Genomes and Genes
Affiliation: University of Bologna
- Sensorineural hearing loss and celiac disease: a coincidental findingUmberto Volta
Department of Clinical Medicine, University of Bologna, St Orsola Malpighi Hospital, Bologna, Italy
Can J Gastroenterol 23:531-5. 2009..Celiac disease (CD) can be associated with a variety of extraintestinal manifestations, including neurological diseases. A new neurological correlation has been found between CD and sensorineural hearing loss (SNHL)...
- Usefulness of antibodies to deamidated gliadin peptides in celiac disease diagnosis and follow-upUmberto Volta
Department of Gastroenterology and Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti, 9, Bologna 40138, Italy
Dig Dis Sci 53:1582-8. 2008..The combined use of tissue transglutaminase and deamidated gliadin peptide antibodies seems to be a very useful tool for celiac disease diagnosis. Moreover, antibodies to deamidated gliadin peptides can be helpful in disease follow-up...
- Clinical and immunological features of celiac disease in patients with Type 1 diabetes mellitusUmberto Volta
Department of Digestive Diseases and Internal Medicine, S Orsola Malpighi Policlinic, University of Bologna, Bologna, Italy
Expert Rev Gastroenterol Hepatol 5:479-87. 2011..Potential CD cases (especially when asymptomatic) should be kept on a gluten-containing diet with a careful clinical and antibody follow-up, since many of them will not develop villous atrophy...
- Anti-ganglioside antibodies in coeliac disease with neurological disordersU Volta
Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Building 11, St Orsola Malpighi Hospital, Via Massarenti, 9, 40138 Bologna, Italy
Dig Liver Dis 38:183-7. 2006..Anti-ganglioside antibodies have been described in sera of coeliac patients with peripheral neuropathy and cerebellar ataxia...
- Old and new serological tests for celiac disease screeningUmberto Volta
Department of Gastroenterology and Internal Medicine, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Expert Rev Gastroenterol Hepatol 4:31-5. 2010..In summary, although both tests represent a very good tool for identifying celiac patients, tTG antibodies display a higher predictive value than DGP antibodies, and must still be considered the best serological test for CD screening...
- Pathogenesis and clinical significance of liver injury in celiac diseaseUmberto Volta
Department of Gastroenterology and Internal Medicine, University of Bologna, S Orsola Malpighi Hospital, Via Massarenti 9, 40138, Bologna, Italy
Clin Rev Allergy Immunol 36:62-70. 2009....
- Serological tests in gluten sensitivity (nonceliac gluten intolerance)Umberto Volta
Department of Clinical Medicine, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
J Clin Gastroenterol 46:680-5. 2012..To characterize the serological pattern of gluten sensitivity (GS) and to compare it with that found in celiac disease...
- Deamidated gliadin peptide antibodies as a routine test for celiac disease: a prospective analysisUmberto Volta
Department of Clinical Medicine, University of Bologna, Bologna, Italy
J Clin Gastroenterol 44:186-90. 2010..This study was designed to establish whether deamidated gliadin peptide antibodies (DGP-AGA) could improve the serologic workup for celiac disease (CD)...
- Multiple nuclear dots and rim-like/membranous IgG isotypes in primary biliary cirrhosisPaolo Muratori
Department of Clinical Medicine, Alma Mater Studiorum, University of Bologna, Italy
Autoimmunity 42:224-7. 2009..In Italian PBC patients MND and RL/M pattern did not seem to characterize any subgroup of patients with a poorer prognosis...
- Celiac disease in autoimmune cholestatic liver disordersUmberto Volta
Department of Internal Medicine, Cardioangiology, Hepatology, S Orsola Malpighi Policlinic, University of Bologna, Italy
Am J Gastroenterol 97:2609-13. 2002....
- Prevalence of celiac disease in children with type 1 diabetes mellitus increased in the mid-1990 s: an 18-year longitudinal study based on anti-endomysial antibodiesSilvana Salardi
Departments of Pediatrics, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy
J Pediatr Gastroenterol Nutr 46:612-4. 2008..6%) than before 1994 (3.3%). The rapid change in the risk of CD among Italian diabetic children that occurred in the mid-1990 s could be related to changes in environmental factors, namely, eating habits and viral infections...
- Non-celiac gluten sensitivity: questions still to be answered despite increasing awarenessUmberto Volta
Department of Medical and Surgical Sciences, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Cell Mol Immunol 10:383-92. 2013..Future research is needed to generate more knowledge regarding non-celiac gluten sensitivity, a condition that has global acceptance but has only a few certainties and many unresolved issues. ..
- Nailfold capillaroscopy in primary biliary cirrhosis: a useful tool for the early diagnosis of sclerodermaFrancesco Tovoli
Department of Medical and Surgical Sciences, University of Bologna, Italy
J Gastrointestin Liver Dis 23:39-43. 2014..Since studies on the prevalence of early SSc in PBC patients are lacking, our aim was to investigate its hitherto unknown prevalence in a large cohort of PBC patients...
- Gut-liver axis: an immune link between celiac disease and primary biliary cirrhosisUmberto Volta
Department of Medical and Surgical Sciences, St Orsola Malpighi Hospital, University of Bologna, Italy
Expert Rev Gastroenterol Hepatol 7:253-61. 2013..Reciprocal screening for both diseases is recommended, as an early diagnosis with the appropriate treatment can improve the outcome of these patients...
- Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patientsGiovanni Ravaglia
Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9, Bologna 40138, Italy
Exp Gerontol 38:589-95. 2003..In conclusion, prevalence of CD is increased in AT but the association is limited to patients aged 65 years or older. Serological screening including anti-tTG-IgA is recommended in these patients...
- Fibromyalgia and coeliac disease: a media hype or an emerging clinical problem?Francesco Tovoli
Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
Clin Exp Rheumatol 31:S50-2. 2013..The aim of our study was to verify a possible association between FM and CD, by assessing the prevalence of CD in a cohort of FM patients and vice versa...
- New understanding of gluten sensitivityUmberto Volta
Department of Clinical Medicine, University of Bologna and St Orsola Malpighi Hospital, Via Massarenti 9, Bologna 40138, Italy
Nat Rev Gastroenterol Hepatol 9:295-9. 2012..Further research is necessary to establish the main clinicopathological features of gluten sensitivity, thus enabling physicians to improve their management of the increasing number of patients who are sensitive to dietary gluten...
- Evidence of a genetic basis for the different geographic occurrences of liver/kidney microsomal antibody type 1 in hepatitis CPaolo Muratori
Department of Internal Medicine, Cardioangiology, Hepatology, Policlinico Sant Orsola Malpighi, Bologna, Italy
Dig Dis Sci 52:179-84. 2007..HLA DR11 may be protective against the development of microsomal antibodies in Italian patients, whereas HLA DR4, HLA DR13, and the B8-DR3-DQ2 haplotype may be protective in North American patients...
- Neurogenic chronic intestinal pseudo-obstruction: antineuronal antibody-mediated activation of autophagy via FasRoberto De Giorgio
Department of Internal Medicine and Gastroenterology, Centro Unificato di Ricerca BioMedica Applicata, University of Bologna, Bologna, Italy
Gastroenterology 135:601-9. 2008..In this study we tested the hypothesis that sera from a subpopulation of patients with CIP contain autoantibodies that activate autophagy via a Fas-dependent pathway in cultured human neuroblastoma SH-Sy5Y cells...
- Recurrent ischemic strokes in a young celiac woman with MTHFR gene mutationElisa Fabbri
Stroke Unit, Department of Internal Medicine, Aging and Nephrological Diseases, University of Bologna, 40138 Bologna, Italy
World J Gastroenterol 18:3472-6. 2012..CD should be kept in mind in the differential diagnosis of ischemic stroke in young patients...
- The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral centerUmberto Volta
Department of Medical and Surgical Sciences, University of Bologna, S, Orsola Malpighi Hospital, Bldg 5 Via Massarenti 9, Bologna, 40138, Italy
BMC Gastroenterol 14:194. 2014..Our goal was to define clinical, serological and histopathological findings in a large cohort of celiacs diagnosed in a single referral center...
- Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivityGiacomo Caio
Department of Medical and Surgical Sciences, St, Orsola Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
BMC Gastroenterol 14:26. 2014..This study was designed to characterize the effect of the gluten-free diet on anti-gliadin antibodies of IgG class in patients with non-celiac gluten sensitivity...
- Fulminant type 1 autoimmune hepatitis in a recently diagnosed celiac disease patientUmberto Volta
Department of Medical and Surgical Sciences, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Arch Iran Med 16:683-5. 2013..At this time, the liver autoantibodies turned to be positive thus confirming the development of a type 1 AIH. The hepatic damage progressed to a late onset liver failure requiring liver transplantation. ..
- A case of leptospirosis simulating colon cancer with liver metastasesAlessandro Granito
Dipartimento di Medicina Interna, Policlinico S Orsola Malpighi, Via Massarenti, 9, 40138 Bologna, Italy
World J Gastroenterol 10:2455-6. 2004..Diagnosis of leptospirosis was considered and confirmed by detection of an elevated titer of antibodies to leptospira. After two mo, biochemical data, CT and colonoscopy were totally normal...
- Non-celiac gluten sensitivity: a work-in-progress entity in the spectrum of wheat-related disordersUmberto Volta
Department of Medical and Surgical Sciences, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy Electronic address
Best Pract Res Clin Gastroenterol 29:477-91. 2015..Although currently limited to a research setting, double-blind, placebo-controlled, cross-over trial strategy is recommended to confirm the diagnosis. Treatment is based on dietary restriction with special care to nutrient intake. ..
- Low risk of colon cancer in patients with celiac diseaseUmberto Volta
Department of Medical and Surgical Sciences Digestive Diseases and Internal Medicine, St Orsola Malpighi Hospital, Bologna, Italy
Scand J Gastroenterol 49:564-8. 2014..In this cohort study, we describe the risk of colon carcinoma in a group of Italian celiac patients...
- Papillary cancer of thyroid in celiac diseaseUmberto Volta
Department of Internal Medicine, S Orsola Malpighi Hospital, Bologna, Italy
J Clin Gastroenterol 45:e44-6. 2011..Celiac disease (CD) has been established as being associated with several thyroid diseases. However, occurrence of thyroid epithelial cancer in celiac patients has been rarely described...
- Growth and adult height in atypical coeliac patients, with or without growth hormone deficiencySilvana Salardi
Department of Pediatrics, University of Bologna, Bologna, Italy
J Pediatr Endocrinol Metab 18:769-75. 2005..To evaluate the effect of a gluten-free diet on growth and adult height, when available, in coeliac children without gastrointestinal symptoms...
- Adult coeliac disease diagnosed by endoscopic biopsies in the duodenal bulbEmilio Brocchi
Department of Internal Medicine and Gastroenterology, Cardio Angiology and Hepatology, University of Bologna, Italy
Eur J Gastroenterol Hepatol 17:1413-5. 2005....
- Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?Roberto De Giorgio
Department of Medical and Surgical Sciences, Centro di Ricerca Bio Medica Applicata C R B A and Digestive System, St Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
Gut 65:169-78. 2016..This knowledge is expected to promote standardisation in dietary strategies (gluten/wheat-free and low FODMAP) as effective measures for the management of IBS symptoms. ..
- Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstructionElena Bonora
Department of Medical and Surgical Sciences, University of Bologna, and St Orsola Malpighi Hospital, Bologna, Italy
Gastroenterology 148:771-782.e11. 2015..We searched for genetic variants associated with CIPO to increase our understanding of its pathogenesis and to identify potential biomarkers...
- Epilepsy in coeliac disease: not just a matter of calcificationsLaura Licchetta
Department of Neurological Sciences, University of Bologna, Via Ugo Foscolo 7, 40123 Bologna, Italy
Neurol Sci 32:1069-74. 2011..Our data also confirm the major involvement of the occipital lobe, and minimise both the importance of calcifications in epileptogenesis and folic acid deficit in the development of calcifications...
- Autoimmune enteropathy and colitis in an adult patientAntonio Carroccio
The Department of Internal Medicine, University Hospital of Palermo, Palermo, Italy
Dig Dis Sci 48:1600-6. 2003..Systematic testing for enterocyte autoantibodies should be performed not only in patients with refractory sprue, but also in subjects with upper and lower intestinal symptoms who have not been definitively diagnosed...
- Sera of patients with celiac disease and neurologic disorders evoke a mitochondrial-dependent apoptosis in vitroElisabetta Cervio
Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia, Italy
Gastroenterology 133:195-206. 2007..The mechanisms underlying neurologic impairment in celiac disease remain unknown. We tested whether antineuronal antibody-positive sera of patients with celiac disease evoke neurodegeneration via apoptosis in vitro...
- Antiendomysial and antihuman recombinant tissue transglutaminase antibodies in the diagnosis of coeliac disease: a biopsy-proven European multicentre studyPekka Collin
Tampere University Hospital and University of Tampere, Finland
Eur J Gastroenterol Hepatol 17:85-91. 2005..The setting allowed a further comparison between the antibody results and the conventional small-intestinal histology...
- Antitransglutaminase antibodies and giardiasisAlessandro Granito
Am J Gastroenterol 99:2505-6. 2004
- Risk of non-Hodgkin lymphoma in celiac diseaseCarlo Catassi
University of Maryland, Division of Pediatric Gastroenterology and Nutrition, 22 S Greene St, N5W70 Box 140, Baltimore, MD 21201, USA
JAMA 287:1413-9. 2002..Celiac disease is one of the most common lifelong disorders. Non-Hodgkin lymphoma is a possible complication of celiac disease and may lead to a large portion of lymphoma cases...
- A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac diseaseCarlo Catassi
Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Clin Nutr 85:160-6. 2007..Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients...
- Delayed diagnosis of coeliac disease increases cancer riskMarco Silano
Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
BMC Gastroenterol 7:8. 2007..The aim of this paper is to estimate the risk of developing a neoplasm among non diagnosed coeliac patients and to evaluate if this risk correlates with the age of patients at diagnosis of coeliac disease...
- Plasma citrulline concentration: a reliable marker of small bowel absorptive capacity independent of intestinal inflammationCinzia Papadia
Department of Gastroenterology, University College Hospital, London, United Kingdom
Am J Gastroenterol 102:1474-82. 2007..The aim of this study was to address the potentially confounding impact of intestinal inflammation...
- Effect of a gluten-free diet on the risk of enteropathy-associated T-cell lymphoma in celiac diseaseMarco Silano
Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Dig Dis Sci 53:972-6. 2008..8 P = 0.01). These results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma...