T Nakamura

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. ncbi Cloning and sequencing of novel genes from Vibrio alginolyticus that support the growth of K+ uptake-deficient mutant of Escherichia coli
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1277:201-8. 1996
  2. ncbi Cloning of the trkAH gene cluster and characterization of the Trk K(+)-uptake system of Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Science, Chiba University, Japan
    Microbiology 144:2281-9. 1998
  3. pmc KtrAB, a new type of bacterial K(+)-uptake system from Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Bacteriol 180:3491-4. 1998
  4. pmc Residue aspartate-147 from the third transmembrane region of Na(+)/H(+) antiporter NhaB of Vibrio alginolyticus plays a role in its activity
    T Nakamura
    Laboratory of Molecular Cell Biology, Faculty of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
    J Bacteriol 183:5762-7. 2001
  5. ncbi Cloning and sequencing of nhaB gene encoding an Na+/H+ antiporter from Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1275:157-60. 1996
  6. ncbi Cloning and sequencing of a K+ transport gene (trk A) from the marine bacterium Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1219:701-5. 1994
  7. ncbi Roles of K+ and Na+ in pH homeostasis and growth of the marine bacterium Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Gen Microbiol 138:1271-6. 1992
  8. ncbi Mechanosensitive channel functions to alleviate the cell lysis of marine bacterium, Vibrio alginolyticus, by osmotic downshock
    Y Nakamaru
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    FEBS Lett 444:170-2. 1999
  9. ncbi Cloning and sequencing of an Na+/H+ antiporter gene from the marine bacterium Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1190:465-8. 1994
  10. ncbi Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for chromosome-associated Chk in chromosome dynamics
    N Yamaguchi
    Laboratory of Molecular Cell Biology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Cell Sci 114:1631-41. 2001

Detail Information

Publications69

  1. ncbi Cloning and sequencing of novel genes from Vibrio alginolyticus that support the growth of K+ uptake-deficient mutant of Escherichia coli
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1277:201-8. 1996
    ..Homologous genes were found in E. coli, but their functions have not been reported...
  2. ncbi Cloning of the trkAH gene cluster and characterization of the Trk K(+)-uptake system of Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Science, Chiba University, Japan
    Microbiology 144:2281-9. 1998
    ..Measurements of net K(+)-uptake rates indicated that the presence of these genes in E. coli renders the Trk systems independent of products from the E. coli sapABCDF (trkE) operon...
  3. pmc KtrAB, a new type of bacterial K(+)-uptake system from Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Bacteriol 180:3491-4. 1998
    ..KtrA and KtrB are peripheral and integral membrane proteins, respectively. Six of the nine sequenced bacterial genomes contain homologs to both ktrA and ktrB, suggesting that KtrAB is widespread...
  4. pmc Residue aspartate-147 from the third transmembrane region of Na(+)/H(+) antiporter NhaB of Vibrio alginolyticus plays a role in its activity
    T Nakamura
    Laboratory of Molecular Cell Biology, Faculty of Pharmaceutical Sciences, Chiba University, Inage Ku, Chiba 263 8522, Japan
    J Bacteriol 183:5762-7. 2001
    ..Replacement of Asp-147 with Glu made high H(+) concentrations a requirement for the NhaB activity. Replacement of Asp-147 with neutral amino acids inactivated NhaB...
  5. ncbi Cloning and sequencing of nhaB gene encoding an Na+/H+ antiporter from Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1275:157-60. 1996
    ..This gene has 62% identity to nhaB gene at the DNA level from Escherichia coli and the deduced amino acid sequence is 67% identical with E. coli NhaB. This gene is presumably the V. alginolyticus nhaB gene and will be named nhaBv...
  6. ncbi Cloning and sequencing of a K+ transport gene (trk A) from the marine bacterium Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1219:701-5. 1994
    ..This gene has 71% homology to trkA gene at the DNA level from E. coli and the deduced amino acid sequence is 79% identical with E. coli TrkA, implying that V. alginolyticus has a trkA-like gene as a component of K+ transport systems...
  7. ncbi Roles of K+ and Na+ in pH homeostasis and growth of the marine bacterium Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    J Gen Microbiol 138:1271-6. 1992
    ..These results indicated the importance of Na+ in acidification of the cell interior via a Na+/H+ antiporter in order to support cell growth at alkaline pH(out) under conditions where the activity of a K+/H+ antiporter is marginal...
  8. ncbi Mechanosensitive channel functions to alleviate the cell lysis of marine bacterium, Vibrio alginolyticus, by osmotic downshock
    Y Nakamaru
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    FEBS Lett 444:170-2. 1999
    ..This is the first report to show a physiological role of the mechanosensitive channel with large conductance...
  9. ncbi Cloning and sequencing of an Na+/H+ antiporter gene from the marine bacterium Vibrio alginolyticus
    T Nakamura
    Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochim Biophys Acta 1190:465-8. 1994
    ..The hydropathy profile is characteristic of a membrane protein with 11 membrane spanning regions. The deduced amino acid sequence is 58% identical with E. coli NhaA...
  10. ncbi Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: a possible role for chromosome-associated Chk in chromosome dynamics
    N Yamaguchi
    Laboratory of Molecular Cell Biology, Faculty of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
    J Cell Sci 114:1631-41. 2001
    ....
  11. doi A multifunctional envelope-type nanodevice for use in nanomedicine: concept and applications
    T Nakamura
    Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo City, Japan
    Acc Chem Res 45:1113-21. 2012
    ..Some of these strategies will soon be tested in the clinic...
  12. ncbi Differential role in lipid peroxidation between rat P450 1A1 and P450 1A2
    S Ohmori
    Faculty of Pharmaceutical Sciences, Chiba University, Japan
    Biochem Pharmacol 46:55-60. 1993
    ..It is furthermore indicated that the difference in the effect of SOD in NADPH-induced lipid peroxidation depends on the P450 used...
  13. pmc The Schizosaccharomyces pombe spo20(+) gene encoding a homologue of Saccharomyces cerevisiae Sec14 plays an important role in forespore membrane formation
    Y Nakase
    Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka 558 8585, Japan
    Mol Biol Cell 12:901-17. 2001
    ..Our results indicate that Spo20 regulates the formation of specialized membrane structures in addition to its recognized role in regulating Golgi secretory function...
  14. ncbi Halotolerant cyanobacterium Aphanothece halophytica contains an Na(+)/H(+) antiporter, homologous to eukaryotic ones, with novel ion specificity affected by C-terminal tail
    R Waditee
    Research Institute, Faculty of Science and Technology, Meijo University, Nagoya 468-8502, Japan
    J Biol Chem 276:36931-8. 2001
    ..These results suggest that the ion specificity of an Na(+)/H(+) antiporter is partly determined by the structural properties of the C-terminal tail, which was well exemplified in the case of A. halophytica...
  15. ncbi Identification of the ABC protein SapD as the subunit that confers ATP dependence to the K+-uptake systems Trk(H) and Trk(G) from Escherichia coli K-12
    C Harms
    Abteilung Mikrobiologie, Barbarastrasse 11, Universitat Osnabruck, D 49069 Osnabruck, Germany
    Microbiology 147:2991-3003. 2001
    ..coli ATP dependence of Trk activity can be independent of Sap proteins. These data are interpreted to mean that Trk systems can interact with an ABC protein other than SapD...
  16. ncbi DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912
    Yu Rebets
    Department of Genetics and Biotechnology of Ivan Franko National University of L viv, Grushevskogo st 4, L viv 79005, Ukraine
    Microbiology 151:281-90. 2005
    ..In solid-phase analysis, lndI expression was evident in substrate mycelia but was absent from aerial hyphae and spores...
  17. ncbi Molecular cloning and sequence analysis of two endoinulinase genes from Aspergillus niger
    K Ohta
    Department of Biological Resource Sciences, Faculty of Agriculture, Miyazaki University, Japan
    Biosci Biotechnol Biochem 62:1731-8. 1998
    ..The deduced amino acid sequences of the mature A. niger enzymes showed 73% identity with that of the Penicillium purpurogenum endoinulinase...
  18. ncbi Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors
    H Itadani
    Banyu Tsukuba Research Institute, Okubo 3, Tsukuba, 300 2611, Japan
    Biochem Biophys Res Commun 250:68-71. 1998
    ..The active metabolite of TRH, histidyl-proline diketopiperazine, or cyclo(His-Pro), showed no specific binding activity. These results suggest that TRHR2 is a novel subtype of TRH receptor...
  19. ncbi Molecular cloning and characterization of a new human histamine receptor, HH4R
    T Nakamura
    Banyu Pharmaceutical Company, Ltd, Tsukuba Research Institute, Okubo 3, Tsukuba, Ibaraki, 300 2611, Japan
    Biochem Biophys Res Commun 279:615-20. 2000
    ..These observations indicate that the clone is a distinct histamine receptor from HH3R, and thus is named HH4R...
  20. pmc Determination of transmembrane topology of an inward-rectifying potassium channel from Arabidopsis thaliana based on functional expression in Escherichia coli
    N Uozumi
    BioScience Center, Nagoya University, Nagoya, 464 8601, Japan
    Proc Natl Acad Sci U S A 95:9773-8. 1998
    ..Furthermore, the functional complementation of a bacterial K+ uptake mutant in this study is shown to be an alternative expression system for plant K+ channel proteins and a potent tool for their topological analysis...
  21. ncbi The pha gene cluster of Rhizobium meliloti involved in pH adaptation and symbiosis encodes a novel type of K+ efflux system
    P Putnoky
    Institute of Genetics, Biological Research Center, Hungarian Academy of Sciences, Szeged
    Mol Microbiol 28:1091-101. 1998
    ..These results suggest that the pha genes of R. meliloti encode for a novel type of K+ efflux system that is involved in pH adaptation and is required for the adaptation to the altered environment inside the plant...
  22. ncbi Cloning and characterization of chemotaxis genes in Pseudomonas aeruginosa
    J Kato
    Department of Fermentation Technology, Hiroshima University, Japan
    Biosci Biotechnol Biochem 63:155-61. 1999
    ..This gene was located at least 1,800 kb away from the chemotaxis gene cluster and encoded a putative polypeptide that had 32% amino acid identity with E. coli CheR...
  23. ncbi Indian hedgehog in the late-phase differentiation in mouse chondrogenic EC cells, ATDC5: upregulation of type X collagen and osteoprotegerin ligand mRNAs
    H Akiyama
    Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Kyoto, Sakyo, 606 8507, Japan
    Biochem Biophys Res Commun 257:814-20. 1999
    ..Our data support the hypothesis that Ihh stimulated the late-phase chondrogenic differentiation in differentiated ATDC5 cells and upregulated the gene expression of OPGL in these cells...
  24. ncbi Structure and function of human prepro-orexin gene
    T Sakurai
    Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305 8575, Japan
    J Biol Chem 274:17771-6. 1999
    ..These mice might also be useful for examining the molecular mechanisms by which orexin gene expression is regulated...
  25. ncbi Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein
    T Nakamura
    Division of Biochemistry, Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, 565 0871, Osaka, Japan
    Biochim Biophys Acta 1518:63-72. 2001
    ..Kringle-SAGE is expected to facilitate further elucidation of structure and functions of kringle proteins...
  26. ncbi Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family
    K Nakamura
    Division of Biochemistry, Osaka University Graduate School of Medicine, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 280:1028-35. 2001
    ..These results indicate that hSRCL is a novel bacteria-binding receptor containing a C-type CRD and this receptor may play an important role in host defense...
  27. pmc Na+/H+ antiporter from Synechocystis species PCC 6803, homologous to SOS1, contains an aspartic residue and long C-terminal tail important for the carrier activity
    A Hamada
    Research Institute of Meijo University, Tenpaku-ku, Nagoya, Aichi 468-8502, Japan
    Plant Physiol 125:437-46. 2001
    ..Thus, it appeared that the SynNhaP would provide a model system for the study of structural and functional properties of eucaryotic Na(+)/H(+) antiporters...
  28. pmc Evidence in support of a four transmembrane-pore-transmembrane topology model for the Arabidopsis thaliana Na+/K+ translocating AtHKT1 protein, a member of the superfamily of K+ transporters
    Y Kato
    Graduate School of Bioagricultural Sciences and Bioscience Center, Nagoya University, Nagoya 464-8601, Japan
    Proc Natl Acad Sci U S A 98:6488-93. 2001
    ..Taken together, our results show that AtHKT1 contains eight transmembrane-spanning segments...
  29. ncbi Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene
    H Ijichi
    First Department of Anatomy, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno Ku, Osaka, Japan
    Gene 248:99-107. 2000
    ....
  30. pmc The Arabidopsis HKT1 gene homolog mediates inward Na(+) currents in xenopus laevis oocytes and Na(+) uptake in Saccharomyces cerevisiae
    N Uozumi
    BioScience Center, Nagoya University, Nagoya, 464 8601, Japan
    Plant Physiol 122:1249-59. 2000
    ..These data demonstrate that AtHKT1 differs in its transport properties from the wheat HKT1, and that AtHKT1 can mediate Na(+) and, to a small degree, K(+) transport in heterologous expression systems...
  31. ncbi DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries
    T Nakamura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:22476-83. 1999
    ..DANCE is thus a novel vascular ligand for integrin receptors and may play a role in vascular development and remodeling...
  32. ncbi Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135
    T Kojima
    Department of Molecular Genetic Research, National Institute for Longevity Sciences NILS, Morioka cho, Oobu, Aichi, 474 8522, Japan
    Biochem Biophys Res Commun 284:1039-47. 2001
    ..The Sck-pp135 interaction was reduced by Src kinase inhibitors. These results suggest that Sck, but not N-Shc nor Shc, transmit signals in conjunction with pp135 following Src activation and/or calcium entry in the cell...
  33. ncbi Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF
    D Yabe
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 272:18232-9. 1997
    ..Calumenin is expressed most strongly in heart of adult and 18.5-day embryos. The calumenin gene (Calu) was mapped at the proximal portion of mouse chromosome 7...
  34. ncbi Nucleotide sequence of the subtilisin NAT gene, aprN, of Bacillus subtilis (natto)
    T Nakamura
    Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan
    Biosci Biotechnol Biochem 56:1869-71. 1992
  35. ncbi Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin
    K Sugimoto
    Division of Biochemistry, Osaka University Medical School, Japan
    J Biol Chem 271:11548-56. 1996
    ..PB-cadherin may play an important role in morphogenesis and tissue formation in neural and non-neural cells for the development and maintenance of the brain and neuroendocrine organs by regulating cell-cell adhesion...
  36. ncbi Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
    T Nakamura
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702, USA
    Nat Genet 12:154-8. 1996
    ....
  37. pmc Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs
    T Nakamura
    Jefferson Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Proc Natl Acad Sci U S A 90:4631-5. 1993
    ..Stretches abundant in basic amino acids are also present in the three proteins. These results suggest that the different proteins fused to ALL-1 polypeptide(s) provide similar functional domains...
  38. pmc Cloning, nucleotide sequence, and expression of the HincII restriction-modification system
    H Ito
    Bioproducts Development Center, Takara Shuzo Co, Ltd, Shiga, Japan
    Nucleic Acids Res 18:3903-11. 1990
    ..influenzae Rc. The amino acid sequence of M.HincII was compared with the sequences of four other adenine-specific type II methylases. Important homology was found between tne M.HincII and these other methylases...
  39. ncbi Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes
    M Onno
    Laboratory of Cellular and Molecular Biology, Centre National de la Recherche Scientifique, Villejuif, France
    DNA Cell Biol 12:107-18. 1993
    ..The results are consistent with the possibility that TRE17 sequences other than oncTRE17 are translated if alternatively spliced. Expression of TRE17 in normal somatic cells was, however, not yet reported...
  40. ncbi Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor
    K Mizuno
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    J Biol Chem 269:1131-6. 1994
    ..Thus, it is likely that the basic clusters in these domains cooperatively contribute to the binding of HGF to the anionic heparin or heparan sulfate molecule...
  41. ncbi Cloning of CRP2, a novel member of the cysteine-rich protein family with two repeats of an unusual LIM/double zinc-finger motif
    I Okano
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    FEBS Lett 333:51-5. 1993
    ..The ubiquitous tissue distribution and high level of expression of CRP2 mRNA suggest an important role for CRP2 in cell functions...
  42. ncbi Cyclin I: a new cyclin encoded by a gene isolated from human brain
    T Nakamura
    Biomedical R and D Department, Sumitomo Electric Industries, Yokohama, Japan
    Exp Cell Res 221:534-42. 1995
    ..The expression of cyclin I mRNA does not correlate directly to the cell cycle, and therefore cyclin I may be a novel cyclin member that functions independently of the cell cycle control...
  43. ncbi Expression of the betaine aldehyde dehydrogenase gene in barley in response to osmotic stress and abscisic acid
    M Ishitani
    Nagoya University, BioScience Center, Japan
    Plant Mol Biol 27:307-15. 1995
    ..Removal of plant roots before transferring the plants to high-salt conditions reduced only slightly the accumulation of BADH transcripts in the leaves...
  44. ncbi Roles of two types of O6-methylguanine-DNA methyltransferases in DNA repair
    K Takano
    Department of Biochemistry, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Mutat Res 254:37-44. 1991
    ..O6-Methylguanine-DNA methyltransferases appear to eliminate premutagenic DNA lesions not only from cells exposed to alkylating agents but also from those grown in the absence of the agents...
  45. ncbi cDNA cloning and expression of the Xenopus laevis vitellogenin receptor
    K Okabayashi
    Department of Life Science, University of Tokyo, Japan
    Biochem Biophys Res Commun 224:406-13. 1996
    ..6 kb in Xenopus ovary, weak but significant expression was observed in other tissues by RT-PCR analysis. The fact that major expression of the gene occurs in the ovary suggests that it has an important function in this organ...
  46. ncbi N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling
    T Nakamura
    Biomedical Research and Development Department, Sumitomo Electric Industries, Sakae ku, Yokohama 244, Japan
    J Biol Chem 273:6960-7. 1998
    ..These results suggest that neurally expressed N-Shc and Sck may have distinct roles in neuronal signaling in the brain...
  47. ncbi DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95
    K Satoh
    Department of Oncogene Research, Institute for Microbial Diseases, Osaka University, Suita, Japan
    Genes Cells 2:415-24. 1997
    ....
  48. ncbi Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA
    V R Wallenius
    Research Centre for Endocrinology and Metabolism RCEM, Department of Internal Medicine, Grona Straket 8, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Mamm Genome 8:661-7. 1997
    ..Therefore, the rat Hgf and HGF receptor/Met genes are located relatively close to each other, in a way similar to humans but not mice...
  49. ncbi Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5
    H Akiyama
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Sakyo, Japan
    Biochem Biophys Res Commun 235:142-7. 1997
    ..Our data suggest that hh signalling molecules may be involved in chondrogenesis and cartilage differentiation in ATDC5 cells...
  50. ncbi Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method
    M Shirozu
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Genomics 37:273-80. 1996
    ..These results indicate that the SST method is effective and useful for the isolation of secreted and membrane proteins without knowledge of their functions...
  51. ncbi Cloning of the RhoB gene from the mouse genome and characterization of its promoter region
    T Nakamura
    Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories, Japan
    Biochem Biophys Res Commun 226:688-94. 1996
    ..Northern blotting analysis showed that the expression of the mouse rhoB gene was induced by serum, suggesting that expression of the rhoB gene might be controlled by some signal-responsive element(s)...
  52. pmc Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia
    R Prasad
    Jefferson Cancer Institute, Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107
    Proc Natl Acad Sci U S A 91:8107-11. 1994
    ..In this model, the partner polypeptide plays an accessory role either by repressing activity of the truncated ALL-1 protein or by blocking the function of the normal protein presumably present in the leukemic cells...
  53. ncbi Isolation, characterization, and chromosome mapping of a human A-C1 Ha-Ras suppressor gene (HRASLS)
    H Ito
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara cho, Sakyo, Kyoto 606 8507, Japan
    Cytogenet Cell Genet 93:36-9. 2001
    ..Moreover, expression of human A-C1 mRNA was detected at a high level in human osteosarcoma-derived U2OS cells in vitro. By FISH analysis the human A-C1 gene (HRASLS) was mapped to human chromosome 3q28--> q29...
  54. pmc Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues
    T Tsuji
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Proc Natl Acad Sci U S A 87:8835-9. 1990
    ..The large subunit mRNA is synthesized in parallel with the expression of TGF-beta 1 mRNA in various rat tissues...
  55. ncbi Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism
    H Sakamoto
    Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Am J Hypertens 3:533-7. 1990
    ....
  56. pmc The Schizosaccharomyces pombe spo3+ gene is required for assembly of the forespore membrane and genetically interacts with psy1(+)-encoding syntaxin-like protein
    T Nakamura
    Department of Biology, Graduate School of Science, Osaka City University, Osaka 558 8585, Japan
    Mol Biol Cell 12:3955-72. 2001
    ..These results suggest that Spo3 is a key component of the forespore membrane and is essential for its assembly acting in collaboration with the syntaxin-like protein...
  57. pmc Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency
    H Hanawa
    J Med Genet 39:286-91. 2002
  58. ncbi Isolation and characterization of the rat chromosomal gene for a polypeptide (pS1) antigenically related to statin
    D K Ann
    Department of Pharmacology, Medical School, University of Minnesota, Minneapolis 55455
    J Biol Chem 266:10429-37. 1991
    ..abstract truncated at 400 words)..
  59. ncbi Molecular cloning and biological activity of a novel lysyl oxidase-related gene expressed in cartilage
    H Ito
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606 8507, Japan
    J Biol Chem 276:24023-9. 2001
    ..Our data indicate that LOXC is expressed in cartilage in vivo and modulates the formation of a collagenous extracellular matrix...
  60. ncbi cDNA cloning, genomic organization, and chromosomal localization of the mouse LIM motif-containing kinase gene, Limk2
    U Koshimizu
    Department of Oncology, Osaka University Medical School, Japan
    Biochem Biophys Res Commun 241:243-50. 1997
    ..Fluorescent in situ hybridization analysis showed the Limk2 gene were mapped to mouse chromosome 1D. These findings provide some important clues to the in vivo functions of LIM kinases...
  61. ncbi Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
    M Wada
    Department of Biochemistry, Kyushu University School of Medicine, Fukuoka 812 82, Japan
    Hum Mol Genet 7:203-7. 1998
    ..These results strongly implicate the cMOAT gene as responsible for the defects in DJS patients...
  62. ncbi p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
    K Kobayashi
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
    J Biol Chem 273:291-5. 1998
    ..Sra-1 was cosedimented with filamentous actin (F-actin), indicating that Sra-1 directly interacts with F-actin. These results suggest that Sra-1 is a novel and specific target for Rac1...
  63. ncbi Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds
    K Kitajima
    Division of Biochemistry, Biomedical Research Center, Osaka University Medical School, Osaka, Japan
    Dev Dyn 215:206-14. 1999
    ..These findings suggested the possibility that PB-cadherin-mediated cell-cell adhesion has a functional role in pattern formation and morphogenesis of mouse embryonic brain and limb. Dev Dyn 1999;215:206-214...
  64. ncbi Characterization of cDNAs expressed in the early stages of microspore embryogenesis in barley (Hordeum vulgare) L
    P L Vrinten
    Tohoku National Agriculture Experimental Station, Iwate, Japan
    Plant Mol Biol 41:455-63. 1999
    ..The identification and characterization of the clones isolated in this study provides new information on the events involved in barley microspore embryogenesis...
  65. ncbi Identification and characterization of a PDZ protein that interacts with activin type II receptors
    H Shoji
    Institute for Enzyme Research, University of Tokushima, 3 18 15 Kuramoto, Tokushima 770 8503, Japan
    J Biol Chem 275:5485-92. 2000
    ..These findings suggest that ARIP1 has a significant role in assembling activin signaling molecules at specific subcellular sites and in regulating signal transduction in neuronal cells...
  66. ncbi The Schizosaccharomyces pombe spo6+ gene encoding a nuclear protein with sequence similarity to budding yeast Dbf4 is required for meiotic second division and sporulation
    T Nakamura
    Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka 558 8585, Japan
    Genes Cells 5:463-79. 2000
    ..The spo6+ gene was identified as a sporulation-specific gene, whose transcription was regulated by the forkhead family transcription factor Mei4...
  67. ncbi Plant mercaptopyruvate sulfurtransferases: molecular cloning, subcellular localization and enzymatic activities
    T Nakamura
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    Eur J Biochem 267:5621-30. 2000
    ..However, the mutation had no effect on levels of iron-sulfur enzyme activities, suggesting that MST1 is not directly involved in iron-sulfur cluster assembly...
  68. ncbi Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia
    Y Gu
    Jefferson Cancer Institute, Jefferson Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107
    Cancer Res 54:2327-30. 1994
    ..We conclude that while there is no specific sequence element present at all the breakpoints, the high density of Alu sequences in the breakpoint cluster region possibly makes the latter more prone to recombination events...
  69. pmc The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex
    O Rozenblatt-Rosen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:4152-7. 1998
    ....