M Suzuki

Summary

Affiliation: Biological Research Laboratories
Country: Japan

Publications

  1. ncbi request reprint Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors
    M Suzuki
    Central Research Laboratories, Nissan Chemical Industries, Ltd, 722 1 Tsuboi cho, Funabashi, 274 8507, Chiba, Japan
    Bioorg Med Chem 9:2727-43. 2001
  2. ncbi request reprint Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors
    M Suzuki
    Central Research Institute, Nissan Chemical Industries, Ltd, Funabashi, Chiba, Japan
    Bioorg Med Chem Lett 11:1285-8. 2001
  3. ncbi request reprint First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104
    M Suzuki
    Central Research Institute, Nissan Chemical Industries Ltd, Funabashi, Chiba, Japan
    Bioorg Med Chem Lett 9:2977-82. 1999
  4. ncbi request reprint Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists
    M Suzuki
    Research Center, Taisho Pharmaceutical Co, Ltd, Ohmiya, Saitama, Japan
    Chem Pharm Bull (Tokyo) 48:2003-8. 2000
  5. ncbi request reprint Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid
    T Nakanishi
    Pharmaceuticals Group, Nippon Kayaku Company, Ltd, 31 12, Shimo 3 Chome, Kita ku, Tokyo 115 8588, Japan
    J Nat Prod 62:864-7. 1999
  6. ncbi request reprint Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682)
    K Hanaoka
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    Int J Cancer 82:226-36. 1999
  7. ncbi request reprint Revision of the structure of fagaridine based on the comparison of UV and NMR data of synthetic compounds
    T Nakanishi
    Pharmaceuticals Group, Nippon Kayaku Company, Ltd, 31 12, Shimo 3 Chome, Kita ku, Tokyo 115 8588, Japan
    J Nat Prod 61:1263-7. 1998
  8. ncbi request reprint Synthesis of derivatives of NK109, 7-OH benzo[c]phenanthridine alkaloid, and evaluation of their cytotoxicities and reduction-resistant properties
    T Nakanishi
    Pharmaceuticals Group, Nippon Kayaku Company, Ltd, Tokyo, Japan
    Bioorg Med Chem Lett 10:2321-3. 2000
  9. ncbi request reprint Neurochemical and behavioral characterization of potential antidepressant properties of indeloxazine hydrochloride
    T Yamaguchi
    Department of Pharmacology, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Tokyo, Japan
    Neuropharmacology 37:1169-76. 1998
  10. ncbi request reprint Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro
    H Ito
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Eur J Pharmacol 409:195-201. 2000

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors
    M Suzuki
    Central Research Laboratories, Nissan Chemical Industries, Ltd, 722 1 Tsuboi cho, Funabashi, 274 8507, Chiba, Japan
    Bioorg Med Chem 9:2727-43. 2001
    ....
  2. ncbi request reprint Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors
    M Suzuki
    Central Research Institute, Nissan Chemical Industries, Ltd, Funabashi, Chiba, Japan
    Bioorg Med Chem Lett 11:1285-8. 2001
    ..It has been shown that these scaffolds can be used as a suitable replacement for the hexahydronaphthalene ring present in naturally occurring HMG-CoA reductase inhibitors...
  3. ncbi request reprint First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104
    M Suzuki
    Central Research Institute, Nissan Chemical Industries Ltd, Funabashi, Chiba, Japan
    Bioorg Med Chem Lett 9:2977-82. 1999
    ..Their purity determinations were effected by chiral HPLC analysis...
  4. ncbi request reprint Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as serotonin 5-HT4 receptor agonists
    M Suzuki
    Research Center, Taisho Pharmaceutical Co, Ltd, Ohmiya, Saitama, Japan
    Chem Pharm Bull (Tokyo) 48:2003-8. 2000
    ..Compound 8c stimulated digestive tract motility in conscious fed dogs (1.0 mg/kg p.o.)...
  5. ncbi request reprint Structural considerations of NK109, an antitumor benzo[c]phenanthridine alkaloid
    T Nakanishi
    Pharmaceuticals Group, Nippon Kayaku Company, Ltd, 31 12, Shimo 3 Chome, Kita ku, Tokyo 115 8588, Japan
    J Nat Prod 62:864-7. 1999
    ..Thus, 3 may be considered to be novel category of benzo[c]phenanthridinium salt from the viewpoint of its structure under biological conditions...
  6. ncbi request reprint Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682)
    K Hanaoka
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    Int J Cancer 82:226-36. 1999
    ..This novel DNA-self-strand-breaking mechanism may contribute to the potent antitumor activity of CS-682...
  7. ncbi request reprint Revision of the structure of fagaridine based on the comparison of UV and NMR data of synthetic compounds
    T Nakanishi
    Pharmaceuticals Group, Nippon Kayaku Company, Ltd, 31 12, Shimo 3 Chome, Kita ku, Tokyo 115 8588, Japan
    J Nat Prod 61:1263-7. 1998
    ..The NMR data of 1 and 2 were very similar, but the UV spectra were completely different. The UV data for fagaridine agreed with these for 2; consequently, the true structure of fagaridine is 2, not 1...
  8. ncbi request reprint Synthesis of derivatives of NK109, 7-OH benzo[c]phenanthridine alkaloid, and evaluation of their cytotoxicities and reduction-resistant properties
    T Nakanishi
    Pharmaceuticals Group, Nippon Kayaku Company, Ltd, Tokyo, Japan
    Bioorg Med Chem Lett 10:2321-3. 2000
    ..8-O-Substituted ones (13a-h), especially 8-O-hydroxyethyl NK109 (13d), suppressed biological reduction and exhibited strong cytotoxic activity...
  9. ncbi request reprint Neurochemical and behavioral characterization of potential antidepressant properties of indeloxazine hydrochloride
    T Yamaguchi
    Department of Pharmacology, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co, Ltd, Tokyo, Japan
    Neuropharmacology 37:1169-76. 1998
    ..In addition, the drug-induced enhancement of serotonin release may contribute to its potent effects on the serotonergic system in vivo...
  10. ncbi request reprint Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro
    H Ito
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Eur J Pharmacol 409:195-201. 2000
    ..These results suggest that YM-31636 is a potent and selective 5-HT3 receptor agonist, preferentially acting on the contraction of the colon...
  11. ncbi request reprint Striatal Distribution of Dopamine Transporters and Dopamine D2 Receptors at Different Stages of Parkinson's Disease. A CFT and RAC PET Study
    M Mishina
    Department of Neurology, Neurological Institute, Nippon Medical School Chiba Hokusoh Hospital Inzai shi, Chiba, Japan Positron Medical Center, Tokyo Metropolitan Institute of Gerontology Itabashi ku, Tokyo, Japan Second Department of Internal Medicine, Nippon Medical School Bunkyo ku, Tokyo, Japan
    Neuroradiol J 24:235-41. 2011
    ..Binding of RAC was largest in the putamen of drug-naïve PD patients, but the enhanced binding could not be detected in the therapeutic patients with PD because of weak D2R affinity of RAC. ..
  12. pmc Characteristics of histologically confirmed endometriosis in cynomolgus monkeys
    A Nishimoto-Kakiuchi
    Research Division, Chugai Pharmaceutical Co, Ltd, 200 Kajiwara, Kamakura shi, Kanagawa 247 8530, Japan
    Hum Reprod 31:2352-9. 2016
    ..What are the characteristics of spontaneous endometriosis in cynomolgus monkeys?..
  13. ncbi request reprint Synthesis of a F-18 labeled analog of antitumor prostaglandin delta 7-PGA1 methyl ester using p-[18F]fluorobenzylamine
    T Haradahira
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Appl Radiat Isot 49:1551-6. 1998
    ..The total synthesis time was 70 min from the start of the radiosynthesis of p-[18F]FBnA...
  14. doi request reprint A novel nonsecosteroidal VDR agonist (CH5036249) exhibits efficacy in a spontaneous benign prostatic hyperplasia beagle model
    K Taniguchi
    Research Division, Chugai Pharmaceutical Co, Ltd, Kamakura Research Labs, 200 Kajiwara, Kamakura, Kanagawa 247 8530, Japan
    J Steroid Biochem Mol Biol 121:204-7. 2010
    ..6 h. Both micro-AMES and micronucleus tests were negative. Although the results are still preliminary, we consider the novel nonsecosteroidal VDR agonist CH5036249 to be a possible new drug candidate for the treatment of BPH in humans...
  15. ncbi request reprint Ca2+ mobilization and activation of extracellular acidification by carbachol in acutely dispersed cells from guinea pig detrusor: Fura 2 fluorometry and microphysiometry using the cytosensor
    K Ikeda
    Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    Life Sci 65:1569-77. 1999
    ..Since this finding agrees with a number of other studies using in vivo and in vitro models (1), cell suspensions such as these may prove to be simple tools for the pharmacological study of urinary bladder smooth muscle tissue...
  16. ncbi request reprint Change in radiosensitivity with fractionated-dose irradiation of carbon-ion beams in five different human cell lines
    M Suzuki
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 48:251-8. 2000
    ..To investigate the change in the surviving fractions by fractionated-dose irradiations with carbon ions, based on the recovery of potentially lethal damage (PLDR) and the change of radiosensitivity by every fractionated-dose irradiation...
  17. doi request reprint Diffusion tensor imaging of radiculopathy in patients with lumbar disc herniation: preliminary results
    Y Eguchi
    Shimoshizu National Hospital, 934 5, Shikawatashi, Yotsukaido, Chiba, 284 0003, Japan
    Bone Joint J 98:387-94. 2016
    ..We also investigated the correlation between the severity of neurological symptoms and these parameters...
  18. doi request reprint Hiatal hernia following total gastrectomy with Roux-en-Y reconstruction
    S Murata
    Department of Surgery, Teikyo University Chiba Medical Center, 3426 3 Anesaki, Ichihara, Chiba, 299 0111, Japan
    Hernia 18:889-91. 2014
    ..He experienced anastomotic leakage and right pyothorax, but recovered. The potential cause is discussed here and the published literature on this rare complication is reviewed briefly. ..
  19. doi request reprint Extensive pneumocephalus extending into the lateral ventricles from a brain abscess: an intracranial complication of cholesteatoma
    Y Tamura
    Department of Otolaryngology, Sakura Medical Center, Toho University, Sakura City, Chiba, Japan
    J Laryngol Otol 127:192-5. 2013
    ..We report the case of a patient with extensive pneumocephalus extending into the lateral ventricles from a brain abscess arising from a cholesteatoma-induced defect in the skull base...
  20. doi request reprint Spontaneous glomerular and tubulointerstitial lesions in common marmosets (Callithrix jacchus)
    K Isobe
    Safety Assessment Department, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Vet Pathol 49:839-45. 2012
    ..Those lesions were thus diagnosed as progressive glomerulonephropathy in common marmosets...
  21. pmc Preoperative embolization of meningiomas with N-butyl cyanoacrylate
    S Kominami
    Chiba Hokuso Hospital, Nippon Medical School, Inzai, Chiba, Japan
    Interv Neuroradiol 18:133-9. 2012
    ..We have used n-butyl cyanoacrylate (NBCA) as the first-choice material since 2001. Thirty-one meningiomas were embolized with NBCA. We report the result of embolization of meningiomas with NBCA in comparison with PVA particles...
  22. ncbi request reprint Structural study on a sulfated polysaccharide-peptidoglycan complex produced by Arthrobacter sp
    K Yamazaki
    Basic Technology Research Laboratory, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Biosci Biotechnol Biochem 62:2138-44. 1998
    ..The sulfated positions of the trisaccharide were identified as C-3 and C-5 of the beta-glucosylated Galf residues, and C-2 or C-3 of the other Galf residue...
  23. ncbi request reprint Synthesis and evaluation of novel 2-oxo-1,2-dihydro-3-quinolinecarboxamide derivatives as potent and selective serotonin 5-HT4 receptor agonists
    M Suzuki
    Research Center Taisho Pharmaceutical Co, Ltd, Ohmiya, Saitama, Japan
    Chem Pharm Bull (Tokyo) 49:29-39. 2001
    ..Furthermore, it remarkably enhanced gastrointestinal motility in conscious fed dogs without unfavorable effects that non-selective serotonin 5-HT4 receptor agonist has. TS-951 may be useful in improving gastrointestinal dysfunction...
  24. ncbi request reprint Taxonomic re-evaluation of 'Nocardiopsis' sp. K-252T (= NRRL 15532T): a proposal to transfer this strain to the genus Nonomuraea as Nonomuraea longicatena sp. nov
    S Chiba
    Technical Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, Yamaguchi, Japan
    Int J Syst Bacteriol 49:1623-30. 1999
    ..Furthermore, on the basis of DNA-DNA reassociation and phenotypic data, strain K-252T (= NRRL 15532T) was classified as a new species of the genus Nonomuraea. This strain is proposed as Nonomuraea longicatena sp. nov...
  25. ncbi request reprint Metabolic fate of (-)-[4-(3)H]epigallocatechin gallate in rats after oral administration
    T Kohri
    Food Research Laboratories, Mitsui Norin Company, Ltd, 223 1 Miyabara, Fujieda City, Shizuoka Prefecture 426 0133, Japan
    J Agric Food Chem 49:4102-12. 2001
    ..Taking into account all of the above findings, a possible metabolic route of EGCg orally administered to rats is proposed...
  26. ncbi request reprint Development of the polymer micelle carrier system for doxorubicin
    T Nakanishi
    Drug Research Department, Nippon Kayaku Co, Ltd, 3 31 12 Shimo, Kita ku, 115 8588, Tokyo, Japan
    J Control Release 74:295-302. 2001
    ..We plan to perform a clinical trial at National Cancer Center Hospital, Japan from 2001...
  27. ncbi request reprint A novel enzymic determination of maltose
    Y Shirokane
    Research and Development Division, Kikkoman Corporation, Noda City, Chiba, Japan
    Carbohydr Res 329:699-702. 2000
    ..997) between the results obtained by the enzymic and HPLC methods. This method fulfills the need for an accurate, specific and simple assay of maltose, and it is less time consuming than HPLC and enzymic methods previously reported...