs useful in treating the metabolic syndrome...
  25. ncbi request reprint Relationship between hyperinsulinemia and pulse wave velocity in moderately hyperglycemic patients
    Miki Koizumi
    Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan
    Diabetes Res Clin Pract 62:17-21. 2003
    ..The influence of hyperinsulinemia on peripheral vascular disease (PVD) is still unknown. We determined the influences of hyperinsulinemia on PVD assessed by PWV in moderately hyperglycemic patients...
  26. ncbi request reprint Primary amenorrhea accompanied by adrenal adenoma: start of menarche soon after tumor resection
    Yoshimi Takahashi
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi
    Intern Med 41:972-6. 2002
    ..Following tumor resection, serum progesterone normalized 4 days later, and menarche occurred 51 days after operation. The present case indicated that adrenal functioning tumor should not be overlooked in patients with primary amenorrhea...
  27. ncbi request reprint The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    J Endocrinol 193:1-9. 2007
    ..We focus on and review the melanocortin signaling system that functions dependently or independently of leptin signaling in the regulation of energy homeostasis...
  28. ncbi request reprint Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution
    Kinuko Kuwata
    Department of Surgery II, Kumamoto University Medical School, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    J Gastroenterol 37:928-34. 2002
    ..Based on this hypothesis, we performed a biochemical analysis of recombinant PSTI protein...
  29. ncbi request reprint Identification of nesfatin-1 as a satiety molecule in the hypothalamus
    Shinsuke Oh-I
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Showa machi, Maebashi 371 8511, Japan
    Nature 443:709-12. 2006
    ..We identify nesfatin-1 as a satiety molecule that is associated with melanocortin signalling in the hypothalamus...
  30. ncbi request reprint Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic beta HC-9 cell
    Tsugumichi Saito
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi shi, Gunma ken, 371 8511, Japan
    J Biol Chem 278:36718-25. 2003
    ..These data demonstrate that syntaxin 4 plays a functional role on insulin release and granule fusion in beta cells and that this process is regulated by the syntaxin 4-specific binding protein Synip...
  31. ncbi request reprint Cigarette smoking, alcohol drinking, and oral and pharyngeal cancer mortality in Japan
    R Ide
    Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyusyu, Japan
    Oral Dis 14:314-9. 2008
    ..To prospectively examine the association of cigarette smoking and alcohol drinking with oral and pharyngeal carcinogenesis, we analyzed data from a nation-wide large-scale cohort study in Japan...
  32. doi request reprint Smoking and risk of cedar pollinosis in Japanese men and women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Int Arch Allergy Immunol 147:117-24. 2008
    ..Pollinosis induced by the cedar pollen antigen is the most common seasonal allergic reaction in Japan. We aimed to examine the relationship between smoking and risk of cedar pollinosis in a population-based cohort of the Japanese...
  33. ncbi request reprint Lifetime and 6-month prevalence of DSM-III-R psychiatric disorders in an urban community in Japan
    Norito Kawakami
    Hygiene and Preventive Medicine, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Psychiatry Res 121:293-301. 2004
    ..The patterns of demographic correlates and comorbidity are similar to those of most other countries...
  34. doi request reprint Dietary and lifestyle correlates of urinary excretion status of equol in Japanese women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Nutr Cancer 60:49-54. 2008
    ..Demographic factors, smoking status, and menstrual and reproductive factors were unrelated to equol excretion. These data suggest that dairy product intake may be associated with the production of equol...
  35. pmc Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk
    Yingsong Lin
    Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan
    J Epidemiol 18:77-83. 2008
    ..We examined the association between breast cancer incidence and active and passive smoking in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk...
  36. ncbi request reprint Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Epidemiol Biomarkers Prev 16:2509-12. 2007
    ..02). There was no significant association between urinary aMT6-s level and the percent density in postmenopausal women. We found no evidence that the melatonin level is inversely associated with mammographic density...
  37. ncbi request reprint The relationships of a rationality/antiemotionality personality scale to mortalities of cancer and cardiovascular disease in a community population in Japan
    Kumi Hirokawa
    Department of Public Health, Gifu University, School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    J Psychosom Res 56:103-11. 2004
    ..To investigate the relationships of an individual's level on the R/A personality to cancer and cardiovascular disease mortality in Japan, we conducted a population-based cohort study...
  38. ncbi request reprint Prospective cohort study of body mass index in adolescence and death from stomach cancer in Japan
    Tagayasu Tanaka
    Department of Epidemiology and Preventive Medicine, Gifu University, Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Sci 98:1785-9. 2007
    ..05). The analysis of BMI at the baseline did not show a significant relationship with the risk of death from stomach cancer. These results suggest that a high BMI(20y) is associated with an increased risk of death from stomach cancer...
  39. doi request reprint Light exposure at night, urinary 6-sulfatoxymelatonin, and serum estrogens and androgens in postmenopausal Japanese women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Epidemiol Biomarkers Prev 17:1418-23. 2008
    ..However, the potential role of melatonin as an intervening factor between light exposure at night and the serum concentrations of estrogen was equivocal...
  40. ncbi request reprint Soy isoflavone intake is not associated with the development of cedar pollinosis in adults
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu 501 1194, Japan
    J Nutr 138:1372-6. 2008
    ..07 (95% CI: 0.81-1.42) in men and 0.89 (95% CI: 0.68-1.15) in women. These data did not support an association between soy isoflavone intake and risk of cedar pollinosis...
  41. ncbi request reprint [A case of intractable epilepsy: diagnosis of tuberous sclerosis based on histopathological findings and immunohistochemical expression of hamartin and tuberin]
    Yasuko Takaishi
    Department of Pediatrics, Nippon Medical School, Tokyo
    No To Hattatsu 34:49-54. 2002
    ..Based on results, we diagnosed this case as having TSC. He has been seizure free since the operation. Although lower than preoperatively, his intelligence quotient has not been declining progressively...
  42. ncbi request reprint Weight change in relation to natural menopause and other reproductive and behavioral factors in Japanese women
    Chisato Nagata
    Department of Public Health, Gifu University School of Medicine, Gifu, Japan
    Ann Epidemiol 12:237-41. 2002
    ..To evaluate the effect of menopause on weight change in Japanese women...
  43. ncbi request reprint Comparison of mammographic densities and their determinants in women from Japan and Hawaii
    Gertraud Maskarinec
    Cancer Research Center of Hawaii, Honolulu, HI 96813, USA
    Int J Cancer 102:29-33. 2002
    ..Therefore, when comparing ethnic groups with distinct physical proportions, the absolute size of the dense areas appears to be a better measure of breast cancer risk than the relative density...
  44. ncbi request reprint Soy and fish oil intake and mortality in a Japanese community
    Chisato Nagata
    Department of Public Health, Gifu University School of Medicine, Japan
    Am J Epidemiol 156:824-31. 2002
    ..For women but not for men, n-3 fatty acids from fish were significantly inversely associated with total mortality. Results showed that soy intake may have moderate but beneficial effects on total mortality...
  45. doi request reprint Alcohol consumption and mortality from stroke and coronary heart disease among Japanese men and women: the Japan collaborative cohort study
    Satoyo Ikehara
    Public Health, Department of Social and Environmental Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan
    Stroke 39:2936-42. 2008
    ..However, the sex-specific association between alcohol consumption and mortality from stroke and coronary heart disease remains unclear...
  46. ncbi request reprint Association of blood pressure with intake of soy products and other food groups in Japanese men and women
    Chisato Nagata
    Department of Public Health, Gifu University School of Medicine, Gifu, Japan
    Prev Med 36:692-7. 2003
    ..Soy diet has been suggested to have antihypertensive effect in animal studies. The present study examined the cross-sectional relationship between blood pressure and intake of soy products and other food groups in Japanese men and women...
  47. ncbi request reprint The impact of changes in marital status on the mortality of elderly Japanese
    Chisato Nagata
    Department of Public Health, Gifu University School of Medicine, Gifu, Japan
    Ann Epidemiol 13:218-22. 2003
    ..To assess the impact of changes in marital status on the mortality of elderly Japanese men and women...
  48. ncbi request reprint Dietary soy and fats in relation to serum insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 levels in premenopausal Japanese women
    Chisato Nagata
    Department of Public Health, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Nutr Cancer 45:185-9. 2003
    ..13, P = 0.04). The correlations of saturated and monounsaturated fats with serum IGFBP-3 were of borderline significance (r = -0.12, P = 0.06 and r = -0.11, P = 0.07, respectively)...
  49. ncbi request reprint [Universal use of inactivated poliovirus vaccine--the needs and challenges]
    Hiroyuki Shimizu
    Department of Virology II, National Institute of Infectious Diseases
    Nihon Rinsho 66:1950-5. 2008
    ..Thus, further polio immunization strategies, including the introduction of Sabin IPV, instead of OPV, to Japan and to developing countries, should be carefully considered...
  50. pmc Rationality/anti-emotionality personality and dietary habits in a community population in Japan
    Kumi Hirokawa
    Department of Epidemiology and Preventive Medicine, Gifu University School of Medicine, Japan
    J Epidemiol 18:183-90. 2008
    ..The purpose of the present study was to examine the relationships between the rationality and anti-emotionality (R/A) personality and dietary consumption in a Japanese community...
  51. ncbi request reprint Chop-deficient mice showed increased adiposity but no glucose intolerance
    Yasuyo Ariyama
    Department of Medicine and Molecular Science, CREST Japan Science and Technology Agency, Gunma, Japan
    Obesity (Silver Spring) 15:1647-56. 2007
    ..The study was undertaken to determine the role of CHOP in obesity in vivo...
  52. ncbi request reprint Factors shaping vividness of memory episodes: visitors' long-term memories of the 1970 Japan World Exposition
    David Anderson
    University of British Columbia, Department of Curriculum Studies, 2125 Main Mall, Vancouver, BC V6T 1Z4, Canada
    Memory 15:177-91. 2007
    ..Stage two analysis, in which all factors were included in a multiple regression analysis, found that rehearsal was positively related to memory vividness and all other factors not significant in the presence of rehearsal...
  53. ncbi request reprint Associations of mammographic density with dietary factors in Japanese women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, 501 1194 Gifu, Japan
    Cancer Epidemiol Biomarkers Prev 14:2877-80. 2005
    ..The present cross-sectional study evaluated the relations of percent density with dietary factors, such as fats, protein, dietary fiber, and soy isoflavones...
  54. ncbi request reprint Fat intake is associated with serum estrogen and androgen concentrations in postmenopausal Japanese women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Japan
    J Nutr 135:2862-5. 2005
    ..8 and 9.3%, respectively, with a 5% increase in the percentage of energy from total fat. These data suggest that a high intake of fat is associated with higher serum levels of estrone and DHEAS in postmenopausal women...
  55. pmc Intratypic recombination among lineages of type 1 vaccine-derived poliovirus emerging during chronic infection of an immunodeficient patient
    Chen Fu Yang
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:12623-34. 2005
    ..The appearance of a chronic VDPV excretor in a tropical, developing country has important implications for the strategy to stop OPV immunization after eradication of wild polioviruses...
  56. ncbi request reprint The Tajimi Study report 2: prevalence of primary angle closure and secondary glaucoma in a Japanese population
    Tetsuya Yamamoto
    Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan
    Ophthalmology 112:1661-9. 2005
    ..To determine the prevalence of primary angle-closure glaucoma (PACG), secondary glaucoma (SG), and all glaucoma in a Japanese population as a part of the Tajimi Study...
  57. ncbi request reprint Brachial-ankle pulse wave velocity
    Hiroyuki Shimizu
    Intern Med 44:688-9. 2005
  58. ncbi request reprint Soy, fat and other dietary factors in relation to premenstrual symptoms in Japanese women
    Chisato Nagata
    Department of Public Health, Gifu University School of Medicine, Gifu, Japan
    BJOG 111:594-9. 2004
    ..To evaluate the relations of intakes of soy, fat and other dietary components to premenstrual symptoms...
  59. ncbi request reprint Association of vegetable intake with urinary 6-sulfatoxymelatonin level
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 502 1194 Gifu, Japan
    Cancer Epidemiol Biomarkers Prev 14:1333-5. 2005
    ..However, data should be regarded as preliminary because it is impossible to estimate dietary melatonin intake from vegetables and or from the entire diet because of incomplete data for melatonin in plants...
  60. ncbi request reprint Urinary cadmium and serum levels of estrogens and androgens in postmenopausal Japanese women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Epidemiol Biomarkers Prev 14:705-8. 2005
    ..Recent laboratory studies have suggested that cadmium is an estrogenic compound and may be a potential risk factor for breast cancer...
  61. ncbi request reprint Cancer-related attitudes: A comparative study in Japan and the US
    Carolyn Cook Gotay
    Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala St, Honolulu, HI 96813, USA
    Psychooncology 13:665-72. 2004
    ..The data support the continued international differences in views about cancer and suggest that some of these differences persist over many generations of US residence...
  62. ncbi request reprint Insulin resistance determines efficacy of glimepiride in Type 2 diabetic patients not well controlled by diet alone
    Hiroyuki Shimizu
    Diabet Med 22:225-6. 2005
  63. ncbi request reprint The relationship between the consumption of meat, fat, and coffee and the risk of colon cancer: a prospective study in Japan
    Shino Oba
    Department of Prevention for Lifestyle Related Diseases, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Cancer Lett 244:260-7. 2006
    ..43, 95% CI: 0.22-0.85). The findings suggest the possible linkage between a western diet and risk of colon cancer...
  64. ncbi request reprint Risk factors for open-angle glaucoma in a Japanese population: the Tajimi Study
    Yasuyuki Suzuki
    Department of Ophthalmology, Teikyo University School of Medicine, Tokyo, Japan
    Ophthalmology 113:1613-7. 2006
    ..To identify the risk factors associated with primary open-angle glaucoma (POAG) in the Tajimi Study...
  65. ncbi request reprint Effectiveness of cervical cancer screening over cervical cancer mortality among Japanese women
    Khandoker Aklimunnessa
    Department of Public Health, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    Jpn J Clin Oncol 36:511-8. 2006
    ..Therefore, the present study evaluated the association of CC mortality with self-reported CC screening and some other factors by a nationwide cohort study...
  66. ncbi request reprint [Brain-adipose axis and leptin resistance]
    Hiroyuki Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
    Nihon Rinsho 64:110-5. 2006
  67. ncbi request reprint Associations of menstrual cycle length with intake of soy, fat, and dietary fiber in Japanese women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, University Graduate School of Medicine, Gifu, Japan
    Nutr Cancer 54:166-70. 2006
    ..The data suggest that polyunsaturated fat and dietary fiber intake are associated with the parameters of menstrual cycle length, but further studies are required to better characterize these associations...
  68. ncbi request reprint Neutralization assays for echovirus 18 isolates in 2006
    Shinichi Takao
    Hiroshima Prefecture Institute of Health and Environment, Hiroshima 734 0007, Japan
    Jpn J Infect Dis 60:65-6. 2007
  69. ncbi request reprint Performance of frequency-doubling technology perimetry in a population-based prevalence survey of glaucoma: the Tajimi study
    Aiko Iwase
    Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
    Ophthalmology 114:27-32. 2007
    ..To evaluate the performance of frequency-doubling technology (FDT) perimetry in a population-based glaucoma prevalence survey...
  70. ncbi request reprint A comparison of dietary habits among women in Japan and Hawaii
    Yumie Takata
    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA
    Public Health Nutr 7:319-26. 2004
    ..To compare the dietary habits of Japanese women in Japan with those of Japanese and Caucasian women living in Hawaii...
  71. ncbi request reprint Quantitative analysis of poliomyelitis-like paralysis in mice induced by a poliovirus replicon
    Minetaro Arita
    Department of Virology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashimurayama shi, Tokyo 208 0011, Japan
    J Gen Virol 87:3317-27. 2006
    ..These results indicate that PV replication in a small population of the motor neurons was critical for severe residual poliomyelitis-like paralysis in TgPVR21 mice...
  72. ncbi request reprint Associations among maternal soy intake, isoflavone levels in urine and blood samples, and maternal and umbilical hormone concentrations (Japan)
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Cancer Causes Control 17:1107-13. 2006
    ..A high intake of soy has been suggested to protect against breast cancer. We examined the hypothesis that maternal soy intake may be inversely associated with pregnancy hormone levels...
  73. pmc Molecular epidemiology of echoviruses 11 and 13, based on an environmental surveillance conducted in Toyama Prefecture, 2002-2003
    Masae Iwai
    Department of Virology, Toyama Institute of Health, Nakataikouyama, Kosugi Machi, Imizu shi, Toyama 939 0363, Japan
    Appl Environ Microbiol 72:6381-7. 2006
    ....
  74. ncbi request reprint Effects of E. coli chaperones on the solubility of human receptors in an in vitro expression system
    Sumiyo Endo
    Biological Science Laboratories, Toray Research Center, Inc, 1111 Tebiro, Kamakura, Kanagawa 248 8555, Japan
    Mol Biotechnol 33:199-209. 2006
    ..The present findings demonstrate that E. coli molecular chaperones are useful in improving the yield of soluble recombinant extracellular domains of human membrane receptors in an E. coli expression system...
  75. ncbi request reprint Sodium intake and risk of death from stroke in Japanese men and women
    Chisato Nagata
    Department of Epidemiology and Preventive Medicine, Gifu University School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Stroke 35:1543-7. 2004
    ..The purpose of this study was to examine the relation between sodium intake and death from stroke in a population-based cohort of Japanese men and women...
  76. ncbi request reprint The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study
    Aiko Iwase
    Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Japan
    Ophthalmology 111:1641-8. 2004
    ..To assess the prevalence of primary open-angle glaucoma (POAG) and its association with intraocular pressure (IOP) in Tajimi City in central Japan...