Hiroyuki Nakamura

Summary

Affiliation: Gakushuin University
Country: Japan

Publications

  1. ncbi request reprint Synthesis of allenes via palladium-catalyzed hydrogen-transfer reactions: propargylic amines as an allenyl anion equivalent
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    J Am Chem Soc 126:5958-9. 2004
  2. ncbi request reprint Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171 8588, Japan
    Chem Commun (Camb) . 2004
  3. ncbi request reprint 1,2-Bis(diphenylphosphino)carborane as a dual mode ligand for both the Sonogashira coupling and hydride-transfer steps in palladium-catalyzed one-pot synthesis of allenes from aryl iodides
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo, Japan
    Org Lett 8:2095-8. 2006
  4. ncbi request reprint Fluorous solvent as a new phase-screen medium between reagents and reactants in the bromination and chlorination of alcohols
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Org Lett 5:1167-9. 2003
  5. doi request reprint Boron lipid-based liposomal boron delivery system for neutron capture therapy: recent development and future perspective
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo
    Future Med Chem 5:715-30. 2013
  6. ncbi request reprint HSP60 as a drug target
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Japan
    Curr Pharm Des 19:441-51. 2013
  7. doi request reprint Development of hypoxia-inducible factor (HIF)-1α inhibitors: effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 23:806-10. 2013
  8. doi request reprint Synthesis of mono- and 1,3-disubstituted allenes from propargylic amines via palladium-catalysed hydride-transfer reaction
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Org Biomol Chem 6:1471-7. 2008
  9. ncbi request reprint Synthesis of heterocyclic allenes via palladium-catalyzed hydride-transfer reaction of propargylic amines
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    J Org Chem 70:2357-60. 2005
  10. doi request reprint Development of boron nanocapsules for neutron capture therapy
    H Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Appl Radiat Isot 67:S84-7. 2009

Detail Information

Publications90

  1. ncbi request reprint Synthesis of allenes via palladium-catalyzed hydrogen-transfer reactions: propargylic amines as an allenyl anion equivalent
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    J Am Chem Soc 126:5958-9. 2004
    ..In the current transformation, propargylic amines can be handled as an allenyl anion equivalent and introduced into various electrophiles to be transformed into allenes under palladium-catalyzed conditions...
  2. ncbi request reprint Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171 8588, Japan
    Chem Commun (Camb) . 2004
    ..The lipid was incorporated into distearoylphosphatidylcholine (DSPC) liposomes at a very high concentration...
  3. ncbi request reprint 1,2-Bis(diphenylphosphino)carborane as a dual mode ligand for both the Sonogashira coupling and hydride-transfer steps in palladium-catalyzed one-pot synthesis of allenes from aryl iodides
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo, Japan
    Org Lett 8:2095-8. 2006
    ..Electron-deficient bidentate phosphines, such as 1,2-bis(diphenylphosphino)carborane 5 and (C(6)F(5))(2)PC(2)H(4)P(C(6)F(5))(2), play the role of a dual mode ligand for both the Sonogashira coupling and hydride-transfer reactions...
  4. ncbi request reprint Fluorous solvent as a new phase-screen medium between reagents and reactants in the bromination and chlorination of alcohols
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Org Lett 5:1167-9. 2003
    ..A fluorous triphasic U-tube method is effective for lighter reagents; the thionyl chloride layer (yellow) vanishes, and the chlorides are obtained from the right top organic layer in the chlorination of alcohols...
  5. doi request reprint Boron lipid-based liposomal boron delivery system for neutron capture therapy: recent development and future perspective
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo
    Future Med Chem 5:715-30. 2013
    ..Boron compounds that have no affinity to tumor can potentially be delivered to tumor tissues by liposomes, therefore, liposomal BDS would be one of the most attractive approaches for efficient BNCT of various cancers...
  6. ncbi request reprint HSP60 as a drug target
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Japan
    Curr Pharm Des 19:441-51. 2013
    ..The possibility of utilizing HSP60 as a new drug target for the treatment of certain diseases is examined...
  7. doi request reprint Development of hypoxia-inducible factor (HIF)-1α inhibitors: effect of ortho-carborane substituents on HIF transcriptional activity under hypoxia
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 23:806-10. 2013
    ..80 ± 0.25 μM) and this inhibition activity was higher than that of ETB (IC(50): 10.9 ± 0.63 μM)...
  8. doi request reprint Synthesis of mono- and 1,3-disubstituted allenes from propargylic amines via palladium-catalysed hydride-transfer reaction
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Org Biomol Chem 6:1471-7. 2008
    ..In the current transformation, propargylic amines can be handled as allenyl anion equivalents and introduced into various electrophiles to be transformed into allenes under palladium-catalyzed conditions...
  9. ncbi request reprint Synthesis of heterocyclic allenes via palladium-catalyzed hydride-transfer reaction of propargylic amines
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    J Org Chem 70:2357-60. 2005
    ..5 mol %) and 1,2-bis[bis(pentafluorophenyl)phosphino]ethane (10 mol %) at 100 degrees C in CHCl(3), giving the corresponding heterocyclic allenes in good to high yields via the palladium-catalyzed hydride-transfer reaction...
  10. doi request reprint Development of boron nanocapsules for neutron capture therapy
    H Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Appl Radiat Isot 67:S84-7. 2009
    ..A high level of (10)B concentration (22 ppm) was observed in tumor tissue at 24 h after the administration of boron liposomes...
  11. ncbi request reprint Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 16:5127-31. 2006
    ..The salicylic amide 4a showed inhibition of both VEGFR-1 and VEGFR-2 tyrosine kinases at a 10 microM concentration...
  12. doi request reprint Synthesis and biological evaluation of boron peptide analogues of Belactosin C as proteasome inhibitors
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 19:3220-4. 2009
    ..A biparametric cytofluorimetric analysis with FITC-labeled annexin V and propidium iodide showed induction of apoptosis by compound 11a at >1 microM concentrations of compound...
  13. doi request reprint Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, 1 5 1 Mejiro, Toshima ku, Tokyo, 171 8588, Japan
    Org Biomol Chem 10:1374-80. 2012
    ..A preliminary in vivo imaging study of tumor-bearing mice revealed that the FL-SBL-labeled DSPC liposomes were delivered to the tumor tissue but not distributed to hypoxic regions...
  14. ncbi request reprint Synthesis and biological evaluation of boronic acid containing cis-stilbenes as apoptotic tubulin polymerization inhibitors
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    ChemMedChem 1:729-40. 2006
    ..Growth inhibitory experiments against a panel of 39 human cancer cell lines revealed 13 c to inhibit growth differently than combretastatin A-4; the correlation coefficient (r) between the two compounds was 0.553 in the COMPARE analysis...
  15. ncbi request reprint [Minimally invasive cytoselective radiation therapy using boron neutron capture reaction]
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan
    Yakugaku Zasshi 130:1687-94. 2010
    ..BDS involves two strategies: (1) encapsulation of boron in the aqueous core of liposomes and (2) accumulation of boron in the liposomal bilayer. In this review, recent development of liposomal boron delivery system is summarized...
  16. ncbi request reprint Benzamides and benzamidines as specific inhibitors of epidermal growth factor receptor and v-Src protein tyrosine kinases
    Toru Asano
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8588, Japan
    Bioorg Med Chem 12:3529-42. 2004
    ..61, whereas that of the benzamide 1c was 5.05. In a similar manner, the LigScore2 value of the cyclic benzamidine 3a was calculated as 5.10...
  17. doi request reprint Allene as an alternative functional group for drug design: effect of C--C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase
    Hyun Seung Ban
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    ChemMedChem 3:1094-103. 2008
    ..Furthermore, one of these allenic quinazolines decreased the proliferation of A431 cells through the induction of cell-cycle arrest and apoptosis...
  18. doi request reprint Dodecaborate lipid liposomes as new vehicles for boron delivery system of neutron capture therapy
    Manabu Ueno
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Bioorg Med Chem 18:3059-65. 2010
    ..Promising BNCT effects were observed in the mice injected with DSBL-25% PEG liposomes: the tumor growth was significantly suppressed after thermal neutron irradiation (1.8 x 10(12)neutrons/cm(2))...
  19. doi request reprint Enhancement of EGFR tyrosine kinase inhibition by C-C multiple bonds-containing anilinoquinazolines
    Hyun Seung Ban
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171 8588, Japan
    Bioorg Med Chem 18:870-9. 2010
    ..Compounds with long carbon chains (n=3-6), such as 6c-f, 7c-f, 11, and 12, displayed prolonged inhibitory activity...
  20. doi request reprint Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1alpha inhibitors
    Kazuki Shimizu
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 20:1453-6. 2010
    ..74 microM). Compound 16 suppressed hypoxia-induced HIF-1alpha accumulation and vascular endothelial growth factor mRNA expression in a concentration-dependent manner without affecting the expression of HIF-1alpha mRNA...
  21. doi request reprint T cell-mediated control of Epstein-Barr virus infection in humanized mice
    Misako Yajima
    Department of Infectious Diseases, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo, Japan
    J Infect Dis 200:1611-5. 2009
    ..These results indicate that humanized NOG mice are capable of T cell-mediated control of EBV infection and imply their usefulness as a tool to evaluate immunotherapeutic and prophylactic strategies for EBV infection...
  22. doi request reprint Discovery of boron-conjugated 4-anilinoquinazoline as a prolonged inhibitor of EGFR tyrosine kinase
    Hyun Seung Ban
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, 171 8588, Japan
    Org Biomol Chem 7:4415-27. 2009
    ....
  23. ncbi request reprint Molecular effects of the tissue-nonspecific alkaline phosphatase gene polymorphism (787T > C) associated with bone mineral density
    Natsuko Sogabe
    Department of Food and Nutrition, Division of Nutrition, Japan Women s University, Tokyo, Japan
    Biomed Res 29:213-9. 2008
    ..01). These results suggest that the significant difference in Km values between the proteins translated from 787T > C and 787T may contribute to regulatory effects on bone metabolism...
  24. ncbi request reprint Transferrin-loaded nido-carborane liposomes: tumor-targeting boron delivery system for neutron capture therapy
    Yusuke Miyajima
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171 8588, Japan
    Bioconjug Chem 17:1314-20. 2006
    ..Longer survival rates were observed in the mice treated with Tf(+)-PEG-CL liposomes; one of them even survived for 52 days after BNCT...
  25. doi request reprint Identification of HSP60 as a primary target of o-carboranylphenoxyacetanilide, an HIF-1alpha inhibitor
    Hyun Seung Ban
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    J Am Chem Soc 132:11870-1. 2010
    ..Furthermore, HSP60 inhibitor 4 suppressed hypoxia-induced HIF activation, indicating that HSP60 affects HIF-1alpha accumulation directly or indirectly...
  26. doi request reprint Development of high boron content liposomes and their promising antitumor effect for neutron capture therapy of cancers
    Hayato Koganei
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Bioconjug Chem 24:124-32. 2013
    ..The current results enabled us to reduce the total dose of liposomes to less than one-fifth compared with that of the BSH-encapsulating liposomes without reducing the efficacy of boron neutron capture therapy (BNCT)...
  27. ncbi request reprint Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening
    Taikou Usui
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 18:285-8. 2008
    ..062 and 0.057 microM, respectively). Compounds 8b and 9a showed inhibitory activity toward both EGFR and VEGFR-2 (KDR) tyrosine kinases, whereas 8d inhibited VEGFR-2 tyrosine kinase, exclusively...
  28. ncbi request reprint Design, synthesis, and biological evaluation of aminoboronic acids as growth-factor receptor inhibitors of EGFR and VEGFR-1 tyrosine kinases
    Toru Asano
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    Chembiochem 5:483-90. 2004
    ....
  29. doi request reprint Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633
    Hyun Seung Ban
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Cancer Lett 296:17-26. 2010
    ....
  30. doi request reprint Liposomal boron delivery for neutron capture therapy
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Toshima ku, Tokyo, Japan
    Methods Enzymol 465:179-208. 2009
    ..Our laboratory has developed boron ion cluster lipids for application of the latter approach. In this chapter, our boron lipid liposome approaches as well as recent developments of the liposomal boron delivery system are summarized...
  31. doi request reprint Boron-containing protoporphyrin IX derivatives and their modification for boron neutron capture therapy: synthesis, characterization, and comparative in vitro toxicity evaluation
    Mohamed E El-Zaria
    Department of Chemistry, Faculty of Science, Gakushuin University, 1 5 1 Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Chemistry 16:1543-52. 2010
    ..Of these compounds, B(12)H(11)NH(2) (2-)-conjugated porphyrin induced a significant increase in the level of boron accumulation and PDT efficacy against HeLa cells...
  32. doi request reprint A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease
    Rumi Taniguchi
    Department of Virology I, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, 162 8640, Japan
    Infection 43:353-9. 2015
    ....
  33. ncbi request reprint Synthesis of boron cluster lipids: closo-dodecaborate as an alternative hydrophilic function of boronated liposomes for neutron capture therapy
    Jong Dae Lee
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Org Lett 9:323-6. 2007
    ..Calcein encapsulation experiments revealed that the liposomes, prepared from the boron cluster lipid 4b, DMPC, PEG-DSPE, and cholesterol, are stable at 37 degrees C in FBS solution for 24 h. [reaction: see text]...
  34. doi request reprint de novo design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors
    Masaharu Uno
    Department of Chemistry, Faculty of Science, Gakushuin University, 1 5 1 Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Org Biomol Chem 6:979-81. 2008
    ..Among compounds synthesized, compound showed the most potent inhibitory activity toward VEGFR-2 (KDR) tyrosine kinase and its IC(50) value was 0.57 microM...
  35. ncbi request reprint Synthesis and biological evaluation of benzamides and benzamidines: structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase
    Toru Asano
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8588, Japan
    Bioorg Med Chem Lett 14:2299-302. 2004
    ..32 mM. The benzamidines 3a and 3b exhibited high inhibition of EGFR tyrosine kinase at a 1.0 microM concentration, although the benzamides 1 and the benzamidines 2 did not show significant kinase inhibition at a 10 microM concentration...
  36. pmc Novel mouse xenograft models reveal a critical role of CD4+ T cells in the proliferation of EBV-infected T and NK cells
    Ken Ichi Imadome
    Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo, Japan
    PLoS Pathog 7:e1002326. 2011
    ..This is the first report of animal models of CAEBV and EBV-HLH that are expected to be useful tools in the development of novel therapeutic strategies for the treatment of the diseases...
  37. ncbi request reprint Phase-vanishing reactions that use fluorous media as a phase screen. Facile, controlled bromination of alkenes by dibromine and dealkylation of aromatic ethers by boron tribromide
    Ilhyong Ryu
    Department of Chemistry, Faculty of Arts and Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    J Am Chem Soc 124:12946-7. 2002
    ....
  38. ncbi request reprint [Development of high boron content liposomes and their promising antitumor effect for neutron capture therapy]
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University
    Yakugaku Zasshi 133:1297-306. 2013
    ..The combination of both approaches has a potential for reduction of the total dose of liposomes without reducing the efficacy of BNCT. ..
  39. doi request reprint Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors
    Masaharu Uno
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 22:5169-73. 2012
    ..Compound 4 exhibited selective inhibition against SENP1 protease activity without inhibiting other protease enzyme activities in vitro...
  40. doi request reprint Zinc(II)-catalyzed redox cross-dehydrogenative coupling of propargylic amines and terminal alkynes for synthesis of N-tethered 1,6-enynes
    Tsuyuka Sugiishi
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    J Am Chem Soc 134:2504-7. 2012
    ....
  41. doi request reprint 1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors
    Masaharu Uno
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    Bioorg Med Chem Lett 19:3166-9. 2009
    ..2 microM). Furthermore, compound 2k suppressed the hypoxia-induced secretion of VEGF in HeLa cells (IC(50)=15 microM)...
  42. ncbi request reprint Synthesis and in vivo biodistribution of BPA-Gd-DTPA complex as a potential MRI contrast carrier for neutron capture therapy
    Kazunori Takahashi
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8578, Japan
    Bioorg Med Chem 13:735-43. 2005
    ..The visualization experiment of boron distribution in the tumor-bearing rat by alpha-autoradiography indicates that boron was accumulated in the tumor and the intestines at 20 min after injection...
  43. doi request reprint Amphiphilic allylation of arylidene-1,3-oxazol-5(4H)-one using bis-π-allylpalladium complexes: an approach to synthesis of cyclohexyl and cyclohexenyl α-amino acids
    Afaf R Genady
    Department of Chemistry, Faculty of Science, University of Tanta, 31527 Tanta, Egypt
    Org Biomol Chem 9:7180-9. 2011
    ..The structures of compounds 9, 12 and 13 were confirmed by X-ray structural analysis. It is an excellent method for creating a wide range of cyclic α,α-disubstituted α-amino acids...
  44. doi request reprint Phase-vanishing methods based on fluorous phase screen: a simple way for efficient execution of organic synthesis
    Ilhyong Ryu
    Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Chem Rec 8:351-63. 2008
    ..Recent advances include a "quadraphasic" PV method, in which an aqueous "scavenger" phase is added to the original triphasic PV method to remove acidic by-products...
  45. doi request reprint Synthesis of protoporphyrin-lipids and biological evaluation of micelles and liposomes
    Shoji Tachikawa
    Chemical Research Laboratory, Tokyo Institute of Technology, Nagatsuta cho, Midori ku, Yokohama 226 8503, Japan Department of Life Science, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Bioorg Med Chem 22:4745-51. 2014
    ..53, 5.65, and 12.9μM, respectively, after irradiation with a xenon lamp in the 400-800nm range for 2min. PL-C17 liposomes were selectively accumulated in the Golgi apparatus in cells. ..
  46. doi request reprint A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses
    Misako Yajima
    Department of Infectious Diseases, National Research Institute for Child Health and Development, Setagaya Ku, Tokyo, Japan
    J Infect Dis 198:673-82. 2008
    ..The NOG mouse is the most comprehensive small-animal model of EBV infection described to date and should facilitate studies of the pathogenesis, prevention, and treatment of EBV infection...
  47. doi request reprint New strategy for synthesis of mercaptoundecahydrododecaborate derivatives via click chemistry: possible boron carriers and visualization in cells for neutron capture therapy
    Mohamed E El-Zaria
    Department of Chemistry, Faculty of Science, Gakushuin University, 1 5 1 Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Inorg Chem 48:11896-902. 2009
    ..We succeeded in the click cycloaddition reaction of compound 1 with Alexa Fluor 488 azide dye and found that 1 accumulated not in the cytoplasm but in the nuclei of HeLa cells...
  48. doi request reprint Localization-dependent cell-killing effects of protoporphyrin (PPIX)-lipid micelles and liposomes in photodynamic therapy
    Shoji Tachikawa
    Chemical Research Laboratory, Tokyo Institute of Technology, Nagatsuta cho, Midori ku, Yokohama 226 8503, Japan Department of Life Science, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Bioorg Med Chem 23:7578-84. 2015
    ....
  49. doi request reprint Antitumor effect of boron nitride nanotubes in combination with thermal neutron irradiation on BNCT
    Hiroyuki Nakamura
    Chemical Resources Laboratory, Tokyo Institute of Technology, Nagatsuta cho, Midori ku, Yokohama 226 8503, Japan Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan Electronic address
    Bioorg Med Chem Lett 25:172-4. 2015
    ....
  50. doi request reprint Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Dalton Trans 43:4941-4. 2014
    ..Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration-dependent manner without affecting HIF-1α mRNA expression...
  51. doi request reprint Synthesis and biological evaluation of diaryl-substituted carboranes as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity
    Hidemitsu Minegishi
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588, Japan
    ChemMedChem 8:265-71. 2013
    ....
  52. doi request reprint Undecahydro-closo-dodecaborates as good leaving groups in organic synthesis: generation of substituted styrenes via elimination of arylethyl dodecaborates
    Afaf R Genady
    Department of Chemistry, Faculty of Science, Gakushuin University, 1 5 1 Mejiro, Toshima ku, Tokyo 171 8588, Japan
    Org Biomol Chem 8:4427-35. 2010
    ....
  53. ncbi request reprint [Liposomal boron delivery system for neutron capture therapy]
    Hiroyuki Nakamura
    Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo, Japan
    Yakugaku Zasshi 128:193-208. 2008
    ..Various boronated liposomes have been developed and significant boron accumulation into tumor tissue with high tumor/blood boron ratios has been achieved by BDS...
  54. doi request reprint Polymorphisms in TLR-2 are associated with congenital cytomegalovirus (CMV) infection but not with congenital CMV disease
    Rumi Taniguchi
    Department of Virology I, National Institute of Infectious Diseases, 1 23 1 Toyama Shinjuku ku, Tokyo 162 8640, Japan Department of Pediatrics, The University of Tokyo, Tokyo, Japan
    Int J Infect Dis 17:e1092-7. 2013
    ..Recent studies have identified associations of specific single nucleotide polymorphisms (SNPs) in Toll-like receptor (TLR) genes with susceptibility to infections of some viruses and with their clinical outcome...
  55. doi request reprint Hypoxia-inducible factor inhibitors: a survey of recent patented compounds (2004 - 2010)
    Hyun Seung Ban
    Gakushuin University, Department of Chemistry, Faculty of Science, 1 5 1, Mejiro, Toshima ku, Tokyo, 171 8588, Japan
    Expert Opin Ther Pat 21:131-46. 2011
    ....
  56. pmc Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin
    Yoshitaka Miyagawa
    Department of Developmental Biology, National Research Institute for Child Health and Development, Setagaya Ku, Tokyo, Japan
    Immunology 128:405-19. 2009
    ..The findings of Foxp3 expression, a characteristic of regulatory T cells, and a low level of IL-17 gene expression suggest that CB-derived CD4(+) T cells may be a more appropriate source for DLI...
  57. ncbi request reprint Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD
    Masae Goseki-Sone
    Department of Food and Nutrition, Japan Women s University, Tokyo, Japan
    J Bone Miner Res 20:773-82. 2005
    ..Furthermore, the effects of amino acid substitution on the catalytic property of the protein translated from the 787T>C gene were examined...
  58. ncbi request reprint Monoclonal antibodies with defined recognition sequences in the stem region of CD44: detection of differential glycosylation of CD44 between tumor and stromal cells in tissue
    Hirokazu Matsuki
    Division of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Cancer Res 63:8278-83. 2003
    ..Thus, these sets of antibodies are useful to detect and analyze the as-yet-unknown roles of site-specific glycosylation of CD44, particularly in tumors...
  59. ncbi request reprint Coexpression of CD40 and CD40 ligand in Epstein-Barr virus-infected T and NK cells and their role in cell survival
    Ken Ichi Imadome
    Department of Infectious Diseases, National Research Institute for Child Health and Development, Tokyo, Japan
    J Infect Dis 192:1340-8. 2005
    ..These results suggest that CD40-CD40L signaling promotes survival of EBV-infected T and NK cells and, thus, plays an important role in the pathogenesis of T/NK lymphoproliferative disorders associated with the virus...
  60. ncbi request reprint Human cytomegalovirus downregulates SLITRK6 expression through IE2
    Huanan Liao
    Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo, 157 8535, Japan
    J Neurovirol . 2016
    ..These findings suggest that the downregulation of SLITRK6 expression by IE2 may have a role in HCMV-induced SNHL and other neurological disorders...
  61. doi request reprint V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors
    Satsuki Matsushima
    Department of Laboratory Medicine Department of Pathology, Kyorin University School of Medicine, Tokyo Chemical Resources Laboratory, Tokyo Institute of Technology, Kanagawa Department of Orthopedic Surgery and Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan
    J Thorac Oncol 9:1377-84. 2014
    ..We report here the further characterization of this mutant EGFR protein in the context of tumorigenicity and resistance to tyrosine kinase inhibitors (TKIs) of EGFR activity...
  62. doi request reprint Ligand-directed selective protein modification based on local single-electron-transfer catalysis
    Shinichi Sato
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Tokyo 171 8588 Japan
    Angew Chem Int Ed Engl 52:8681-4. 2013
    ..N'-Acetyl-N,N-dimethyl-1,4-phenylenediamine was used as the tyrosyl radical trapping agent and used in a radical addition to afford selective modification of the target protein. ..
  63. ncbi request reprint m-Carborane-based chiral NBN pincer-metal complexes: synthesis, structure, and application in asymmetric catalysis
    Mohamed E El-Zaria
    Department of Chemistry, Faculty of Science, Gakushuin University, 1 5 1 Mejiro, Tokyo 171 8588, Japan
    Inorg Chem 50:4149-61. 2011
    ..Among these catalysts, [(S,S)-Carbox-iPr]Rh(OAc)(2)·H(2)O (18) showed the highest enantioselective catalytic ability for both asymmetric conjugate reduction and reductive aldol reaction...
  64. ncbi request reprint Stem cell transplantation using non-myeloablative conditioning regimen with fludarabine for hematological malignancies
    Kenji Tajika
    Department of Pathophysiological Management Medical Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 77:254-9. 2010
    ..3%. We concluded that stem cell transplantation using a non-myeloablative conditioning regimen with Flu was a useful therapeutic approach for patients with hematological malignancies...
  65. ncbi request reprint Computed tomographic features of Legionella pneumophila pneumonia in 38 cases
    Fumikazu Sakai
    Department of Diagnostic Radiology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
    J Comput Assist Tomogr 31:125-31. 2007
    ..To characterize the imaging features of Legionella pneumophila pneumonia (LPP)...
  66. ncbi request reprint Hemophagocytic syndrome in ileum-origin B-cell lymphoma
    Shigeyuki Motegi
    Digestive and Liver Disease Center, Tokai University Tokyo Hospital, 1 2 5 Yoyogi, Shibuya ku, 153 0065, Tokyo, Japan
    J Gastroenterol 38:995-9. 2003
    ..B-cell lymphoma-associated hemophagocytic syndrome (B-LAHS) was diagnosed. This case is extremely rare because: (1) LAHS occurred in an ileum-origin B-cell lymphoma, and (2) LAHS developed during an interval after chemotherapy...
  67. pmc Epstein-Barr-Virus-Infected CD15 (Lewis X)-Positive Hodgkin-Lymphoma-Like B Cells in Patients with Rheumatoid Arthritis
    Hirotake Inomata
    Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
    Open Rheumatol J 3:41-7. 2009
    ..These results indicate that EBV-infected B-lymphoblastoid cells from patients with RA tend to acquire properties similar to HL cells...
  68. ncbi request reprint Copper(I)-catalyzed substitution reactions of propargylic amines: importance of C(sp)-C(sp3) bond cleavage in generation of iminium intermediates
    Tsuyuka Sugiishi
    Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima ku, Tokyo 171 8588, Japan
    J Am Chem Soc 132:5332-3. 2010
    ....
  69. ncbi request reprint [Boron delivery system for neutron capture therapy of cancer]
    Hiroyuki Nakamura
    Rinsho Ketsueki 49:294-301. 2008
  70. ncbi request reprint Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho
    Toshiyuki Kusama
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan kusama to mc pref osaka jp
    Int J Oncol 29:217-23. 2006
    ..These results suggest that geranylgeranylation step of RhoA and RhoC could be a good therapeutic target for the prevention of invasion and metastasis of breast cancer cells...
  71. ncbi request reprint Selective inhibition of cancer cell invasion by a geranylgeranyltransferase-I inhibitor
    Toshiyuki Kusama
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Clin Exp Metastasis 20:561-7. 2003
    ....
  72. ncbi request reprint Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model
    Teruo Iwasaki
    First Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Int J Cancer 100:381-7. 2002
    ..These findings raise the possibility that ipriflavone may be of use as a therapeutic agent against osteolytic bone metastasis...
  73. ncbi request reprint Inhibition of lysophosphatidic acid-induced RhoA activation and tumor cell invasion by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors
    Toshiyuki Kusama
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    Int J Oncol 23:1173-8. 2003
    ..These results indicate that HMG-CoA reductase inhibitors have the potential to reduce RhoA activation and cancer cell invasion by targeting the Rho protein isoprenylation...
  74. ncbi request reprint Cyclic phosphatidic acid inhibits RhoA-mediated autophosphorylation of FAK at Tyr-397 and subsequent tumor-cell invasion
    Mutsuko Mukai
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka 537 8511, Japan
    Int J Oncol 22:1247-56. 2003
    ..Pal-cPA also inhibited endogenous (LPA-independent) activation of RhoA in human fibrosarcoma HT-1080 cells. Pal-cPA may potentially provide a new therapy for the treatment of cancer invasion and metastasis...
  75. ncbi request reprint Immunohistochemical artifact for nitrotyrosine in eosinophils or eosinophil containing tissue
    Keiki Ogino
    Department of Environmental and Preventive Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Japan
    Free Radic Res 36:1163-70. 2002
    ....
  76. ncbi request reprint Sustained tyrosine-phosphorylation of FAK through Rho-dependent adhesion to fibronectin is essential for cancer cell migration
    Mutsuko Mukai
    Department of Tumor Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1 3 3 Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    Anticancer Res 22:3175-84. 2002
    ..Co-stimulation with lysophosphatidic acid (LPA) and fibronectin (FN) is essential for migration of rat ascites hepatoma MMI cells. We examined the roles of LPA and FN in Rho-FAK pathway to migration...
  77. ncbi request reprint Gamma-knife radiosurgery for brain metastasis of renal cell carcinoma: results in 42 patients
    Senji Hoshi
    Department of Urology, Tohoku University School of Medicine, Aobaku, Sendai, Japan
    Int J Urol 9:618-25; discussion 626; author reply 627. 2002
    ..The present study provides data from clinical experience with gamma-knife radiosurgery (GK) in patients with brain metastasis from renal cell carcinoma (RCC) and shows the value of this less invasive treatment modality...
  78. ncbi request reprint Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase
    Hiroyuki Nakamura
    Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Japan
    Cancer Res 64:876-82. 2004
    ..Thus, the cleavage sites for the shedding of CD44H were identified for the first time, and the results provide a basis for exploring the unknown biologic roles of shedding at different sites...
  79. doi request reprint Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha
    Maiko Nabemoto
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1 8 1, Chuo Ku, Chiba 260 8675, Japan
    Eur J Pharmacol 590:1-11. 2008
    ..These data reveal that cannabinoids activated cPLA(2)alpha in a Src-phospholipase C-protein kinase C-dependent manner probably via cannabinoid CB(1) receptor and/or CB(1)-like receptor in neuronal cells...
  80. doi request reprint Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha
    Masaya Shimizu
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chuo Ku, Chiba 260 8675, Japan
    Cell Signal 20:815-24. 2008
    ..Our findings show a possible effect of CaM kinase on cPLA(2)alpha in a catalytic domain A-dependent and Ser515-independent manner...
  81. ncbi request reprint Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
    Kazunari Fushimi
    Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, Hammersmith, London W6 8LH, United Kingdom
    J Biol Chem 283:6706-16. 2008
    ..However, removal of the spacer domain from ADAMTS-4 greatly enhanced more general proteolytic activity against non-aggrecan substrates, e.g. E. coli-expressed interglobular domain, fibromodulin, and carboxymethylated transferrin...
  82. ncbi request reprint Absolute quantification of four isoforms of the class I phosphoinositide-3-kinase catalytic subunit by real-time RT-PCR
    Hiroyuki Nakamura
    Biol Pharm Bull 30:1181-4. 2007
    ..The biological implications of the expression level of the four isoforms of class I PI3K catalytic subunit are discussed...
  83. ncbi request reprint Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation
    Masumi Sasaki
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
    Biol Pharm Bull 30:682-6. 2007
    ..Genistein, a soy isoflavone that has the pro-apoptotic activity, also caused cell death with DNA fragmentation. Further evaluation of the potential of dietary flavonoids as neuroprotective reagents is needed...
  84. ncbi request reprint Hydrogen peroxide-induced arachidonic acid release in L929 cells; roles of Src, protein kinase C and cytosolic phospholipase A2alpha
    Tomoko Taniguchi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana 1 8 1, Chiba 260 8675, Japan
    Eur J Pharmacol 546:1-10. 2006
    ..These findings suggest that H(2)O(2) with Ca(2+) stimulates arachidonic acid release via cPLA(2)alpha in a Src- and PKC-dependent manner in L929 cells. The role of cross-talk between Src and PKC in arachidonic acid release is discussed...
  85. ncbi request reprint Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis
    Toshiyuki Kusama
    Department of Biochemistry, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    Cancer Sci 97:848-53. 2006
    ..These data suggest that the inhibitory action of p190 RhoGAP toward RhoA offers a novel approach to the treatment of invasion and metastasis of cancer cells...
  86. pmc Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1
    Young C Shin
    Department of Microbiology and Molecular Genetics and Tumor Virology Division, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Virol 80:2257-66. 2006
    ....
  87. ncbi request reprint Ceramide-1-phosphate activates cytosolic phospholipase A2alpha directly and by PKC pathway
    Hiroyuki Nakamura
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Biochem Pharmacol 71:850-7. 2006
    ..We propose that C1P stimulates AA release via two mechanisms; direct activation of cPLA2alpha, and the PKC-dependent pathway...
  88. ncbi request reprint Novel carboranes with a DNA binding unit for the treatment of cancer by boron neutron capture therapy
    Lutz F Tietze
    Institut für Organische, Chemie Georg August Universität Göttingen, Tammannstrasse 2, 37077 Gottingen, Germany
    Chembiochem 3:219-25. 2002
    ..Boron uptake from the ortho-carborane derivatives into B-16 melanoma cells was higher and faster than that observed with L-p-boronophenylalanine (BPA), which is in use in the clinic...
  89. ncbi request reprint Efficient immobilization of enzymes on microchannel surface through His-tag and application for microreactor
    Masaya Miyazaki
    Micro space Chemistry Laboratory, National Institute of Advanced Industrial Science and Technology AIST, Saga, Japan
    Protein Pept Lett 12:207-10. 2005
    ..By this method, we could immobilize proteins on microcapillary constantly. This method might be useful for further development of microreactor with reversibly immobilized enzymes...
  90. ncbi request reprint Integrated microreaction system for optical resolution of racemic amino acids
    Takeshi Honda
    Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, 807 1 Shuku, Tosu, Saga, 841 0052, Japan
    Lab Chip 7:366-72. 2007
    ..Using this integrated device, we could perform efficient continuous production of optically pure unnatural amino acids...