Satoru Motoyama

Summary

Affiliation: Akita University School of Medicine
Country: Japan

Publications

  1. doi Evaluation of the risk of lymph node metastasis using CRP 1846C>T genetic polymorphism in submucosal thoracic esophageal squamous cell carcinoma
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Ann Surg Oncol 20:1978-84. 2013
  2. doi Outcomes of patients receiving additional esophagectomy after endoscopic resection for clinically mucosal, but pathologically submucosal, squamous cell carcinoma of the esophagus
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 43:638-42. 2013
  3. doi A CRP genetic polymorphism associated with the tumoral expression of CRP in esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 43:339-40. 2013
  4. doi Interleukin-6 -634G>C genetic polymorphism is associated with prognosis following surgery for advanced thoracic esophageal squamous cell carcinoma
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Dig Surg 29:194-201. 2012
  5. ncbi Outcome and treatment strategy for mid- and lower-thoracic esophageal cancer recurring locally in the lymph nodes of the neck
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    World J Surg 30:191-8. 2006
  6. ncbi Treating gastric tube cancer with distal gastrectomy preserving the gastroepiploic artery
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Thorac Surg 81:751-3. 2006
  7. doi Interleukin-2 -330T>G genetic polymorphism associates with prognosis following surgery for thoracic esophageal squamous cell cancer
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Ann Surg Oncol 18:1995-2002. 2011
  8. doi C-reactive protein -717C>T genetic polymorphism associates with esophagectomy-induced stress hyperglycemia
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    World J Surg 34:1001-7. 2010
  9. doi Estimating the need for neck lymphadenectomy in submucosal esophageal cancer using superparamagnetic iron oxide-enhanced magnetic resonance imaging: clinical validation study
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    World J Surg 36:83-9. 2012
  10. ncbi REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Surg Oncol 13:1724-31. 2006

Collaborators

Detail Information

Publications95

  1. doi Evaluation of the risk of lymph node metastasis using CRP 1846C>T genetic polymorphism in submucosal thoracic esophageal squamous cell carcinoma
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Ann Surg Oncol 20:1978-84. 2013
    ..Extending the indication for endoscopic resection, a minimally invasive treatment, to superficial ESCCs will require more accurate and individualized evaluation of lymph node metastasis...
  2. doi Outcomes of patients receiving additional esophagectomy after endoscopic resection for clinically mucosal, but pathologically submucosal, squamous cell carcinoma of the esophagus
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 43:638-42. 2013
    ....
  3. doi A CRP genetic polymorphism associated with the tumoral expression of CRP in esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 43:339-40. 2013
    ..This finding suggests that tumoral CRP production controlled by CRP genetics significantly influences tumor behavior...
  4. doi Interleukin-6 -634G>C genetic polymorphism is associated with prognosis following surgery for advanced thoracic esophageal squamous cell carcinoma
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Dig Surg 29:194-201. 2012
    ..We assessed the associations between IL-6 and IL-6 receptor (IL-6R) genetic polymorphisms, tumoral IL-6 expression and survival rates following surgery...
  5. ncbi Outcome and treatment strategy for mid- and lower-thoracic esophageal cancer recurring locally in the lymph nodes of the neck
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    World J Surg 30:191-8. 2006
    ....
  6. ncbi Treating gastric tube cancer with distal gastrectomy preserving the gastroepiploic artery
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Thorac Surg 81:751-3. 2006
    ..The distal gastric tube was mobilized and resected with preservation of the right gastroepiploic artery, and the Roux-en-Y gastrojejunostomy was used for reconstruction. This procedure was curative with less surgical stress...
  7. doi Interleukin-2 -330T>G genetic polymorphism associates with prognosis following surgery for thoracic esophageal squamous cell cancer
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Ann Surg Oncol 18:1995-2002. 2011
    ..We investigated the relationship between Th1/Th2 cytokine polymorphism and prognosis in patients with thoracic esophageal squamous cell cancer...
  8. doi C-reactive protein -717C>T genetic polymorphism associates with esophagectomy-induced stress hyperglycemia
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    World J Surg 34:1001-7. 2010
    ..The influence of genetics on surgery-induced hyperglycemia remains only partially understood...
  9. doi Estimating the need for neck lymphadenectomy in submucosal esophageal cancer using superparamagnetic iron oxide-enhanced magnetic resonance imaging: clinical validation study
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    World J Surg 36:83-9. 2012
    ....
  10. ncbi REG I expression predicts long-term survival among locally advanced thoracic squamous cell esophageal cancer patients treated with neoadjuvant chemoradiotherapy followed by esophagectomy
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Surg Oncol 13:1724-31. 2006
    ....
  11. ncbi Sound spectrogram analysis in patients receiving Kawahara's surgical voice restoration for advanced carcinoma of the hypopharynx and cervical esophagus
    S Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Dis Esophagus 20:42-6. 2007
    ..Thus, the voice produced by Kawahara's surgical voice restoration is superior to that produced by the electronic larynx...
  12. ncbi Methylprednisolone-induced expression of mitochondrial heat shock protein 60 protects mitochondrial membrane potential in the hypoxic rat liver
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Shock 22:234-9. 2004
    ..This raises the possibility that one way in which methylprednisolone protects the mitochondrial membrane potential under hypoxic conditions is to induce expression of mitochondrial hsp 60...
  13. ncbi Use of autologous instead of allogeneic blood transfusion during esophagectomy prolongs disease-free survival among patients with recurrent esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita City, Japan
    J Surg Oncol 87:26-31. 2004
    ....
  14. doi Interferon-gamma 874A>T genetic polymorphism is associated with infectious complications following surgery in patients with thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Surgery 146:931-8. 2009
    ..Our aim in this study was to assess whether cytokine polymorphisms were associated with infectious complications following esophagectomy in a Japanese population...
  15. ncbi Surgical outcome of colon interposition by the posterior mediastinal route for thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Thorac Surg 83:1273-8. 2007
    ..Our aim was to review our experience with reconstruction by the posterior mediastinal route and assess the surgical outcomes...
  16. ncbi Prospective endoscopic follow-up results of reconstructed gastric tube
    Satoru Motoyama
    Second Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Hepatogastroenterology 50:666-9. 2003
    ..This prospective study determined secondary disease of the reconstructed gastric tube after esophagectomy for esophageal cancer...
  17. ncbi Preoperative mapping of lymphatic drainage from the tumor using ferumoxide-enhanced magnetic resonance imaging in clinical submucosal thoracic squamous cell esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Japan
    Surgery 141:736-47. 2007
    ..The aim of the present study was to evaluate the potential clinical utility of a new method of mapping lymphatic drainage from tumors using ferumoxide-enhanced magnetic resonance imaging (MRI)...
  18. doi CRP genetic polymorphism is associated with lymph node metastasis in thoracic esophageal squamous cell cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Surg Oncol 16:2479-85. 2009
    ..The purpose of this study is to examine the association between inflammation-related genetic polymorphisms and lymph node metastasis...
  19. ncbi Hydrogen peroxide-dependent declines in Bcl-2 induces apoptosis in hypoxic liver
    Satoru Motoyama
    The Second Department of Surgery, Akita University School of Medicine 1 1 1 Hondo, 010 8543, Akita City, Japan
    J Surg Res 110:211-6. 2003
    ....
  20. doi Status of involved lymph nodes and direction of metastatic lymphatic flow between submucosal and t2-4 thoracic squamous cell esophageal cancers
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    World J Surg 33:512-7. 2009
    ....
  21. doi C-reactive protein 1059G>C genetic polymorphism influences serum C-reactive protein levels after esophagectomy in patients with thoracic esophageal cancer
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan
    J Am Coll Surg 209:477-83. 2009
    ..The purpose of this study was to assess the association between CRP polymorphisms and acute-phase serum CRP levels after esophagectomy for thoracic esophageal cancer...
  22. doi REG1A expression status suggests chemosensitivity among advanced thoracic esophageal squamous cell carcinoma patients treated with esophagectomy followed by adjuvant chemotherapy
    Yusuke Sato
    Department of Surgery, Akita University Graduate School of Medicine, Akita, 010 8543, Japan
    Ann Surg Oncol 20:3044-51. 2013
    ....
  23. doi CXCL10 Expression Status is Prognostic in Patients with Advanced Thoracic Esophageal Squamous Cell Carcinoma
    Yusuke Sato
    Department of Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Ann Surg Oncol 23:936-42. 2016
    ..However, the precise relationship between CXCL10 and the prognosis of patients with esophageal squamous cell carcinoma (ESCC) is not fully understood...
  24. doi Transforming growth factor-β1 29T>C genetic polymorphism is associated with lymph node metastasis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 31:437-41. 2010
    ..045) are factors associated with a significantly greater likelihood of developing lymph node metastasis. TGF-β1 29T>C genetic polymorphism is an independent factor associated with lymph node metastasis in adenocarcinoma of the lung...
  25. ncbi Superior mediastinal and neck lymphatic mapping in mid- and lower-thoracic esophageal cancer as defined by ferumoxides-enhanced magnetic resonance imaging
    Hiroshi Imano
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Jpn J Thorac Cardiovasc Surg 52:445-50. 2004
    ....
  26. ncbi Subpleural injection of tracer improves detection of mediastinal sentinel lymph nodes in non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City 010 8543, Japan
    Eur J Cardiothorac Surg 32:770-5. 2007
    ....
  27. doi The CRP 1846T/T genotype is associated with a poor prognosis in patients with non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Tumour Biol 31:673-9. 2010
    ..76; 95% confidence interval, 1.003-3.16; p = 0.049) to be independent factors affecting 5-year overall survival. These findings suggest the CRP 1846T/T genotype is an independent predictor of a poor prognosis in patients with NSCLC...
  28. doi Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature
    Aki Ito
    Department of Surgery, Akita University, Hondo, Akita City, Japan
    Cancer Sci 100:558-64. 2009
    ..Thus, the combination of FMP-mediated, self-regulating hyperthermia with Hsp90 inhibition has important implications for the treatment of cancer...
  29. doi Sentinel node mapping and micrometastasis in patients with clinical stage IA non-small cell lung cancer
    Takashi Ono
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City 010 8543, Japan
    Interact Cardiovasc Thorac Surg 9:659-61. 2009
    ..Evaluation of micrometastases of all dissected lymph nodes may be substituted by evaluating micrometastases of SNs. We believe that further studies are warranted to determine the most useful clinical applications...
  30. doi C-reactive protein inhibits expression of N-cadherin and ZEB-1 in murine colon adenocarcinoma
    Satoshi Kudo
    Department of Surgery, Division of Thoracic Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 36:7035-43. 2015
    ..01). These findings suggest that CRP inhibits EMT in a MCA-38 tumor-bearing mouse model. CRP may thus be a potentially useful tool for preventing cancer progression through suppression of EMT...
  31. doi Evaluation of the potential for lymph node metastasis using CRP 1846C>T genetic polymorphism in invasive breast cancer
    Kaori Terata
    Division of Brest Surgery, Akita Red Cross Hospital, Akita, Japan
    Tumour Biol 35:5931-5. 2014
    ..2 in multivariate logistic regression models. CRP genetic polymorphism may be a novel predictor of the risk of lymph node metastasis in invasive breast cancer...
  32. pmc Bronchioloalveolar invasion in non-small cell lung cancer is associated with expression of transforming growth factor-β1
    Kazuhiro Imai
    Department of Chest, Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    World J Surg Oncol 11:113. 2013
    ..We therefore analyzed the relationship between TGF-β1 expression and clinicopathological microinvasion in patients with small lung adenocarcinoma...
  33. doi Tracheobronchial lesions following esophagectomy: erosions, ulcers, and fistulae, and the predictive value of lymph node-related factors
    Kiyotomi Maruyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    World J Surg 33:778-84. 2009
    ..In this study we assessed the causes and clinical features of these complications, paying particular attention to lymph node (LN)-related factors...
  34. doi Detection of pleural lymph flow using indocyanine green fluorescence imaging in non-small cell lung cancer surgery: a preliminary study
    Kazuhiro Imai
    Department of Chest, Breast and Endocrinologic Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 43:249-54. 2013
    ..This phenomenon is termed as "skip metastasis." This study investigated the subpleural lymphatic flow to the mediastinum using indocyanine green (ICG) with a near-infrared fluorescence imaging system...
  35. ncbi A second malignancy is the major cause of death among thoracic squamous cell esophageal cancer patients negative for lymph node involvement
    Yusuke Sato
    Department of Surgery, Akita University School of Medicine, Akita City, Japan
    J Am Coll Surg 201:188-93. 2005
    ....
  36. doi Expression of the transient receptor potential channel c3 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    Hajime Saito
    Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Ann Surg Oncol 18:3377-83. 2011
    ..Therefore, we investigated the relationship between TRP expression and the prognosis of patients with adenocarcinoma of the lung...
  37. doi Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    The Division of Thoracic Surgery, Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 31:533-9. 2010
    ..06; 95% CI, 1.07-7.55; P = 0.037) to be independent factors affecting the 5-DFS rate. Strong tumoral expression of HDAC3 is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung...
  38. doi Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Lung Cancer 68:466-71. 2010
    ..We therefore investigated the relationship between CXCR4 expression and prognosis in patients with adenocarcinoma of the lung...
  39. ncbi Mesojejunal lymph node metastasis in esophageal cancer following total gastrectomy
    Takashi Ono
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Jpn J Thorac Cardiovasc Surg 52:542-4. 2004
    ..We believe this case highlights the need for detailed examinations in esophageal cancer patients who have had prior gastrectomy...
  40. doi Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells
    Shuetsu Usami
    Department of Biochemistry, Akita University Graduate School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 392:4-8. 2010
    ..The elevated IL-6 expression seen in REG Ialpha transfectants was silenced by small interfering RNA-mediated knockdown. These finding suggest that REG I may act through IL-6 to exert effects on squamous esophageal cancer cell biology...
  41. doi Expression of the chemokine receptor CCR6 correlates with a favorable prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    Department of Chest, Breast and Endoclinologic Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Tumour Biol 32:197-202. 2011
    ..11 to 0.93; P = 0.034) to be independent factors affecting the 5-year disease-free survival rate. Greater expression of CCR6 by tumor cells is an independent predictor of a better prognosis in patients with adenocarcinoma of the lung...
  42. doi REG Iα activates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells
    Akiyuki Wakita
    Department of Surgery, Graduate School of Medicine, Akita University, Akita, Japan
    Tumour Biol 36:5249-54. 2015
    ..Immunohistochemical analysis confirmed the activation of c-Jun in tumors expressing REG Iα. Collectively, these findings suggest that REG Iα activates c-Jun via the JNK and ERK pathway, thereby enhancing radiosensitivity. ..
  43. ncbi Survival advantage of using autologous blood transfusion during surgery for esophageal cancer
    Satoru Motoyama
    Second Department of Surgery, Akita University School of Medicine, Japan
    Surg Today 32:951-8. 2002
    ..This study was conducted to assess the survival advantage of giving autologous blood instead of allogeneic blood during surgery for esophageal cancer...
  44. ncbi Methylprednisolone inhibits low-flow hypoxia-induced mitochondrial dysfunction in isolated perfused rat liver
    Satoru Motoyama
    Second Department of Surgery, Akita University School of Medicine, Akita City, Japan
    Crit Care Med 31:1468-74. 2003
    ..To investigate the mechanism by which methylprednisolone protects the liver from hypoxia-induced injury...
  45. ncbi Visualization of lymphatic basin from the tumor using magnetic resonance lymphography with superparamagnetic iron oxide in patients with thoracic esophageal cancer
    Koichi Ishiyama
    Department of Radiology, Akita University School of Medicine, Akita, Japan
    J Comput Assist Tomogr 30:270-5. 2006
    ..To evaluate magnetic resonance (MR) lymphography with submucosal injection of superparamagnetic iron oxide (SPIO) for imaging lymphatic pathways from thoracic esophageal cancer...
  46. ncbi Cervical approach for resection of a pedunculated giant atypical lipomatous tumor of the esophagus
    Kiyotomi Maruyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 37:173-5. 2007
    ..We suggest that if the base of the tumor is located in the cervical portion of the esophagus, and if the tumor is not aggressive, the cervical approach is best, irrespective of the size of the tumor...
  47. doi Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung
    Yoshihiro Minamiya
    The Division of Thoracic Surgery, Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Lung Cancer 74:300-4. 2011
    ..We therefore investigated the relationship between HDAC1 expression by tumors and the clinicopathological characteristics of patients with adenocarcinoma of the lung...
  48. doi Polymorphonuclear leukocytes are activated during atelectasis before lung reexpansion in rat
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan
    Shock 30:81-6. 2008
    ..During atelectasis, PMNs accumulate in the lung, where they are primed for respiratory bursting. After pulmonary reexpansion, oxygen is supplied from the alveoli, and PMN respiratory bursting occurs...
  49. doi Tumoral CRP expression in thoracic esophageal squamous cell cancers is associated with poor outcomes
    Toshinobu Nakatsu
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 42:652-8. 2012
    ..Cancer cells reportedly produce C-reactive protein (CRP) locally within tumors. The aim of this study was to determine whether tumoral CRP is associated with clinical outcome and recurrence in thoracic esophageal squamous cell cancer...
  50. doi REG1A expression is an independent factor predictive of poor prognosis in patients with breast cancer
    Yasuhiro Sasaki
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Ann Surg Oncol 15:3244-51. 2008
    ..Although REG1A expression has also been observed in various malignant tumors, the correlation between REG1A expression and the clinicopathological characteristics of breast cancer and patient prognosis has not been evaluated...
  51. ncbi Long-term survival after salvage resection of recurrent esophageal cancer with anterior mediastinal lymph node involvement: report of a case
    Satoru Motoyama
    Departments of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 36:827-30. 2006
    ....
  52. ncbi REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer
    Yoshihiro Minamiya
    Division of Thoracic Surgery, Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo Akita City, 010 8543 Japan
    Lung Cancer 60:98-104. 2008
    ..Although REG1A expression also has been observed in various tumors, the correlation between REG1A expression and the clinicopathological characteristics of non-small cell lung cancer (NSCLC) and patient prognosis has not been evaluated...
  53. ncbi Hand-sewn cervical anastomosis versus stapled intrathoracic anastomosis after esophagectomy for middle or lower thoracic esophageal cancer: a prospective randomized controlled study
    Manabu Okuyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 37:947-52. 2007
    ..We compared the outcomes of cervical hand-sewn anastomosis (CHS) and intrathoracic stapled anastomosis (ITS) performed after esophagectomy and gastric reconstruction...
  54. doi Use of CT to evaluate pleural invasion in non-small cell lung cancer: measurement of the ratio of the interface between tumor and neighboring structures to maximum tumor diameter
    Kazuhiro Imai
    Department of Chest, Breast and Endocrinologic Surgery and Department of Integrated Medicine, Division of Radiology and Radiation Medicine, Akita University Graduate School of Medicine, 1 1 1 Hondo Akita City 010 8543, Japan
    Radiology 267:619-26. 2013
    ..To develop a simple noninvasive technique for evaluating pleural invasion by using routine preoperative computed tomography (CT)...
  55. doi Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients
    Yoshihiro Minamiya
    The Department of Chest Surgery, Akita University Hospital, Akita University Graduate School of Medicine, Hondo Akita, Japan
    Cancer Biomark 11:139-46. 2012
    ..Ratio of ZFHX3 mRNA in tumor against normal lung in low-ZFHX3 tumor was lower than in high-ZFHX3 tumor. In conclusion, suppression of ZFHX3 expression in tumor cells decreases the survival rate among patients with NSCLC...
  56. pmc Inhibition of dendritic cell migration by transforming growth factor-β1 increases tumor-draining lymph node metastasis
    Kazuhiro Imai
    Department of Chest, Breast and Endocrinologic Surgery, Akita University Graduate School of Medicine, Japan
    J Exp Clin Cancer Res 31:3. 2012
    ..Moreover, although TGF-β1 has been shown to promote tumor progression, there is still no direct, in vivo evidence as to whether TGF-β1 is able to directly induce distant metastasis...
  57. ncbi Hydrogen peroxide derived from intestine through the mesenteric lymph induces lung edema after surgical stress
    Masakatsu Nakamura
    Department of Surgery, Akita University School of Medicine, Hondo Akita City, Japan
    Shock 21:160-4. 2004
    ..The H2O2 then enters the mesenteric lymph and travels to the lung, where it increases capillary permeability and thus induces edema...
  58. doi IGFBP3 and BAG1 enhance radiation-induced apoptosis in squamous esophageal cancer cells
    Kei Yoshino
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Biochem Biophys Res Commun 404:1070-5. 2011
    ..IGFBP3 and BAG1 may thus be useful targets for improved and more individualized treatments for patients with esophageal squamous cell carcinoma...
  59. doi Pathological finding of subclinical interstitial pneumonia as a predictor of postoperative acute respiratory distress syndrome after pulmonary resection
    Hajime Saito
    Department of Surgery, Akita University School of Medicine, Hondo, Akita City 010 8543, Japan
    Eur J Cardiothorac Surg 39:190-4. 2011
    ..In this study, we evaluated IP on preoperative computed tomography (CT) and histopathological findings in patients who underwent thoracic surgery, and attempted to identify high-risk patients who might develop postoperative ARDS...
  60. doi REG Ialpha is a reliable marker of chemoradiosensitivity in squamous cell esophageal cancer patients
    Kaori Hayashi
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, Japan, 010 8543
    Ann Surg Oncol 15:1224-31. 2008
    ..A reliable marker of chemoradiosensitivity that would enable appropriate and individualized treatment of thoracic squamous cell esophageal cancer has long been sought. We investigated whether regenerating gene (REG) Ialpha is such a marker...
  61. doi Development of a New Magnetometer for Sentinel Lymph Node Mapping Designed for Video-Assisted Thoracic Surgery in Non-Small Cell Lung Cancer
    Kazuhiro Imai
    Akita University Graduate School of Medicine, Akita, Japan
    Surg Innov 22:401-5. 2015
    ..The purpose of the present study was to develop a smaller, thinner VATS-compatible magnetometer...
  62. ncbi C-reactive protein reduces the relative number of tumor-associated M2 macrophages and intratumoral angiogenesis in mice
    Kuniaki Kuribayashi
    Department of Surgery, Akita University Graduate School of Medicine
    Tohoku J Exp Med 233:249-55. 2014
    ..0028). These findings suggest that CRP has therapeutic potential against cancer through decreasing the accumulation of M2 macrophages and angiogenesis within tumors. ..
  63. doi Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
    Shinogu Takashima
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Tumour Biol 35:4257-65. 2014
    ..Stronger expression of cyclin B2 mRNA in tumor cells is an independent predictor of a poor prognosis in patients with adenocarcinoma of lung. ..
  64. doi New CT criteria for nodal staging in non-small cell lung cancer
    Satoshi Kudo
    Department of General Thoracic Surgery and Breast and Endocrine Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Clin Imaging 38:448-53. 2014
    ..The purpose of our study was to develop a simple noninvasive technique for nodal staging using routine preoperative computed tomography (CT)...
  65. doi Diagnostic imaging in the preoperative management of lung cancer
    Kazuhiro Imai
    Department of Chest and Endocrinological Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 44:1197-206. 2014
    ..However, thoracic surgeons should also be aware of the limitations of these techniques...
  66. doi C-reactive protein inhibits lymphangiogenesis and resultant lymph node metastasis of squamous cell carcinoma in mice
    Tomohiko Sasaki
    Department of Surgery, Akita University Graduate School of Medicine, Akita, Japan
    Surgery 154:1087-92. 2013
    ..We hypothesized that host CRP directly inhibits lymph node metastasis...
  67. pmc Esophagotracheal fistula caused by gastroesophageal reflux 9 years after esophagectomy
    Kiyotomi Maruyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    World J Gastroenterol 13:801-3. 2007
    ..It was successfully treated with transposition of a pedicled pectoralis major muscle flap...
  68. doi REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells
    Kaori Hayashi
    Department of Biochemistry, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Cancer Sci 99:2491-5. 2008
    ....
  69. doi Influence of CYP2C19 and ABCB1 polymorphisms on plasma concentrations of lansoprazole enantiomers after enteral administration
    Masatomo Miura
    Department of Pharmacy, Akita University Hospital, Akita, Japan
    Xenobiotica 40:630-6. 2010
    ..With enteral administration, CYP2C19 phenotyping of patients using the lansoprazole R/S enantiomer index at C(4h) could be possible...
  70. ncbi Proton pump inhibitors relieve and prevent symptoms related to gastric acidity after esophagectomy
    Manabu Okuyama
    Department of Surgery, Akita University School of Medicine, Hondo, Akita City, 010 8543, Japan
    World J Surg 32:246-54. 2008
    ....
  71. doi Acquired xanthine dehydrogenase expression shortens survival in patients with resected adenocarcinoma of lung
    Hayato Konno
    Division of Chest Surgery, Akita University Hospital, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita City, 010 8543, Japan
    Tumour Biol 33:1727-32. 2012
    ..11-5.02; P = 0.026) were all independent factors affecting 5-year disease-free survival. In conclusion, high tumoral XDH expression is an independent predictor of a poor prognosis in patients with adenocarcinoma of the lung...
  72. doi Transhiatal jejunal interposition preserving the whole stomach and vagal trunk for a benign esophageal stricture in a male adolescent: report of a case
    Satoru Motoyama
    Department of Surgery, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Surg Today 41:1567-70. 2011
    ....
  73. ncbi Soluble and cell-associated forms of some yet to be identified factor in transfused blood which promotes solid tumor growth in mice
    Manabu Okuyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 34:673-7. 2004
    ..The aim of the present study was to determine whether the transfusion of a soluble or insoluble factor present in stored blood can induce immunomodulation, which would thereby promote solid tumor growth...
  74. ncbi Clinical presentation of pulmonary edema following esophagectomy on chest radiograph
    Hideki Ota
    Second Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Hepatogastroenterology 50:1403-6. 2003
    ..To determine whether the clinical presentation of pulmonary edema following esophagectomy can be objectively determined by changes in X-ray density in the lung field on chest radiography...
  75. ncbi Usefulness of circumference difference for estimating the likelihood of malignancy in small solitary pulmonary nodules on CT
    Hajime Saito
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita City 010 8543, Japan
    Lung Cancer 58:348-54. 2007
    ..We measured the extent of ground-glass opacity (GGO) and our own original method of circumference difference (CD) as an additional approach in classifying SSPN revealed on CT, and evaluated the likelihood of malignancy...
  76. doi Radio-guided thoracoscopic surgery with (99m)Tc-methoxy-isobutylisonitrile for treating an ectopic mediastinal parathyroid adenoma in an adolescent girl
    Yoshihiro Minamiya
    Department of Surgery, Akita University School of Medicine, Hondo, Japan
    Gen Thorac Cardiovasc Surg 57:657-9. 2009
    ..This approach could be especially useful for young female patients, given its cosmetic advantage...
  77. doi Self-regulating hyperthermia induced using thermosensitive ferromagnetic material with a low Curie temperature
    Hajime Saito
    Department of Surgery, Akita University, 1 1 1 Hondo, Akita City 010 8543, Japan
    Cancer Sci 99:805-9. 2008
    ..A key advantage of this hyperthermia system is that it is minimally invasive, requiring only a single injection for repeated treatments with automatic temperature control...
  78. ncbi Magnetic resonance imaging for chylothorax after esophagectomy
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Jpn J Thorac Cardiovasc Surg 53:434-6. 2005
    ..It thus appears that this non-invasive new approach using MRI is effective and suitable for diagnosis and establishment of an appropriate treatment plan for chylothorax after thoracic surgery...
  79. ncbi Simultaneous esophagectomy and coronary artery bypass grafting without cardiopulmonary bypass: report of a case
    Reijiro Saito
    Second Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 34:156-8. 2004
    ..This case report demonstrates that simultaneous OPCAB and esophagectomy is advantageous for a selected population with surgically correctable coronary artery disease and resectable esophageal cancer...
  80. ncbi Outcomes of active operation during intensive followup for second primary malignancy after esophagectomy for thoracic squamous cell esophageal carcinoma
    Satoru Motoyama
    Second Department of Surgery, Akita University School of Medicine, Hondo, Akita City, Japan
    J Am Coll Surg 197:914-20. 2003
    ....
  81. ncbi Successful surgical treatment for diffuse esophageal spasm
    Kiyotomi Maruyama
    From Department of Gastroenterological Surgery, Akita University School of Medicine, Akita, Japan
    Jpn J Thorac Cardiovasc Surg 53:169-72. 2005
    ..We therefore recommend long myotomy of the esophageal wall with antireflux surgery for DES with sever dysphagia that is resistant to conservative treatment...
  82. ncbi Histological confirmation of healing of gastrobronchial fistula using a muscle flap
    Manabu Okuyama
    Second Department of Surgery, Akita University School of Medicine, Japan
    Ann Thorac Surg 73:1298-9. 2002
    ..Complete healing was confirmed histologically by epithelialization of the fistula site and at autopsy 12 months after surgery. Muscle flap transposition effectively repairs gastrobronchial fistula...
  83. ncbi Laparoscopic long esophagomyotomy with Dor's fundoplication using a transhiatal approach for an epiphrenic esophageal diverticulum
    Satoru Motoyama
    Department of Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Surg Today 36:758-60. 2006
    ..This approach eliminates the need for thoracotomy and pleural drainage, and permits a complete laparoscopic procedure, including diverticulectomy, myotomy, and antireflex surgery...
  84. doi Correlation between R/S enantiomer ratio of lansoprazole and CYP2C19 activity after single oral and enteral administration
    Masatomo Miura
    Department of Pharmacy, Akita University Hospital, Akita, Japan
    Chirality 22:635-40. 2010
    ..70 and (S)-lansoprazole concentration at 4 h > or = 50 ng/ml...
  85. ncbi Surgical treatment of esophageal varices caused by an arteriovenous fistula between an artery of the thyroid gland and the submucosal venous network of the esophageal wall
    Manabu Okuyama
    Department of Surgery, Akita University School of Medicine, Akita, Japan
    Ann Thorac Surg 80:1513-5. 2005
    ..Angiography confirmed the presence of both an arteriovenous fistula of the peripheral residual thyroid gland and the esophageal varices, after which we successfully treated the varices by surgical resection of the fistula...
  86. ncbi [A case of thoracic esophageal cancer with invasion of the main bronchus in which long-term survival with high quality of life was achieved through chemoradiotherapy, esophageal bypass and then additional chemotherapy]
    Satoru Motoyama
    Dept of Surgery, Akita University School of Medicine
    Gan To Kagaku Ryoho 34:2283-5. 2007
    ..This case, however, highlights how to treat such a patient so that he retains a high quality of life...
  87. ncbi Neoadjuvant high-dose intraarterial infusion chemotherapy under percutaneous pelvic perfusion with extracorporeal chemofiltration in patients with stages IIIa-IVa cervical cancer
    Satoru Motoyama
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Gynecol Oncol 95:576-82. 2004
    ....
  88. ncbi [S-1 chemotherapy for cancer of the gastric tube used for esophageal reconstruction following surgery for esophageal cancer]
    Satoru Motoyama
    Dept of Surgery, Akita University School of Medicine
    Gan To Kagaku Ryoho 34:2287-90. 2007
    ..And the third has survived 46 months after endoscopic treatment, radiation therapy and S-1 chemotherapy. S-1 chemotherapy thus appears to be an effective treatment for cancer of the gastric tube after surgery for esophageal cancer...
  89. ncbi The tumor necrosis factor-alpha promoter -1031C polymorphism is associated with decreased risk of endometriosis in a Japanese population
    Tasneem Asghar
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Hum Reprod 19:2509-14. 2004
    ..In this study, we investigated the possible association between endometriosis and the TNF-alpha gene promoter polymorphisms -238G/A, -308G/A, -857C/T, -863C/A and -1031T/C in a Japanese population...
  90. ncbi Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population
    Masashi Deguchi
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Soc Gynecol Investig 12:208-13. 2005
    ....
  91. ncbi Lack of association between endometriosis and the CYP17 MspA1 polymorphism in UK and Japanese populations
    Tasneem Asghar
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
    Gynecol Endocrinol 20:59-63. 2005
    ..2%] (cases) and 89/179 [49.7%] (controls) for A1A2; and 26/130 [20.0%] (cases) and 33/179 [18.4%] (controls) for A2A2. The CYP17 MspA1 polymorphism is probably not associated with endometriosis in either the UK or the Japanese population...
  92. ncbi Association study of endometriosis and intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms in a Japanese population
    Masako Yamashita
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Soc Gynecol Investig 12:267-71. 2005
    ..In this study, we investigated the possible association between endometriosis and the G241R and K469E polymorphisms in the intercellular adhesion molecule-1 (ICAM-1) gene in a Japanese population...
  93. ncbi Vaginoplasty with Interceed absorbable adhesion barrier for complete squamous epithelialization in vaginal agenesis
    Satoru Motoyama
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Am J Obstet Gynecol 188:1260-4. 2003
    ..The purpose of this study was to present our experiences of an innovative surgical approach for vaginal agenesis with the use of Interceed absorbable adhesion barrier (Ethicon) to achieve a satisfactory neovagina...
  94. ncbi Laminin-5 gamma2 chain and matrix metalloproteinase-2 expression in the neoplastic changes of uterine cervical squamous epithelium
    Robin Malina
    Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 50:123-30. 2004
    ..These results suggest that the expression of laminin-5 gamma2 chain and MMP-2 may be involved in the process of neoplastic changes of uterine cervical squamous epithelium...
  95. ncbi [Chemotherapy for an esophageal cancer patient undergoing continuous ambulatory peritoneal dialysis for chronic renal failure and measurement of plasma concentration of the drug]
    Manabu Okuyama
    Dept of Gastroenterological Surgery, Akita University School of Medicine
    Gan To Kagaku Ryoho 32:1029-32. 2005
    ..Although chemotherapy consisting of low-doses of cisplatin and 5-FU and a half dose of nedaplatin was administered safely, further study is needed to determine the suitable regimens for a patient maintained on CAPD...