Etsuko Kobayashi

Summary

Affiliation: Chiba University
Country: Japan

Publications

  1. doi request reprint Changes in renal tubular and glomerular functions and biological Acid-base balance after soil replacement in Cd-polluted rice paddies calculated with a general linear mixed model
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Biol Trace Elem Res 124:164-72. 2008
  2. doi request reprint Influence of drinking and/or cooking with Jinzu River water on the development of Itai-itai disease
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Biol Trace Elem Res 129:46-57. 2009
  3. ncbi request reprint Estimation of benchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, beta2-microglobulin, and N-acetyl-beta-D-glucosaminidase in cadmium nonpolluted regions in Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, 260 8670 Japan
    Environ Res 101:401-6. 2006
  4. doi request reprint Estimation of benchmark doses as threshold levels of urinary cadmium, based on excretion of beta2-microglobulin in cadmium-polluted and non-polluted regions in Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670 Japan
    Toxicol Lett 179:108-12. 2008
  5. doi request reprint Influence of consumption of cadmium-polluted rice or Jinzu River water on occurrence of renal tubular dysfunction and/or Itai-itai disease
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Biol Trace Elem Res 127:257-68. 2009
  6. doi request reprint Serial follow-up study on renal handling of calcium and phosphorus after soil replacement in Cd-polluted rice paddies estimated using a general linear mixed model
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Biol Trace Elem Res 129:261-9. 2009
  7. ncbi request reprint Serial changes in urinary cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Toxicol Lett 176:124-30. 2008
  8. doi request reprint Association of lifetime cadmium intake or drinking Jinzu River water with the occurrence of renal tubular dysfunction
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Environ Toxicol 24:421-8. 2009
  9. ncbi request reprint Estimation of benchmark dose for renal dysfunction in a cadmium non-polluted area in Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    J Appl Toxicol 26:351-5. 2006
  10. ncbi request reprint A longitudinal study on the relationship between shift work and the progression of hypertension in male Japanese workers
    Mitsuhiro Oishi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba bHealth Care Center, University of Tokyo, Tokyo, Japan
    J Hypertens 23:2173-8. 2005

Collaborators

Detail Information

Publications64

  1. doi request reprint Changes in renal tubular and glomerular functions and biological Acid-base balance after soil replacement in Cd-polluted rice paddies calculated with a general linear mixed model
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Biol Trace Elem Res 124:164-72. 2008
    ..Interventions such as soil replacement appear to be too late to prevent progressive renal failure in Cd-exposed populations...
  2. doi request reprint Influence of drinking and/or cooking with Jinzu River water on the development of Itai-itai disease
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Biol Trace Elem Res 129:46-57. 2009
    ....
  3. ncbi request reprint Estimation of benchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, beta2-microglobulin, and N-acetyl-beta-D-glucosaminidase in cadmium nonpolluted regions in Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, 260 8670 Japan
    Environ Res 101:401-6. 2006
    ....
  4. doi request reprint Estimation of benchmark doses as threshold levels of urinary cadmium, based on excretion of beta2-microglobulin in cadmium-polluted and non-polluted regions in Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670 Japan
    Toxicol Lett 179:108-12. 2008
    ..To prevent the adverse health effects caused by exposure to Cd, it is important to establish the threshold level of Cd exposure at each age...
  5. doi request reprint Influence of consumption of cadmium-polluted rice or Jinzu River water on occurrence of renal tubular dysfunction and/or Itai-itai disease
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Biol Trace Elem Res 127:257-68. 2009
    ....
  6. doi request reprint Serial follow-up study on renal handling of calcium and phosphorus after soil replacement in Cd-polluted rice paddies estimated using a general linear mixed model
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Biol Trace Elem Res 129:261-9. 2009
    ..TRP values remained low throughout the observation period and the values did not recover in either sex. However, the results of P-U and P-S suggested that the renal handling of P may recover after the completion of soil replacement...
  7. ncbi request reprint Serial changes in urinary cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Toxicol Lett 176:124-30. 2008
    ....
  8. doi request reprint Association of lifetime cadmium intake or drinking Jinzu River water with the occurrence of renal tubular dysfunction
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Environ Toxicol 24:421-8. 2009
    ..When assuming user/nonuser status of the river water, the threshold level was calculated as 0.75/0.93 g in women. The difference of 0.18 g was interpreted as representing the influence of drinking/cooking with the river water...
  9. ncbi request reprint Estimation of benchmark dose for renal dysfunction in a cadmium non-polluted area in Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    J Appl Toxicol 26:351-5. 2006
    ....
  10. ncbi request reprint A longitudinal study on the relationship between shift work and the progression of hypertension in male Japanese workers
    Mitsuhiro Oishi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba bHealth Care Center, University of Tokyo, Tokyo, Japan
    J Hypertens 23:2173-8. 2005
    ..In this 1991-2001 cohort study of 6495 male workers in a Japanese steel company, we investigated whether shift work affects progression from mild hypertension to severe hypertension...
  11. ncbi request reprint Total cadmium intake and mortality among residents in the Jinzu River Basin, Japan
    Kaori Matsuda
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Arch Environ Health 58:218-22. 2003
    ..0 gm group, compared with the < 2.0 gm group. In the Jinzu River Basin, a total cadmium intake > or = 2.0 gm exerts an adverse influence on life prognosis...
  12. ncbi request reprint G-protein beta 3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism A1330V are risk factors for hypercholesterolemia in Japanese males--a prospective study over 5 years
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Metabolism 55:751-7. 2006
    ....
  13. doi request reprint A longitudinal study on the effect of shift work on weight gain in male Japanese workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Obesity (Silver Spring) 16:1887-93. 2008
    ..This study compared the effect of alternating shift work and day work on weight gain in Japanese male workers...
  14. ncbi request reprint Lack of association of human G-protein beta 3 subunit variant with hypertension in Japanese workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chuoku, Chiba, Japan
    J Hypertens 22:493-500. 2004
    ..To examine the association between hypertension and the C825T polymorphism in the G-protein beta 3 subunit gene in Japanese workers...
  15. ncbi request reprint Low-density lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Blood Press 15:80-7. 2006
    ..1 compared to the QQ genotype. This study indicates that the Q89R polymorphism is an independent factor for hypertension in Japanese females...
  16. ncbi request reprint The -1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased gamma-glutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: a prospective cohort study over
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Int J Mol Med 17:77-82. 2006
    ....
  17. ncbi request reprint Low-density lipoprotein receptor-related protein 5 variant A1330V is a determinant of blood pressure in Japanese males
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Life Sci 78:2475-9. 2006
    ..5 mm Hg lower diastolic blood pressure and a 2.3 mm Hg lower mean blood pressure than the AA genotype. This study indicates that the 1330V allele is an independent factor for lower diastolic and mean blood pressure in Japanese males...
  18. doi request reprint Shift work is a risk factor for increased blood pressure in Japanese men: a 14-year historical cohort study
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chuoku, Chiba, Japan
    Hypertension 52:581-6. 2008
    ..Moreover, the effect of shift work on blood pressure was more pronounced than other well-established factors, such as age and body mass index...
  19. ncbi request reprint Association between urinary calcium excretion level and mortality in inhabitants of the Jinzu River basin area of Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Biol Trace Elem Res 89:145-53. 2002
    ..These values were statistically significant in both sexes for the Jinzu River water system and in women for the non-Jinzu River water system. We conclude that the life-span becomes shorter as urinary Ca excretion levels become lower...
  20. ncbi request reprint Allowable level of lifetime cadmium intake calculated from the individuals in the Jinzu River basin of Japan
    Nobuhiro Chiyoda
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Biol Trace Elem Res 96:9-20. 2003
    ..The allowable levels of lifetime cadmium intake were less than 1.58 g for both sexes and each age group using proteinuria with glucosuria measurements...
  21. ncbi request reprint Excretion levels of urinary calcium and phosphorus among the inhabitants of Cd-polluted Kakehashi River basin of Japan
    Yasuhiro Hayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Biol Trace Elem Res 91:45-55. 2003
    ..Bone damage is not thought to be caused by increased excretion of Ca alone because urinary excretion levels of Ca do not differ greatly between people with and without bone damage...
  22. ncbi request reprint Association between renal dysfunction and mortality among inhabitants in the region around the Jinzu River basin polluted by cadmium
    Toshihiro Matsuda
    Department of Occupational and Environmental Medicine, Chiba University, Japan
    Environ Res 88:156-63. 2002
    ..This was not the case in the other water systems. Mortality of inhabitants with Cd-induced renal injury is increased in the Jinzu River basin...
  23. ncbi request reprint G-protein beta3 subunit gene variant is unlikely to have a significant influence on serum uric acid level in Japanese workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Tohoku J Exp Med 209:149-57. 2006
    ..The targeting of this polymorphism is unlikely to be beneficial in the prevention of hyperuricemia in the general Japanese population...
  24. ncbi request reprint Relationship between cadmium concentration in rice and renal dysfunction in individual subjects of the Jinzu River basin determined using a logistic regression analysis
    Yoshitaka Watanabe
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, 1 8 1 Inohana, Chuohku, 260 8670, Chiba, Japan
    Toxicology 172:93-101. 2002
    ..The value for subjects aged 50 years was 0.13 and 0.17 ppm for males and females, respectively, with regard to proteinuria and 0.15 and 0.10 ppm for males and females, respectively, with regard to proteinuria+glucosuria...
  25. ncbi request reprint Cadmium exposure aggravates mortality more in women than in men
    Mirei Uetani
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Int J Environ Health Res 16:273-9. 2006
    ..This study revealed that Cd exposure aggravates mortality more in women than in men...
  26. ncbi request reprint The relation between cumulative fatigue and marital status in Japanese workers
    Mirei Dochi
    The Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Behav Med 33:55-65. 2007
    ..The results verified that unmarried status was more associated with fatigue than was married status and being overworked...
  27. doi request reprint Shiftwork and impaired glucose metabolism: a 14-year cohort study on 7104 male workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Chronobiol Int 26:926-41. 2009
    ..Our study on male Japanese workers revealed alternating shiftwork (in addition to other established factors, such as age and body mass index) was a consistent risk factor for impaired glucose metabolism...
  28. ncbi request reprint Dose-response relationship between total cadmium intake calculated from the cadmium concentration in rice collected from each household of farmers and renal dysfunction in inhabitants of the Jinzu River basin, Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    J Appl Toxicol 22:431-6. 2002
    ..It was demonstrated that the greater the increase in total Cd intake, the greater the increase in abnormal urinary findings in the Jinzu River basin, and the association of the two factors was very close...
  29. ncbi request reprint Investigation of renal damage among residents in the cadmium-polluted Jinzu River basin, based on health examinations in 1967 and 1968
    Mirei Uetani
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba 260 8670, Japan
    Int J Environ Health Res 17:231-42. 2007
    ..The findings of this study verified the regional accumulation of renal disorders in the Jinzu River basin and indicate an association of the occurrence of renal disorders with the water from the Jinzu River...
  30. ncbi request reprint Changes in urinary excretions of cadmium, copper, and zinc in Japanese workers
    Toshiaki Miyamoto
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiha University, Japan
    Arch Environ Occup Health 61:215-22. 2006
    ..This fact suggests the necessity of further nationwide investigation and comprehensive measures to reduce cadmium exposure in Japanese society...
  31. ncbi request reprint Estimation of the number of working hours critical for the development of mental and physical fatigue symptoms in Japanese male workers - application of benchmark dose method
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Inohana, Chuoku, Chiba, Japan
    Am J Ind Med 50:173-82. 2007
    ....
  32. ncbi request reprint G-protein beta3 subunit gene variant (C825T) is unlikely to have a significant influence on serum total cholesterol level in Japanese workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Clin Exp Hypertens 28:47-56. 2006
    ..The targeting of this polymorphism therefore is unlikely to be beneficial in preventing hypercholesterolemia in the general Japanese population...
  33. ncbi request reprint Estimation of benchmark doses for urinary cadmium based on beta2-microglobulin excretion in cadmium-polluted regions of the Kakehashi River basin, Japan
    Akane Shimizu
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, Chiba, Japan
    Int J Environ Health Res 16:329-37. 2006
    ....
  34. doi request reprint Benchmark duration of work hours for development of fatigue symptoms in Japanese workers with adjustment for job-related stress
    Yasushi Suwazono
    Department of Ocuupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Risk Anal 28:1689-98. 2008
    ..The results strongly suggest that special attention should be paid to employees whose working hours exceed threshold amounts based on individual levels of job-related stress...
  35. ncbi request reprint Association between exposure to cadmium and blood pressure in Japanese peoples
    Isao Kurihara
    Chiba University Graduate School of Medicine, Department of Occupational and Environmental Medicine, Chiba, Japan
    Arch Environ Health 59:711-6. 2004
    ..The results suggest a significant negative association between cadmium exposure and BP in inhabitants in Japan...
  36. ncbi request reprint Estimation of cumulative cadmium intake causing Itai-itai disease
    Takeya Inaba
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, Japan
    Toxicol Lett 159:192-201. 2005
    ..6 and 3.3 g, respectively. The present results clarify that Itai-itai disease, the most severe stage of chronic Cd poisoning, occurs at levels of Cd consumption amounting to approximately three-fold of those currently seen in Japan...
  37. ncbi request reprint Three-shift system increases job-related stress in Japanese workers
    Hideto Harada
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    J Occup Health 47:397-404. 2005
    ..To reduce job stress in this occupational population, a reduction in the amount of overtime and an increase in the number of holidays seem to be useful interventions...
  38. doi request reprint Estimation of benchmark rice cadmium doses as threshold values for abnormal urinary findings with adjustment for consumption of Jinzu River water
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, 1 8 1 Inohana, Chuohku, Chiba, Japan
    Bull Environ Contam Toxicol 83:102-7. 2009
    ..13-0.27 ppm and 0.09-0.18 ppm in women, without adjustment for use of Jinzu River water. The additional influence of drinking and/or cooking with Jinzu River water was estimated to be about 0.008 ppm...
  39. ncbi request reprint Health effects of cadmium exposure in the general environment in Japan with special reference to the lower limit of the benchmark dose as the threshold level of urinary cadmium
    Tsukasa Uno
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Scand J Work Environ Health 31:307-15. 2005
    ..This study investigates renal dysfunction in areas without known environmental cadmium pollution and calculates the threshold level of urinary cadmium...
  40. doi request reprint Longitudinal evaluation of the effect of smoking initiation on body weight, blood pressure, and blood biochemistry
    Yumi Kadonaga
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba, Japan
    Prev Med 48:567-71. 2009
    ..To evaluate the effect of smoking initiation on annual changes in body weight, blood pressure, and blood biochemistry...
  41. ncbi request reprint Smoking as an independent risk factor for hypertension: a 14-year longitudinal study in male Japanese workers
    Mirei Dochi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Tohoku J Exp Med 217:37-43. 2009
    ..These results provide important information necessary to define the effect of smoking on blood pressure...
  42. ncbi request reprint A longitudinal study of the influence of smoking on the onset of obesity at a telecommunications company in Japan
    Mika Watari
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prev Med 43:107-12. 2006
    ..Pooled logistic regression analyses by sex were performed with age, working conditions and lifestyle as independent variables and the onset of obesity (BMI> or =26.4) as a dependent variable adjusted for the time period...
  43. ncbi request reprint Benchmark dose of working hours in relation to subjective fatigue symptoms in Japanese male workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Inohana, Chiba, Japan
    Ann Epidemiol 16:726-32. 2006
    ..We used a multiple logistic regression model to calculate benchmark doses (BMDs) and their 95% lower confidence bound (BMDL) of working hours for subjective fatigue symptoms...
  44. ncbi request reprint Environmental cadmium exposure, adverse effects and preventive measures in Japan
    Koji Nogawa
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, Chuohku, Chiba 260 8670, Japan
    Biometals 17:581-7. 2004
    ..Renal dysfunction caused by exposure to Cd was associated with an increased mortality in both regions. The increased total Cd intake and high concentration of Cd in rice also exerts an adverse influence on life prognosis...
  45. ncbi request reprint Long-term longitudinal study on the relationship between alternating shift work and the onset of diabetes mellitus in male Japanese workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Occup Environ Med 48:455-61. 2006
    ..This study investigated the effect of alternating shift work (ASW) on the onset of diabetes mellitus in Japanese workers compared with onset in day-shift work (DSW)...
  46. ncbi request reprint Association of working conditions and lifestyle with increased serum gamma-glutamyltransferase: a follow-up study
    Asako Higashikawa
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Arch Med Res 36:567-73. 2005
    ..This study investigated the association of working conditions and lifestyle with the development of increased serum gamma-glutamyltransferase (GGT) in Japanese workers...
  47. ncbi request reprint Smoking does not influence cadmium concentrations in blood and urine in relatively high levels of environmental cadmium areas in Japan
    Mirei Uetani
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chuohku, Chiba, Japan
    Biol Trace Elem Res 110:107-18. 2006
    ..3 mug/g creatinine in urine, respectively. Therefore, it was suggested that an influence of smoking on blood and urinary Cd concentrations was not observed in areas exposed to relatively high levels of environmental Cd...
  48. ncbi request reprint Estimation of benchmark dose as the threshold amount of alcohol consumption for blood pressure in Japanese workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Risk Anal 27:1487-95. 2007
    ..The threshold amount of alcohol consumption determined in this study provides valuable information for preventing alcohol-induced hypertension...
  49. ncbi request reprint Relationship among prevalence of patients with Itai-itai disease, prevalence of abnormal urinary findings, and cadmium concentrations in rice of individual hamlets in the Jinzu River basin, Toyama prefecture of Japan
    Takeshi Ogawa
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    Int J Environ Health Res 14:243-52. 2004
    ..This study demonstrated that Itai-itai disease is induced by exposure to environmental Cd and that renal dysfunction plays an important role in its development...
  50. ncbi request reprint Tissue cadmium (Cd) concentrations of people living in a Cd polluted area, Japan
    Mirei Uetani
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba, 260 8670, Japan
    Biometals 19:521-5. 2006
    ....
  51. ncbi request reprint Excretion of urinary cadmium, copper, and zinc in cadmium-exposed and nonexposed subjects, with special reference to urinary excretion of beta2-microglobulin and metallothionein
    Maki Nakajima
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku 260 8670 Japan
    Biol Trace Elem Res 108:17-31. 2005
    ....
  52. ncbi request reprint Working hours and mental and physical fatigue in Japanese workers
    Shouji Nagashima
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Occup Med (Lond) 57:449-52. 2007
    ..Establishing a threshold number of working hours is very important when making recommendations to protect people from the potentially harmful health effects caused by long working hours...
  53. ncbi request reprint Relationship between shift work and hypercholesterolemia in Japan
    Mirei Dochi
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Scand J Work Environ Health 34:33-9. 2008
    ..The objective of this study was to clarify the influence of shift work on total cholesterol levels in serum in male Japanese workers...
  54. doi request reprint Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Biomarkers 14:77-81. 2009
    ..2 years (11.2-19.4 years) and 23.5 years (17.7-35.0 years) in men and women, respectively. The biological half-lives of U-Cd obtained in this study were identical with the values of total body burden determined by a different method...
  55. ncbi request reprint Association between total cadmium intake calculated from the cadmium concentration in household rice and mortality among inhabitants of the cadmium-polluted Jinzu River basin of Japan
    Etsuko Kobayashi
    Department of Occupational and Environmental Medicine, Graduate School of Medicine A2, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Toxicol Lett 129:85-91. 2002
    ..045, 1.146 and 1.049 in men, women, and men+women (significant in the women), respectively. In the Jinzu River basin, increased total Cd intake appears to exert an adverse influence on life prognosis...
  56. ncbi request reprint Health status of workers in small and medium-sized companies as compared to large companies in Japan
    Hajime Yamataki
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    J Occup Health 48:166-74. 2006
    ..Endeavors to maintain a certain level of hygiene and health management play an important role in maintaining worker health in small companies...
  57. ncbi request reprint Lack of association between human G-protein beta3 subunit variant and overweight in Japanese workers
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Obes Res 12:4-8. 2004
    ..In conclusion, this study indicated that the GNB3 C825T polymorphism is not a significant factor for overweight in Japanese people...
  58. ncbi request reprint The relationship between shift work and the onset of hypertension in male Japanese workers
    Kouichi Sakata
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Japan
    J Occup Environ Med 45:1002-6. 2003
    ..10 and significant. Our study revealed that shift work independently affected the onset of hypertension, and suggested that shift work is a risk factor for the onset of hypertension...
  59. ncbi request reprint A longitudinal study of the influence of shift work on serum uric acid levels in workers at a telecommunications company
    Mirei Uetani
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuohku, Chiba 260 8670, Japan
    Occup Med (Lond) 56:83-8. 2006
    ....
  60. doi request reprint Impact of urinary cadmium on mortality in the Japanese general population in cadmium non-polluted areas
    Yasushi Suwazono
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuoku, Chiba 260 8670, Japan Electronic address
    Int J Hyg Environ Health 217:807-12. 2014
    ..The aim of the present study was to evaluate the dose-effect relationship between urinary cadmium (U-Cd as an index of internal Cd exposure) and mortality in a cohort of the Japanese general population...
  61. ncbi request reprint Association between duration of daily VDT use and subjective symptoms
    Tetsuya Nakazawa
    Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan
    Am J Ind Med 42:421-6. 2002
    ..Although visual display terminal (VDT) work has become a common task among office workers, surveys which would help to determine the allowable duration of daily VDT use are limited...
  62. ncbi request reprint An association between smoking habits and blood pressure in normotensive Japanese men: a 5-year follow-up study
    Yasushi Okubo
    Department of Occupational and Environmental Medicine A2, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Drug Alcohol Depend 73:167-74. 2004
    ..As such, we conducted a 5-year follow-up study to clarify the effects of smoking habits on blood pressure in normotensive Japanese men...
  63. ncbi request reprint The relation of individual cadmium concentration in urine with total cadmium intake in Kakehashi River basin, Japan
    Teruhiko Kido
    Department of Community Health Nursing, Kanazawa University School of Health Sciences, 5 11 80 Kodatsuno, Kanazawa, Japan
    Toxicol Lett 152:57-61. 2004
    ..879 and 0.835 were obtained in men and women, respectively, with both values statistically significant. Therefore, T-Cd is confirmed to be a useful indicator for external Cd exposure even on the basis of individual data of U-Cd...
  64. ncbi request reprint Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan
    Hideaki Nakagawa
    Department of Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Environ Res 100:323-9. 2006
    ..These results suggest that a causal association between Cd body burden and mortality exists among inhabitants environmentally exposed to Cd but that no special disease may be induced except renal diseases...