Wei Zhang

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. pmc Leptin: a potential novel antidepressant
    Xin Yun Lu
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 103:1593-8. 2006
  2. ncbi Respiratory and cardiovascular actions of orexin-A in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Inohana 1 8 1 Chuo ku, Chiba City, Chiba 260 8670, Japan
    Neurosci Lett 385:131-6. 2005
  3. ncbi Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    Auton Neurosci 126:139-45. 2006
  4. ncbi Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice
    Ben Shiang Deng
    Dept of Molecular and Integrative Physiology, Chiba Univ Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    J Appl Physiol (1985) 103:1772-9. 2007
  5. ncbi Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin
    Jiro Terada
    Dept of Molecular and Integrative Physiology, Chiba Univ Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    J Appl Physiol (1985) 104:499-507. 2008
  6. doi Emotional and state-dependent modification of cardiorespiratory function: role of orexinergic neurons
    Tomoyuki Kuwaki
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Auton Neurosci 142:11-6. 2008
  7. doi Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Chiba City, Chiba 260 8670, Japan
    Brain Res 1262:25-37. 2009
  8. ncbi Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice
    Akira Nakamura
    Department of Autonomic Physiology, Chiba University Graduate School of Medicine, Chiba City, Chiba, Japan
    J Appl Physiol (1985) 102:241-8. 2007
  9. ncbi Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    Am J Physiol Regul Integr Comp Physiol 290:R1654-63. 2006
  10. pmc Orexin neurons are indispensable for stress-induced thermogenesis in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Physiol 588:4117-29. 2010

Collaborators

Detail Information

Publications65

  1. pmc Leptin: a potential novel antidepressant
    Xin Yun Lu
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 103:1593-8. 2006
    ....
  2. ncbi Respiratory and cardiovascular actions of orexin-A in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Inohana 1 8 1 Chuo ku, Chiba City, Chiba 260 8670, Japan
    Neurosci Lett 385:131-6. 2005
    ..Moreover, orexin can affect the cardiorespiratory control system at multiple sites in different ways. Orexin-A seems not to be involved in respiratory reflex regulation in mice at least under anesthetized condition...
  3. ncbi Multiple components of the defense response depend on orexin: evidence from orexin knockout mice and orexin neuron-ablated mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    Auton Neurosci 126:139-45. 2006
    ..In this brief review, here we summarize our recent discovery using orexin knockout mice and orexin neuron-ablated mice of possible contribution of orexin in the defense response and discuss future directions...
  4. ncbi Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice
    Ben Shiang Deng
    Dept of Molecular and Integrative Physiology, Chiba Univ Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    J Appl Physiol (1985) 103:1772-9. 2007
    ..Our findings suggest that orexin plays a crucial role in CO(2) sensitivity at least during wake periods in mice...
  5. ncbi Ventilatory long-term facilitation in mice can be observed during both sleep and wake periods and depends on orexin
    Jiro Terada
    Dept of Molecular and Integrative Physiology, Chiba Univ Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    J Appl Physiol (1985) 104:499-507. 2008
    ..We conclude that LTF occurs during both sleep and wake periods, that orexin is necessary for eliciting LTF, and that LTF cannot prevent sleep apnea, at least in mice...
  6. doi Emotional and state-dependent modification of cardiorespiratory function: role of orexinergic neurons
    Tomoyuki Kuwaki
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    Auton Neurosci 142:11-6. 2008
    ..The orexin system likely functions as one essential modulator for coordinating circuits controlling autonomic functions and behaviors...
  7. doi Orexin neurons in the hypothalamus mediate cardiorespiratory responses induced by disinhibition of the amygdala and bed nucleus of the stria terminalis
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Chiba City, Chiba 260 8670, Japan
    Brain Res 1262:25-37. 2009
    ..We conclude that orexin-containing neurons in the medial hypothalamus mediate at least a part of AMG- and BNST-induced cardiorespiratory responses...
  8. ncbi Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice
    Akira Nakamura
    Department of Autonomic Physiology, Chiba University Graduate School of Medicine, Chiba City, Chiba, Japan
    J Appl Physiol (1985) 102:241-8. 2007
    ..Our findings suggest that orexin plays a crucial role both in CO(2) sensitivity during wakefulness and in preserving ventilation stability during sleep...
  9. ncbi Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, 1 8 1 Chuo ku, Chiba 260 8670, Japan
    Am J Physiol Regul Integr Comp Physiol 290:R1654-63. 2006
    ....
  10. pmc Orexin neurons are indispensable for stress-induced thermogenesis in mice
    Wei Zhang
    Department of Molecular and Integrative Physiology, Chiba University Graduate School of Medicine, Chiba 260 8670, Japan
    J Physiol 588:4117-29. 2010
    ....
  11. ncbi A toolbox for light control of Drosophila behaviors through Channelrhodopsin 2-mediated photoactivation of targeted neurons
    Wei Zhang
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Eur J Neurosci 26:2405-16. 2007
    ..This non-invasive method for remote control of animal behaviors also provides a potential tool for conducting 'gain of function' studies toward understanding how animal behaviors are controlled by neural activity...
  12. ncbi HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein
    Anthony Orvedahl
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Host Microbe 1:23-35. 2007
    ..Our findings suggest that autophagy inhibition is a novel molecular mechanism by which viruses evade innate immunity and cause fatal disease...
  13. pmc Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase
    Li Qian
    Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neuroinflammation 4:23. 2007
    ..Microglia-mediated inflammation has recently been implicated as a critical mechanism responsible for progressive neurodegeneration...
  14. pmc Formyl-methionyl-leucyl-phenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration?
    Xi Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Environ Health Perspect 116:593-8. 2008
    ..Microglial activation is important in the pathogenesis of PD...
  15. pmc Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Box 1020, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 26:3764-72. 2006
    ..These results indicate that CDO promotes neuronal differentiation and support the hypothesis that CDO coordinates differentiation of multiple cell lineages by regulating the activity of tissue-specific bHLH factors...
  16. pmc Pten regulates neuronal arborization and social interaction in mice
    Chang Hyuk Kwon
    Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 50:377-88. 2006
    ..Thus, our data suggest that abnormal activation of the PI3K/AKT pathway in specific neuronal populations can underlie macrocephaly and behavioral abnormalities reminiscent of certain features of human ASD...
  17. ncbi MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity
    Zhong Pei
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Glia 55:1362-73. 2007
    ..Together, these data demonstrate that MAC1 is essential for LPS-induced superoxide from microglia, implicating MAC1 as a critical trigger of microglial-derived oxidative stress during inflammation-mediated neurodegeneration...
  18. pmc Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr1+ myeloid-derived suppressor cells that promote long-term survival of allografts
    Wei Zhang
    Department of Medicine, Center for Molecular Chaperone Radiobiology and Cancer Virology, Medical College of Georgia, Augusta, GA, USA
    Transplantation 86:1125-34. 2008
    ..One of the potential mechanisms in the immunosuppressive accomplishment of HLA-G-ILT2 interactions involves the expansion of myeloid-derived suppressor cells (MDSCs). The potential of MDSCs in transplantation has not yet been exploited...
  19. pmc The melanocortinergic pathway is rapidly recruited by emotional stress and contributes to stress-induced anorexia and anxiety-like behavior
    Jing Liu
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Endocrinology 148:5531-40. 2007
    ..These results indicate that the melancortinergic pathway can be rapidly recruited by acute emotional stress, and that activation of melanocortin signaling is involved in mediating stress-induced anorexia and anxiety...
  20. pmc Neurotrophin-dependent dendritic filopodial motility: a convergence on PI3K signaling
    Bryan W Luikart
    Department of Developmental Biology and Kent Waldrep Foundation Center for Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical School, Dallas, Texas 75390 9133, USA
    J Neurosci 28:7006-12. 2008
    ..Our results suggest that filopodial movement is not random, but responsive to synaptic guidance molecules...
  21. ncbi Polymorphic TP53BP1 and TP53 gene interactions associated with risk of squamous cell carcinoma of the head and neck
    Kexin Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:4300-5. 2007
    ....
  22. ncbi 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Science National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 20:2496-511. 2006
    ..In summary, we show the potent neuroprotection by 3-HM in LPS and MPTP PD models investigated. With its high efficacy and low toxicity, 3-HM may be a novel therapy for PD...
  23. doi Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region
    Jian Zhang
    The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, 710032, People s Republic of China
    Gene 417:5-12. 2008
    ..Taken together, our results demonstrate that, in common with NDRG2, human NDRG1 can be indirectly transcriptionally down-regulated by Myc via interaction with the NDRG1 core promoter...
  24. ncbi Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents
    Chang Hoon Cho
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8066, USA
    Neuron 55:890-904. 2007
    ..The results show that heterogeneity in the composition of AMPA receptor/TARP complexes contributes to synapse-specific differences in EPSC decays and frequency-dependent modulation of neurotransmission...
  25. ncbi Effects of myocardial constraint on the passive mechanical behaviors of the coronary vessel wall
    Yi Liu
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, IN 46202, USA
    Am J Physiol Heart Circ Physiol 294:H514-23. 2008
    ..This study provides a mechanical basis for understanding the local growth and remodeling of vessels subjected to various degrees of surrounding tissue...
  26. ncbi Effects of presenilins and beta-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons
    Wei Zhang
    Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100050, China
    Acta Pharmacol Sin 25:181-5. 2004
    ..To study the effects of presenilin-1 (PS-1), presenilin-2 (PS-2), and amyloid beta-protein precursor (APP695) on delayed rectifier potassium channels (IK) in the cultured rat hippocampal neurons...
  27. ncbi WWOX tumor suppressor gene
    Jilong Yang
    Department of Bone and Soft Tissue Tumor, Tianjin Cancer Hospital and Institute, Tianjin Medical University, Tianjin, China
    Histol Histopathol 23:877-82. 2008
    ..However, there is not universal agreement that WWOX is a tumor suppressor gene. Further analysis is needed to reveal the true nature of WWOX...
  28. doi The diastatic pressure-volume relationship is not the same as the end-diastolic pressure-volume relationship
    Wei Zhang
    Cardiovascular Biophysics Laboratory, Cardiovascular Division, Department of Internal Medicine and Department of Physics, College of Arts and Sciences, Washington University, St Louis, Missouri, USA
    Am J Physiol Heart Circ Physiol 294:H2750-60. 2008
    ..Because it is not coupled to a contracted atrium, the D-PVR conveys passive LV stiffness better than the EDPVR. Additional studies that fully elucidate the physiology and biology of diastasis in health and disease are in progress...
  29. doi Attenuated Listeria infection activates natural killer cell cytotoxicity to regress melanoma growth in vivo
    Hua Shen
    Department of Immunology and Host Defenses, Ehime University Graduate School of Medicine, Ehime, Japan
    Microbiol Immunol 52:107-17. 2008
    ..We demonstrated that the attenuated Lm entrance into the cytoplasm induces the production of type I IFN followed by the activation of NK cells, which is essential for the Lm-induced antitumor response...
  30. pmc Leptin increases adult hippocampal neurogenesis in vivo and in vitro
    Jacob C Garza
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Biol Chem 283:18238-47. 2008
    ..Taken together, our results support a role for leptin in adult hippocampal neurogenesis and suggest the involvement of the Akt and STAT3 signaling pathways in mediating the actions of leptin on neurogenesis...
  31. pmc Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma
    Kimberly J Briggs
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21231, USA
    Genes Dev 22:770-85. 2008
    ....
  32. ncbi Pressor and non-pressor effects of sodium loading on stroke in stroke-prone spontaneously hypertensive rats
    Wei Zhang
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai, China
    Clin Exp Pharmacol Physiol 35:83-8. 2008
    ..4. Sodium loading increases death from stroke in SHRSP. The increased blood pressure, impaired BRS, inflammatory reaction and the formation of cerebral aneurysms may contribute to the development of stroke...
  33. doi Sex differences in the white matter and myelinated nerve fibers of Long-Evans rats
    Shu Yang
    Department of Neurology, First Affiliated Hospital, Chongqing Medical University, Chongqing, PR China
    Brain Res 1216:16-23. 2008
    ..The results obtained in the present study will provide baseline data for future studies related to white matter changes in various experimental conditions and in various neurodegenerative diseases...
  34. doi FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma
    Yihua Wang
    Laboratory of Cell and Molecular Biology, Cancer Institute and Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Int J Cancer 123:561-8. 2008
    ....
  35. ncbi Venous resistance increases during rat anaphylactic shock
    Sen Cui
    Department of Physiology II, Kanazawa Medical University, Uchinada Ishikawa, Japan
    Shock 29:733-9. 2008
    ..In conclusion, in rat anaphylactic shock, a substantial increase in Rv presumably due to hepatic venoconstriction may decrease venous return, resulting in systemic hypotension...
  36. pmc Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptors
    Zhou Fei
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, PR China
    BMC Neurosci 8:96. 2007
    ....
  37. ncbi PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis
    Wei Zhang
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Cell Metab 4:491-7. 2006
    ....
  38. pmc Coimmunization with IL-15 plasmid enhances the longevity of CD8 T cells induced by DNA encoding hepatitis B virus core antigen
    Wei Zhang
    Key Laboratory of Medical Molecular Virology, Shanghai Medical College of Fudan University, Shanghai 200032, China
    World J Gastroenterol 12:4727-35. 2006
    ..To test the feasibility of delivering a plasmid encoding IL-15 as a DNA vaccine adjuvant for improving the immune responses induced by hepatitis B virus core gene DNA vaccine...
  39. ncbi Effect of surrounding tissue on vessel fluid and solid mechanics
    Wei Zhang
    Department of Mechanical and Aerospace Engineering, University of California, 204 Rockwell Engineering Center, Irvine, CA 92657, USA
    J Biomech Eng 126:760-9. 2004
    ..The importance of FSI in deformable vessels with pulsatile flow is discussed and the fluid and solid mechanics differences between epicardial and intramural vessels are highlighted...
  40. ncbi Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 19:550-7. 2005
    ....
  41. ncbi Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:533-42. 2005
    ..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
  42. ncbi Screening of specific antigens for SARS clinical diagnosis using a protein microarray
    Dan Dan Lu
    Beijing Institute of Radiation Medicine, Beijing, 100850, People s Republic of China
    Analyst 130:474-82. 2005
    ..1% and 1 : 200) compared with the traditional ELISA screening method, and could provide a rapid, parallel and high-throughput antigen screening platform...
  43. ncbi [Inhibition of tacrine on delayed rectifier and transient outward potassium currents in cultured rat hippocampal neurons]
    Wei Zhang
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 39:93-6. 2004
    ..To study the effects of tacrine on IK and IA potassium current in primary cultured rat hippocampal neurons...
  44. ncbi Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase
    Wei Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Science, Research Triangle Park, North Carolina, USA
    FASEB J 18:589-91. 2004
    ..More importantly, due to its proven safety record of long-term clinical use in humans, DM may be a promising agent for the treatment of degenerative neurological disorders such as PD...
  45. ncbi [Electrophysiological correspondence between Kv4.2 current and transient outward potassium current in the cultured rat hippocampal neuron]
    Hong Wei Jin
    Institute of Materia Medica, Chinese Academy of Medical Science Peking Union Medical College, Beijing 100050
    Sheng Li Xue Bao 55:711-6. 2003
    ..The time constants (tau) of recovery from inactivation of I(A) and Kv4.2 were 27.9+/-14.1 ms and 172.8+/-10.0 ms, respectively. These results suggest that Kv4.2 is probably a major isoform contributing to I(A) in hippocampus neurons...
  46. ncbi Temporal changes in ventricular function assessed echocardiographically in conscious and anesthetized mice
    Jeffrey N Rottman
    Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6300, USA
    J Am Soc Echocardiogr 16:1150-7. 2003
    ..Serial echocardiographic assessments of cardiac function, dimension, and mass can be performed with high reproducibility in conscious mice...
  47. ncbi The other side of the engram: experience-driven changes in neuronal intrinsic excitability
    Wei Zhang
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
    Nat Rev Neurosci 4:885-900. 2003
  48. ncbi Tetraarsenic oxide, a novel orally administrable angiogenesis inhibitor
    Myung Jin Park
    Laboratory of Cell Biology, Korea Cancer Center Hospital, Seoul 139 706, Korea
    Int J Oncol 22:1271-6. 2003
    ..Thus, we provide evidence that tetraarsenic oxide has effective antiangiogenic activities...
  49. pmc Correction of a rat model of Parkinson's disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector
    Mei Sun
    Department of Neurology, West Roxbury VA Hospital Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Hum Gene Ther 14:415-24. 2003
    ..This improved system efficiently corrects the rat model of PD...
  50. ncbi Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation
    Yuxin Liu
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 305:212-8. 2003
    ..These results suggest that DM may be a promising therapeutic agent for the treatment of Parkinson's disease...
  51. ncbi [Expression of CNTF and PDGF in spared dorsal root ganglion after partial dorsal root rhizotomy]
    Lian Shuang Zhang
    Department of Histology, Embryology and Neurobiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 36:176-9. 2005
    ..To investigate the expression of ciliary neurotrophic factor (CNTF) and platelet derived growth factor (PDGF) in spared dorsal root ganglion (DRG) after partial dorsal root rhizotomy...
  52. ncbi MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:1134-6. 2005
    ..Thus inhibition of microgliosis and COX-2 activity may stop this vicious circle and be valuable strategies in PD therapy...
  53. pmc Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia
    Bjorn C Knollmann
    Oates Institute for Experimental Therapeutics and Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0575, USA
    J Clin Invest 116:2510-20. 2006
    ....
  54. ncbi [Impact of acupuncture on NP-1 expression in spared dorsal root ganglion]
    Qian Huang
    Department of Histology, Embryology and Neurobiolgy, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:381-3, 403. 2006
    ..To investigate the impact of acupuncture on NP-1 expression in spared dorsal root ganglion (DRG)...
  55. ncbi Liposomal quercetin efficiently suppresses growth of solid tumors in murine models
    Zhi Ping Yuan
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Clin Cancer Res 12:3193-9. 2006
    ..To overcome this limitation, this study is aimed to develop liposomal quercetin and investigate its distribution in vivo and antitumor efficacy in vivo and in vitro...
  56. ncbi Reactive microgliosis participates in MPP+-induced dopaminergic neurodegeneration: role of 67 kDa laminin receptor
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 20:906-15. 2006
    ..Laminin is a potential ligand for activating this LR receptor. This study also suggests that laminin/LR is a potential target for developing new therapeutic drugs against neurodegenerative disorders such as PD...
  57. ncbi Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly
    Wei Zhang
    Brookdale Department of Molecular, Cell, and Developmental Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Cell 10:657-65. 2006
    ..Specific Cdo domains required for its promyogenic effect are dispensable for its Shh signaling role, suggesting that Cdo has multiple, independent functions...
  58. ncbi SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation
    Yun He
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Biol Chem 281:5559-66. 2006
    ..We concluded that SOCS1 functions as a negative regulator in TNF-induced inflammation in EC, in part, by inducing ASK1 degradation...
  59. ncbi [Effects of losartan, ramipril and their combination on left ventricular remodeling and function in spontaneous hypertensive rats]
    Rui Xu
    Department of Cardiology, Qilu Hospital of Shandong University, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan 250012, China
    Zhonghua Yi Xue Za Zhi 85:3199-204. 2005
    ....
  60. ncbi Antioxidant N-acetylcysteine restores systemic nitric oxide availability and corrects depressions in arterial blood pressure and heart rate in diabetic rats
    Zhengyuan Xia
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Division of Pharmacology, 2146 East Mall, Vancouver BC, V6T 1Z3, Canada
    Free Radic Res 40:175-84. 2006
    ..05 vs. C) and NAC normalised the changes that occurred in the diabetic rats. The protective effects may be attributable to restoration of NO bioavailability in the circulation...
  61. ncbi Effects of estrogen replacement therapies on mouse platelet function and glycoprotein VI levels
    Xing Hong Leng
    Medicine Thrombosis Research, Baylor College of Medicine, Houston, Texas 77030, USA
    Circ Res 97:415-7. 2005
    ..The GPVI collagen receptor likely mediated some of these effects, because the ERT regimens induced changes in platelet surface GPVI expression corresponding to the observed platelet activation...
  62. ncbi Atrial fibrillation in KCNE1-null mice
    Joel Temple
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232 6602, USA
    Circ Res 97:62-9. 2005
    ..Thus, KCNE1 deletion in mice unexpectedly leads to increased outward current in atrial myocytes, shortens atrial action potentials, and enhances susceptibility to atrial fibrillation...
  63. ncbi [A study on the expression of HSP70 and iNOS after human brain contusion]
    Wei Zhang
    School of Forensic Medicine, China Medical University, Shenyang 110001, China
    Fa Yi Xue Za Zhi 21:24-6. 2005
    ..To study the relationship between expression of HSP70, iNOS and traumatic brain contusion (TBI) in different posttraumatic intervals...
  64. ncbi The role of microglia in paraquat-induced dopaminergic neurotoxicity
    Xue Fei Wu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Antioxid Redox Signal 7:654-61. 2005
    ..Here we report a novel mechanism of PQinduced oxidative stress, where at lower doses, the indirect insult generated from microglial NADPH oxidase is the essential factor mediating DA neurotoxicity...
  65. ncbi Postnatal growth, neurobehavioral and neurophysiologic changes of prenatal low-dose beta-radiation from tritiated water in mice
    Wei Min Gao
    Department of Environmental and Occupational Health, Room 307, Graduate School of Public Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Neurotoxicol Teratol 24:247-54. 2002
    ..071 and 0.213 Gy groups. In conclusion, even prenatal low-dose beta-radiation may impair murine central nervous system (CNS) development suggesting the potential importance of minimizing environmental exposure during human pregnancy...