M Zhou

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. doi Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Neurosci Res 74:91-105. 2012
  2. ncbi Localization of sulfonylurea receptor subunits, SUR2A and SUR2B, in rat heart
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Histochem Cytochem 55:795-804. 2007
  3. ncbi Localization of the ATP-sensitive potassium channel subunit (Kir6. 1/uK(ATP)-1) in rat brain
    M Zhou
    Department of Morphology, Tokai University School of Medicine, Bohseidai, Isehara, Japan
    Brain Res Mol Brain Res 74:15-25. 1999
  4. ncbi Expression of ATP sensitive K+ channel subunit Kir6.1 in rat kidney
    M Zhou
    Department of Anatomy, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Eur J Histochem 51:43-51. 2007
  5. pmc ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, Japan
    J Histochem Cytochem 53:1491-500. 2005
  6. ncbi Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine
    Tohoku J Exp Med 214:247-56. 2008
  7. doi Different localization of ATP sensitive K+ channel subunits in rat testis
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, Hondo 1 1 1, Akita, Japan
    Anat Rec (Hoboken) 294:729-37. 2011
  8. ncbi Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, Hondo 1 1 1 Akita 010 8543, Japan
    Brain Res Mol Brain Res 101:23-32. 2002
  9. pmc Localization of ATP-sensitive K+ channel subunits in rat submandibular gland
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Histochem Cytochem 58:499-507. 2010
  10. doi Observation of the upside-down stomach esophageal hiatal hernia in a cadaver
    Akimitsu Ishizawa
    Department of Anatomy, Akita University School of Medicine, Japan
    Anat Sci Int 85:171-9. 2010

Collaborators

Detail Information

Publications46

  1. doi Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Neurosci Res 74:91-105. 2012
    ....
  2. ncbi Localization of sulfonylurea receptor subunits, SUR2A and SUR2B, in rat heart
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Histochem Cytochem 55:795-804. 2007
    ..Thus, SUR2A and SUR2B are not only the regulatory subunits of sarcolemmal K(ATP) channels but may also function as regulatory subunits in mitochondrial K(ATP) channels and play important roles in cardioprotection...
  3. ncbi Localization of the ATP-sensitive potassium channel subunit (Kir6. 1/uK(ATP)-1) in rat brain
    M Zhou
    Department of Morphology, Tokai University School of Medicine, Bohseidai, Isehara, Japan
    Brain Res Mol Brain Res 74:15-25. 1999
    ..The present study indicates that this K(ATP) subunit is localized in the mitochondria and may play a fundamental role in vital brain function...
  4. ncbi Expression of ATP sensitive K+ channel subunit Kir6.1 in rat kidney
    M Zhou
    Department of Anatomy, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Eur J Histochem 51:43-51. 2007
    ..In immunoelectron microscopy, Kir6.1 is mainly localized in the mitochondria, endoplasmic reticulum (ER), and very weakly in cell membranes. Thus, Kir6.1 is contained in the kidney and may be a candidate of mitochondrial K(ATP) channels...
  5. pmc ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, Japan
    J Histochem Cytochem 53:1491-500. 2005
    ..The data obtained in this study will be useful for analyzing the composition of K(ATP) channels of cardiomyocytes and help to understanding the cardioprotective role of K(ATP) channels during heart ischemia...
  6. ncbi Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine
    Tohoku J Exp Med 214:247-56. 2008
    ..In conclusion, the regulatory subunits of the K(ATP) channel in the rat kidney are SUR2A and SUR2B; they also are candidate regulatory subunits for the mitochondrial K(ATP) channel...
  7. doi Different localization of ATP sensitive K+ channel subunits in rat testis
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, Hondo 1 1 1, Akita, Japan
    Anat Rec (Hoboken) 294:729-37. 2011
    ..Different localizations of the K(ATP) channel subunits in the cell membrane and membranous organelles of spermatogenic cells and Sertoli cells indicated the complex and multiple functions of K(ATP) channels in rat testis...
  8. ncbi Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, Hondo 1 1 1 Akita 010 8543, Japan
    Brain Res Mol Brain Res 101:23-32. 2002
    ..2. Under the electron microscope, we showed in vivo for the first time that the immunoreactive products were localized in the endoplasmic reticulum and Golgi apparatus as well as the plasma membranes of neurons and glial cells...
  9. pmc Localization of ATP-sensitive K+ channel subunits in rat submandibular gland
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Histochem Cytochem 58:499-507. 2010
    ..1, Kir6.2, SUR2A, and SUR2B, with various combinations of colocalization with each other, and may play important roles in rat SMG during salivary secretion...
  10. doi Observation of the upside-down stomach esophageal hiatal hernia in a cadaver
    Akimitsu Ishizawa
    Department of Anatomy, Akita University School of Medicine, Japan
    Anat Sci Int 85:171-9. 2010
    ..This specimen was classified as the sliding type of esophageal hiatal hernia. We consider the excessive kyphosis of the vertebral column to likely be associated with the formation of such a highly advanced hernia...
  11. doi Intersection patterns of human coronary veins and arteries
    Akimitsu Ishizawa
    Department of Anatomy, Akita University School of Medicine, Akita, Japan
    Anat Sci Int 83:26-30. 2008
    ..The present observations suggest that the CV on the right side may be formed prior to CA, while the CV on the left side may be formed simultaneously with CA...
  12. ncbi Anomalous venous system in the human heart
    Akimitsu Ishizawa
    Department of Anatomy, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Anat Sci Int 82:242-6. 2007
    ..5) The abnormal orifice existed between the left atrium and the coronary sinus. The formation process and functional significance of such venous variations are discussed...
  13. ncbi Observation of root variations in human coronary arteries
    Akimitsu Ishizawa
    Department of Anatomy, Akita University School of Medicine, Akita, Japan
    Anat Sci Int 81:50-6. 2006
    ..In specimen 5, the vessel near the left aortic sinus was poorly developed as a small thin artery. Instead, the LCA was developed from the anterior and posterior interventricular septal branches...
  14. ncbi Cardiac-specific overexpression of fibroblast growth factor-2 protects against myocardial dysfunction and infarction in a murine model of low-flow ischemia
    Stacey L House
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, 231 Albert Sabin Way, ML 0575, Cincinnati, Ohio 45267, USA
    Circulation 108:3140-8. 2003
    ..However, because of the number of FGFs expressed in the heart and the promiscuity of FGF ligand-receptor interactions, the specific role of FGF2 during ischemia-reperfusion injury remains unclear...
  15. ncbi Inhibition of tyrosine hydroxylase expression in alpha-synuclein-transfected dopaminergic neuronal cells
    Shun Yu
    Department of Neurobiology and the Sino Japan Joint Laboratory on Neurodegenerative Diseases, Beijing Institute of Geriatrics, Xuanwu Hospital of the Capital University of Medical Sciences, 45 Changchun Street, Beijing 100053, China
    Neurosci Lett 367:34-9. 2004
    ..No apparent cell injury or death was observed. These results suggest that an abnormal expression of alpha-Syn may inhibit TH synthesis in dopaminergic cells...
  16. ncbi Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells
    Shengli Xu
    Department of Neurobiology and the Sino Japan Joint Laboratory of Neurodegenerative diseases, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, China
    Biochem Biophys Res Commun 342:330-5. 2006
    ..Our present results indicated that 200microM H(2)O(2) treatment induces the intranuclear accumulation of the C-terminal fragment of alpha-synuclein in dopaminergic neurons, whose role remains to be investigated...
  17. pmc Structural and thermodynamic properties of selective ion binding in a K+ channel
    Steve W Lockless
    Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, New York, United States of America
    PLoS Biol 5:e121. 2007
    ..We conclude that ion selectivity in a K(+) channel is a property of size-matched ion binding sites created by the protein structure...
  18. ncbi [Blockage of U251 cells in G0/G1 through MAPK signaling pathway by LRRC4]
    Ming Hua Wu
    Cancer Research Institute, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:226-30. 2007
    ..To explore the effect of LRRC4, a glioma suppressive gene, on blocking U251 cells in G0/G1 by MAPK signaling pathway...
  19. ncbi The prognostic significance of epidermal growth factor receptor expression in clear-cell renal cell carcinoma: a call for standardized methods for immunohistochemical evaluation
    David Cohen
    Department of Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Clin Genitourin Cancer 5:264-70. 2007
    ..The prognostic significance of EGFR overexpression after nephrectomy, however, is controversial because of different methods used in the immunohistochemical (IHC) evaluation of EGFR expression...
  20. ncbi Differential expression of caveolin-1 in renal neoplasms
    Ila Tamaskar
    Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Cancer 110:776-82. 2007
    ..In the current study, the authors used immunohistochemistry to investigate the membranous and cytoplasmic expression of caveolin-1 and its correlation with other pathologic parameters in different subtypes of renal neoplasms...
  21. ncbi The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells
    Shu Ping Peng
    Cancer Research Institute, Central South University, Changsha, Hunan, China
    Oncology 71:273-81. 2006
    ..To demonstrate the subcellular localization of nasopharyngeal carcinoma (NPC)-associated gene 6 (NGX6) and its basic structure and function...
  22. pmc Phycobilin:cystein-84 biliprotein lyase, a near-universal lyase for cysteine-84-binding sites in cyanobacterial phycobiliproteins
    Kai Hong Zhao
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People s Republic of China
    Proc Natl Acad Sci U S A 104:14300-5. 2007
    ....
  23. ncbi Lyase activities of CpcS- and CpcT-like proteins from Nostoc PCC7120 and sequential reconstitution of binding sites of phycoerythrocyanin and phycocyanin beta-subunits
    Kai Hong Zhao
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China
    J Biol Chem 282:34093-103. 2007
    ..In sequential binding experiments with CpcT1 and CpcS1, a chromophore at cysteine 84 inhibited the subsequent attachment to cysteine 155, whereas the inverse sequence generates subunits carrying both chromophores...
  24. ncbi Leucine-rich repeat C4 protein is involved in nervous tissue development and neurite outgrowth, and induction of glioma cell differentiation
    Minghua Wu
    Cancer Research Institute, Central South University, Changsha 410078, China
    Acta Biochim Biophys Sin (Shanghai) 39:731-8. 2007
    ....
  25. ncbi Renal mass biopsy--a renaissance?
    Brian R Lane
    Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 179:20-7. 2008
    ....
  26. ncbi The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation
    Yien Che Tsai
    Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA
    Nat Med 13:1504-9. 2007
    ....
  27. pmc Preparation of polyclonal antibody specific for BRD7 and detection of its expression pattern in the human fetus
    Huaying Liu
    Cancer Research Institute, Central South University, Changsha, Hunan, People s Republic of China
    J Histochem Cytochem 56:531-8. 2008
    ..These data may help to further study the cellular role of the BRD7 gene. In particular, the prepared BRD7 antibody will be helpful for studying the bio-functions of endogenously expressed BRD7 protein...
  28. ncbi BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways
    Jie Zhou
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, People s Republic of China
    J Cell Physiol 200:89-98. 2004
    ....
  29. ncbi Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)
    Ming Zhou
    Regulation of Cell Growth Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
    J Mol Biol 315:435-46. 2002
    ..Together, these results underscore the functional specificity of these important regulatory domains and demonstrate that the structural features of the C1 domains can provide valuable insight into their ligand-binding properties...
  30. ncbi alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer
    Mark A Rubin
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    JAMA 287:1662-70. 2002
    ..Molecular profiling of prostate cancer has led to the identification of candidate biomarkers and regulatory genes. Discoveries from these genome-scale approaches may have applicability in the analysis of diagnostic prostate specimens...
  31. ncbi Inhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats
    Wang Yue
    Department of Pharmacology, Medical College, Qingdao University, Qingdao 266021, China
    Acta Pharmacol Sin 23:847-50. 2002
    ..To investigate the effects and mechanism of succinic acid on pentylenetetrazol (PTZ) chemical kindling and amygdala electrical kindling in rats...
  32. ncbi [The protective effects of small dose of dopamine on the intestinal mucosa of scalded rats in shock stage]
    Wendong Pan
    Department of Burns, The 59th Central Hospital of People s Liberation Army, Kaiyuan 661000 Yun nan Province, P R China
    Zhonghua Shao Shang Za Zhi 18:213-5. 2002
    ..To investigate the protective effects of small dose of dopamine on the intestinal mucosa of scalded rats in shock stage...
  33. ncbi Effects of L-arginine on spontaneous contraction of the rat portal vein
    Keiichi Shimamura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari Tobetsu, Hokkaido 061 0293, Japan
    Pflugers Arch 446:30-5. 2003
    ....
  34. ncbi Identification of tissue-specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray
    Bicheng Zhang
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, China
    Genes Chromosomes Cancer 38:80-90. 2003
    ..Seventeen differentially expressed genes in NPC were obtained. Among these genes, we identified SPLUNC1 and LPLUNC1 to be down-expressed in NPC biopsies (34/48, 33/48)...
  35. ncbi IONP-PLL: a novel non-viral vector for efficient gene delivery
    Juan Juan Xiang
    Cancer Research Institute, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Gene Med 5:803-17. 2003
    ..Non-viral methods of gene delivery have been an attractive alternative to virus-based gene therapy. However, the vectors that are currently available have drawbacks limiting their therapeutic application...
  36. ncbi Profiling the activity of G proteins in patient-derived tissues by rapid affinity-capture of signal transduction proteins (GRASP)
    David M Berman
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proteomics 4:812-8. 2004
    ..GRASP represents an advance in the field of proteomics as it detects protein interactions present in cells as they exist in their native tissue microenvironment...
  37. ncbi A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution
    Ming Zhou
    Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA
    J Mol Biol 338:839-46. 2004
    ..The mutation does not affect the conduction of Rb(+). These results can be understood in the context of a conduction mechanism in which a pair of K ions switch between energetically balanced 1,3 and 2,4 configurations...
  38. ncbi Differential expression of Epstein-Barr virus-encoded RNA and several tumor-related genes in various types of nasopharyngeal epithelial lesions and nasopharyngeal carcinoma using tissue microarray analysis
    Song Qing Fan
    Cancer Research Institute, Xiang Ya School of Medicine, Central South University, Changsha, Hunan, China Department of Pathology, The Second Xiang Ya Hospital, Central South University, Changsha, Hunan, China
    Hum Pathol 37:593-605. 2006
    ..179-29.111, P < .001). In conclusion, EBV infection, together with overexpressions of p53, and loss expressions of p16 and p27 proteins are involved in the multistep process of human nasopharyngeal epithelial carcinogenesis...
  39. ncbi Quantitative proteomic analysis of inorganic phosphate-induced murine MC3T3-E1 osteoblast cells
    Kelly A Conrads
    Laboratory of Cancer Prevention, Center for Cancer Research, Fredrick, MD, USA
    Electrophoresis 25:1342-52. 2004
    ..41-fold increase as determined by Western blotting. These results demonstrate that quantitative proteomics is capable of providing a quantitative view of thousands of proteins in mammalian cells within a defined set of experiments...
  40. ncbi Photochromic biliproteins from the cyanobacterium Anabaena sp. PCC 7120: lyase activities, chromophore exchange, and photochromism in phytochrome AphA
    Kai Hong Zhao
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, People s Republic of China kaihongzhao 163 com
    Biochemistry 43:11576-88. 2004
    ..f) Long-range interactions in AphA are further supported by blue-shifted absorptions (<or=12 nm) of both the Pr and Pfr forms of truncated chromoproteins...
  41. ncbi Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells
    Jian Ma
    Cancer Research Institute, Xiang Ya School of Medicine, 110 Xiang Ya Road, Changsha, Hunan 410078, China
    Carcinogenesis 26:281-91. 2005
    ..The data revealed that NGX6 plays a role in cell adhesion modulation in NPC cells...
  42. ncbi Expression of EphA2 is prognostic of disease-free interval and overall survival in surgically treated patients with renal cell carcinoma
    Christopher J Herrem
    Department of Immunology and Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 1863, USA
    Clin Cancer Res 11:226-31. 2005
    ....
  43. ncbi Amino acid residues associated with enzymatic activities of the isomerizing phycoviolobilin-lyase PecE/F
    Kai Hong Zhao
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, PR China
    Biochemistry 44:8126-37. 2005
    ..c) PecE and PecF, as well as most of the mutants, bind PCB covalently in substoichiometric amounts, as assayed by Zn(2+)-induced fluorescence on denaturing gels...
  44. ncbi Evidence for the involvement of the cyclooxygenase-metabolic pathway in diclofenac-induced inhibition of spontaneous contraction of rat portal vein smooth muscle cells
    Keiichi Shimamura
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan
    J Smooth Muscle Res 41:195-206. 2005
    ..These results indicate that diclofenac inhibits the amplitude of spontaneous contractions of the rat portal vein through inhibition of electrical activity, which may be related to an inhibition of the cyclooxygenase pathway...
  45. ncbi Chromophore attachment to phycobiliprotein beta-subunits: phycocyanobilin:cysteine-beta84 phycobiliprotein lyase activity of CpeS-like protein from Anabaena Sp. PCC7120
    Kai Hong Zhao
    College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, Hubei, PR China
    J Biol Chem 281:8573-81. 2006
    ..coli with cpcB(C155I) or pecB(C155I), respectively, together with genes ho1 (encoding heme oxygenase) and pcyA (encoding PCB:ferredoxin oxidoreductase), thereby further proving the lyase function of CpeS...
  46. ncbi Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression
    Ming Zhou
    Cancer Research Institute, Central South University Xiang Ya School of Medicine, 110 Xiang Ya Road, Changsha, Hunan 410078, China
    J Cell Biochem 98:920-30. 2006
    ..In conclusion, NLS is an essential motif affecting BRD7 nuclear distribution, and the nuclear localization of BRD7 is critical for the expression of cell cycle related molecules and cell biological function...