Guido Iaccarino

Summary

Affiliation: Via Ponte Don Melillo
Country: Italy

Publications

  1. pmc CaMK4 Gene Deletion Induces Hypertension
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy G S, E C, D S, C D G, A A, B T
    J Am Heart Assoc 1:e001081. 2012
  2. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
  3. doi request reprint Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo
    Daniela Sorriento
    Department of Medicine and Surgery, Universita di Salerno, Via Salvador Allende, 84081 Baronissi, Italy
    Hypertension 60:129-36. 2012
  4. ncbi request reprint AKT participates in endothelial dysfunction in hypertension
    Guido Iaccarino
    Department of Clinical Medicine, University of Naples Federico II, Italy
    Circulation 109:2587-93. 2004
  5. ncbi request reprint Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system
    Guido Iaccarino
    Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Naples, Italy
    Circ Res 97:1182-9. 2005
  6. pmc Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species
    Michele Ciccarelli
    From the Department of Medicine and Surgery, University of Salerno, Salerno, Italy M C, E C, G l Department of Pharmacology, Center for Translational Medicine, Temple University, Philadelphia, PA M C Department of Biomedical Sciences, University of Naples Federico II, Naples, Italy D S, A F, C D G, R A, M G M, B T Department of Internal Medicine, Washington University School of Medicine, St Louis, MO G W D and IRCCS Multimedica, Milan, Italy G I
    Arterioscler Thromb Vasc Biol 33:2415-24. 2013
  7. ncbi request reprint Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC
    Michele Ciccarelli
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Cell Signal 19:1949-55. 2007
  8. doi request reprint β2-Adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis
    Gennaro Galasso
    Department of Medicine and Surgery, University of Salerno, San Giovanni di Dio and Ruggi D Aragona Academic Hospital, Cardiology Tower, Room S1, Largo Città d Ippocrate, 84131 Salerno, Italy
    Circ Res 112:1026-34. 2013
  9. doi request reprint Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression
    Daniela Sorriento
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
    Hypertension 56:696-704. 2010
  10. doi request reprint Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors
    Alfonso Carotenuto
    Dipartimento di Farmacia, Federico II University of Naples, Italy
    Eur J Med Chem 69:384-92. 2013

Collaborators

Detail Information

Publications38

  1. pmc CaMK4 Gene Deletion Induces Hypertension
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy G S, E C, D S, C D G, A A, B T
    J Am Heart Assoc 1:e001081. 2012
    ....
  2. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
    ..We investigated the association of 9p21.3 variants with severity of CAD (defined by the number of vessel diseased [VD]) in the presence and absence of T2D...
  3. doi request reprint Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo
    Daniela Sorriento
    Department of Medicine and Surgery, Universita di Salerno, Via Salvador Allende, 84081 Baronissi, Italy
    Hypertension 60:129-36. 2012
    ..In conclusion, our study demonstrates for the first time that ECs are able to synthesize and release catecholamines in response to ischemia...
  4. ncbi request reprint AKT participates in endothelial dysfunction in hypertension
    Guido Iaccarino
    Department of Clinical Medicine, University of Naples Federico II, Italy
    Circulation 109:2587-93. 2004
    ..It was recently reported that AKT phosphorylates and activates endothelial nitric oxide synthase and that impaired kinase activity may be involved in endothelial dysfunction...
  5. ncbi request reprint Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system
    Guido Iaccarino
    Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Naples, Italy
    Circ Res 97:1182-9. 2005
    ..Therefore, beta2ARs play a critical role in endothelial cell proliferation and function including revascularization, suggesting a novel and physiologically relevant role in neoangiogenesis in response to ischemia...
  6. pmc Endothelial G protein-coupled receptor kinase 2 regulates vascular homeostasis through the control of free radical oxygen species
    Michele Ciccarelli
    From the Department of Medicine and Surgery, University of Salerno, Salerno, Italy M C, E C, G l Department of Pharmacology, Center for Translational Medicine, Temple University, Philadelphia, PA M C Department of Biomedical Sciences, University of Naples Federico II, Naples, Italy D S, A F, C D G, R A, M G M, B T Department of Internal Medicine, Washington University School of Medicine, St Louis, MO G W D and IRCCS Multimedica, Milan, Italy G I
    Arterioscler Thromb Vasc Biol 33:2415-24. 2013
    ..The role of endothelial G protein-coupled receptor kinase 2 (GRK2) was investigated in mice with selective deletion of the kinase in the endothelium (Tie2-CRE/GRK2(fl/fl))...
  7. ncbi request reprint Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC
    Michele Ciccarelli
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Cell Signal 19:1949-55. 2007
    ..We propose a novel signal transduction pathway for beta(2)AR stimulation trough G(alphai) and SRC, leading to activation of AKT...
  8. doi request reprint β2-Adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis
    Gennaro Galasso
    Department of Medicine and Surgery, University of Salerno, San Giovanni di Dio and Ruggi D Aragona Academic Hospital, Cardiology Tower, Room S1, Largo Città d Ippocrate, 84131 Salerno, Italy
    Circ Res 112:1026-34. 2013
    ..2-Adrenergic receptor (β2AR) plays a critical role in vascular tone regulation and neoangiogenesis...
  9. doi request reprint Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression
    Daniela Sorriento
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
    Hypertension 56:696-704. 2010
    ..In conclusion, our study supports the regulation of LVH based on the GRK5-NT inhibition of the NF-κB transduction signaling...
  10. doi request reprint Design, synthesis and efficacy of novel G protein-coupled receptor kinase 2 inhibitors
    Alfonso Carotenuto
    Dipartimento di Farmacia, Federico II University of Naples, Italy
    Eur J Med Chem 69:384-92. 2013
    ..In a cellular system, this peptide confirms the beneficial signaling properties of a potent GRK2 inhibitor. Preferred conformations of the most potent analog were investigated by NMR spectroscopy. ..
  11. pmc Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis
    Anna Fusco
    Clinical Medicine, Cardiovascular and Immunological Sciences Federico II University, Naples, Italy
    Cell Signal 24:468-75. 2012
    ..Our data show a novel sub-cellular localization of GRK2 in the mitochondria and an unexpected role in regulating mitochondrial biogenesis and ATP generation...
  12. pmc The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events
    Gennaro Galasso
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University School of Medicine, Naples, Italy
    BMC Cardiovasc Disord 10:41. 2010
    ..We aimed to explore the effect of PlA2 polymorphism on outcome in patients with atherosclerosis...
  13. doi request reprint Enhanced GRK2 expression and desensitization of betaAR vasodilatation in hypertensive patients
    Raffaele Izzo
    Dipartimento di Medicina Clinica Scienze Cardiovascolari ed Immunologiche, Federico II University of Naples, Italy
    Clin Transl Sci 1:215-20. 2008
    ..We conclude that desensitization participates to impaired betaAR vasodilation in hypertension...
  14. pmc Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy
    Ersilia Cipolletta
    Department of Medicine and Surgery, University of Salerno, Baronissi SA, Italy
    PLoS ONE 10:e0130477. 2015
    ..We hypothesize that CaMKII association with extracellular regulated kinase (ERK), promotes cardiac hypertrophy through ERK nuclear localization...
  15. doi request reprint Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy
    Daniela Sorriento
    Institute of Biostructure and Bioimaging IBB of the Italian National Research Council CNR, Naples, Italy
    J Cardiovasc Transl Res 8:493-502. 2015
    ..Our results suggest a previously undisclosed role for GRK2 in the regulation of hypertrophic responses and propose GRK2 as potential therapeutic target for limiting LVH. ..
  16. pmc Insufficient control of blood pressure and incident diabetes
    Raffaele Izzo
    Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, Federico II University Naples, Naples, Italy
    Diabetes Care 32:845-50. 2009
    ..There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients...
  17. doi request reprint Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease
    Federico Piscione
    Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Naples, Italy
    J Am Coll Cardiol 52:1381-8. 2008
    ..This study investigated the relationship between beta(2)-adrenergic receptor (B2AR) Ile164 polymorphism and coronary artery disease (CAD)...
  18. ncbi request reprint Good at Heart: Preserving Cardiac Metabolism during aging
    Daniela Sorriento
    Department of Medicine and Surgery, University of Salerno, Italy
    Curr Diabetes Rev 12:90-9. 2015
    ..This article reviews the central role played by this organelle in aging and the role of new molecular players involved into the progression toward heart failure and potentially susceptible of new "anti-aging" strategies. ..
  19. pmc Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy
    Diabetes 61:692-701. 2012
    ..Our data indicate that reduced β(2)AR expression contributes to the age-related decline of glucose tolerance in mice...
  20. pmc Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Italy
    J Transl Med 9:7. 2011
    ..We have recently synthesized a new and selective ligand of αVβ3 receptor, referred to as RGDechiHCit, that contains a cyclic RGD motif and two echistatin moieties...
  21. doi request reprint Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure
    Gennaro Galasso
    Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Via S Pansini, 5, 80131 Naples, Italy
    Eur J Heart Fail 12:1290-6. 2010
    ..The aim of this study was to investigate the expression of Atrogin-1 and the molecular pathway involved in Atrogin-1 regulation in human HF...
  22. pmc Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells
    Maria Soprano
    Department of Translational Medical Science, University of Naples Federico II, Naples, Italy
    PLoS ONE 11:e0155970. 2016
    ....
  23. doi request reprint G protein-coupled receptor kinase 2 in patients with acute myocardial infarction
    Gaetano Santulli
    Division of Internal Medicine, Department of Clinical Medicine and Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
    Am J Cardiol 107:1125-30. 2011
    ..Taken together, these data indicate that GRK2 could be predictive of ventricular remodeling after myocardial infarction and could facilitate the tailoring of appropriate therapy for high-risk patients...
  24. ncbi request reprint The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients
    Francesca Lanni
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    J Hypertens 25:551-6. 2007
    ..We explored the possibility that this polymorphism represents a risk factor for stroke in hypertensive patients...
  25. ncbi request reprint The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension
    Guido Iaccarino
    Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Naples, Italy
    J Hypertens 22:2117-22. 2004
    ..We evaluated the impact on hypertension-associated TOD of a highly polymorphic gene with elevated significance for the regulation of the cardiovascular system, the beta2AR gene...
  26. doi request reprint SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors
    Isabel Gomez-Monterrey
    Department of Pharmacy, Federico II University of Naples, Naples, Italy
    Biopolymers 101:121-8. 2014
    ..Conformational analysis identified two β-turns that involve N-terminal residues, followed by a short extended region. These information can help the design of peptides and peptido-mimetics with enhanced GRK2 inhibition properties...
  27. doi request reprint G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms
    Gaetano Santulli
    Department of Advanced Biomedical Sciences, Federico II University of Naples, 80131, Naples, Italy
    High Blood Press Cardiovasc Prev 20:5-12. 2013
    ..This review attempts to assemble the currently available information concerning GRK2 and hypertension, opening new potential fields of translational investigation to treat this vexing disease...
  28. ncbi request reprint Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries
    Emanuele Barbato
    Division of Cardiology, Federico II University of Naples, Italy
    Circulation 111:288-94. 2005
    ..This study aimed at assessing the role of beta2-ARs in normal, mildly atherosclerotic, and stenotic human coronary arteries...
  29. doi request reprint GRK2 levels in umbilical arteries of pregnancies complicated by gestational hypertension and preeclampsia
    Raffaele Napolitano
    Department of Obstetrics and Gynecology, Prenatal Diagnosis and High Risk Pregnancy Unit, University of Naples, Federico II, Naples, Italy
    Am J Hypertens 25:366-71. 2012
    ..The aim of this study is to ascertain if this feature is present in the fetal placental vasculature of pregnancies complicated by hypertensive disorders...
  30. ncbi request reprint GRK2 at the control shaft of cellular metabolism
    Michele Ciccarelli
    Department of Clinical Medicine and Cardiovascular Science, Federico II University of Naples, Italy
    Curr Pharm Des 18:121-7. 2012
    ....
  31. doi request reprint Characterization of a selective CaMKII peptide inhibitor
    Isabel Gomez-Monterrey
    Depart of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, Naples, Italy
    Eur J Med Chem 62:425-34. 2013
    ..Structural analysis of CN17β by CD and NMR indicated an α-helix conformation in the Leu6-Arg11 segment well overlapping with the crystal structure of 21-residue segment of CaM-KNtide bound to the kinase domain of CaMKII...
  32. doi request reprint A novel crosstalk between calcium/calmodulin kinases II and IV regulates cell proliferation in myeloid leukemia cells
    Sara Monaco
    Dipartimento di Scienze Mediche Traslazionali, Federico II University, Naples, Italy
    Cell Signal 27:204-14. 2015
    ..Our data reveal a novel cross-talk between CaMKII and CaMKIV and suggest that CaMKII suppresses the expression of CaMKIV to promote leukemia cell proliferation. ..
  33. ncbi request reprint In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis
    Guido Iaccarino
    Dipartmento di Medicina Clinica, Scienze Cardiovasculari ed Immunologiche, Federico II University, Naples, Italy
    Methods Mol Biol 237:181-92. 2004
    ....
  34. pmc Pinpointing beta adrenergic receptor in ageing pathophysiology: victim or executioner? Evidence from crime scenes
    Gaetano Santulli
    Departments of Translational Medical Sciences and Advanced Biomedical Sciences, Federico II University, Naples, Italy
    Immun Ageing 10:10. 2013
    ....
  35. ncbi request reprint Beta(2)-adrenergic receptor gene delivery to the endothelium corrects impaired adrenergic vasorelaxation in hypertension
    Guido Iaccarino
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Circulation 106:349-55. 2002
    ....
  36. ncbi request reprint Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets
    Guido Iaccarino
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Napoli, Italy
    Assay Drug Dev Technol 1:347-55. 2003
    ..These genetic approaches or the development of small molecule inhibitors of betaARK1 and GRK activity may advance therapeutic options for heart disease...