Chemicals Evaluation and Research Institute

Summary

Organization: Chemicals Evaluation and Research Institute
Country: Japan

Top Publications

  1. doi Enhanced OECD TG 407 in detection of endocrine-mediated effects of 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol
    Takaaki Umano
    Chemicals Evaluation and Research Institute, 1 4 25 Kouraku, Bunkyo ku, Tokyo 112 0004, Japan
    Arch Toxicol 84:175-82. 2010
  2. ncbi Application of RNAi inducible TNFRI knockdown cells to the analysis of TNFalpha-induced cytotoxicity
    Fumiyo Saito
    Chemicals Evaluation and Research Institute, Japan, 1600 Shimo Takano, Sugito, Kitakatsushika, Saitama 345 0043, Japan
    Toxicol In Vitro 20:1343-53. 2006
  3. ncbi A two-generation reproductive toxicity study of butyl benzyl phthalate in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:39-58. 2005
  4. ncbi A two-generation reproductive toxicity study of 4-nitrotoluene in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:117-134. 2005
  5. ncbi Two-generation reproductive toxicity studies in rats with extra parameters for detecting endocrine disrupting activity: introductory overview of results for nine chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:1-4. 2005
  6. ncbi Influence of dispersants on bioconcentration factors of seven organic compounds with different lipophilicities and structures
    Naoaki Yakata
    Chemicals Evaluation and Research Institute Japan, Kurume Laboratory, 3 2 7 Miyanojin, Kurume, Fukuoka 839 0801, Japan
    Chemosphere 64:1885-91. 2006
  7. ncbi Determination of mustard and lewisite related compounds in abandoned chemical weapons (Yellow shells) from sources in China and Japan
    Shigeyuki Hanaoka
    Tokyo Laboratory, Chemicals Evaluation and Research Institute, Environmental Technology Department, Kitakatsushika, Saitama 345 0043, Japan
    J Chromatogr A 1101:268-77. 2006
  8. ncbi Two-step models to predict binding affinity of chemicals to the human estrogen receptor alpha by three-dimensional quantitative structure-activity relationships (3D-QSARs) using receptor-ligand docking simulation
    Y Akahori
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Japan, 1600 Shimotakano, Sugito machi, Kitakatsushika gun, Saitama 345 0043, Japan
    SAR QSAR Environ Res 16:323-37. 2005
  9. ncbi Advantage of using CBA/N strain mice in a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 26:5-9. 2006
  10. ncbi Fish full life-cycle testing for 17beta-estradiol on medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan CERI, 3 2 7, Miyanojin, Kurume shi, Fukuoka 839 0801, Japan
    Environ Toxicol Chem 24:1259-66. 2005

Scientific Experts

Detail Information

Publications54

  1. doi Enhanced OECD TG 407 in detection of endocrine-mediated effects of 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol
    Takaaki Umano
    Chemicals Evaluation and Research Institute, 1 4 25 Kouraku, Bunkyo ku, Tokyo 112 0004, Japan
    Arch Toxicol 84:175-82. 2010
    ..It was concluded that the estrogenic effects were detected in growing rats given 4,4'-(octahydro-4,7-methano-5H-inden-5-ylidene)bisphenol, and thyroid dysfunction was also observed as the endocrine-mediated effects...
  2. ncbi Application of RNAi inducible TNFRI knockdown cells to the analysis of TNFalpha-induced cytotoxicity
    Fumiyo Saito
    Chemicals Evaluation and Research Institute, Japan, 1600 Shimo Takano, Sugito, Kitakatsushika, Saitama 345 0043, Japan
    Toxicol In Vitro 20:1343-53. 2006
    ..Further exposure study using xenobiotics needs to be done to validate the potential utility of RNAi technology...
  3. ncbi A two-generation reproductive toxicity study of butyl benzyl phthalate in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:39-58. 2005
    ..The NOEL and NOAEL for the growth and development of offspring were concluded to be less than 100 mg/kg/day...
  4. ncbi A two-generation reproductive toxicity study of 4-nitrotoluene in rats
    Sunao Aso
    Chemicals Evaluation and Research Institute, Ishii machi, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:117-134. 2005
    ....
  5. ncbi Two-generation reproductive toxicity studies in rats with extra parameters for detecting endocrine disrupting activity: introductory overview of results for nine chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    J Toxicol Sci 30:1-4. 2005
    ....
  6. ncbi Influence of dispersants on bioconcentration factors of seven organic compounds with different lipophilicities and structures
    Naoaki Yakata
    Chemicals Evaluation and Research Institute Japan, Kurume Laboratory, 3 2 7 Miyanojin, Kurume, Fukuoka 839 0801, Japan
    Chemosphere 64:1885-91. 2006
    ..This result indicates that the dispersants had no influence on the evaluation of the bioconcentration potential of these test substances...
  7. ncbi Determination of mustard and lewisite related compounds in abandoned chemical weapons (Yellow shells) from sources in China and Japan
    Shigeyuki Hanaoka
    Tokyo Laboratory, Chemicals Evaluation and Research Institute, Environmental Technology Department, Kitakatsushika, Saitama 345 0043, Japan
    J Chromatogr A 1101:268-77. 2006
    ..Comparison of the components in the Yellow agents with mustard recovered in both Japan and China showed a difference in the impurities between the CWAs produced by the former Imperial navy and those by the former Imperial army...
  8. ncbi Two-step models to predict binding affinity of chemicals to the human estrogen receptor alpha by three-dimensional quantitative structure-activity relationships (3D-QSARs) using receptor-ligand docking simulation
    Y Akahori
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Japan, 1600 Shimotakano, Sugito machi, Kitakatsushika gun, Saitama 345 0043, Japan
    SAR QSAR Environ Res 16:323-37. 2005
    ..75 and 0.74, respectively. However good MLR relationships were not obtained for phthalates and benzophenones as the observed binding affinities of chemicals in these categories were weak and in a too narrow range...
  9. ncbi Advantage of using CBA/N strain mice in a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 26:5-9. 2006
    ....
  10. ncbi Fish full life-cycle testing for 17beta-estradiol on medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan CERI, 3 2 7, Miyanojin, Kurume shi, Fukuoka 839 0801, Japan
    Environ Toxicol Chem 24:1259-66. 2005
    ..66 ng/L, suggesting that the ecological risk of E2 is higher than that of weak estrogens, such as nonylphenol and octylphenol...
  11. ncbi Identification and quantitative determination of diphenylarsenic compounds in abandoned toxic smoke canisters
    Shigeyuki Hanaoka
    Tokyo Laboratory, Chemicals Evaluation and Research Institute, Environmental Technology Department, 1600 Shimo Takano, Sugito, Kitakatsushika, Saitama 3450043, Japan
    J Chromatogr A 1085:213-23. 2005
    ....
  12. ncbi Ability of the Hershberger assay protocol to detect thyroid function modulators
    Shuji Noda
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 822, 3 Chome, Ishii machi, Hita shi, Oita 877 0061, Japan
    Arch Toxicol 79:627-35. 2005
    ..These results suggest that the effect of AT can be detected by the Hershberger assay 10-day administration protocol and may be useful for screening for thyroid function modulators regardless of whether the animals have been castrated...
  13. ncbi Comparison of response to 17 beta-estradiol and 17 beta-trenbolone among three small fish species
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan, 3 2 7, Miyanojin, Kurume shi, Fukuoka 839 0801, Japan
    Environ Toxicol Chem 25:2742-52. 2006
    ....
  14. ncbi Quantitative proteomic analysis of rat liver for carcinogenicity prediction in a 28-day repeated dose study
    Hidenori Yamanaka
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Saitama, Japan
    Proteomics 7:781-95. 2007
    ..The list of proteins identified in this study and the zoomed gel images of the top ranked proteins in statistic analysis are provided in Supplementary Data...
  15. ncbi Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4 -[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] based on the OECD draft protocols
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita, 877 0061, Japan
    Arch Toxicol 81:749-57. 2007
    ..407. However, the changes were observed in rats given a high dose of the chemical, 1,000 mg/kg day...
  16. doi Evaluation for skin sensitization based on published literatures (existing information) of major PRTR designated chemical substances in Japan
    Satoko Ishii
    Chemicals Evaluation and Research Institute, Japan, Chemicals Assessment and Research Center, 1 4 25 Kouraku, Bunkyou ku, Tokyo 112 0004, Japan
    Regul Toxicol Pharmacol 55:43-51. 2009
    ....
  17. doi Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p'-DDE in Sprague-Dawley rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 1 4 25, Kouraku, Bunkyo ku, Tokyo 112 0004, Japan
    Toxicol Lett 189:14-20. 2009
    ....
  18. ncbi Comprehensive identification of cytochrome p450 isoforms from solubility-based fractionated rat liver microsomes
    Hidenori Yamanaka
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 1600, Shimo Takano, Sugito machi, Kitakatsushika gun, Saitama 345 0043, Japan
    Drug Metab Lett 1:281-6. 2007
    ..The combination of proteomic analysis and the solubility-based fractionation would provide powerful tool for the expression analysis of the superfamily proteins having great similarities between the amino acids sequences...
  19. doi Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 3-amino-1,2,4-triazole based on the Organization for Economic Co-operation and Development draft protocols
    Takaaki Umano
    Chemicals Evaluation and Research Institute, Bunkyo ku, Tokyo, Japan
    Arch Toxicol 83:459-67. 2009
    ..In addition, decreased body weight, and abnormal biochemical parameters attributed to thyroid, liver or kidney dysfunction were observed in male and female rats in the 25 and/or 125 mg/kg groups...
  20. ncbi High-accuracy prediction of carcinogenicity by global quantitative analysis of post-translational modifications in a 28-day in vivo rat study
    Hidenori Yamanaka
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Saitama, Japan
    Cancer Genomics Proteomics 5:105-16. 2008
    ..4%) than prediction from protein expression data (74.2%). This novel approach holds great promise as a way of revealing the roles of charge modifications and molecular weight variations of proteins in biological processes...
  21. ncbi Effects of toluene-2,4-diamine on red sea bream, Pagrus major: biochemical and histological evaluation
    Toshiki Nozaka
    Kurume Laboratory, Chemicals Evaluation and Research Institute, Japan, 3 2 7 Miyanojin, Kurume shi, Fukuoka, Japan
    Environ Sci 14:1-8. 2007
    ..In addition, cytoplasmic changes were observed in the cells of fish exposed to the highest concentration. It is suggested that the changes were caused by the decrease in feed efficiency derived from the exposure to 2,4-TDA...
  22. doi Development and application of a stable HeLa cell line capable of site-specific transgenesis using the Cre-lox system: establishment and application of a stable TNFRI knockdown cell line to cytotoxicity assay
    Fumiyo Saito
    Chemicals Assessment Center, Environmental Effect Research Section, Chemicals Evaluation and Research Institute, Japan
    Toxicol In Vitro 22:1077-87. 2008
    ..Thus, we showed the feasibility of RNAi-based stable knockdown cells for xenobiotics-induced cytotoxicity, and HeLa55 has wide application for the generation of stable knock-in and knock-down cells mediated by RNAi...
  23. ncbi Skin sensitization potency of isoeugenol and its dimers evaluated by a non-radioisotopic modification of the local lymph node assay and guinea pig maximization test
    Masahiro Takeyoshi
    Health Effect Research Section, Chemicals Assessment Center, Chemicals Evaluation and Research Institute CERI Japan, 1600, Shimotakano, Sugito machi, Kitakatsushika gun, Saitama 345 0043, Japan
    J Appl Toxicol 28:530-4. 2008
    ..The data may also provide useful information for the structure-activity relationship (SAR) in skin sensitization...
  24. ncbi Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the OECD draft protocols
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita, Japan
    Arch Toxicol 82:301-11. 2008
    ....
  25. ncbi Relationship between the results of in vitro receptor binding assay to human estrogen receptor alpha and in vivo uterotrophic assay: comparative study with 65 selected chemicals
    Yumi Akahori
    Department of Human Environmental Science, Ochanomizu University, 2 1 1, Otsuka, Bunkyo ku, Tokyo 112 8610, Japan
    Toxicol In Vitro 22:225-31. 2008
    ..The usage of this value as cutoff provided the best concordance rate (82%). These findings are useful in a tiered approach for identifying chemicals that have potential to induce ER-mediated effects in vivo...
  26. ncbi Subacute oral toxicity study of bisphenol F based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"
    Nobuhiko Higashihara
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita, 877 0061, Japan
    Arch Toxicol 81:825-32. 2007
    ....
  27. ncbi Changes in serum alpha2u-globulin levels in castrated male rats treated with testosterone propionate in a Hershberger assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 25:176-8. 2005
    ....
  28. ncbi Development of vitellogenin assay for endocrine disrupters using medaka (Oryzias latipes)
    Toshiki Nozaka
    Kurume Research Laboratory, Chemicals Evaluation and Research Institute, 19 14 Chuo machi, Kurume shi, Fukuoka 830 0023, Japan
    Environ Sci 11:99-121. 2004
    ..This is because the sensitivity of the VTG response in medaka may be almost the same as that of other fish using blood samples...
  29. ncbi Development of a high-performance reporter plasmid for detection of chemicals with androgenic activity
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, 8770061, Oita, Japan
    Arch Toxicol 77:274-9. 2003
    ..This new type of reporter plasmid, ARE-AUG- Luc+, should be of value in endocrine research and in screening to identify endocrine-modulating chemicals...
  30. ncbi Unique bioconcentration characteristics of new aryl fluoroalkyl ethers in common carp (Cyprinus carpio)
    Naoaki Yakata
    Chemicals Evaluation and Research Institute, Kurume Laboratory, 19 14 Chuo machi, Kurume, Fukuoka 830 0023, Japan
    Chemosphere 51:153-61. 2003
    ..In addition, the logP(ow) of the bis-type compounds calculated by commercially available computer software was remarkably different from that measured...
  31. ncbi Immature rat uterotrophic assay of 18 chemicals and Hershberger assay of 30 chemicals
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 183:93-115. 2003
    ..In the Hershberger assay, a clear androgen agonistic effect was detected in the androgen derivatives testosterone enanthate and methyltestosterone...
  32. ncbi Immature uterotrophic assay of estrogenic compounds in rats given diets of different phytoestrogen content and the ovarian changes with ICI 182,780 or antide
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 0877 0061, Japan
    Arch Toxicol 76:613-20. 2002
    ....
  33. ncbi Comparison of toxicity studies based on the draft protocol for the 'Enhanced OECD Test Guideline no. 407' and the research protocol of 'Pubertal Development and Thyroid Function in Immature Male Rats' with 6-n-propyl-2-thiouracil
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Arch Toxicol 76:495-501. 2002
    ....
  34. ncbi Effect of gonadotropin-releasing hormone antagonist on ovarian and uterine weights in immature female rats
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    Reprod Toxicol 16:367-9. 2002
    ....
  35. ncbi Effect of ethinylestradiol on the reproduction and induction of vitellogenin and testis-ova in medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan, Kurume shi, Fukuoka
    Environ Toxicol Chem 21:1692-8. 2002
    ..This suggests that the elevated VTG levels and testis-ova may not be definitely responsible for reproductive impairment of the fish...
  36. ncbi Changes of serum alpha 2u-globulin in the subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the 'Enhanced OECD Test Guideline No. 407'
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, Chemicals Assessment Center, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Toxicology 176:101-12. 2002
    ..Although the alpha 2u-globulin level was reduced in this assay using BPA and EE, further studies are necessary before this assay becomes a useful method for detecting endocrine-mediated effects...
  37. ncbi Subacute oral toxicity study of ethynylestradiol and bisphenol A, based on the draft protocol for the "Enhanced OECD Test Guideline no. 407"
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, Oita 877 0061, Japan
    Arch Toxicol 76:65-74. 2002
    ....
  38. ncbi Uterotrophic and Hershberger assays for n-butylbenzene in rats
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, Oita, Japan
    Arch Toxicol 75:703-6. 2002
    ..These findings suggest that nBB does not have any endocrine-disrupting properties on in vivo screening tests...
  39. ncbi The efficacy of endocrine disruptor screening tests in detecting anti-estrogenic effects downstream of receptor-ligand interactions
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, 8770061, Oita, Japan
    Toxicol Lett 126:91-8. 2002
    ..Particularly, the reporter gene assay may be a promising prescreening procedure, because it can be adopted in the high throughput screening process for thousands of chemicals and it requires no use of experimental animals...
  40. ncbi Fish full life-cycle testing for the weak estrogen 4-tert-pentylphenol on medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan, 19 14, Chuo machi, Kurume shi, Fukuoka, 830 0023, Japan
    Environ Toxicol Chem 22:1487-96. 2003
    ..Thus, 4-PP has estrogenic effects that reduce the reproductive potential of medaka. The results indicate that the FFLC with medaka is applicable to the evaluation of weak estrogens...
  41. ncbi Effects of 4-nonylphenol and 4-tert-octylphenol on sex differentiation and vitellogenin induction in medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan 19 14, Chuo machi, Kurume shi, Fukuoka 830 0023, Japan
    Environ Toxicol Chem 22:1507-16. 2003
    ....
  42. ncbi Verification of the BALB/c 3T3 cell transformation assay after improvement by using an ITES-medium
    Yoshitsugu Kajiwara
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Japan, 3 822, Ishii machi, 877 0061, Hita shi, Oita, Japan
    Toxicol In Vitro 17:489-96. 2003
    ....
  43. ncbi Novel approach for classifying chemicals according to skin sensitizing potency by non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Hita Laboratory, Chemicals Evaluation and Research Institute, 3 822 Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 25:129-34. 2005
    ..Accordingly, this approach would be an effective modification of LLNA with regard to its experimental design. Moreover, this procedure can be applied also to the standard LLNA with radioisotopes and to other modifications of the LLNA...
  44. ncbi Effects of in utero and lactational exposure to tamoxifen in SD rats
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicol Lett 156:289-96. 2005
    ..6 and 3 microg/kg/day groups. No abnormalities were detected in the reproductive performance of the male and female offspring...
  45. ncbi Effects of in utero and lactational exposure to flutamide in SD rats: comparison of the effects of administration periods
    Kanji Yamasaki
    Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 209:47-54. 2005
    ..The present data demonstrated that the endocrine-mediated effects on rats were more appreciable in offspring treated with FLUT after weaning than in offspring untreated after weaning...
  46. ncbi Effects of 4-tert-pentylphenol on the gene expression of P450 11beta-hydroxylase in the gonad of medaka (Oryzias latipes)
    Hirofumi Yokota
    Chemical Assessment Center, Chemicals Evaluation and Research Institute, Kitakatsushika gun, Saitama 345 0043, Japan
    Aquat Toxicol 71:121-32. 2005
    ..These results suggest that xeno-estrogen 4-PP may have inhibitory effects on the synthesis of testicular 11-oxygenated androgens through downregulation of P450(11beta) expression in the genetically male fish...
  47. ncbi Fish full life-cycle testing for androgen methyltestosterone on medaka (Oryzias latipes)
    Masanori Seki
    Chemicals Evaluation and Research Institute, Japan CERI, 19 14, Chuo machi, Kurume shi, Fukuoka, 830 0023, Japan
    Environ Toxicol Chem 23:774-81. 2004
    ..These results indicate that MT reduces the reproductive potential of medaka and that the FFLC with this species is applicable to the evaluation of androgens...
  48. ncbi Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, Oita 877 0061, Japan
    Toxicology 195:177-86. 2004
    ..On the other hand, the Hershberger assays of three phthalates were performed at the same dosages, and the results showed androgen antagonistic affinity only in the assay of phthalic acid di-n-amyl ester without receptor binding affinity...
  49. ncbi Assessment of the skin sensitization potency of eugenol and its dimers using a non-radioisotopic modification of the local lymph node assay
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita 8770061, Japan
    J Appl Toxicol 24:77-81. 2004
    ..These investigations provide support for the proposal that the non-radioisotopic LLNA may serve as an effective alternative to the GPMT where there is a need to avoid the use of radioisotopes...
  50. pmc OECD validation of the Hershberger assay in Japan: phase 2 dose response of methyltestosterone, vinclozolin, and p,p'-DDE
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, Hita, Oita, Japan
    Environ Health Perspect 111:1912-9. 2003
    ..Therefore, the Japanese studies support the Hershberger assay as a reliable and reproducible screening assay for the detection of androgen agonistic and antagonistic effects...
  51. ncbi Comparative study of the uterotrophic potency of 14 chemicals in a uterotrophic assay and their receptor-binding affinity
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822 Ishii, Hita, 877 0061 Oita, Japan
    Toxicol Lett 146:111-20. 2004
    ....
  52. ncbi Assessment of statistic analysis in non-radioisotopic local lymph node assay (non-RI-LLNA) with alpha-hexylcinnamic aldehyde as an example
    Masahiro Takeyoshi
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii machi, Hita shi, Oita, 8770061, Japan
    Toxicology 191:259-63. 2003
    ..The challenge is to develop strategies for further refinement of this approach...
  53. ncbi In utero through lactational exposure to ethinyl estradiol induces cleft phallus and delayed ovarian dysfunction in the offspring
    Masakuni Sawaki
    Chemicals Evaluation and Research Institute, Chemicals Assessment Center, Hita, Oita, Japan
    Toxicol Sci 75:402-11. 2003
    ..These findings are consistent with delayed anovulation syndrome. The results suggest that observation of cyclicity at 6 months old is able to detect possible delayed ovarian dysfunction induced by perinatal exposure to chemicals...
  54. ncbi Comparison of reporter gene assay and immature rat uterotrophic assay of twenty-three chemicals
    Kanji Yamasaki
    Chemicals Assessment Center, Chemicals Evaluation and Research Institute, 3 822, Ishii, Hita, 877 0061, Oita, Japan
    Toxicology 170:21-30. 2002
    ..9202). These findings demonstrate that PC10 values are preferable to EC50 and PC50 values for predicting the estrogenic activities of chemicals...