Mitsuo Iinuma

Summary

Affiliation: Asahi University School of Dentistry
Country: Japan

Publications

  1. ncbi request reprint Malocclusion induces chronic stress
    Mitsuo Iinuma
    Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Mizuho, Gifu 501 0296, Japan
    Okajimas Folia Anat Jpn 85:35-42. 2008
  2. ncbi request reprint Relationship between light and dark period activity cycles and oral condition in senescence-accelerated mice
    Mitsuo Iinuma
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 88:29-36. 2011
  3. ncbi request reprint The bite-raised condition in aged SAMP8 mice reduces the expression of glucocorticoid receptors in the dorsal and ventral hippocampus
    Yukiko Ichihashi
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 84:137-42. 2008
  4. ncbi request reprint Duration-dependent effects of the bite-raised condition on hippocampal function in SAMP8 mice
    Yoko Arakawa
    Department of Pediatric Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 84:115-9. 2007
  5. ncbi request reprint Occlusal disharmony attenuates glucocorticoid negative feedback in aged SAMP8 mice
    Yukiko Ichihashi
    Department of Pediatric Dentistry, Asahi University School of Dentistry, Mizuho, Japan
    Neurosci Lett 427:71-6. 2007
  6. ncbi request reprint The bite-raised condition enhances the aging process in the dorsal and ventral hippocampus
    Kin ya Kubo
    Departments of Oral Anatomy, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 85:43-8. 2008
  7. doi request reprint Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment
    Hiroko Kondo
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Arch Oral Biol 61:1-7. 2016
  8. ncbi request reprint Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice
    Kin ya Kubo
    Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Neurosci Lett 414:188-91. 2007
  9. doi request reprint Maternal chewing during prenatal stress ameliorates stress-induced hypomyelination, synaptic alterations, and learning impairment in mouse offspring
    Ayumi Suzuki
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Brain Res 1651:36-43. 2016
  10. pmc Chewing Maintains Hippocampus-Dependent Cognitive Function
    Huayue Chen
    1 Department of Anatomy Gifu University Graduate School of Medicine, Gifu, 501 1194, Gifu, Japan
    Int J Med Sci 12:502-9. 2015

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Malocclusion induces chronic stress
    Mitsuo Iinuma
    Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Mizuho, Gifu 501 0296, Japan
    Okajimas Folia Anat Jpn 85:35-42. 2008
    ..These datas suggest that the bite-raised condition may enhance the aging process in hippocampus, thereby leading to impairment of spatial memory by stress...
  2. ncbi request reprint Relationship between light and dark period activity cycles and oral condition in senescence-accelerated mice
    Mitsuo Iinuma
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 88:29-36. 2011
    ..Significant correlations were noted among total activity, degree of senescence, and percent dark period activity in each experimental group. Functional masticatory insufficiency promoted dementia and behavioral abnormalities in SAMP1...
  3. ncbi request reprint The bite-raised condition in aged SAMP8 mice reduces the expression of glucocorticoid receptors in the dorsal and ventral hippocampus
    Yukiko Ichihashi
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 84:137-42. 2008
    ..These findings suggest that in aged SAMP8 mice, the bite-raised condition decreases the number of GR-immunoreactive cells in both the dorsal and ventral hippocampus...
  4. ncbi request reprint Duration-dependent effects of the bite-raised condition on hippocampal function in SAMP8 mice
    Yoko Arakawa
    Department of Pediatric Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 84:115-9. 2007
    ..Thus, behavioral and morphologic deficits induced by the bite-raised condition in aged SAMP8 mice are influenced by the duration of the occlusal disharmony...
  5. ncbi request reprint Occlusal disharmony attenuates glucocorticoid negative feedback in aged SAMP8 mice
    Yukiko Ichihashi
    Department of Pediatric Dentistry, Asahi University School of Dentistry, Mizuho, Japan
    Neurosci Lett 427:71-6. 2007
    ..These findings suggest that the bite-raised condition in aged SAMP8 mice decreases GR and GRmRNA, which impairs the hypothalamic-pituitary-adrenal feedback inhibition, thereby leading to memory deficits...
  6. ncbi request reprint The bite-raised condition enhances the aging process in the dorsal and ventral hippocampus
    Kin ya Kubo
    Departments of Oral Anatomy, Asahi University School of Dentistry, 1851 1 Hozumi, Mizuho, Gifu, 501 0296, Japan
    Okajimas Folia Anat Jpn 85:43-8. 2008
    ..These data suggest that in aged SAMP8 mice, the bite-raised condition enhanced aging processes in both the dorsal and ventral hippocampus...
  7. doi request reprint Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment
    Hiroko Kondo
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Arch Oral Biol 61:1-7. 2016
    ..Here, we explored the effects of an enriched environment on learning deficits and hippocampal morphologic changes in aged senescence-accelerated mouse strain P8 (SAMP8) mice with tooth loss...
  8. ncbi request reprint Occlusal disharmony induces spatial memory impairment and hippocampal neuron degeneration via stress in SAMP8 mice
    Kin ya Kubo
    Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Neurosci Lett 414:188-91. 2007
    ..The findings suggest that the bite-raised condition in aged SAMP8 mice induces hippocampal neuron loss, thereby leading to senile memory deficits...
  9. doi request reprint Maternal chewing during prenatal stress ameliorates stress-induced hypomyelination, synaptic alterations, and learning impairment in mouse offspring
    Ayumi Suzuki
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Brain Res 1651:36-43. 2016
    ..These findings suggest that chewing during prenatal stress in dams could be an effective coping strategy to prevent hippocampal behavioral and morphologic impairments in their offspring...
  10. pmc Chewing Maintains Hippocampus-Dependent Cognitive Function
    Huayue Chen
    1 Department of Anatomy Gifu University Graduate School of Medicine, Gifu, 501 1194, Gifu, Japan
    Int J Med Sci 12:502-9. 2015
    ..We also discussed several possible mechanisms involved in the interaction between mastication and the hippocampal neurogenesis and the future directions for this unique fascinating research. ..
  11. ncbi request reprint Denture-handling ability of elderly persons with dementia: examination of time spent inserting and removing dentures
    Kin ya Kubo
    Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, Mizuho, Gifu, Japan
    Spec Care Dentist 27:149-53. 2007
    ..The results indicate that elderly people with mild to moderate dementia are able to insert and remove their dentures without help...
  12. doi request reprint Tooth loss early in life accelerates age-related bone deterioration in mice
    Minori Kurahashi
    Department of Pediatric Dentistry, Asahi University School of Dentistry
    Tohoku J Exp Med 235:29-37. 2015
    ..Long-term tooth loss may have a cumulative detrimental effect on bone health. It is important to take appropriate measures to treat tooth loss in older people for preventing and/or treating senile osteoporosis. ..
  13. doi request reprint Learning deficits and suppression of the cell proliferation in the hippocampal dentate gyrus of offspring are attenuated by maternal chewing during prenatal stress
    Mika Onishi
    Department of Pediatric Dentistry, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501 0296, Japan
    Neurosci Lett 560:77-80. 2014
    ..These findings suggest that maternal chewing during prenatal stress is an effective stress-coping method for the dam to prevent learning deficits and suppression of cell proliferation in offspring. ..