Kanji Yamasaki

Summary

Affiliation: Chemicals Evaluation and Research Institute
Country: Japan

Publications

  1. doi request reprint Endocrine-mediated effects of two benzene related compounds, 1-chloro-4-(chloromethyl)benzene and 1,3-diethyl benzene, based on subacute oral toxicity studies using rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, Tokyo, Japan
    Food Chem Toxicol 50:2635-42. 2012
  2. pmc OECD validation of the Hershberger assay in Japan: phase 2 dose response of methyltestosterone, vinclozolin, and p,p'-DDE
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, Oita, Japan
    Environ Health Perspect 111:1912-9. 2003
  3. ncbi request reprint Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 195:177-86. 2004
  4. ncbi request reprint Effects of in utero and lactational exposure to flutamide in SD rats: comparison of the effects of administration periods
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 209:47-54. 2005
  5. ncbi request reprint Effects of in utero and lactational exposure to tamoxifen in SD rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicol Lett 156:289-96. 2005
  6. ncbi request reprint Two-generation reproductive toxicity studies in rats with extra parameters for detecting endocrine disrupting activity: introductory overview of results for nine chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:1-4. 2005
  7. ncbi request reprint Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4 -[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] based on the OECD draft protocols
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita, 877 0061, Japan
    Arch Toxicol 81:749-57. 2007
  8. doi request reprint Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 1 4 25, Kouraku, Bunkyo ku, Tokyo 112 0004, Japan
    Toxicol Lett 189:14-20. 2009
  9. ncbi request reprint Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the OECD draft protocols
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita, Japan
    Arch Toxicol 82:301-11. 2008
  10. doi request reprint Comparison of endocrine-mediated effects of two bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol, based on subacute oral toxicity studies using rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, Tokyo, Japan
    Toxicol Lett 208:162-7. 2012

Detail Information

Publications43

  1. doi request reprint Endocrine-mediated effects of two benzene related compounds, 1-chloro-4-(chloromethyl)benzene and 1,3-diethyl benzene, based on subacute oral toxicity studies using rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, Tokyo, Japan
    Food Chem Toxicol 50:2635-42. 2012
    ..Our results indicated that endocrine-mediated effects such as thyroid dysfunction were associated with some benzene-related compounds...
  2. pmc OECD validation of the Hershberger assay in Japan: phase 2 dose response of methyltestosterone, vinclozolin, and p,p'-DDE
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, Oita, Japan
    Environ Health Perspect 111:1912-9. 2003
    ..Therefore, the Japanese studies support the Hershberger assay as a reliable and reproducible screening assay for the detection of androgen agonistic and antagonistic effects...
  3. ncbi request reprint Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 195:177-86. 2004
    ..On the other hand, the Hershberger assays of three phthalates were performed at the same dosages, and the results showed androgen antagonistic affinity only in the assay of phthalic acid di-n-amyl ester without receptor binding affinity...
  4. ncbi request reprint Effects of in utero and lactational exposure to flutamide in SD rats: comparison of the effects of administration periods
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 209:47-54. 2005
    ..The present data demonstrated that the endocrine-mediated effects on rats were more appreciable in offspring treated with FLUT after weaning than in offspring untreated after weaning...
  5. ncbi request reprint Effects of in utero and lactational exposure to tamoxifen in SD rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicol Lett 156:289-96. 2005
    ..6 and 3 microg/kg/day groups. No abnormalities were detected in the reproductive performance of the male and female offspring...
  6. ncbi request reprint Two-generation reproductive toxicity studies in rats with extra parameters for detecting endocrine disrupting activity: introductory overview of results for nine chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:1-4. 2005
    ....
  7. ncbi request reprint Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4 -[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] based on the OECD draft protocols
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita, 877 0061, Japan
    Arch Toxicol 81:749-57. 2007
    ..407. However, the changes were observed in rats given a high dose of the chemical, 1,000 mg/kg day...
  8. doi request reprint Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 1 4 25, Kouraku, Bunkyo ku, Tokyo 112 0004, Japan
    Toxicol Lett 189:14-20. 2009
    ....
  9. ncbi request reprint Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the OECD draft protocols
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita, Japan
    Arch Toxicol 82:301-11. 2008
    ....
  10. doi request reprint Comparison of endocrine-mediated effects of two bisphenol A related compounds, 2,2-bis(4-cyanatophyenyl)propane and 4,4'-cyclohexylidenebisphenol, based on subacute oral toxicity studies using rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, Tokyo, Japan
    Toxicol Lett 208:162-7. 2012
    ....
  11. ncbi request reprint Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, 877 0061 Oita, Japan
    Toxicol Lett 146:111-20. 2004
    ....
  12. ncbi request reprint Immature uterotrophic assay of estrogenic compounds in rats given diets of different phytoestrogen content and the ovarian changes with ICI 182,780 or antide
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 0877 0061, Japan
    Arch Toxicol 76:613-20. 2002
    ....
  13. ncbi request reprint Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, 877 0061, Oita, Japan
    Toxicology 170:21-30. 2002
    ..9202). These findings demonstrate that PC10 values are preferable to EC50 and PC50 values for predicting the estrogenic activities of chemicals...
  14. ncbi request reprint Changes of serum alpha 2u-globulin in the subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the 'Enhanced OECD Test Guideline No. 407'
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, Chemicals Assessment Center, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Toxicology 176:101-12. 2002
    ..Although the alpha 2u-globulin level was reduced in this assay using BPA and EE, further studies are necessary before this assay becomes a useful method for detecting endocrine-mediated effects...
  15. ncbi request reprint Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 183:93-115. 2003
    ..In the Hershberger assay, a clear androgen agonistic effect was detected in the androgen derivatives testosterone enanthate and methyltestosterone...
  16. ncbi request reprint Uterotrophic and Hershberger assays for n-butylbenzene in rats
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, Oita, Japan
    Arch Toxicol 75:703-6. 2002
    ..These findings suggest that nBB does not have any endocrine-disrupting properties on in vivo screening tests...
  17. ncbi request reprint Comparison of toxicity studies based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407' and the research protocol of 'Pubertal Development and Thyroid Function in Immature Male Rats' with 6-n-propyl-2-thiouracil
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Arch Toxicol 76:495-501. 2002
    ....
  18. ncbi request reprint Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Arch Toxicol 76:65-74. 2002
    ....
  19. ncbi request reprint Subacute oral toxicity study of bisphenol F based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"
    Nobuhiko Higashihara
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita, 877 0061, Japan
    Arch Toxicol 81:825-32. 2007
    ....
  20. doi request reprint Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 3-amino-1,2,4-triazole based on the Organization for Economic Co-operation and Development draft protocols
    Takaaki Umano
    Chemicals Evaluation and Research Institute, Bunkyo ku, Tokyo, Japan
    Arch Toxicol 83:459-67. 2009
    ..In addition, decreased body weight, and abnormal biochemical parameters attributed to thyroid, liver or kidney dysfunction were observed in male and female rats in the 25 and/or 125 mg/kg groups...
  21. ncbi request reprint Evaluation of an in utero through lactational exposure protocol for detection of estrogenic effects of ethinyl estradiol on the offspring of rats: preliminary trial
    Masakuni Sawaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita, Oita 877 0061, Japan
    Reprod Toxicol 17:335-43. 2003
    ....
  22. ncbi request reprint In utero through lactational exposure to ethinyl estradiol induces cleft phallus and delayed ovarian dysfunction in the offspring
    Masakuni Sawaki
    Chemicals Evaluation and Research Institute, Chemicals Assessment Center, Hita, Oita, Japan
    Toxicol Sci 75:402-11. 2003
    ..These findings are consistent with delayed anovulation syndrome. The results suggest that observation of cyclicity at 6 months old is able to detect possible delayed ovarian dysfunction induced by perinatal exposure to chemicals...
  23. ncbi request reprint Effect of gonadotropin-releasing hormone antagonist on ovarian and uterine weights in immature female rats
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    Reprod Toxicol 16:367-9. 2002
    ....
  24. ncbi request reprint Preliminary evaluation of an in utero-lactation assay using 6-n-propyl-2-thiouracil
    Shuji Noda
    Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi Oita, 877 0061, Japan
    Arch Toxicol 79:414-21. 2005
    ....
  25. ncbi request reprint OECD validation of the Hershberger assay in Japan: Phase 3. Blind study using coded chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Toxicol Lett 163:121-9. 2006
    ..Therefore, the Japanese studies support the Hershberger assay as a reliable and reproducible screening assay for the detection of androgen agonistic and antagonistic effects...
  26. ncbi request reprint Advantage of using CBA/N strain mice in a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 26:5-9. 2006
    ....
  27. ncbi request reprint Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"
    Katsumi Miyata
    Chemicals Evaluation and Research Institute, 3 822, Ishii, 877 0061 Hita, Oita, Japan
    Arch Toxicol 80:181-6. 2006
    ..DEHA was orally administered to SD rats at doses of 0, 40, 200 and 1,000 mg/kg/day for at least 28 days, and disturbance of the estrous cycle and increased ovarian follicle atresia were detected in the 1,000 mg/kg group...
  28. ncbi request reprint Comparison of the reporter gene assay for ER-alpha antagonists with the immature rat uterotrophic assay of 10 chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 087 0061, Japan
    Toxicol Lett 142:119-31. 2003
    ....
  29. doi request reprint Enhanced OECD TG 407 in detection of endocrine-mediated effects of 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol
    Takaaki Umano
    Chemicals Evaluation and Research Institute, 1 4 25 Kouraku, Bunkyo ku, Tokyo 112 0004, Japan
    Arch Toxicol 84:175-82. 2010
    ..It was concluded that the estrogenic effects were detected in growing rats given 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol, and thyroid dysfunction was also observed as the endocrine-mediated effects...
  30. ncbi request reprint The efficacy of endocrine disruptor screening tests in detecting anti-estrogenic effects downstream of receptor-ligand interactions
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, 8770061, Oita, Japan
    Toxicol Lett 126:91-8. 2002
    ..Particularly, the reporter gene assay may be a promising prescreening procedure, because it can be adopted in the high throughput screening process for thousands of chemicals and it requires no use of experimental animals...
  31. ncbi request reprint Ability of the Hershberger assay protocol to detect thyroid function modulators
    Shuji Noda
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 822, 3 Chome, Ishii machi, Hita shi, Oita 877 0061, Japan
    Arch Toxicol 79:627-35. 2005
    ..These results suggest that the effect of AT can be detected by the Hershberger assay 10-day administration protocol and may be useful for screening for thyroid function modulators regardless of whether the animals have been castrated...
  32. ncbi request reprint Subacute oral toxicity study of diethylphthalate based on the draft protocol for "Enhanced OECD Test Guideline no. 407"
    Keiji Shiraishi
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Arch Toxicol 80:10-6. 2006
    ....
  33. ncbi request reprint Age-related changes of genital systems in the female Crj:CD (SD) IGS rats during sexual maturation
    Shuji Noda
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Oita, Japan
    J Vet Med Sci 64:315-9. 2002
    ..In addition, it is assumed that the first ovulation precedes or occurs simultaneously with vaginal opening...
  34. ncbi request reprint Changes in serum alpha2u-globulin levels in castrated male rats treated with testosterone propionate in a Hershberger assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 25:176-8. 2005
    ....
  35. doi request reprint Endocrine-mediated effects of 4,4'-(hexafluoroisopropylidene)diphenol in SD rats, based on a subacute oral toxicity study
    Takaaki Umano
    Chemicals Evaluation and Research Institute, Bunkyo ku, Tokyo, Japan
    Arch Toxicol 86:151-7. 2012
    ..Our results demonstrate that in a repeated-dose toxicity study, 4,4'-(hexafluoroisopropylidene)diphenol has various endocrine-mediated effects and its NOAEL (no observed adverse effect level) is 10 mg/kg/day...
  36. ncbi request reprint Assessment of the skin sensitization potency of eugenol and its dimers using a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 24:77-81. 2004
    ..These investigations provide support for the proposal that the non-radioisotopic LLNA may serve as an effective alternative to the GPMT where there is a need to avoid the use of radioisotopes...
  37. ncbi request reprint Relationship between the results of in vitro receptor binding assay to human estrogen receptor alpha and in vivo uterotrophic assay: comparative study with 65 selected chemicals
    Yumi Akahori
    Department of Human Environmental Science, Ochanomizu University, 2 1 1, Otsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Toxicol In Vitro 22:225-31. 2008
    ..The usage of this value as cutoff provided the best concordance rate (82%). These findings are useful in a tiered approach for identifying chemicals that have potential to induce ER-mediated effects in vivo...
  38. ncbi request reprint Development of a high-performance reporter plasmid for detection of chemicals with androgenic activity
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, 8770061, Oita, Japan
    Arch Toxicol 77:274-9. 2003
    ..This new type of reporter plasmid, ARE-AUG- Luc+, should be of value in endocrine research and in screening to identify endocrine-modulating chemicals...
  39. doi request reprint The inhalation exposure of carbon tetrachloride promote rat liver carcinogenesis in a medium-term liver bioassay
    Kazunari Tsujimura
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita City, Oita 877 0061, Japan
    Toxicol Lett 176:207-14. 2008
    ..This is the first report of the use of inhalation exposure in this medium-term predictive assay...
  40. ncbi request reprint Differences in responsiveness of mouse strain against p-benzoquinone as assessed by non-radioisotopic murine local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, Japan, Oita, Japan
    Exp Anim 53:171-3. 2004
    ..These results support the recommendation in the OECD test guideline 429 and the skin sensitization test guideline of US-EPA with regard to the selection of mouse strain for LLNA...
  41. ncbi request reprint Assessment of statistic analysis in non-radioisotopic local lymph node assay (non-RI-LLNA) with alpha-hexylcinnamic aldehyde as an example
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita, 8770061, Japan
    Toxicology 191:259-63. 2003
    ..The challenge is to develop strategies for further refinement of this approach...
  42. doi request reprint Risk assessment study of dioxins in sanitary napkins produced in Japan
    Satoko Ishii
    Chemicals Evaluation and Research Institute, Tokyo, Japan Electronic address
    Regul Toxicol Pharmacol 70:357-62. 2014
    ..This fact indicated that the risk of exposure to dioxins from sanitary napkins produced in Japan was negligible. ..
  43. pmc The OECD program to validate the rat Hershberger bioassay to screen compounds for in vivo androgen and antiandrogen responses: phase 2 dose-response studies
    William Owens
    Procter and Gamble, Cincinnati, Ohio 45253 8707, USA
    Environ Health Perspect 115:671-8. 2007
    ..The Organisation for Economic Co-operation and Development (OECD) has completed phase 2 of an international program to validate the rodent Hershberger bioassay...