Makio Mogi

Summary

Affiliation: Aichi-Gakuin University
Country: Japan

Publications

  1. doi request reprint ELISA for RANKL-OPG complex in mouse sera
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    J Immunoassay Immunochem 31:103-10. 2010
  2. ncbi request reprint Activation of caspases is required for osteoblastic differentiation
    Makio Mogi
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    J Biol Chem 278:47477-82. 2003
  3. ncbi request reprint Dual roles for NF-kappaB activation in osteoblastic cells by serum deprivation: osteoblastic apoptosis and cell-cycle arrest
    M Mogi
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    Bone 35:507-16. 2004
  4. ncbi request reprint p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464 8650, Japan
    Neurosci Lett 414:94-7. 2007
  5. ncbi request reprint Expression of cathepsin-K in gingival crevicular fluid of patients with periodontitis
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464 8650, Japan
    Arch Oral Biol 52:894-8. 2007
  6. doi request reprint Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan
    Biochem Biophys Res Commun 384:82-6. 2009
  7. doi request reprint Down-regulation of NF-kappaB led to up-regulation of NGF production in mouse osteoblasts
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    J Immunoassay Immunochem 31:92-101. 2010
  8. pmc Wnt16 Signaling Is Required for IL-1β-Induced Matrix Metalloproteinase-13-Regulated Proliferation of Human Stem Cell-Derived Osteoblastic Cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464 8651, Japan
    Int J Mol Sci 17:221. 2016
  9. doi request reprint IL-1β-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, Nagoya, Aichi 464 8651, Japan
    Exp Cell Res 323:165-77. 2014
  10. doi request reprint Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells
    Naoko Hase
    Department of Endodontics, School of Dentistry, Aichi Gakuin University
    Biosci Trends 9:228-36. 2015

Collaborators

  • A Togari
  • Ayami Kondo
  • Hiroshi Nakamura
  • Toshihide Noguchi
  • Hiroaki Takeda
  • Yoshikuni Mizuno
  • Tomoyoshi Kondo
  • T Nagatsu
  • Nobuyuki Udagawa
  • Naoyuki Takahashi
  • S Akira
  • Y Nanke
  • Shigeru Kotake
  • Naoto Saito
  • Nobuaki Ozeki
  • Taiki Hiyama
  • Kazuhiko Nakata
  • Hideyuki Yamaguchi
  • Rie Kawai
  • Naoko Hase
  • Akio Mitani
  • Takeki Fujimura
  • Takeshi Kikuchi
  • Toru Matsumoto
  • Hisashi Goto
  • Iichiro Okabe
  • Yuichi Ishihara
  • Naoya Higuchi
  • Yosuke Kamiya
  • Kosuke Okada
  • Makoto Aino
  • Mitsuo Fukuda
  • Yuko Nakamichi
  • Genta Yamamoto
  • Toshimitsu Hishikawa
  • Takayuki Suga
  • Yasuhiro Kobayashi
  • Masatoshi Kuzushima
  • Teruhito Yamashita
  • Shuhua Yang
  • Midori Nakamura
  • Yoshiaki Hasegawa
  • Michiko Tazoe
  • Masami Hattori
  • Ario Izawa
  • Yasuyuki Sasaki
  • Yoshinobu Tanaka
  • Hiroki Mizutani
  • Hatsuhiko Maeda
  • Makoto Mizutani
  • Norikazu Ohno
  • Shin Miyamae
  • Yusuke Ozawa
  • Eijiro Okabe
  • Wanda Niedbala
  • Atsushi Abe
  • Kenichi Kurita
  • Shinichi Miyajima
  • Hiromitsu Yamamoto
  • Randall H Kramer
  • Shinko Takahashi
  • Yuki Iwamura
  • Katsue Kinoshita
  • Tsuyoshi Tanaka
  • Kazuhiro Osawa
  • Jun Ichiro Hayashi
  • Toshihide Mizoguchi
  • Yohei Yamamoto
  • Masahiro Sato
  • Midrori Nakamura
  • Josef M Penninger
  • Nobuaki Sato
  • Kiyoshi Takeda
  • Haruhiko Takada
  • Takashi Uematsu
  • Masahiro Takahashi
  • Kiyofumi Furusawa
  • Hiroo Miyazawa
  • Shigemi Goto
  • Sachiko Matsuura
  • Hiroshi Horiuchi
  • Kunio Takaoka
  • Hidehiro Ozawa
  • B Yukihiro Hiraoka

Detail Information

Publications41

  1. doi request reprint ELISA for RANKL-OPG complex in mouse sera
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    J Immunoassay Immunochem 31:103-10. 2010
    ..Employing this assay system, we demonstrated that the RANKL-OPG complex was constitutively present in the serum of OPG+/- mice, but not in that of OPG-/- or wild-type C57BL/6 J mice...
  2. ncbi request reprint Activation of caspases is required for osteoblastic differentiation
    Makio Mogi
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    J Biol Chem 278:47477-82. 2003
    ..Taken together, these results confirm a unique and unanticipated role for the caspase-mediated signal cascade in the differentiation of osteoblasts...
  3. ncbi request reprint Dual roles for NF-kappaB activation in osteoblastic cells by serum deprivation: osteoblastic apoptosis and cell-cycle arrest
    M Mogi
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    Bone 35:507-16. 2004
    ..Taken together, our present results identify a novel role for NF-kappaB in cell-cycle and apoptosis regulation and underscore the significance of each independent signal cascade in serum-deprived osteoblastic cells...
  4. ncbi request reprint p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464 8650, Japan
    Neurosci Lett 414:94-7. 2007
    ....
  5. ncbi request reprint Expression of cathepsin-K in gingival crevicular fluid of patients with periodontitis
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464 8650, Japan
    Arch Oral Biol 52:894-8. 2007
    ..005 versus control subjects). Also, there was a positive correlation between cathepsin-K and RANKL levels (r=0.726), suggesting that both of them contribute to osteoclastic bone destruction in periodontal disease...
  6. doi request reprint Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan
    Biochem Biophys Res Commun 384:82-6. 2009
    ..Thus, suitable suppression of mTOR phosphorylation is a necessary requirement for OPG production in bone marrow stromal cells...
  7. doi request reprint Down-regulation of NF-kappaB led to up-regulation of NGF production in mouse osteoblasts
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    J Immunoassay Immunochem 31:92-101. 2010
    ..These findings demonstrate that the suitable suppression of NF-kappaB nuclear translocation induced NGF production in non-neuronal osteoblastic cells...
  8. pmc Wnt16 Signaling Is Required for IL-1β-Induced Matrix Metalloproteinase-13-Regulated Proliferation of Human Stem Cell-Derived Osteoblastic Cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464 8651, Japan
    Int J Mol Sci 17:221. 2016
    ....
  9. doi request reprint IL-1β-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, Nagoya, Aichi 464 8651, Japan
    Exp Cell Res 323:165-77. 2014
    ..Overall, our results suggest that IL-1β-induced MMP-13 expression and changes in cell proliferation and apoptosis in α7(+)hSMSC-OB cells are regulated by ADAM-28...
  10. doi request reprint Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells
    Naoko Hase
    Department of Endodontics, School of Dentistry, Aichi Gakuin University
    Biosci Trends 9:228-36. 2015
    ..Taken together, our current study demonstrates the sequential involvement of Wnt5, MMP-3, DMP-1 expression, and DMP-1 degradation products by MMP-3, in effecting IL-1β-induced proliferation of ESC-derived odontoblast-like cells. ..
  11. doi request reprint Α2 integrin, extracellular matrix metalloproteinase inducer, and matrix metalloproteinase-3 act sequentially to induce differentiation of mouse embryonic stem cells into odontoblast-like cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464 8651, Japan
    Exp Cell Res 331:21-37. 2015
    ..These results demonstrate a unique and unanticipated role for an α2 integrin-, Emmprin-, and MMP-3-mediated signaling cascade in driving mouse ES cell differentiation into odontoblast-like cells...
  12. doi request reprint Autophagy-related gene 5 and Wnt5 signaling pathway requires differentiation of embryonic stem cells into odontoblast-like cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, Nagoya, Aichi 464 8651, Japan Electronic address
    Exp Cell Res 341:92-104. 2016
    ....
  13. ncbi request reprint Polyphosphate-induced matrix metalloproteinase-13 is required for osteoblast-like cell differentiation in human adipose tissue derived mesenchymal stem cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University
    Biosci Trends 10:365-371. 2016
    ..Taken together, Poly(P)-induced MMP-13 regulates differentiation of osteogenic cells from hAT-MSCs...
  14. doi request reprint IL-15 and RANKL Play a Synergistically Important Role in Osteoclastogenesis
    Iichiro Okabe
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, 2 11 Suemoridori, Chikusa ku, Nagoya, Aichi, 464 8651, Japan
    J Cell Biochem . 2016
    ..J. Cell. Biochem. 9999: 1-9, 2016. © 2016 Wiley Periodicals, Inc...
  15. doi request reprint Gelatin scaffold combined with bone morphogenetic protein-4 induces odontoblast-like cell differentiation involving integrin profile changes, autophagy-related gene 10, and Wnt5 sequentially in human induced pluripotent stem cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi, 464 8651 Japan
    Differentiation 93:1-14. 2017
    ..We have revealed a unique sequential cascade involving Atg10, Wnt5a, α1 integrin, and matrix metalloproteinase-3 in GS/BMP-4-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage...
  16. doi request reprint Polyphosphate induces matrix metalloproteinase-3-mediated proliferation of odontoblast-like cells derived from induced pluripotent stem cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, Nagoya, Aichi 464 8651, Japan
    Exp Cell Res 333:303-15. 2015
    ..Using specific siRNAs, we revealed that a unique signaling cascade, Poly(P)→MMP-3→DSPP and/or DMP-1, was intimately involved in the proliferation of odontoblast-like cells...
  17. doi request reprint Bone morphogenetic protein-induced cell differentiation involves Atg7 and Wnt16 sequentially in human stem cell-derived osteoblastic cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, Nagoya, Aichi 464 8651, Japan Electronic address
    Exp Cell Res 347:24-41. 2016
    ....
  18. doi request reprint Polyphosphate-induced matrix metalloproteinase-3-mediated differentiation in rat dental pulp fibroblast-like cells
    Taiki Hiyama
    Department of Endodontics, School of Dentistry, Aichi Gakuin University
    Biosci Trends 9:360-6. 2015
    ..MMP-3 siRNA potently suppressed the expression of osteogenic biomarkers ALP, OC, OP, DSPP, and DMP-1, and blocked osteogenic calcification. Taken together, Poly(P)-induced MMP-3 regulates differentiation of osteogenic cells from DPFCs. ..
  19. doi request reprint Polyphosphate-induced matrix metalloproteinase-3-mediated proliferation in rat dental pulp fibroblast-like cells is mediated by a Wnt5 signaling cascade
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University
    Biosci Trends 9:160-8. 2015
    ..These results demonstrate the sequential involvement of Wnt5 and MMP-3 in Poly(P)-induced proliferation of DPFCs, and may have relevance in our understanding and ability to improve wound healing following dental pulp injury. ..
  20. pmc Interleukin-1β-induced autophagy-related gene 5 regulates proliferation of embryonic stem cell-derived odontoblastic cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, Nagoya, Aichi, 464 8651, Japan
    PLoS ONE 10:e0124542. 2015
    ..These results demonstrate the unique involvement of Atg5 in IL-1β-induced proliferation of embryonic stem cell-derived odontoblast-like cells. ..
  21. doi request reprint Unique proliferation response in odontoblastic cells derived from human skeletal muscle stem cells by cytokine-induced matrix metalloproteinase-3
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, Nagoya 464 8651, Aichi, Japan
    Exp Cell Res 331:105-14. 2015
    ..This siRNA-mediated increase in apoptosis could be reversed by exogenous MMP-3. These results demonstrate that cytokine-induced MMP-3 activity regulates cell proliferation and suppresses apoptosis in human odontoblast-like cells...
  22. doi request reprint IL-1β-induced, matrix metalloproteinase-3-regulated proliferation of embryonic stem cell-derived odontoblastic cells is mediated by the Wnt5 signaling pathway
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464 8651, Japan
    Exp Cell Res 328:69-86. 2014
    ..These results demonstrate the sequential involvement of Wnt5, Lrp5 and MMP-3 in effecting IL-1β-induced proliferation of ES cell-derived odontoblast-like cells...
  23. pmc Differentiation of human skeletal muscle stem cells into odontoblasts is dependent on induction of α1 integrin expression
    Nobuaki Ozeki
    From the Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464 8651, Japan
    J Biol Chem 289:14380-91. 2014
    ..These results strongly suggest that the differentiation of α7(+)hSMSCs along the odontogenic lineage is dependent on the concurrent expression of α1 integrin. ..
  24. pmc Matrix metalloproteinase-3 in odontoblastic cells derived from ips cells: unique proliferation response as odontoblastic cells derived from ES cells
    Taiki Hiyama
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi, Japan
    PLoS ONE 8:e83563. 2013
    ..05). Taken together, IL-1β induced MMP-3-regulated cell proliferation and suppressed apoptosis in odontoblast-like cells derived from iPS and ES cells. ..
  25. pmc Mouse-induced pluripotent stem cells differentiate into odontoblast-like cells with induction of altered adhesive and migratory phenotype of integrin
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi, Japan
    PLoS ONE 8:e80026. 2013
    ....
  26. doi request reprint Proinflammatory cytokines induce stromelysin-1-mediated cell proliferation in dental pulp fibroblast-like cells
    Hideyuki Yamaguchi
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Aichi, Japan
    J Endod 40:89-94. 2014
    ....
  27. ncbi request reprint Cytokine-induced nitric-oxide-dependent apoptosis in mouse osteoblastic cells: involvement of p38MAP kinase
    Masatoshi Kuzushima
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    Arch Oral Biol 51:1048-53. 2006
    ..These results demonstrate that this cytokine-induced apoptosis in mouse osteoblastic cells was mediated by a p38MAP-kinase-dependent iNOS system...
  28. pmc Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression
    Hisashi Goto
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, Chikusa ku, Nagoya, Aichi, Japan
    PLoS ONE 10:e0140942. 2015
    ..In conclusion, IL-1Ra is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 signaling cascade. ..
  29. ncbi request reprint Differential expression of the Fas-Fas ligand system on cytokine-induced apoptotic cell death in mouse osteoblastic cells
    Nobuaki Ozeki
    Department of Endodontics, School of Dentistry, Aichi Gakuin University, Nagoya 464 8651, Japan
    Arch Oral Biol 47:511-7. 2002
    ....
  30. pmc Adjunctive Application of Antimicrobial Photodynamic Therapy in Nonsurgical Periodontal Treatment: A Review of Literature
    Takeshi Kikuchi
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Aichi 464 8651, Japan
    Int J Mol Sci 16:24111-26. 2015
    ..In the light of these previous reports, the aim of this review is to provide comprehensive information about aPDT and help extend knowledge of advanced laser therapy. ..
  31. doi request reprint Increased expression of interleukin (IL)-35 and IL-17, but not IL-27, in gingival tissues with chronic periodontitis
    Akio Mitani
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan
    J Periodontol 86:301-9. 2015
    ..Here, IL-35, IL-17, and IL-27 production/expression in gingival crevicular fluid (GCF) and human gingival tissue were investigated...
  32. ncbi request reprint Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells
    Michiko Tazoe
    Department of Pharmacology, School of Dentistry, Aichi Gakuin University, Nagoya 464 8650, Japan
    Arch Oral Biol 48:615-9. 2003
    ..These results clearly suggest that activation of the p38MAP kinase pathway is necessary for BMP-4-induced OPG induction in ST2 cells...
  33. doi request reprint The presence of RANKL-OPG complex in human osteosarcoma U2OS
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    J Immunoassay Immunochem 34:356-64. 2013
    ....
  34. doi request reprint Irradiation with a low-level diode laser induces the developmental endothelial locus-1 gene and reduces proinflammatory cytokines in epithelial cells
    Takeki Fujimura
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, 2 11 Suemori dori, Chikusa ku, 464 8651, Nagoya, Aichi, Japan
    Lasers Med Sci 29:987-94. 2014
    ....
  35. doi request reprint Activation of caspase-8 and caspase-9 are required for PC12 cells differentiation
    Makio Mogi
    a Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    J Immunoassay Immunochem 36:547-58. 2015
    ..In conclusion, present results confirm a unique role for the caspase-8 and caspase-9 mediated signal cascade in the differentiation of PC12 cells. ..
  36. doi request reprint Aggregatibacter actinomycetemcomitans lipopolysaccharide stimulated epithelial cells produce interleukin-15 that regulates T cell activation
    Takayuki Suga
    Department of Periodontology, School of Dentistry, Aichi Gakuin University, 2 11 Suemoridori, Chikusa ku, Nagoya, Aichi 464 8651, Japan
    Arch Oral Biol 58:1541-8. 2013
    ....
  37. doi request reprint The presence of TRAIL-OPG complex in human osteosarcoma and human salivary gland adenocarcinoma
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan
    J Immunoassay Immunochem 32:70-8. 2011
    ..Employing this assay system, we demonstrated that the TRAIL-OPG complex was constitutively present in the human osteosarcoma cell lines, HOS, MG-63, and human salivary gland adenocarcinoma cell line, HSG...
  38. ncbi request reprint IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL
    Shigeru Kotake
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Eur J Immunol 35:3353-63. 2005
    ..Contrary to our hypothesis, IFN-gamma(+) human T cells induced osteoclastogenesis through the expression of RANKL, suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA...
  39. ncbi request reprint Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts
    Shuhua Yang
    Department of Oral and Maxillofacial Surgery, Matsumoto Dental University, Shiojiri, Nagano, Japan
    J Immunol 175:1956-64. 2005
    ....
  40. ncbi request reprint Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts
    Yuko Nakamichi
    Institute for Oral Science, Matsumoto Dental University, Nagano, Japan
    J Immunol 178:192-200. 2007
    ..These results suggest that OPG suppresses the shedding of RANKL from osteoblasts and that the serum RANKL in OPG(-/-) mice exactly reflects the state of bone resorption...
  41. ncbi request reprint Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption
    Midori Nakamura
    Department of Pediatric Dentistry, Institute for Oral Science, Matsumoto Dental University, Nagano 399 0781, Japan
    Endocrinology 144:5441-9. 2003
    ..These results suggest that bone formation is coupled with bone resorption at local sites in OPG-/- mice, and that serum RANKL levels do not reflect this coupling...