Y Kitajima

Summary

Affiliation: Gifu University
Country: Japan

Publications

  1. ncbi request reprint A perspective of pemphigus from bedside and laboratory-bench
    Yasuo Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Rev Allergy Immunol 33:57-66. 2007
  2. ncbi request reprint Current and prospective understanding of clinical classification, pathomechanisms and therapy in pemphigus
    Yasuo Kitajima
    Department of Dermatology, Gifu University School of Medicine, 40 Tsukasamachi, 500 8705 Gifu City, Japan
    Arch Dermatol Res 295:S17-23. 2003
  3. ncbi request reprint Mechanisms of desmosome assembly and disassembly
    Y Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Exp Dermatol 27:684-90. 2002
  4. ncbi request reprint Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line
    Y Matsuoka
    Department of Dermatology, Gifu University School of Medicine, 40 Tsukasamachi, 5008705, Gifu City, Japan
    J Dermatol Sci 27:206-14. 2001
  5. doi request reprint Binding of pemphigus vulgaris IgG to antigens in desmosome core domains excludes immune complexes rather than directly splitting desmosomes
    Y Aoyama
    Department of Dermatology, Okayama Rosai Hospital and Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Br J Dermatol 162:1049-55. 2010
  6. ncbi request reprint Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
  7. ncbi request reprint Detection of nonmelanoma skin cancer micrometastases in lymph nodes by using reverse transcriptase-polymerase chain reaction for keratin 19 mRNA
    M Kamiya
    Department of Dermatology, Gifu University School of Medicine, Tsukasamachi 40, Gifu 500 8705, Japan
    Br J Dermatol 149:998-1005. 2003
  8. ncbi request reprint Chemotherapy induces or increases expression of multidrug resistance-associated protein in malignant melanoma cells
    N Ichihashi
    Department of Dermatology, Gifu University School of Medicine, 40 Tukasa machi, Gifu City 500 8705, Japan
    Br J Dermatol 144:745-50. 2001
  9. ncbi request reprint "Apocrine" poroma: review of the literature and case report
    H Kamiya
    Department of Dermatology, Gifu University School of Medicine, Japan
    J Cutan Pathol 28:101-4. 2001
  10. ncbi request reprint An experience for ELISA for desmoglein 1, suggesting a possible diagnostic help to determine the initial therapy for pemphigus foliaceus
    Y Aoyama
    Department of Dermatology, Gifu University School of Medicine, Gifu 500 8705, Japan
    Eur J Dermatol 10:18-21. 2000

Collaborators

Detail Information

Publications47

  1. ncbi request reprint A perspective of pemphigus from bedside and laboratory-bench
    Yasuo Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Rev Allergy Immunol 33:57-66. 2007
    ..In this article, the classification of pemphigus and the characteristic pathomechanisms for acantholysis will be reviewed, with particular emphasis on the molecular and biochemical cell biology of these diseases...
  2. ncbi request reprint Current and prospective understanding of clinical classification, pathomechanisms and therapy in pemphigus
    Yasuo Kitajima
    Department of Dermatology, Gifu University School of Medicine, 40 Tsukasamachi, 500 8705 Gifu City, Japan
    Arch Dermatol Res 295:S17-23. 2003
  3. ncbi request reprint Mechanisms of desmosome assembly and disassembly
    Y Kitajima
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Clin Exp Dermatol 27:684-90. 2002
    ..The key implications for understanding desmosome dynamics from these findings are summarized in this review...
  4. ncbi request reprint Transient translocation of hemidesmosomal bullous pemphigoid antigen 1 from cytosol to membrane fractions by 12-O-tetradecanoylphorbol-13-acetate treatment and Ca2+-switch in a human carcinoma cell line
    Y Matsuoka
    Department of Dermatology, Gifu University School of Medicine, 40 Tsukasamachi, 5008705, Gifu City, Japan
    J Dermatol Sci 27:206-14. 2001
    ....
  5. doi request reprint Binding of pemphigus vulgaris IgG to antigens in desmosome core domains excludes immune complexes rather than directly splitting desmosomes
    Y Aoyama
    Department of Dermatology, Okayama Rosai Hospital and Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Br J Dermatol 162:1049-55. 2010
    ..Pemphigus vulgaris (PV) is characterized by autoantibodies against desmoglein (Dsg) 3 or both Dsg1 and Dsg3, i.e. desmosomal adhesion molecules...
  6. ncbi request reprint Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
    ....
  7. ncbi request reprint Detection of nonmelanoma skin cancer micrometastases in lymph nodes by using reverse transcriptase-polymerase chain reaction for keratin 19 mRNA
    M Kamiya
    Department of Dermatology, Gifu University School of Medicine, Tsukasamachi 40, Gifu 500 8705, Japan
    Br J Dermatol 149:998-1005. 2003
    ..A new sensitive method for the detection of skin cancer micrometastases in lymph nodes is based on amplification of keratin 19 (K19) mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR)...
  8. ncbi request reprint Chemotherapy induces or increases expression of multidrug resistance-associated protein in malignant melanoma cells
    N Ichihashi
    Department of Dermatology, Gifu University School of Medicine, 40 Tukasa machi, Gifu City 500 8705, Japan
    Br J Dermatol 144:745-50. 2001
    ..This phenotype is often due to P-glycoprotein (Pgp) and the MDR-associated protein (MRP), which are drug transporter proteins associated with resistance to a broad spectrum of lipophilic drugs...
  9. ncbi request reprint "Apocrine" poroma: review of the literature and case report
    H Kamiya
    Department of Dermatology, Gifu University School of Medicine, Japan
    J Cutan Pathol 28:101-4. 2001
    ..Apocrine" poroma has recently been proposed as a new term to designate a distinctive benign skin neoplasm with differentiation toward the folliculosebaceous-apocrine unit...
  10. ncbi request reprint An experience for ELISA for desmoglein 1, suggesting a possible diagnostic help to determine the initial therapy for pemphigus foliaceus
    Y Aoyama
    Department of Dermatology, Gifu University School of Medicine, Gifu 500 8705, Japan
    Eur J Dermatol 10:18-21. 2000
    ..05% betamethasone ointment twice a day. These results suggest that ELISA index values for rDsg1 will provide a promising tool for monitoring the disease severity and for determining the initial therapy for pemphigus foliaceus...
  11. ncbi request reprint A refractory case of secondary erythermalgia successfully treated with lumbar sympathetic ganglion block
    M Seishima
    Department of Dermatology, Ogaki Municipal Hospital, Minaminokawa cho 4 86, Ogaki 503 8502, Japan
    Br J Dermatol 143:868-72. 2000
    ..Although the mechanism of this effect is uncertain, microcirculation disturbance in secondary erythermalgia, if any, may be improved by this block...
  12. ncbi request reprint Loss of heterozygosity of adenomatous polyposis coli gene in cutaneous tumors as determined by using polymerase chain reaction and paraffin section preparations
    N Ichihashi
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    J Dermatol Sci 22:102-6. 2000
    ....
  13. ncbi request reprint An extremely severe case of cutaneous calcinosis with juvenile dermatomyositis, and successful treatment with diltiazem
    Y Ichiki
    Department of Dermatology and Department of Paediatrics, School of Medicine, Gifu University, 40 Tsukasa Machi, Gifu 500 8705, Japan
    Br J Dermatol 144:894-7. 2001
    ..These nodules gradually increased in size despite continual therapy with steroids and aluminium hydroxide. Treatment with diltiazem completely suppressed the development of calcinosis...
  14. ncbi request reprint Demonstration of antibody to 230 kDa bullous pemphigoid antigen in lichen planus-like keratosis
    M Seishima
    Department of Dermatology, Ogaki Municipal Hospital, Minaminokawa cho 4 86, Ogaki City, 503 8502, Japan
    Eur J Dermatol 9:393-6. 1999
    ..These observations suggest that the presence of an antibody to BPAG1 could be caused by the damage of basal cells following lichen planus-like keratosis...
  15. ncbi request reprint A pathogenic autoantibody, pemphigus vulgaris-IgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes
    Y Aoyama
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    Eur J Immunol 29:2233-40. 1999
    ....
  16. ncbi request reprint Pustular vasculitis with clinical feature of pustular psoriasis and sternoclavicular hyperostosis
    T Demitsu
    Department of Dermatology, Jichi Medical School, Tochigi, Japan
    Dermatology 186:213-6. 1993
    ..The patient had also sternoclavicular hyperostosis. We think that this represents a unique type of pustular vasculitis distinct from pustular psoriasis...
  17. ncbi request reprint Phosphatidylinositol-specific-phospholipase C cleaves urokinase plasminogen activator receptor from the cell surface and leads to inhibition of pemphigus-IgG-induced acantholysis in DJM-1 cells, a squamous cell carcinoma line
    S Asano
    Department of Dermatology, Gifu University School of Medicine, Gifu, Japan
    Clin Exp Dermatol 26:289-95. 2001
    ..Although uPAR expression on the pemphigus IgG-bound cell surface and uPA activation may contribute significantly to the pathogenesis of acantholysis in pemphigus, the mechanisms are complicated and should be defined further...
  18. ncbi request reprint Prevalence of atopic dermatitis in Japanese elementary schoolchildren
    H Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Dermatol 152:110-4. 2005
    ....
  19. ncbi request reprint The number and distribution of Merkel cells in rudimentary polydactyly
    M Ban
    Department of Dermatology, Hashima City Hospital, Hashima, Japan
    Dermatology 202:31-4. 2001
    ..Merkel cells may be associated with the generation of cutaneous nerve plexus and nerve endings in the upper dermis, and possibly with the development of Meissner corpuscles, at the early stage of rudimentary polydactyly...
  20. ncbi request reprint [Ultrastructure and molecular biochemistry on pathogenic fungal cells: the architecture of septal cell walls of dermatophytes]
    Y Kitajima
    Department of Dermatology, Gifu University School of Medicine, 40 Tsukasamachi, Gifu City 500-8705, Japan
    Nippon Ishinkin Gakkai Zasshi 42:55-9. 2001
    ....
  21. ncbi request reprint Thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus
    Yoshiro Ichiki
    Department of Dermatology, School of Medicine, Gifu University, Gifu, Japan
    Eur J Dermatol 17:548-9. 2007
  22. ncbi request reprint Pemphigus vulgaris-IgG reduces the desmoglein 3/desmocollin 3 ratio on the cell surface in cultured keratinocytes as revealed by double-staining immunoelectron microscopy
    En Shu
    J Dermatol Sci 40:209-11. 2005
  23. ncbi request reprint Bowen's disease with invasive adnexal carcinoma: the pluripotential nature of Bowen's disease cells
    Hideki Kamiya
    Department of Dermatology, Graduate School of Medicine, Gifu University, Gifu, Japan
    J Dermatol 33:858-64. 2006
    ..Immunohistochemically, the tumor cells of Bowen's disease and the adnexal carcinoma differed in antigenicities. The present cases support a notion that Bowen's disease maintains a pluripotential nature...
  24. doi request reprint P120 catenin is associated with desmogleins when desmosomes are assembled in high-Ca2+ medium but not when disassembled in low-Ca2+ medium in DJM-1 cells
    Miho Kanno
    Department of Dermatology, Gifu University School of Medicine, Gifu City, Japan
    J Dermatol 35:317-24. 2008
    ..Thus, these proteins are not co-localized in low Ca2+ medium. These results suggest that p120ctn plays an important role in Ca2+-induced desmosome formation...
  25. ncbi request reprint Desmoglein versus non-desmoglein signaling in pemphigus acantholysis: characterization of novel signaling pathways downstream of pemphigus vulgaris antigens
    Alex I Chernyavsky
    Department of Dermatology, University of California, Davis, California 95816, USA
    J Biol Chem 282:13804-12. 2007
    ..Therefore, the early acantholytic events are triggered by non-Dsg antibodies...
  26. ncbi request reprint Anti-desmoglein 3 (Dsg3) monoclonal antibodies deplete desmosomes of Dsg3 and differ in their Dsg3-depleting activities related to pathogenicity
    Yukari Yamamoto
    Department of Dermatology, Gifu University School of Medicine, Gifu City 501 1194, Japan
    J Biol Chem 282:17866-76. 2007
    ....
  27. ncbi request reprint Herpes gestationis in a mother and newborn: immunoclinical perspectives based on a weekly follow-up of the enzyme-linked immunosorbent assay index of a bullous pemphigoid antigen noncollagenous domain
    Yumi Aoyama
    Department of Dermatology, Gifu University School of Medicine, Yanagido 1 1, Gifu City 501 1194, Japan
    Arch Dermatol 143:1168-72. 2007
    ....
  28. ncbi request reprint P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes
    Hiroyuki Matsuno
    Department of Clinical and Pathological Biochemistry, Doshisha Women s College of Liberal Arts, Kyotanabe 610 0395, Japan
    J Clin Endocrinol Metab 90:920-7. 2005
    ..These findings present a possible new means for patients with diabetes to prevent ischemic events...
  29. ncbi request reprint Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis
    En Shu
    Department of Dermatology, Gifu University School of Medicine, Yanagido1 1, Gifu City, Japan
    Arch Dermatol Res 299:165-7. 2007
    ..Our data suggests the reduction of Dsg3 might be relevant to blister formation. These results also suggest that even a partial depletion of Dsg3 may contribute to blistering in PV patients...
  30. ncbi request reprint Successful use of preserved sclera of eyelid reconstruction
    Hideki Kamiya
    Department of Dermatology, Gifu University School of Medicine, Tsukasa mach 40, Gifu 500 8705, Japan
    Eur J Dermatol 13:267-71. 2003
    ..Previous papers as to this method, even though small in number, also reported no functional and esthetic problems. This method is recommended for eyelid reconstruction due to the good results and its simplicity...
  31. ncbi request reprint Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes
    Vu Thuong Nguyen
    Department of Dermatology, University of California School of Medicine, Davis, CA 95616, USA
    J Biol Chem 279:2135-46. 2004
    ..These results suggested that therapeutic effects of MP in PV include both the up-regulated synthesis and post-translational modification of the keratinocyte adhesion molecules...
  32. ncbi request reprint Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes
    Vu Thuong Nguyen
    Department of Dermatology, University of California, Davis, Sacramento, CA 95817, USA
    Exp Cell Res 294:534-49. 2004
    ..These findings may aid in the development of novel methods useful for the treatment of skin adhesion diseases and tumor metastasis...
  33. ncbi request reprint Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists
    Vu Thuong Nguyen
    Departments of Dermatology, University of California Davis, Sacramento, CA 95817, USA
    Arch Dermatol 140:327-34. 2004
    ..Patients develop autoantibodies to adhesion molecules mediating intercellular adhesion and to keratinocyte cholinergic receptors regulating cell adhesion...
  34. ncbi request reprint Monitoring of ELISA for anti-BP180 antibodies: clinical and therapeutic analysis of steroid-treated patients with bullous pemphigoid
    Tomoko Izumi
    Department of Dermatology, Gifu University, School of Medicine, Gifu, Japan
    J Dermatol 31:383-91. 2004
    ..Relapses did not occur with the tapering of PSL dosage when the ELISA values decreased to 40% of initial values, although they were still not within the normal range...
  35. ncbi request reprint Nodular fasciitis of the cheek
    Hideki Kamiya
    Department of Dermatology, Gifu University School of Medicine, Tsukasa mach 40, Japan
    Eur J Dermatol 13:189-91. 2003
    ..Local excision to completely remove the tumor proved curative at 1 year of follow-up. We concluded that nodular fasciitis can be encountered on the cheek and should be regarded as a benign tumor...
  36. pmc Bone marrow cell transfer into fetal circulation can ameliorate genetic skin diseases by providing fibroblasts to the skin and inducing immune tolerance
    Takenao Chino
    Division of Gene Therapy Science, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Am J Pathol 173:803-14. 2008
    ..Thus, gene therapy using E-BMT into the fetal circulation may offer a potential treatment option to ameliorate genetic skin diseases that are characterized by fibroblast dysfunction through the introduction of immune-tolerated BMDFs...
  37. ncbi request reprint A novel nonsense mutation at E106 of the 2B rod domain of keratin 14 causes dominant epidermolysis bullosa simplex
    Li Hong Gu
    Department of Dermatology, Gifu University, School of Medicine, Japan
    J Dermatol 29:136-45. 2002
    ..It is the first premature stop codon mutation of K14 found in dominant EBS...
  38. doi request reprint P120-catenin is a novel desmoglein 3 interacting partner: identification of the p120-catenin association site of desmoglein 3
    Miho Kanno
    Department of Dermatology, Gifu University School of Medicine, Gifu City 501 1194, Japan
    Exp Cell Res 314:1683-92. 2008
    ..In summary, we show that p120ctn is a novel interactor of the Dsg proteins, and may play a role in desmosome remodeling...
  39. pmc Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus
    Dedee F Murrell
    Department of Dermatology at St George Hospital, University of NSW, Sydney, Australia
    J Am Acad Dermatol 58:1043-6. 2008
    ..These should assist in development of consistent reporting of outcomes in future studies...
  40. ncbi request reprint Aberrant expression of p16 and RB protein in eccrine porocarcinoma
    Li Hong Gu
    Department of Dermatology, Gifu University School of Medicine, Gifu, Japan
    J Cutan Pathol 29:473-9. 2002
    ..Eccrine porocarcinoma is a rare malignant tumor of the sweat gland and very little is known about its etiology and molecular basis...
  41. ncbi request reprint Keratinocyte acetylcholine receptors regulate cell adhesion
    Vu Thuong Nguyen
    Department of Dermatology, University of California, School of Medicine, Davis, 4860 Y Street, 3400 Sacramento, CA 95817, USA
    Life Sci 72:2081-5. 2003
    ..5 mM CCh. Thus, keratinocyte cholinergic receptors regulate desmosomal adhesion of KC by altering the level of expression of both Dsg 1 and Dsg 3 and the phosphorylation status of Dsg 3...
  42. ncbi request reprint Community validation of the U.K. diagnostic criteria for atopic dermatitis in Japanese elementary schoolchildren
    Hidehisa Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 47:227-31. 2007
    ..K. working party. This list served well for both hospital patients with skin diseases and in general population within the U.K...
  43. ncbi request reprint No activation of urokinase plasminogen activator by anti-desmoglein 3 monoclonal IgG antibodies in cultured human keratinocytes
    Yukari Yamamoto
    Department of Dermatology, Gifu University School of Medicine, Yanagido 1 1, Gifu City 501 1194, Japan
    J Dermatol Sci 47:119-25. 2007
    ....
  44. pmc Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome
    Dawn H Siegel
    Department of Dermatology, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Am J Hum Genet 73:174-87. 2003
    ..Thus, Kindler syndrome is, to our knowledge, the first skin fragility disorder caused by a defect in actin-ECM linkage, rather than keratin-ECM linkage...
  45. ncbi request reprint Microcystic adnexal carcinoma with lymph node metastasis
    Masanori Ban
    Department of Dermatology, Hashima City Hospital, Hashima, Japan
    Dermatology 207:395-7. 2003
    ..The present case confirms that MAC can metastasize, although it may also be hypothesized that the recurrent lesion represented transformation into a higher-grade carcinoma...
  46. ncbi request reprint Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment
    Tomohiro Makino
    Institute for Medicinal Research and Development, Daiichi Suntory Pharma Co, Ltd, Ohra, Gunma 370 0503, Japan corrected
    Biopolymers 79:238-47. 2005
    ..A recombinant precursor peptide was Boc protected and subsequently cleaved using two distinct proteases, OmpT and Kex2. The peptides were then coupled to each other and, after deprotection, resulted in fully active human ghrelin...
  47. ncbi request reprint [Significance of the cardiovascular function tests in patients with collagen diseases, especially for SSc (systemic scleroderma)]
    Harumi Kawase
    Section of Clinical Laboratory, Gifu University Hospital, Gifu 500 8705
    Rinsho Byori 52:401-5. 2004
    ..The incidence of abnormal cardiovascular function tests in SSSD was relatively less than that in SSc. The cardiovascular function tests are useful to find cardiovascular abnormalities in these collagen diseases...