Futoshi Akiyama

Summary

Affiliation: Cancer Institute Hospital
Country: Japan

Publications

  1. pmc Skin invasion and prognosis in node negative breast cancer: a retrospective study
    Keiichiro Tada
    Department of Breast Surgery, Cancer Institute Hospital, Tokyo, Japan
    World J Surg Oncol 6:10. 2008
  2. pmc Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer
    Keiichiro Tada
    Department of Breast Surgery, Cancer Institute Hospital, Tokyo, Japan
    World J Surg Oncol 8:6. 2010
  3. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
  4. doi request reprint Therapeutic strategies for breast cancer based on histological type
    Futoshi Akiyama
    Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 16:168-72. 2009
  5. doi request reprint Triple negative breast cancer: clinicopathological characteristics and treatment strategies
    Futoshi Akiyama
    Department of Pathology, Cancer Institute, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 16:252-3. 2009
  6. doi request reprint Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy
    Tomo Osako
    Division of Pathology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3 10 6, Ariake, Koto ku, Tokyo, 135 8550, Japan
    J Cancer Res Clin Oncol 136:233-41. 2010
  7. doi request reprint High-grade breast cancers include both highly sensitive and highly resistant subsets to cytotoxic chemotherapy
    Tomo Osako
    Divisions of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 8 31, Ariake, Koto ku, Tokyo, 135 8550, Japan
    J Cancer Res Clin Oncol 136:1431-8. 2010
  8. pmc Incidence and prediction of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ
    Tomo Osako
    Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan Department of Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Cancer Sci 105:576-82. 2014
  9. doi request reprint Clinicopathologic study of 53 metaplastic breast carcinomas: their elements and prognostic implications
    Rin Yamaguchi
    Department of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    Hum Pathol 41:679-85. 2010
  10. doi request reprint Sentinel node tumour burden quantified based on cytokeratin 19 mRNA copy number predicts non-sentinel node metastases in breast cancer: molecular whole-node analysis of all removed nodes
    Tomo Osako
    Division of Pathology, The Cancer Institute of Japanese Foundation for Cancer Research, 3 8 31, Ariake, Koto ku, Tokyo 135 8550, Japan
    Eur J Cancer 49:1187-95. 2013

Detail Information

Publications49

  1. pmc Skin invasion and prognosis in node negative breast cancer: a retrospective study
    Keiichiro Tada
    Department of Breast Surgery, Cancer Institute Hospital, Tokyo, Japan
    World J Surg Oncol 6:10. 2008
    ..The impact of skin invasion in node negative breast cancer is uncertain...
  2. pmc Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer
    Keiichiro Tada
    Department of Breast Surgery, Cancer Institute Hospital, Tokyo, Japan
    World J Surg Oncol 8:6. 2010
    ..The impact of sentinel lymph node biopsy on breast cancer mimicking ductal carcinoma in situ (DCIS) is a matter of debate...
  3. pmc Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years
    Naoko Honma
    Research Team for Geriatric Diseases, Tokyo Metropolitan Institute of Gerontology, Sakaecho 35 2, Itabashi ku, Tokyo 173 0015, Japan
    Breast Cancer Res 11:R48. 2009
    ..The aim of the present study is to elucidate whether there are any specific patterns in use of multiple exons 1 in elderly breast tissue...
  4. doi request reprint Therapeutic strategies for breast cancer based on histological type
    Futoshi Akiyama
    Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 16:168-72. 2009
    ..Histological diagnosis is also significant from the viewpoint of drug sensitivity, and it is important to maintain the accuracy of histological diagnosis...
  5. doi request reprint Triple negative breast cancer: clinicopathological characteristics and treatment strategies
    Futoshi Akiyama
    Department of Pathology, Cancer Institute, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 16:252-3. 2009
    ..This special issue consists of five conference papers that have been agreed on by the speakers and the commentator of the symposium of the 16th Annual Meeting of the Japanese Breast Cancer Society in September 2008 in Osaka...
  6. doi request reprint Common and discriminative clinicopathological features between breast cancers with pathological complete response or progressive disease in response to neoadjuvant chemotherapy
    Tomo Osako
    Division of Pathology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3 10 6, Ariake, Koto ku, Tokyo, 135 8550, Japan
    J Cancer Res Clin Oncol 136:233-41. 2010
    ....
  7. doi request reprint High-grade breast cancers include both highly sensitive and highly resistant subsets to cytotoxic chemotherapy
    Tomo Osako
    Divisions of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 8 31, Ariake, Koto ku, Tokyo, 135 8550, Japan
    J Cancer Res Clin Oncol 136:1431-8. 2010
    ..To determine the highly sensitive and highly resistant subsets to cytotoxic chemotherapy, we evaluated predictive factors for pCR and PD to NAC, and assessed the similarities in these factors...
  8. pmc Incidence and prediction of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ
    Tomo Osako
    Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan Department of Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Cancer Sci 105:576-82. 2014
    ..More accurate application of SN biopsy is required for patients with a preoperative diagnosis of DCIS...
  9. doi request reprint Clinicopathologic study of 53 metaplastic breast carcinomas: their elements and prognostic implications
    Rin Yamaguchi
    Department of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo 135 8550, Japan
    Hum Pathol 41:679-85. 2010
    ..The presence of high-grade spindle cells in metaplastic breast carcinoma may indicate aggressive behavior...
  10. doi request reprint Sentinel node tumour burden quantified based on cytokeratin 19 mRNA copy number predicts non-sentinel node metastases in breast cancer: molecular whole-node analysis of all removed nodes
    Tomo Osako
    Division of Pathology, The Cancer Institute of Japanese Foundation for Cancer Research, 3 8 31, Ariake, Koto ku, Tokyo 135 8550, Japan
    Eur J Cancer 49:1187-95. 2013
    ..We aim to reveal the usefulness of the OSNA assay regarding the prediction of non-SN metastasis...
  11. doi request reprint Long-term prognoses and outcomes of axillary lymph node recurrence in 2,578 sentinel lymph node-negative patients for whom axillary lymph node dissection was omitted: results from one Japanese hospital
    Akiko Ogiya
    Breast Oncology Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Breast Cancer 23:318-22. 2016
    ..We examined the long-term results of omission of axillary dissection in sentinel lymph node-negative patients treated at our hospital, as well as their axillary lymph node recurrence characteristics and outcomes...
  12. doi request reprint Detection of occult invasion in ductal carcinoma in situ of the breast with sentinel node metastasis
    Tomo Osako
    Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Cancer Sci 104:453-7. 2013
    ..Patient follow-up is required to elucidate the prognostic impact of nodal metastasis and occult invasion...
  13. doi request reprint Reoperative sentinel lymph node biopsy for ipsilateral breast tumor recurrence after previous axillary lymph node dissection: report of a case
    Masaya Hattori
    Department of Breast Oncology, Cancer Institute Hospital of Japanese Foundation For Cancer Research, 3 10 6 Ariake, Koto ku, Tokyo, Japan
    Surg Today 41:247-50. 2011
    ....
  14. doi request reprint Intraoperative molecular assay for sentinel lymph node metastases in early stage breast cancer: a comparative analysis between one-step nucleic acid amplification whole node assay and routine frozen section histology
    Tomo Osako
    Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Cancer 117:4365-74. 2011
    ..The authors compared the performance in intraoperative detection of sentinel lymph node metastases with OSNA assay using a whole lymph node versus routine frozen section (FS) histology with a 2 mm-sectioned lymph node...
  15. doi request reprint What causes discrepancies in HER2 testing for breast cancer? A Japanese ring study in conjunction with the global standard
    Shinobu Umemura
    Department of Pathology, Tokai University School of Medicine, Isehara, Japan
    Am J Clin Pathol 130:883-91. 2008
    ..By performing FISH retesting for these samples, consistency among multiple institutions could be archived. The quality of the staining procedures performed and the consistency of evaluations require regular assessment...
  16. doi request reprint Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors
    Makoto Abe
    Department of Breast Oncology, Cancer Institute Hospital, 3 10 6 Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 18:268-72. 2011
    ..We examined the clinical behavior of these lesions in an attempt to determine appropriate management. We evaluated long-term outcome and clinical characteristics of malignant phyllodes tumors arising from fibroadenomas of the breast...
  17. ncbi request reprint Intraductal papilloma with bloody discharge from Montgomery's areolar tubercle examined by ductoscopy from the areola
    Takehiko Sakai
    Breast Pathology Section, Cancer Institute, Japanese Foundation for Cancer Research, 3 10 6, Ariake, Tokyo 135 8550, Japan
    Breast Cancer 13:104-6. 2006
    ..Although there are a few breast carcinomas that cause bloody discharge and eruption of areola, areolar preservation should be performed with the knowledge that disease may also involve the areola through the lactiferous ducts...
  18. doi request reprint Histogenesis of metaplastic breast carcinoma and axillary nodal metastases
    Tomo Osako
    Division of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Ariake, Koto ku, Tokyo, Japan
    Pathol Int 59:116-20. 2009
    ..This suggested that the ductal component metastasized to the nodes and that epithelial-mesenchymal transition subsequently occurred within the nodes...
  19. ncbi request reprint Histological features of breast cancer, highly sensitive to chemotherapy
    Rie Horii
    Department of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Koto ku, Tokyo, 135 8550, Japan
    Breast Cancer 14:393-400. 2007
    ..To establish tailor-made therapy for breast cancer, we investigated the possibility of predicting chemotherapy sensitive cases based on pre-therapeutic histological features...
  20. doi request reprint Breast cancer associated with mammary hamartoma
    Masaya Kai
    Department of Breast Surgery, Cancer Institute Hospital, Koto ku, Tokyo, Japan
    Breast Cancer 19:183-6. 2012
    ..We describe a case of invasive ductal carcinoma arising in the mammary hamartoma during the follow-up period of a previously diagnosed hamartoma...
  21. doi request reprint Clinicopathological significance of invasive micropapillary carcinoma component in invasive breast carcinoma
    Yoshimi Ide
    Division of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Pathol Int 61:731-6. 2011
    ..The presence of IMP components was a significant predictive factor for nodal metastasis, even if it is detected in only a small proportion of the tumor...
  22. doi request reprint Apocrine metaplasia of breast cancer: clinicopathological features and predicting response
    Akiko Ogiya
    Department of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, Koto ku, Tokyo, Japan
    Breast Cancer 17:290-7. 2010
    ..We thus considered that apocrine metaplasia (AM) might represent a predictive marker for breast cancer...
  23. doi request reprint Non-sentinel lymph node analysis with one-step nucleic acid amplification in breast cancer patients
    Akiko Ogiya
    Department of Surgical Oncology, Breast Oncology Center, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo 135 8550, Japan Electronic address
    Breast 24:476-80. 2015
    ..In this study, we conducted a whole-node analysis of non-sentinel lymph nodes (SLNs) using the OSNA method in SLN metastasis-positive breast cancer patients...
  24. pmc Differences in clinical importance of Bcl-2 in breast cancer according to hormone receptors status or adjuvant endocrine therapy
    Naoko Honma
    Department of Pathology, School of Medicine, Toho University, 5 21 16 Omori nishi, Ota ku, Tokyo, 143 8540, Japan
    BMC Cancer 15:698. 2015
    ..We constructed a large systematic study to determine whether Bcl-2 has an independent role in breast cancer...
  25. doi request reprint Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristics
    Rie Horii
    Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Int J Clin Oncol 20:490-8. 2015
    ..The aim of this study was to extensively analyze the signaling pathway molecules in breast cancer and to explore candidate biomarkers for clinicopathological relevance...
  26. ncbi request reprint Assessment of hormone receptor status in breast cancer
    Rie Horii
    Department of Pathology, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo, Japan
    Pathol Int 57:784-90. 2007
    ..When assessing hormone receptors of breast cancer in routine clinical settings, it is sufficient to determine the proportion of positive cells in the entire cancer area...
  27. ncbi request reprint Spontaneous " healing" of breast cancer
    Rie Horii
    Department of Breast Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 12:140-4. 2005
    ..Healing is a phenomenon by which the intraductal component of breast cancer disappears and is replaced by fibrous tissue. Focally localized healing often prevents confirmation of the continuity of intraductal carcinoma...
  28. ncbi request reprint A case of carcinosarcoma of the breast
    Nahomi Tokudome
    Department of Breast Pathology, The Cancer Institute, 3 10 16 Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 12:149-53. 2005
    ..Such tumors are very rare, and there have been no detailed reports of recurrence patterns of carcinosarcoma. Here we report our pathological findings in detail...
  29. doi request reprint Neoadjuvant chemotherapy followed by radical hysterectomy plus postoperative chemotherapy but no radiotherapy for Stage IB2-IIB cervical cancer--irinotecan and platinum chemotherapy
    Maki Matsumura
    Department of Gynecology, Cancer Institute Hospital, Ariake 3 8 31, Koutou ku, Tokyo 135 8550, Japan
    Gynecol Oncol 119:212-6. 2010
    ..To evaluate the effectiveness of neoadjuvant chemotherapy (NAC) followed by radical hysterectomy plus postoperative chemotherapy but no radiotherapy for stage IB2-IIB cervical cancer...
  30. doi request reprint Comparison of dual-color in-situ hybridization and fluorescence in-situ hybridization in HER2 gene amplification in breast cancer
    Rie Horii
    Division of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Breast Cancer 21:598-604. 2014
    ..HER2 tests are essential in invasive and metastatic breast cancer. Dual-color in-situ hybridization (DISH) is a novel genetic test, and we investigated its utility in HER2 testing in breast cancer...
  31. doi request reprint Secretory carcinoma of the breast and its histopathological mimics: value of markers for differential diagnosis
    Tomo Osako
    Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
    Histopathology 63:509-19. 2013
    ..However, differential markers have not yet been assessed systematically, and we aimed to identify and evaluate novel and existing markers...
  32. ncbi request reprint Clinical and pathologic features of fibroadenoma of the mastopathic type
    Hajime Kuroda
    Department of Pathology, Saitama Medical Center, Saitama Medical School, 1981 Tsujido, Kamoda, Kawagoe, Saitama, Japan
    Surg Today 36:590-5. 2006
    ..This histological subtype remains poorly understood because of its rarity. Many questions remain unanswered about its clinicopathological importance, especially in the differential diagnosis of breast cancers...
  33. ncbi request reprint General rules for clinical and pathological recording of breast cancer 2005
    Goi Sakamoto
    Cancer Institute Ariake Hospital, 3 10 6 Ariake, Koto ku, Tokyo135 8550, Japan
    Breast Cancer 12:S1-27. 2005
  34. ncbi request reprint Present state of and problems with core needle biopsy for non-palpable breast lesions
    Takuji Iwase
    Department of Breast Surgery, Cancer Institute Hospital, Tokyo 135 8550, Japan
    Breast Cancer 13:32-7. 2006
    ....
  35. doi request reprint Carcinoma in a solitary intraductal papilloma of the breast
    Rin Yamaguchi
    Department of Pathology, Cancer Institute Hospital, Tokyo, Japan
    Pathol Int 59:185-7. 2009
    ..An additional partial mastectomy was performed after the lumpectomy but no carcinoma foci were noted in the excised tissue. Possible occurrence of cancerous change in solitary intraductal papilloma of the breast was suspected...
  36. doi request reprint Mammary ductoscopy and watchful follow-up substitute microdochectomy in patients with bloody nipple discharge
    Masujiro Makita
    Department of Breast Surgical Oncology, Breast Center, Cancer Institute Hospital, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Breast Cancer 23:242-51. 2016
    ....
  37. doi request reprint Development of an easy method to test for HER2 in breast cancer using dual-color in situ hybridization
    Tomoe Nakagawa
    Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Breast Cancer 23:78-84. 2016
    ..We devised an easy method for HER2 gene testing and investigated its utility...
  38. doi request reprint Efficacy of fulvestrant 500 mg in Japanese postmenopausal advanced/recurrent breast cancer patients and factors associated with prolonged time-to-treatment failure
    Kazuhiro Araki
    a Breast Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3 8 1 Ariake, Koto ku, Tokyo 135 8550, Japan
    Expert Opin Pharmacother 16:2561-8. 2015
    ..We aimed to confirm the efficacy of fulvestrant in Japanese postmenopausal advanced/recurrent breast cancer (ABC) patients, and investigate factors contributing to time-to-treatment failure (TTF) prolongation...
  39. doi request reprint A clinico-pathological study on cancer in sclerosing adenosis
    Kaoru Ogura
    Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan
    Breast Cancer 21:732-7. 2014
    ..This study aimed to elucidate the features of the former by comparing both types...
  40. doi request reprint Proportion of estrogen or progesterone receptor expressing cells in breast cancers and response to endocrine therapy
    Naoko Honma
    Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, Tokyo 173 0015, Japan Department of Pathology, Cancer Institute, 3 8 31 Ariake, Koto ku, Tokyo 135 8550, Japan Electronic address
    Breast 23:754-62. 2014
    ..Patients having tumors without any ER/PR-positive cells should be excluded from endocrine therapy, whereas this therapy should be strongly recommended for those with ≥67% ER/PR-positive cells. ..
  41. pmc Proposal of a novel method for observing the breast by high-resolution ultrasound imaging: understanding the normal breast structure and its application in an observational method for detecting deviations
    Ayumi Izumori
    The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3 8 31 Ariake, Koto ku, Tokyo, 135 8550, Japan
    Breast Cancer 20:83-91. 2013
    ..We elucidated the detailed histological architecture of the normal breast, information indispensable for diagnostic US of the breast...
  42. doi request reprint Histopathological criteria for assessment of therapeutic response in breast cancer (2007 version)
    Masafumi Kurosumi
    Department of Pathology, Saitama Cancer Center, Saitama, Japan
    Breast Cancer 15:5-7. 2008
  43. ncbi request reprint One-step nucleic acid amplification for intraoperative detection of lymph node metastasis in breast cancer patients
    Masahiko Tsujimoto
    Department of Pathology, Osaka Police Hospital, Japan
    Clin Cancer Res 13:4807-16. 2007
    ..The purpose of this study is to develop a more efficient method for intraoperative detection of lymph node metastasis...
  44. ncbi request reprint Recommendations for 'adequate evaluation of hormone receptors' a report of the task force of the Japanese Breast Cancer Society
    Shinobu Umemura
    Department of Pathology, Tokai University School of Medicine, Isehara 259 1193, Japan
    Oncol Rep 24:299-304. 2010
    ..Herein, we summarize the evidence, on which the recommendations were made, and customize the recommendations suitable for the current status...
  45. doi request reprint Prognostic value of matrix Gla protein in breast cancer
    Keiko Yoshimura
    Genome Center, Japanese Foundation for Cancer Research, Cancer Institute Hospital, Tokyo 135 8550, Japan
    Mol Med Report 2:549-53. 2009
    ..In breast cancer cases, the mRNA level of MGP may be a marker indicating poor prognosis; however, protein expression determined by immunohistostaining is not...
  46. ncbi request reprint Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer
    Yoko Oishi
    Department of Molecular Diagnosis, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    J Hum Genet 52:271-9. 2007
    ..We also determined that immunohistostaining for the Stathmin1 gene product is a potential tool for predicting the outcome of breast cancer patients with supraclavicular lymph node metastasis...
  47. ncbi request reprint [Histological features of breast cancer as predictive factors for chemotherapy]
    Rie Horii
    Department of Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research
    Nihon Rinsho 65:160-4. 2007
  48. ncbi request reprint Classification of ipsilateral breast tumor recurrence after breast-conserving therapy: new primary cancer allows a good prognosis
    Seiichiro Nishimura
    Department of Breast Surgery, Cancer Institute Ariake Hospital, 3 10 6, Ariake, Koto ku, Tokyo 135 8550, Japan
    Breast Cancer 12:112-7. 2005
    ..To classify and assess ipsilateral breast tumor recurrences (IBTR) after breast-conserving therapy...
  49. ncbi request reprint Evaluation of HER-2 status in breast carcinoma by fluorescence in situ hybridization and immunohistochemistry
    Hiroyuki Ogura
    Department of Breast Pathology, The Cancer Institute of the Japanese Foundation for Cancer Research, 1 37 1, Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Breast Cancer 10:234-40. 2003
    ..Evaluation of HER-2 status is essential for selecting appropriate candidates for treatment with trastuzumab, a recombinant humanized monoclonal antibody active against human epidermal growth factor receptor-2 (HER-2) protein...