Peixin Dong

Summary

Affiliation: Graduate School
Country: Japan

Publications

  1. pmc Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
    P Dong
    Department of Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 32:3286-95. 2013
  2. pmc Emerging therapeutic biomarkers in endometrial cancer
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 060 8638, Japan
    Biomed Res Int 2013:130362. 2013
  3. pmc Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
    Peixin Dong
    Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, PR China
    Mol Cancer 8:103. 2009
  4. doi request reprint MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan
    Mol Carcinog 53:349-59. 2014
  5. pmc Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 0608638, Japan
    Sci Rep 6:35480. 2016
  6. pmc MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo, 0608638, Japan
    J Exp Clin Cancer Res 35:132. 2016
  7. ncbi request reprint MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells
    Yosuke Konno
    Department of Gynecology, Hokkaido University, Sapporo, Japan
    Oncotarget . 2014
  8. pmc MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
    Peixin Dong
    Department of Gynecology, Hokkaido University Graduate School of Medicine and School of Medicine, Hokkaido University, Sapporo, Japan
    Mol Cancer 10:99. 2011
  9. doi request reprint Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo 0608638, Japan
    Carcinogenesis 35:760-8. 2014
  10. pmc Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo, Japan
    Oncotarget 7:20260-70. 2016

Collaborators

Detail Information

Publications19

  1. pmc Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
    P Dong
    Department of Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan
    Oncogene 32:3286-95. 2013
    ..These data provide a novel understanding of the roles of p53 gain-of-function mutations in accelerating tumor progression and metastasis through modulation of the miR-130b-ZEB1 axis. ..
  2. pmc Emerging therapeutic biomarkers in endometrial cancer
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 060 8638, Japan
    Biomed Res Int 2013:130362. 2013
    ....
  3. pmc Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
    Peixin Dong
    Hospital and Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, PR China
    Mol Cancer 8:103. 2009
    ..In human endometrial cancer, p53 mutation is more often associated with aggressive nonendometrioid cancer. However, it was unknown if p53 mutants contributed to endometrial cancer progression through the GOF properties...
  4. doi request reprint MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan
    Mol Carcinog 53:349-59. 2014
    ..Our data suggest that TWIST1 is a critical inducer of EMT in invasive EC cells and that miR-106b could suppress EC cell invasion by downregulating TWIST1 expression...
  5. pmc Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 0608638, Japan
    Sci Rep 6:35480. 2016
    ..Altogether, the restoration of miR-124 reduces iASPP expression and leads to p53-dependent tumor suppression, suggesting a therapeutic strategy to treat iASPP-associated CC...
  6. pmc MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo, 0608638, Japan
    J Exp Clin Cancer Res 35:132. 2016
    ..At present little is known about controlling Snail expression in OC cells by using specific microRNAs (miRNAs)...
  7. ncbi request reprint MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells
    Yosuke Konno
    Department of Gynecology, Hokkaido University, Sapporo, Japan
    Oncotarget . 2014
    ..The microRNA-101-EZH2/MCL-1/FOS axis is a potential therapeutic target for endometrial cancer...
  8. pmc MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
    Peixin Dong
    Department of Gynecology, Hokkaido University Graduate School of Medicine and School of Medicine, Hokkaido University, Sapporo, Japan
    Mol Cancer 10:99. 2011
    ..The aims of this study was to determine the roles of BMI-1 in inducing EMT of endometrial cancer (EC) cells and the possible role of miRNA in controlling BMI-1 expression...
  9. doi request reprint Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo 0608638, Japan
    Carcinogenesis 35:760-8. 2014
    ..Thus, KLF17 may have an oncogenic role during EEC progression via initiating EMT through the regulation of TWIST1. ..
  10. pmc Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo, Japan
    Oncotarget 7:20260-70. 2016
    ..MiR-124, a novel tumor suppressor miRNA that is epigenetically silenced in EC, can reverse EMT and the invasive properties, by attenuating the expression of the IQGAP1 oncogene. ..
  11. doi request reprint Distribution of lymph node metastasis sites in endometrial cancer undergoing systematic pelvic and para-aortic lymphadenectomy: a proposal of optimal lymphadenectomy for future clinical trials
    Tetsuji Odagiri
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ann Surg Oncol 21:2755-61. 2014
    ..The aim of this study was to demonstrate the precise mapping of lymph node metastasis (LNM) sites in endometrial cancer...
  12. doi request reprint EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis
    Kei Ihira
    Department of Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo 0608638, Japan
    Oncotarget . 2017
    ..Our findings suggest that EZH2 drives EC progression by regulating miR-361/Twist signaling, and support EZH2 inhibition as a promising anti-EC therapeutic strategy...
  13. pmc MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells
    Yosuke Konno
    Department of Gynecology, Hokkaido University, Sapporo, Japan These authors contributed equally to this work
    Oncotarget 5:6049-62. 2014
    ..The microRNA-101-EZH2/MCL-1/FOS axis is a potential therapeutic target for endometrial cancer. ..
  14. doi request reprint HPV self-sampling in Japanese women: A feasibility study in a population with limited experience of tampon use
    Sharon Jb Hanley
    Department of Women s Health Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Med Screen 23:164-70. 2016
    ..We also sought to identify any practical, logistical, or safety issues in women already attending for screening, before carrying out further large-scale studies in non-responders...
  15. pmc Reactivating p53 functions by suppressing its novel inhibitor iASPP: a potential therapeutic opportunity in p53 wild-type tumors
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan
    Oncotarget 6:19968-75. 2015
    ..Reactivating WT p53 functions by targeting its novel inhibitor iASPP holds promise for potential therapeutic interventions in the treatment of WT p53-containing tumors...
  16. pmc The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer
    Peixin Dong
    Department of Women s Health Educational System, Hokkaido University School of Medicine, Hokkaido University, N15, W7, Sapporo 0608638, Japan
    J Transl Med 12:231. 2014
    ..Targeting key signaling components of PI3K/AKT pathway by restoring or inhibiting miRNA function holds promise as a potential therapeutic approach to suppress EMT and CSC in endometrial cancer. ..
  17. ncbi request reprint p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells
    Peixin Dong
    Department of Gynecology, Hokkaido University Graduate School of Medicine and School of Medicine, Hokkaido University, Sapporo 060 8638, Japan
    Clin Exp Metastasis 24:471-83. 2007
    ..Taken together, these results suggest that transdominance of R273H mutant over wt p53 rather than a gain-of-function promotes tumor metastasis by increasing invasion and migration in HHUA cells...
  18. doi request reprint New revised FIGO 2008 staging system for endometrial cancer produces better discrimination in survival compared with the 1988 staging system
    Tatsuya Kato
    Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Surg Oncol 106:938-41. 2012
    ..The aim of this study was to analyze the stage migration and survival of endometrial cancer by the revised FIGO 2008 staging system compared with the 1988 staging system...
  19. doi request reprint Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction
    Nan Jia
    Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University Medical School, Shanghai, PR China
    Cardiovasc Ther 30:117-23. 2012
    ..We tested whether allopurinol could decrease myocardial oxidative stress and attenuate cardiac fibrosis and left ventricular diastolic dysfunction in angiotensin II (AngII)-induced hypertensive mice...