Asahito Hama

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. doi request reprint Total body irradiation and melphalan as a conditioning regimen for children with hematological malignancies undergoing transplantation with stem cells from HLA-identical related donors
    Nobuhiro Watanabe
    Children s Medical Center, Japanese Red Cross, Nagoya, Japan
    Pediatr Transplant 15:642-9. 2011
  2. doi request reprint Correlation of CYP2C19 phenotype with voriconazole plasma concentration in children
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 35:e219-23. 2013
  3. doi request reprint Prognostic factors for outcomes of pediatric patients with refractory or relapsed acute leukemia undergoing allogeneic progenitor cell transplantation
    Nobuhiro Watanabe
    Division of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Biol Blood Marrow Transplant 17:516-23. 2011
  4. doi request reprint Clinical impact of HLA-DR15, a minor population of paroxysmal nocturnal haemoglobinuria-type cells, and an aplastic anaemia-associated autoantibody in children with acquired aplastic anaemia
    Nao Yoshida
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 142:427-35. 2008
  5. doi request reprint Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Transplant 13:831-7. 2009
  6. doi request reprint Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation
    Itzel Bustos Villalobos
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Blood 115:3158-61. 2010
  7. doi request reprint Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 58:780-4. 2012
  8. doi request reprint Reduced-intensity conditioning for alternative donor hematopoietic stem cell transplantation in patients with dyskeratosis congenita
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Pediatr Transplant 15:161-6. 2011
  9. doi request reprint CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, Aichi 466 8650, Japan
    Int J Hematol 93:779-81. 2011
  10. doi request reprint Excellent outcome of allogeneic bone marrow transplantation for Fanconi anemia using fludarabine-based reduced-intensity conditioning regimen
    Akira Shimada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Int J Hematol 95:675-9. 2012

Collaborators

Detail Information

Publications35

  1. doi request reprint Total body irradiation and melphalan as a conditioning regimen for children with hematological malignancies undergoing transplantation with stem cells from HLA-identical related donors
    Nobuhiro Watanabe
    Children s Medical Center, Japanese Red Cross, Nagoya, Japan
    Pediatr Transplant 15:642-9. 2011
    ..2%, 88.1%, and 23.1%, respectively (p < 0.05). MEL/TBI for pediatric patients with hematological malignancies was associated with lower relapse rates and no increase in toxicity, resulting in better survival...
  2. doi request reprint Correlation of CYP2C19 phenotype with voriconazole plasma concentration in children
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 35:e219-23. 2013
    ..Here, we report an analysis of CYP2C19 phenotype and voriconazole plasma concentrations in children...
  3. doi request reprint Prognostic factors for outcomes of pediatric patients with refractory or relapsed acute leukemia undergoing allogeneic progenitor cell transplantation
    Nobuhiro Watanabe
    Division of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Biol Blood Marrow Transplant 17:516-23. 2011
    ....
  4. doi request reprint Clinical impact of HLA-DR15, a minor population of paroxysmal nocturnal haemoglobinuria-type cells, and an aplastic anaemia-associated autoantibody in children with acquired aplastic anaemia
    Nao Yoshida
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 142:427-35. 2008
    ..53.1%) or anti-PMS1 antibody (40.0% vs. 59.1%). The current study did not confirm a correlation between these markers and the response to IST, suggesting that there is a difference in the pathophysiologies of adult and paediatric AA...
  5. doi request reprint Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Transplant 13:831-7. 2009
    ..Event-free survival did not significantly differ between patients with and without ES regardless of the presence of malignant or non-malignant diseases...
  6. doi request reprint Relapse of leukemia with loss of mismatched HLA resulting from uniparental disomy after haploidentical hematopoietic stem cell transplantation
    Itzel Bustos Villalobos
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, 466 8550, Japan
    Blood 115:3158-61. 2010
    ..Accordingly, the status of mismatched HLA on relapsed leukemic cells should be checked before donor lymphocyte infusion...
  7. doi request reprint Incidence, clinical features, and risk factors of idiopathic pneumonia syndrome following hematopoietic stem cell transplantation in children
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 58:780-4. 2012
    ..Idiopathic pneumonia syndrome (IPS) is a severe complication that can occur after hematopoietic stem cell transplantation (HSCT) and is often associated with a fatal outcome despite intensive supportive care...
  8. doi request reprint Reduced-intensity conditioning for alternative donor hematopoietic stem cell transplantation in patients with dyskeratosis congenita
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Clinical Research Center for Blood Diseases, National Hospital Organization Nagoya Medical Center, Nagoya, Japan
    Pediatr Transplant 15:161-6. 2011
    ..They were alive 10, 66, and 72 months after transplantation, respectively. Long-term follow-up is crucial to determine the late effects of our conditioning regimen...
  9. doi request reprint CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai cho Showa ku, Nagoya, Aichi 466 8650, Japan
    Int J Hematol 93:779-81. 2011
    ..Similar to other types of lymphoma, the absence of CD20 antigen is likely to be characteristic of rituximab-refractory EBV-PTLD...
  10. doi request reprint Excellent outcome of allogeneic bone marrow transplantation for Fanconi anemia using fludarabine-based reduced-intensity conditioning regimen
    Akira Shimada
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Int J Hematol 95:675-9. 2012
    ..BMT using FLU/low-dose CY/ATG -based regimens regardless to the donor is a beneficial therapeutic approach for FA patients...
  11. doi request reprint Aberrant phosphorylation of STAT5 by granulocyte-macrophage colony-stimulating factor in infant cytomegalovirus infection mimicking juvenile myelomonocytic leukemia
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Shouwa ku, Nagoya, Japan
    Leuk Res 35:1261-4. 2011
    ..We conclude that patients with CMV infection cannot be discriminated from patients with JMML by this new diagnostic method...
  12. pmc Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia
    Atsushi Narita
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haematologica 100:1546-52. 2015
    ..The trial was registered in www.umin.ac.jp with number UMIN000017972. ..
  13. doi request reprint Markedly High Plasma Thrombopoietin (TPO) Level is a Predictor of Poor Response to Immunosuppressive Therapy in Children With Acquired Severe Aplastic Anemia
    Shaimaa Elmahdi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 63:659-64. 2016
    ..Because the clinical response rate and therapeutic outcome for individual patients to IST varies, an in vitro test that identifies potential responders would be desirable...
  14. ncbi request reprint Feasibility and results of bone marrow transplantation from an HLA-mismatched unrelated donor for children and young adults with acquired severe aplastic anemia
    Hiroshi Yagasaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Hematol 85:437-42. 2007
    ..All patients are alive at 9 to 56 months after transplantation (median, 33 months). Considering our encouraging results, HLA-mismatched unrelated-donor BMT for SAA is feasible as a salvage therapy for nonresponders to IST...
  15. doi request reprint Molecular lesions in childhood and adult acute megakaryoblastic leukaemia
    Asahito Hama
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 156:316-25. 2012
    ..ASXL1, IDH1/2, DNMT3A, RUNX1 and CBL mutations were not found in any of the patient group studied, while NRAS mutation was identified in two patients with paediatric non-DS-AMKL...
  16. doi request reprint Plasmacytoid dendritic cell leukemia in children
    Asahito Hama
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 31:339-43. 2009
    ..The CD4, CD56, CD3, CD13, CD19, CD33 profile is highly suggestive of this disease, and the CD123 and blood dendritic cell antigen-2 markers are useful in helping to diagnose pDC leukemia...
  17. doi request reprint Correlation of rabbit antithymocyte globulin serum levels and clinical outcomes in children who received hematopoietic stem cell transplantation from an alternative donor
    Shaimaa Elmahdi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Transplant 20:105-13. 2016
    ..The probability of five-yr OS among patients was 70.3% (95% CI, 59.8-79.2%). Our results suggest that targeted rATG administration may protect patients from severe acute GVHD without increasing the risk of EBV reactivation or relapse. ..
  18. pmc Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    PLoS ONE 10:e0145394. 2015
    ....
  19. doi request reprint Mutations profile of polycythemia vera and essential thrombocythemia among Japanese children
    Olfat Ismael
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Pediatr Blood Cancer 59:530-5. 2012
    ..Acquired somatic mutations of JAK2 have been reported to play a pivotal role in the pathogenesis of BCR-ABL1-negative myeloproliferative neoplasm (MPN). However, the molecular characteristics of childhood MPN remain to be elucidated...
  20. doi request reprint Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era
    Hideki Muramatsu
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi 466 8650, Japan
    Int J Hematol 93:186-91. 2011
    ..28.6%, p = 0.006). In summary, the survival outcomes of pediatric patients with CML were dramatically improved by treatment with IM compared to HSCT...
  21. doi request reprint Acute megakaryoblastic leukaemia (AMKL) in children: a comparison of AMKL with and without Down syndrome
    Asahito Hama
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Haematol 140:552-61. 2008
    ..81) with a median follow-up of 78 months (range, 20-243 months). Our study shows the diverse heterogeneity of childhood AMKL and the need for subclassification according to cytogenetic and morphological features...
  22. doi request reprint De novo childhood myelodysplastic/myeloproliferative disease with unique molecular characteristics
    Olfat Ismael
    Department of Paediatrics, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Br J Haematol 158:129-37. 2012
    ..Moreover, two patients had constitutional alterations of genes frequently found in AML. Further investigations are required to define the roles of these genetic alterations in the pathogenesis of childhood MDS/MPN-U...
  23. doi request reprint Congenital erythroid and myeloid hypoplasia terminating myelodysplastic syndrome
    Nobuhiro Nishio
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pediatr Hematol Oncol 30:692-5. 2008
    ..She was transplanted with cord blood from an unrelated human leukocyte antigen-matched donor and has since remained in complete remission for 20 months...
  24. doi request reprint A Cytokine-Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood
    Shaimaa Elmahdi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 63:652-8. 2016
    ..In the present study, we addressed whether thrombopoietin (TPO) and interleukin 17 (IL-17) plasma levels are useful for differentiating between the two diseases...
  25. doi request reprint Choreito formula for BK virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation
    Nozomu Kawashima
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Biol Blood Marrow Transplant 21:319-25. 2015
    ..No adverse effects related to choreito administration were observed. Choreito may be a safe and considerably promising therapy for the hemostasis of BKV-HC after HSCT...
  26. pmc Predicting response to immunosuppressive therapy in childhood aplastic anemia
    Nao Yoshida
    Department of Hematology and Oncology, Children s Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    Haematologica 96:771-4. 2011
    ..The finding that response rate worsens with increasing interval between diagnosis and treatment highlights the importance of prompt immunosuppressive therapy for patients with aplastic anemia...
  27. doi request reprint Fulminant adenovirus hepatitis after hematopoietic stem cell transplant: Retrospective real-time PCR analysis for adenovirus DNA in two cases
    Nozomu Kawashima
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Infect Chemother 21:857-63. 2015
    ....
  28. doi request reprint RUNX1 mutation associated with clonal evolution in relapsed pediatric acute myeloid leukemia with t(16;21)(p11;q22)
    Olfat Ismael
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, Aichi, 466 8550, Japan
    Int J Hematol 99:169-74. 2014
    ..Our results suggest that precedent genetic alterations may be essential to drive the progression and relapse of t(16;21)-AML patients. ..
  29. doi request reprint Progressive hearing loss following acquired cytomegalovirus infection in an immunocompromised child
    Ken Kato
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Japan
    Am J Otolaryngol 34:89-92. 2013
    ..This case demonstrates the possibility that, under the immunodeficiency, the acquired CMV infection causes progressive sensorineural hearing loss...
  30. doi request reprint Successful treatment with rituximab of refractory idiopathic thrombocytopenic purpura in a patient with Kabuki syndrome
    Yuka Torii
    Department of Pediatrics, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    Int J Hematol 90:174-6. 2009
    ..KS patients are often more susceptible to infection, so splenectomy should be avoided. Therefore, rituximab therapy is an alternative option for KS patients with ITP who fail to respond to first-line therapy...
  31. doi request reprint Concurrent Langerhans cell histiocytosis and nephroblastoma
    Ryoko Narui
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Pediatr Blood Cancer 52:662-4. 2009
    ..After complete resection of the nephroblastoma, she received standard chemoradiotherapy for nephroblastoma. She is alive without relapse 14 months after initial presentation...
  32. doi request reprint Somatic mosaicism for oncogenic NRAS mutations in juvenile myelomonocytic leukemia
    Sayoko Doisaki
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Blood 120:1485-8. 2012
    ..These patients are the first reported to have somatic mosaicism for oncogenic NRAS mutations. The clinical course of these patients suggests that NRAS mosaicism may be associated with a mild disease phenotype in JMML...
  33. ncbi request reprint Mutations in telomerase catalytic protein in Japanese children with aplastic anemia
    Juan Liang
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Haematologica 91:656-8. 2006
    ..This genetic difference does not explain the higher incidence of AA in Asian populations...
  34. ncbi request reprint Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia
    Hirokazu Hidaka
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Leuk Res 31:1045-51. 2007
    ..Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL...
  35. doi request reprint Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia
    Hirotoshi Sakaguchi
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Nat Genet 45:937-41. 2013
    ..Our findings provide new insights into the pathogenesis and progression of JMML. ..