H Hara

Summary

Affiliation: Gifu Pharmaceutical University
Country: Japan

Publications

  1. doi request reprint Apomorphine prevents LPS-induced IL-23 p19 mRNA expression via inhibition of JNK and ATF4 in HAPI cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu501 1196, Japan Electronic address
    Eur J Pharmacol . 2016
  2. doi request reprint Plasma-activated medium-induced intracellular zinc liberation causes death of SH-SY5Y cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan Electronic address
    Arch Biochem Biophys 584:51-60. 2015
  3. doi request reprint Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    FEBS J 280:3313-27. 2013
  4. ncbi request reprint Protective effects of apomorphine against zinc-induced neurotoxicity in cultured cortical neurons
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Biol Pharm Bull 36:585-91. 2013
  5. ncbi request reprint [Molecular mechanism of neuroprotective drugs against oxidative stress-induced neuronal cell death]
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Yakugaku Zasshi 127:1199-205. 2007
  6. ncbi request reprint Loss of CYP3A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3A7 gene
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Biochem Biophys Res Commun 321:909-15. 2004
  7. ncbi request reprint Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine-induced neurotoxicity
    Hirokazu Hara
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neurochem Res 32:489-95. 2007
  8. doi request reprint Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neurochem Res 34:1498-506. 2009
  9. ncbi request reprint Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells
    H Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Free Radic Res 33:279-85. 2000
  10. ncbi request reprint Alteration of cellular phosphorylation state affects vitamin D receptor-mediated CYP3A4 mRNA induction in Caco-2 cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
    Biochem Biophys Res Commun 296:182-8. 2002

Collaborators

Detail Information

Publications55

  1. doi request reprint Apomorphine prevents LPS-induced IL-23 p19 mRNA expression via inhibition of JNK and ATF4 in HAPI cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu501 1196, Japan Electronic address
    Eur J Pharmacol . 2016
    ..We also found that Apo inhibited Tg-induced ATF4 accumulation and IL-23 p19 mRNA expression. Taken together, our findings suggest that Apo exerts anti-inflammatory effects through inhibition of JNK and ATF4 signaling pathways...
  2. doi request reprint Plasma-activated medium-induced intracellular zinc liberation causes death of SH-SY5Y cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan Electronic address
    Arch Biochem Biophys 584:51-60. 2015
    ..Moreover, TPEN suppressed all of these events elicited by PAM. Taken together, we demonstrated here that Zn(2+) released from intracellular Zn(2+) stores serves as a key mediator of PAM-induced cell death in SH-SY5Y cells. ..
  3. doi request reprint Zinc-induced modulation of SRSF6 activity alters Bim splicing to promote generation of the most potent apoptotic isoform BimS
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    FEBS J 280:3313-27. 2013
    ..Taken together, our findings suggest that Zn(2+) inhibits the activity of SRSF6 and promotes elimination of exon 4, leading to preferential generation of BimS...
  4. ncbi request reprint Protective effects of apomorphine against zinc-induced neurotoxicity in cultured cortical neurons
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Biol Pharm Bull 36:585-91. 2013
    ....
  5. ncbi request reprint [Molecular mechanism of neuroprotective drugs against oxidative stress-induced neuronal cell death]
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Yakugaku Zasshi 127:1199-205. 2007
    ..In this review, our recent studies on the mechanism underlying Apo-induced neuroprotection are summarized...
  6. ncbi request reprint Loss of CYP3A7 gene induction by 1,25-dihydroxyvitamin D3 is caused by less binding of VDR to the proximal ER6 in CYP3A7 gene
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Biochem Biophys Res Commun 321:909-15. 2004
    ..Taken together, the decrease of VDR binding to the proximal ER6 caused by the mutation results in the loss of CYP3A7 gene activation by 1,25(OH)(2)D(3)...
  7. ncbi request reprint Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine-induced neurotoxicity
    Hirokazu Hara
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neurochem Res 32:489-95. 2007
    ..Therefore, our results suggest the protective effect of PQQ on 6-OHDA-induced neurotoxicity is involved, at least in part, in its function as a scavenger of ROS, especially superoxide...
  8. doi request reprint Zinc induces expression of the BH3-only protein PUMA through p53 and ERK pathways in SH-SY5Y neuroblastoma cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neurochem Res 34:1498-506. 2009
    ..Taken together, these results indicate that Zn2+ regulates the induction of PUMA through p53 and ERK pathways...
  9. ncbi request reprint Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells
    H Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Free Radic Res 33:279-85. 2000
    ..8-Bromo cGMP had no effect on 1,25(OH)2D3-induced CYP3A4 gene expression. Therefore, the suppression of CYP3A4 mRNA by NO might be mediated through a guanylate cyclase-independent pathway...
  10. ncbi request reprint Alteration of cellular phosphorylation state affects vitamin D receptor-mediated CYP3A4 mRNA induction in Caco-2 cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
    Biochem Biophys Res Commun 296:182-8. 2002
    ..Taken together, these findings suggest that the change in the phosphorylation state via PKC and tyrosine kinase might, at least in part, modulate 1,25(OH)(2)D(3)-induced CYP3A4 mRNA expression via VDR...
  11. doi request reprint Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Bioorg Med Chem 19:5559-68. 2011
    ....
  12. doi request reprint Endoplasmic reticulum stress inducers provide protection against 6-hydroxydopamine-induced cytotoxicity
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Neurochem Int 58:35-43. 2011
    ..Taken together, our data suggest that preconditioning effects induced by Tg mediate an adaptive response to 6-OHDA-induced cytotoxicity via phosphorylation of eIF2α and activation of the ARE...
  13. ncbi request reprint Contribution of hepatocyte nuclear factor-4 to down-regulation of CYP2D6 gene expression by nitric oxide
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Mol Pharmacol 61:194-200. 2002
    ..These results demonstrated that NO down-regulates CYP2D6 gene expression, at least in part, by directly inhibiting HNF4 binding to the CYP2D6 promoter...
  14. doi request reprint Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson's disease
    A Oyagi
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res 1214:169-76. 2008
    ..These findings indicate that SUN N8075 exerts protective effects, at least in part via an anti-oxidation mechanism, in these in vitro and in vivo models of Parkinson's disease...
  15. doi request reprint Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil
    Y Oida
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res 1208:217-24. 2008
    ..These findings indicate that this selective inducer of BiP could be used to prevent the neuronal damage both in vitro and in vivo...
  16. ncbi request reprint Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia
    K Wakida
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neuroscience 148:105-14. 2007
    ..These findings indicate that MTs are induced, and may be neuroprotective against neuronal damage, after MCAO. Furthermore, EPO is neuroprotective in vivo during permanent MCAO, and this may be at least partly mediated by MTs...
  17. ncbi request reprint Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice
    N Morimoto
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neuroscience 147:957-67. 2007
    ..These findings suggest that permanent MCAO induces expression of ER-stress related genes mainly in the periphery of the MCA territory...
  18. ncbi request reprint Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properti
    Y Kotani
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neuroscience 149:779-88. 2007
    ..These findings indicate that SUN N8075 has neuroprotective effects against acute ischemic neuronal damage in mice and may prove promising as a therapeutic drug for stroke...
  19. ncbi request reprint Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil
    Y Oida
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu 502 8585, Japan
    Neuroscience 151:111-9. 2008
    ..These findings are consistent with ER stress playing a pivotal role in post-ischemic neuronal death in the gerbil hippocampal CA1 subfield...
  20. doi request reprint Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury
    A Oyagi
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    Neuroscience 185:116-24. 2011
    ....
  21. doi request reprint A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion
    Y Inokuchi
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    J Neurosci Res 87:906-17. 2009
    ..In conclusion, these results suggest that NCX1 may play a role in retinal cell death induced by NMDA and ischemia-reperfusion...
  22. doi request reprint A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice
    A Koumura
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 5858, Japan
    Neuroscience 157:309-18. 2008
    ..SNJ-1945 may therefore be a potential drug for stroke...
  23. doi request reprint Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
    K Hyakkoku
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    Neuroscience 171:258-67. 2010
    ..These data suggest that TLR4 knockout, but not TLR3 or TLR9 knockout, may play a neuroprotective role in ischemic brain injury induced by MCAO in mice...
  24. doi request reprint Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice
    K Hyakkoku
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Neuroscience 159:760-9. 2009
    ....
  25. ncbi request reprint Apomorphine protects against 6-hydroxydopamine-induced neuronal cell death through activation of the Nrf2-ARE pathway
    Hirokazu Hara
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    J Neurosci Res 84:860-6. 2006
    ..Taken together, our findings suggest that not only the function as a radical scavenger but also the function as an Nrf2-ARE pathway activator may be involved in the neuroprotective effects of Apo...
  26. ncbi request reprint Increase of antioxidative potential by tert-butylhydroquinone protects against cell death associated with 6-hydroxydopamine-induced oxidative stress in neuroblastoma SH-SY5Y cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res Mol Brain Res 119:125-31. 2003
    ..These results indicate that an increase of intracellular antioxidative potential in SH-SY5Y cells by tBHQ treatment protects cells from 6-OHDA-induced oxidative stress...
  27. doi request reprint A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator
    M Ishiguro
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
    Neuroscience 220:302-12. 2012
    ..These findings indicate that fasudil prevents the hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA, at least in part, by inhibiting the increased activity of MMP-9 in endothelial cells...
  28. ncbi request reprint Increase of urinary extracellular-superoxide dismutase level correlated with cyclic adenosine monophosphate
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    FEBS Lett 458:370-4. 1999
    ..Together these observations suggest that factor(s) that stimulate the adenylate cyclase-cAMP system regulate the urinary EC-SOD level...
  29. ncbi request reprint Nitric oxide and its decomposed derivatives decrease the binding of extracellular-superoxide dismutase to the endothelial cell surface
    M Yamamoto
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan
    FEBS Lett 505:296-300. 2001
    ....
  30. ncbi request reprint C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression
    Yoko Yasunami
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Drug Metab Dispos 32:685-8. 2004
    ..However, SP600125 did not affect 1,25(OH)(2)D(3)-induced transactivation of the DR3 via VDR. These results indicate that JNK, but not ERK or p38, is required for the optimal activation of the CYP3A4 gene induced by 1,25(OH)(2)D(3)...
  31. doi request reprint Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia-reperfusion injury
    Y Nakano
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu, Pharamaceutical University, Gifu 501 1196, Japan
    Neuroscience 277:123-31. 2014
    ..In conclusion, these findings indicate that GPNMB has neuroprotective effects against IRI, via phosphorylation of ERK1/2 and Akt, suggesting that GPNMB may be a therapeutic target for ischemia-reperfusion injuries...
  32. ncbi request reprint Heparin-stimulated expression of extracellular-superoxide dismutase in human fibroblasts
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, 502 8585, Gifu, Japan
    Atherosclerosis 159:307-12. 2001
    ..The stimulatory effect seemed to increase roughly with the degree of glycosaminoglycan sulfation. The enhanced expression of EC-SOD by heparin must contribute to the antiatherosclerotic effect of heparin...
  33. ncbi request reprint Apomorphine attenuates 6-hydroxydopamine-induced apoptotic cell death in SH-SY5Y cells
    Hirokazu Hara
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Redox Rep 8:193-7. 2003
    ..These findings suggested that apomorphine acts principally as a radical scavenger to suppress the level of ROS and ROS-stimulated apoptotic signaling pathway, whereas the other mechanisms might be involved in the protective effects...
  34. pmc Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis
    M Takata
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
    Br J Pharmacol 170:341-51. 2013
    ..In previous reports, fasudil improved pathology in mouse models of Alzheimer's disease and spinal muscular atrophy, but there is no evidence in that it can affect ALS. We therefore investigated its effects on experimental models of ALS...
  35. ncbi request reprint Heparin-Affinity of human extracellular-superoxide dismutase in the brain
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Japan
    Biol Pharm Bull 24:191-3. 2001
    ..The intracellular localization of EC-SOD could contribute to its slow clearance from the brain and maintenance of its physiological functions in the brain...
  36. ncbi request reprint Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2
    K Wakida
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res 1116:187-93. 2006
    ....
  37. ncbi request reprint Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients
    T Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu 502 8585, Japan
    J Endocrinol 181:413-7. 2004
    ..It is possible that the increase in the EC-SOD level by pioglitazone administration in diabetic patients is due to a decline of TNF-alpha, which is known to suppress EC-SOD expression...
  38. doi request reprint Regulation of extracellular-superoxide dismutase in rat retina pericytes
    Tetsuo Adachi
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Redox Rep 15:250-8. 2010
    ....
  39. doi request reprint The effect of hypoxia mimetic cobalt chloride on the expression of EC-SOD in 3T3-L1 adipocytes
    Tetsuro Kamiya
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 1 25 4 Daigaku nishi, Gifu 501 1196, Japan
    Redox Rep 15:131-7. 2010
    ....
  40. ncbi request reprint Infliximab neutralizes the suppressive effect of TNF-alpha on expression of extracellular-superoxide dismutase in vitro
    Tetsuo Adachi
    Department of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Biol Pharm Bull 29:2095-8. 2006
    ..This reveals a potential usefulness of infliximab on TNF-alpha related pathological conditions such as arthritis and insulin resistance...
  41. doi request reprint Expression of extracellular superoxide dismutase during adipose differentiation in 3T3-L1 cells
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Redox Rep 14:34-40. 2009
    ..It is possible that the expression of EC-SOD in adipocytes was stimulated to protect them from oxidative stress in the co-culture system...
  42. ncbi request reprint [Effort to improve advanced problem-based learning tutorial]
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Mitahora Higashi, Gifu, Japan
    Yakugaku Zasshi 129:177-82. 2009
    ..In addition, the usefulness of customer satisfaction (CS) analysis was demonstrated as a result of applying it to the data analysis of evaluation performed on group presentations...
  43. doi request reprint Cobalt chloride decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells
    Tetsuro Kamiya
    Department of Biomedical Pharmaceutics, Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan
    Free Radic Res 42:949-56. 2008
    ....
  44. ncbi request reprint Effects of PPARgamma ligands and C/EBPbeta enhancer on expression of extracellular-superoxide dismutase
    Tetsuo Adachi
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Redox Rep 9:207-12. 2004
    ..Increasing the EC-SOD expression by treatment with ligands of transcription factors might be one approach to ameliorate the pathological conditions of insulin resistance...
  45. doi request reprint Extracellular-superoxide dismutase expression during monocytic differentiation of U937 cells
    Tetsuro Kamiya
    Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    J Cell Biochem 112:244-55. 2011
    ..Overall, our results suggest that the expression of EC-SOD is decreased by TPA through intracellular signaling consisting of PKC, NOX-derived ROS and MEK/ERK, but not of NF-κB signaling...
  46. doi request reprint A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice
    K Mishiro
    Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu 501 1196, Japan
    Neuroscience 205:39-48. 2012
    ..This suggests that GM6001 may be a useful candidate for combination therapy against the hemorrhagic complications induced by tPA...
  47. ncbi request reprint Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain
    Y Oida
    Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res 1082:196-204. 2006
    ....
  48. ncbi request reprint The expression of extracellular-superoxide dismutase is increased by lysophosphatidylcholine in human monocytic U937 cells
    Masayuki Yamamoto
    Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5 6 1, Mitahora Higashi, Japan
    Atherosclerosis 163:223-8. 2002
    ..Therefore, it is speculated that EC-SOD is induced by lysoPC-stimulated monocytes as a feedback mechanism in vascular homeostasis...
  49. ncbi request reprint TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes
    Masataka Nishimura
    Department of the Clinical Neuroscience, Tokushima University Hospital, Japan
    Hum Immunol 64:302-9. 2003
    ..These results suggest that the TNFR1 gene region might be a susceptible locus to type 1 diabetes in Japanese...
  50. ncbi request reprint A critical role for allograft inflammatory factor-1 in the pathogenesis of rheumatoid arthritis
    Mizuho Kimura
    Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto, Japan
    J Immunol 178:3316-22. 2007
    ..618, p < 0.01). These findings suggest that AIF-1 is closely associated with the pathogenesis of RA and is a novel member of the cytokine network involved in the immunological processes underlying RA...
  51. pmc A molecular technique for detecting the liberation of intracellular zinc in cultured neurons
    Hirokazu Hara
    Department of Neurobiology, University of Pittsburgh School of Medicine, E1456 BST, Pittsburgh, PA 15261, USA
    J Neurosci Methods 137:175-80. 2004
    ..Our results indicate that Cd(2+) can effectively induce transactivation of MRE in neurons by liberating Zn(2+) from its intracellular binding sites...
  52. pmc Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge
    Megan E Knoch
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Glia 56:89-96. 2008
    ..These results establish a direct link between microglial-generated oxygen and nitrogen reactive products and neuronal cell death mediated by intracellular Zn(2+) release and a surge in K(+) currents...
  53. ncbi request reprint Serum extracellular superoxide dismutase in patients with type 2 diabetes: relationship to the development of micro- and macrovascular complications
    Fumiaki Kimura
    First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Diabetes Care 26:1246-50. 2003
    ....
  54. ncbi request reprint Expression of allograft inflammatory factor-1 in human eutopic endometrium and endometriosis: possible association with progression of endometriosis
    Hisato Koshiba
    Department of Obstetrics and Gynecology, Graduate School of Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kamigyo ku, Kyoto 602 8566, Japan
    J Clin Endocrinol Metab 90:529-37. 2005
    ..AIF-1 derived from peritoneal macrophages may also possibly play a significant role in the pathophysiology and progression of endometriosis...
  55. ncbi request reprint Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type 2 diabetes and hypertension
    Hyohun Park
    Department of Internal Medicine, Saiseikai Suita Hospital, Osaka 564 0013, Japan
    Clin Chim Acta 374:129-34. 2006
    ..It is now well established that vascular inflammation and endothelial dysfunction associated with cardiovascular diseases contributes to insulin resistance...