Hiroki Kurahashi

Summary

Affiliation: Fujita Health University
Country: Japan

Publications

  1. pmc Cruciform extrusion propensity of human translocation-mediating palindromic AT-rich repeats
    Hiroshi Kogo
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Nucleic Acids Res 35:1198-208. 2007
  2. pmc Failure of homologous synapsis and sex-specific reproduction problems
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Front Genet 3:112. 2012
  3. doi request reprint Molecular basis of maternal age-related increase in oocyte aneuploidy
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Congenit Anom (Kyoto) 52:8-15. 2012
  4. doi request reprint Recent advance in our understanding of the molecular nature of chromosomal abnormalities
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    J Hum Genet 54:253-60. 2009
  5. ncbi request reprint Chromosomal translocations mediated by palindromic DNA
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Cell Cycle 5:1297-303. 2006
  6. pmc Palindrome-mediated chromosomal translocations in humans
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    DNA Repair (Amst) 5:1136-45. 2006
  7. pmc The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements
    H Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Clin Genet 78:299-309. 2010
  8. pmc Molecular cloning of a translocation breakpoint hotspot in 22q11
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Genome Res 17:461-9. 2007
  9. pmc Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells
    Hiroki Kurahashi
    Division of Molecular Genetics, Fujita Health University, Toyoake, Aichi, Japan
    Hum Mol Genet 18:3397-406. 2009
  10. pmc DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation
    Takema Kato
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Mol Cytogenet 4:18. 2011

Collaborators

Detail Information

Publications64

  1. pmc Cruciform extrusion propensity of human translocation-mediating palindromic AT-rich repeats
    Hiroshi Kogo
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Nucleic Acids Res 35:1198-208. 2007
    ..Taken together, cruciform extrusion propensity depends on the length and central symmetry of the PATRR, and is likely to determine the instability that leads to recurrent translocations in humans...
  2. pmc Failure of homologous synapsis and sex-specific reproduction problems
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Front Genet 3:112. 2012
    ..We also discuss the sexual dimorphism of the involved pathways that leads to the differences in reproductive outcomes between males and females...
  3. doi request reprint Molecular basis of maternal age-related increase in oocyte aneuploidy
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Congenit Anom (Kyoto) 52:8-15. 2012
    ..The present review focuses on the current understanding of age-related aneuploidy and provides an overview of the mechanisms involved. We refer to recent data to illustrate some of the new paradigms that have arisen in this field...
  4. doi request reprint Recent advance in our understanding of the molecular nature of chromosomal abnormalities
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    J Hum Genet 54:253-60. 2009
    ..We also discuss some perspectives on the sexual dimorphism of some of the pathways that leads to these chromosomal abnormalities...
  5. ncbi request reprint Chromosomal translocations mediated by palindromic DNA
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Cell Cycle 5:1297-303. 2006
    ..We propose that the symmetric PATRR is likely to adopt a cruciform structure in male meiotic cells, creating genomic instability that leads to the recurrent translocation...
  6. pmc Palindrome-mediated chromosomal translocations in humans
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    DNA Repair (Amst) 5:1136-45. 2006
    ..We propose that the PATRR adopts a cruciform structure in male meiotic cells, creating genomic instability that leads to the recurrent translocation...
  7. pmc The constitutional t(11;22): implications for a novel mechanism responsible for gross chromosomal rearrangements
    H Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Clin Genet 78:299-309. 2010
    ..This observation has important implications pertaining to the predominantly paternal origin of de novo gross chromosomal rearrangements in humans...
  8. pmc Molecular cloning of a translocation breakpoint hotspot in 22q11
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Genome Res 17:461-9. 2007
    ..All of these results support a previously proposed paradigm that unusual DNA secondary structure plays a role in the mechanism by which palindrome-mediated translocations occur...
  9. pmc Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells
    Hiroki Kurahashi
    Division of Molecular Genetics, Fujita Health University, Toyoake, Aichi, Japan
    Hum Mol Genet 18:3397-406. 2009
    ..Our data suggest that stalled or slow replication induces deletions within PATRRs, but that other mechanisms might contribute to PATRR-mediated recurrent translocations in humans...
  10. pmc DNA secondary structure is influenced by genetic variation and alters susceptibility to de novo translocation
    Takema Kato
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Mol Cytogenet 4:18. 2011
    ..These studies were designed to determine whether PATRR polymorphisms affect DNA secondary structure, thus leading to variation in translocation frequency...
  11. doi request reprint HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity
    Hiroshi Kogo
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, 470 1192, Japan
    Genes Cells 17:897-912. 2012
    ..Our results thus show a HORMAD2-dependent quality control mechanism that recognizes unsynapsis and recruits ATR activity during mammalian meiosis...
  12. pmc Polymorphisms of the 22q11.2 breakpoint region influence the frequency of de novo constitutional t(11;22)s in sperm
    MaoQing Tong
    Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    Hum Mol Genet 19:2630-7. 2010
    ..These data lend support to our hypothesis that the PATRRs form secondary structures in the nucleus that induce genomic instability leading to the recurrent translocation...
  13. doi request reprint HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes
    Hiroshi Kogo
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Genes Cells 17:439-54. 2012
    ..Our present results provide clues to HORMAD1-dependent checkpoint in response to asynapsis in mammalian meiosis...
  14. doi request reprint Screening of genes involved in chromosome segregation during meiosis I: in vitro gene transfer to mouse fetal oocytes
    Makiko Tsutsumi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan
    J Hum Genet 57:515-22. 2012
    ..This gene set can thus serve as a resource for targeted sequence analysis via next-generation sequencing to identify the genes associated with human reproduction failure due to meiotic defects...
  15. ncbi request reprint Global expression profiles in 1-hour biopsy specimens of human kidney transplantation from donors after cardiac death
    Mamoru Kusaka
    Department of Urology, Division of Molecular Genetics, Institute for Comprehensive Medical Science and 21st Century COE Program, Development Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University School of Medicine, Aichi 470 1192, Japan
    Cell Transplant 18:647-56. 2009
    ..These data provide a good source for candidates of biomarkers that are potentially useful for the control of DGF...
  16. doi request reprint Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans
    Hiroshi Kogo
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    J Hum Genet 55:293-9. 2010
    ..These 726 candidates for human infertility genes might serve as a useful resource for next-generation sequencing combined with exon capture by microarray...
  17. pmc Genetic variation affects de novo translocation frequency
    Takema Kato
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake Aichi 470 1192, Japan corrected
    Science 311:971. 2006
    ..Alleles with an asymmetric center do not form the t(11;22). Our data show the importance of genome sequence on chromosomal rearrangements, a class of human mutation that is thought to be random...
  18. doi request reprint Increased urinary neutrophil gelatinase associated lipocalin levels in a rat model of upper urinary tract infection
    Manabu Ichino
    Department of Urology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    J Urol 181:2326-31. 2009
    ..We have further investigated the product of an up-regulated gene product, NGAL, in this animal model to evaluate its potential usefulness as a biomarker of renal scarring...
  19. doi request reprint Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations
    Hidehito Inagaki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Nat Commun 4:1592. 2013
    ....
  20. doi request reprint Analysis of nitric oxide metabolism as a placental or maternal factor underlying the etiology of pre-eclampsia
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University, Toyoake, Japan
    Gynecol Obstet Invest 68:239-47. 2009
    ..Defective nitric oxide (NO)-mediated vasodilation is widely regarded as an underlying cause of hypertension in pre-eclampsia, although there are also arguments against this hypothesis...
  21. doi request reprint Two different forms of palindrome resolution in the human genome: deletion or translocation
    Takema Kato
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Hum Mol Genet 17:1184-91. 2008
    ....
  22. doi request reprint Serum neutrophil gelatinase associated lipocalin during the early postoperative period predicts the recovery of graft function after kidney transplantation from donors after cardiac death
    Mamoru Kusaka
    Department of Urology, Fujita Health University School of Medicine, Toyoake, Japan
    J Urol 187:2261-7. 2012
    ..We evaluated serum neutrophil gelatinase-associated lipocalin as a potential biomarker to predict the functional recovery of kidneys transplanted from donors after cardiac death...
  23. doi request reprint Serum tissue inhibitor of metalloproteinases 1 (TIMP-1) predicts organ recovery from delayed graft function after kidney transplantation from donors after cardiac death
    Mamoru Kusaka
    Department of Urology, Division of Molecular Genetics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Cell Transplant 19:723-9. 2010
    ..These data suggest that monitoring of serum TIMP-1 levels allow the prediction of graft recovery and the need for HD after a KTx from a DCD...
  24. pmc Palindromic AT-rich repeat in the NF1 gene is hypervariable in humans and evolutionarily conserved in primates
    Hidehito Inagaki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 1 98 Dengakugakubo, Kutsukake, Toyoake, Aichi 470 1192, Japan
    Hum Mutat 26:332-42. 2005
    ..Although such palindromic regions are usually unstable and disappear rapidly due to deletion, the 17PATRR in the NF1 gene was stably conserved during evolution for reasons that are still unknown...
  25. doi request reprint Genetic variation in the indoleamine 2,3-dioxygenase gene in pre-eclampsia
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Am J Reprod Immunol 64:68-76. 2010
    ..To investigate the contribution of genomic variations in the indoleamine 2,3-dioxygenase (IDO) gene to the onset of pre-eclampsia...
  26. doi request reprint Global gene expression profiling of renal scarring in a rat model of pyelonephritis
    Manabu Ichino
    Department of Urology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi, Japan
    Pediatr Nephrol 23:1059-71. 2008
    ..The products of these genes may thus potentially be novel non-invasive diagnostic or prognostic biomarkers of renal scarring...
  27. doi request reprint Characterization of a novel mouse gene encoding an SYCP3-like protein that relocalizes from the XY body to the nucleolus during prophase of male meiosis I
    Makiko Tsutsumi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Biol Reprod 85:165-71. 2011
    ....
  28. pmc Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans
    Hidehito Inagaki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Genome Res 19:191-8. 2009
    ..Our data suggest that PATRR-mediated translocations are attributable to unusual DNA conformations that confer a common pathway for chromosomal rearrangements in humans...
  29. doi request reprint Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake, Toyoake, Aichi 470 1192, Japan
    Mol Hum Reprod 14:595-602. 2008
    ..These data might imply that PAPP-A2 may be up-regulated in pre-eclamptic pregnancy to compensate for IGFBP5-mediated suppression of the IGF pathway, although final birthweights are still low in pre-eclamptic pregnancy...
  30. doi request reprint Mouse model for allogeneic immune reaction against fetus recapitulates human pre-eclampsia
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    J Obstet Gynaecol Res 34:1-6. 2008
    ..From this observation, we hypothesized that induction of maternal allogeneic immune reaction by reduced IDO activity is one of the causes of pre-eclampsia...
  31. pmc Paternal origin of the de novo constitutional t(11;22)(q23;q11)
    Tamae Ohye
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Eur J Hum Genet 18:783-7. 2010
    ..All of the eight translocations were found to be of paternal origin. This result implicates a possible novel mechanism of sperm-specific generation of palindrome-mediated chromosomal translocations...
  32. pmc Mutations of the SYCP3 gene in women with recurrent pregnancy loss
    Hasbaira Bolor
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Am J Hum Genet 84:14-20. 2009
    ..Combined with the fact that similar mutations have been previously identified in two males with azoospermia, our current data suggest that sexual dimorphism in response to meiotic disruption occurs even in humans...
  33. ncbi request reprint Serum neutrophil gelatinase-associated lipocalin as a predictor of organ recovery from delayed graft function after kidney transplantation from donors after cardiac death
    Mamoru Kusaka
    Dept of Urol, Div of Molecular Genetics, Inst for Comp Med Sci and 21st Century COE Program, Dev Center for Targeted and Minimally Invasive Diagnosis and Treatment, Fujita Health University School of Medicine, Japan
    Cell Transplant 17:129-34. 2008
    ..These data suggest that monitoring of serum NGAL levels may allow us to predict graft recovery and the need for HD after a KTx from a DCD...
  34. doi request reprint CD9 gene variations are not associated with female infertility in humans
    Sachie Nishiyama
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Toyoake, Japan
    Gynecol Obstet Invest 69:116-21. 2010
    ..To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans...
  35. pmc Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Fujita Health University, Toyoake, Japan
    Reprod Biol Endocrinol 9:107. 2011
    ..The aim of this study was to further investigate the mechanisms underlying pre-eclampsia and unexplained FGR...
  36. doi request reprint Decreased expression of apelin in placentas from severe pre-eclampsia patients
    Hiromi Inuzuka
    Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan
    Hypertens Pregnancy 32:410-21. 2013
    ..Apelin is a small peptide that may potentially act as an angiogenic factor. The expression of apelin was examined at the RNA and protein levels in this study...
  37. pmc Cruciform DNA structure underlies the etiology for palindrome-mediated human chromosomal translocations
    Hiroki Kurahashi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Biol Chem 279:35377-83. 2004
    ..Our data imply that for human chromosomes, translocation susceptibility is mediated by PATRRs and likely results from their unstable conformation...
  38. pmc Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease
    Daisuke Yoshihara
    Education and Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Aichi 4701192, Japan
    PPAR Res 2012:695898. 2012
    ..These data show that PIO alters the expression of genes involved in cell cycle progression, cell proliferation, and fatty acid metabolism...
  39. doi request reprint Urinary neutrophil-gelatinase associated lipocalin is a potential noninvasive marker for renal scarring in patients with vesicoureteral reflux
    Manabu Ichino
    Department of Urology, Fujita Health University, Toyoake, Japan
    J Urol 183:2001-7. 2010
    ..In this study we evaluated urinary neutrophil-gelatinase associated lipocalin as a potential biomarker for progression of renal scarring in patients with vesicoureteral reflux...
  40. pmc Age has no effect on de novo constitutional t(11;22) translocation frequency in sperm
    Takema Kato
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Fertil Steril 88:1446-8. 2007
    ..Translocation-specific polymerase chain reaction demonstrated no age-dependent increment in the frequency of the rearrangements...
  41. pmc Pheochromocytoma as the first manifestation of MEN2A with RET mutation S891A: report of a case
    Yatsuka Hibi
    Department of Endocrine Surgery, Fujita Health University School of Medicine, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    Surg Today 44:2195-200. 2014
    ..In addition, it is indicated that calcitonin stimulation test should be performed even in the unaffected elder cases with S891A mutation although the mutation is classified as lowest risk group on MTC in guidelines...
  42. doi request reprint A functional variation in the hypocretin neuropeptide precursor gene may be associated with obstructive sleep apnea syndrome in Japan
    Wael A Ahmed
    Department of Otolaryngology, Second Hospital, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    Laryngoscope 122:925-9. 2012
    ....
  43. doi request reprint Impact of indoleamine 2,3-dioxygenase on the antioxidant system in the placentas of severely pre-eclamptic patients
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Syst Biol Reprod Med 57:174-8. 2011
    ..These results show that oxidative stress is associated with decreased IDO activity in the pre-eclamptic placenta and suggest an impact of low IDO activity other than immune modulation in promoting the onset of this disorder...
  44. pmc PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease
    Daisuke Yoshihara
    Education and Research Center of Animal Models for Human Diseases, Fujita Health University, Toyoake, Aichi, Japan
    Am J Physiol Renal Physiol 300:F465-74. 2011
    ..These findings suggest that PPAR-γ agonists may have therapeutic value in the treatment of the renal and hepatic manifestations of ARPKD...
  45. pmc Age-related decrease of meiotic cohesins in human oocytes
    Makiko Tsutsumi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    PLoS ONE 9:e96710. 2014
    ....
  46. doi request reprint Polymorphisms in the annexin A5 gene promoter in Japanese women with recurrent pregnancy loss
    Hironori Miyamura
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi 470 1192, Japan
    Mol Hum Reprod 17:447-52. 2011
    ..Our data indicate that SNP5 is a novel risk factor for this disease in the Japanese population...
  47. pmc Palindrome-Mediated Translocations in Humans: A New Mechanistic Model for Gross Chromosomal Rearrangements
    Hidehito Inagaki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health UniversityToyoake, Japan Genome and Transcriptome Analysis Center, Fujita Health UniversityToyoake, Japan
    Front Genet 7:125. 2016
    ..Analysis of PATRR-mediated translocations in humans will provide further understanding of gross chromosomal rearrangements in many organisms. ..
  48. doi request reprint Increased levels of soluble corin in pre-eclampsia and fetal growth restriction
    Jun Miyazaki
    Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Japan Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Placenta 48:20-25. 2016
    ..These data suggest that corin may be upregulated in maternal decidua in response to an etiologic pathway that is common to pre-eclampsia and FGR...
  49. pmc Intragenic duplication in the PKHD1 gene in autosomal recessive polycystic kidney disease
    Jun Miyazaki
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, 1 98 Dengakugakubo, Kutsukake cho, Toyoake, Aichi, 470 1192, Japan
    BMC Med Genet 16:98. 2015
    ..In the present study, we report on a couple who underwent prenatal genetic diagnosis for autosomal recessive polycystic kidney disease (ARPKD)...
  50. doi request reprint Serum liver-type fatty acid-binding protein predicts recovery of graft function after kidney transplantation from donors after cardiac death
    Akihiro Kawai
    Department of Urology, Fujita Health University School of Medicine, Toyoake, Japan
    Clin Transplant 28:749-54. 2014
    ..0 on POD 2. DGF >7 d was predicted with 83% SE and 78% SP at 11.0 on POD 1 and 67% SE and 78% SP at 6.5 on POD 2. Serum L-FABP levels may predict graft recovery and need for HD after DCD KTx...
  51. doi request reprint Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling
    Masanori Kugita
    Education and Research Center of Animal Models for Human Diseases, Faculty of Rehabilitation, Institute for Comprehensive Medical Science, Fujita Health University, 1 98 Dengakugakubo Kutsukake cho, Toyoake, Aichi, Japan 470 1192
    Am J Physiol Renal Physiol 300:F177-88. 2011
    ..Taken together, cell proliferation and organ morphogenesis signals transduced by RXR-mediated pathways may have important roles for cystogenesis in early-stage PKD in this Pkdr1-mutated Cy rat...
  52. doi request reprint A simple cytogenetic method to detect chromosomally integrated human herpesvirus-6
    Tamae Ohye
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan Department of Clinical Hematology, Faculty of Medical Technology, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    J Virol Methods 228:74-8. 2016
    ..Interestingly, in all seven Japanese iciHHV-6A patients, signals were detected exclusively on chromosome 22q. This method provides a simple and fast approach for iciHHV-6 diagnosis in the clinical laboratory. ..
  53. doi request reprint Prevalence of Emanuel syndrome: theoretical frequency and surveillance result
    Tamae Ohye
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan
    Pediatr Int 56:462-6. 2014
    ..Further efforts should be made to increase the awareness of Emanuel syndrome to ensure a better quality of life for affected patients and their families...
  54. ncbi request reprint Genomewide expression profiles of rat model renal isografts from brain dead donors
    Mamoru Kusaka
    Department of Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Transplantation 83:62-70. 2007
    ..It has been well documented that two factors, brain death (BD) and ischemia/reperfusion (I/R) injury, have distinct but overlapping adverse influences on the clinical outcome of renal transplantation...
  55. doi request reprint A PDE3A mutation in familial hypertension and brachydactyly syndrome
    Hiroko Boda
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan
    J Hum Genet 61:701-3. 2016
    ..This mutation may also affect the phosphodiesterase activity of PDE3A to reduce the cyclic AMP level in the cell and thereby influencing the development of limbs and the function of the cardiovascular system. ..
  56. doi request reprint Signature of backward replication slippage at the copy number variation junction
    Tamae Ohye
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    J Hum Genet 59:247-50. 2014
    ..The structure of the junction is consistent with backward replication slippage proposed previously. Our data lend support to the notion that a common DNA replication-mediated pathway generates copy number variation in the human genome...
  57. pmc Novel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy
    Makiko Tsutsumi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan
    Eur J Hum Genet 24:1702-1706. 2016
    ..Our data lend support to the hypothesis that impaired centriole duplication caused by PLK4 variants may be involved in the etiology of microcephaly disorder...
  58. pmc Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand
    Satoshi Komoto
    Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    PLoS ONE 10:e0141739. 2015
    ..Our observations will provide important insights into the evolutionary dynamics of emerging DS-1-like G1P[8] rotaviruses. ..
  59. doi request reprint Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient patient
    Ikuya Tsuge
    Department of Pediatrics, Fujita Health University, Toyoake, Aichi, Japan
    Pediatr Pulmonol 49:E52-5. 2014
    ..DOCK8 cDNA sequencing revealed a nonsense mutation at position 740 (E740X). As far as we know, this is the first Japanese case of DOCK8 deficiency...
  60. pmc Dual roles for the telomeric repeats in chromosomally integrated human herpesvirus-6
    Tamae Ohye
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Sci Rep 4:4559. 2014
    ..We conclude that the viral TRS in the DR regions fulfill dual functions for CIHHV-6: homology-mediated integration into the telomeric region of the chromosome and neo-telomere formation that is then stably transmitted...
  61. ncbi request reprint A MEN2A family with two asymptomatic carriers affected by unilateral renal agenesis
    Yatsuka Hibi
    Department of Endocrine Surgery, Fujita Health University School of Medicine, Toyoake 470 1192, Japan
    Endocr J 61:19-23. 2014
    ..Our data lend support to the hypothesis that constitutive active RET mutation in MEN type 2 might partially impair RET function and thereby cause loss of function phenotype such as renal agenesis or HSCR. ..
  62. ncbi request reprint The etiological role of allogeneic fetal rejection in pre-eclampsia
    Haruki Nishizawa
    Department of Obstetrics and Gynecology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    Am J Reprod Immunol 58:11-20. 2007
    ..It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia...
  63. ncbi request reprint CDH1 is a specific marker for undifferentiated spermatogonia in mouse testes
    Masutaka Tokuda
    Division of Cell Biology, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470 1192, Japan
    Biol Reprod 76:130-41. 2007
    ..Our data clearly demonstrated that spermatogenic stem cells reside among undifferentiated type A spermatogonia, which express CDH1...
  64. ncbi request reprint [Single gene disorder]
    Mariko Taniguchi
    Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University
    Nihon Rinsho 63:57-63. 2005