Giampietro Viola

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity
    Venusia Gasparotto
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    J Med Chem 49:1910-5. 2006
  2. pmc MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells
    Giampietro Viola
    Department of Pediatrics, Laboratory of Oncohematology, University of Padova, Italy
    Biochem Pharmacol 83:16-26. 2012
  3. doi request reprint Pitavastatin, a new HMG-CoA reductase inhibitor, induces phototoxicity in human keratinocytes NCTC-2544 through the formation of benzophenanthridine-like photoproducts
    Giampietro Viola
    Department of Pediatrics, Laboratory of Oncohematology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
    Arch Toxicol 86:483-96. 2012
  4. ncbi request reprint Photosensitization of biomolecules by phenothiazine derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, Padova, Italy
    Curr Drug Targets 7:1135-54. 2006
  5. ncbi request reprint Induction of apoptosis by photoexcited tetracyclic compounds derivatives of benzo[b]thiophenes and pyridines
    Giampietro Viola
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Photochem Photobiol B 82:105-16. 2006
  6. ncbi request reprint Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues
    Giampietro Viola
    Dipartimento di Scienze Farmaceutiche, Via Marzolo 5, I 35131 Padova
    Chem Biodivers 1:1265-80. 2004
  7. ncbi request reprint Mast cell--pituitary interaction: modulation by serine phospholipids
    G Viola
    Department of Pharmaceutical Sciences, University of Padova, Italy
    Pharmazie 59:948-51. 2004
  8. ncbi request reprint Induction of apoptosis in Jurkat cells by photoexcited psoralen derivatives: Implication of mitochondrial dysfunctions and caspases activation
    G Viola
    Department of Pharmaceutical Sciences, University of Padova, Italy
    Toxicol In Vitro 21:211-6. 2007
  9. ncbi request reprint 6-Aminoquinolones: photostability, cellular distribution and phototoxicity
    G Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Toxicol In Vitro 18:581-92. 2004
  10. ncbi request reprint Photophysical and phototoxic properties of the antibacterial fluoroquinolones levofloxacin and moxifloxacin
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, I 35131 Padova
    Chem Biodivers 1:782-801. 2004

Detail Information

Publications73

  1. ncbi request reprint Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity
    Venusia Gasparotto
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    J Med Chem 49:1910-5. 2006
    ....
  2. pmc MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells
    Giampietro Viola
    Department of Pediatrics, Laboratory of Oncohematology, University of Padova, Italy
    Biochem Pharmacol 83:16-26. 2012
    ..Taken together, these results indicated that the autophagy induced by MG-2477 delayed apoptosis by exerting an adaptive response following microtubule damage...
  3. doi request reprint Pitavastatin, a new HMG-CoA reductase inhibitor, induces phototoxicity in human keratinocytes NCTC-2544 through the formation of benzophenanthridine-like photoproducts
    Giampietro Viola
    Department of Pediatrics, Laboratory of Oncohematology, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
    Arch Toxicol 86:483-96. 2012
    ..The present results suggest that the phototoxicity of pitavastatin may be mediated by the formation of benzophenanthridine-like photoproducts that appear to have high potential as photosensitizers...
  4. ncbi request reprint Photosensitization of biomolecules by phenothiazine derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, Padova, Italy
    Curr Drug Targets 7:1135-54. 2006
    ....
  5. ncbi request reprint Induction of apoptosis by photoexcited tetracyclic compounds derivatives of benzo[b]thiophenes and pyridines
    Giampietro Viola
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Photochem Photobiol B 82:105-16. 2006
    ..Altogether these data suggest that DNA is not a preferential target of these molecules and other subcellular structures may be responsible for their high phototoxic activity...
  6. ncbi request reprint Synthesis, cytotoxicity, and apoptosis induction in human tumor cells by geiparvarin analogues
    Giampietro Viola
    Dipartimento di Scienze Farmaceutiche, Via Marzolo 5, I 35131 Padova
    Chem Biodivers 1:1265-80. 2004
    ..Interestingly, the apoptotic pathway did not appear to be mediated by the activation of caspase-3...
  7. ncbi request reprint Mast cell--pituitary interaction: modulation by serine phospholipids
    G Viola
    Department of Pharmaceutical Sciences, University of Padova, Italy
    Pharmazie 59:948-51. 2004
    ..After this event, the reacylation of this phospholipid into lysophosphatidylserine in the pituitary membrane may enhance the inhibitory control by dopamine...
  8. ncbi request reprint Induction of apoptosis in Jurkat cells by photoexcited psoralen derivatives: Implication of mitochondrial dysfunctions and caspases activation
    G Viola
    Department of Pharmaceutical Sciences, University of Padova, Italy
    Toxicol In Vitro 21:211-6. 2007
    ..Furthermore the activation of caspases -3, -8 and -9 was also investigated. The obtained data indicated that, upon UVA irradiation, the two compounds induce a strong decrease in mitochondrial functions and activate caspase-3, -8 and -9...
  9. ncbi request reprint 6-Aminoquinolones: photostability, cellular distribution and phototoxicity
    G Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Toxicol In Vitro 18:581-92. 2004
    ....
  10. ncbi request reprint Photophysical and phototoxic properties of the antibacterial fluoroquinolones levofloxacin and moxifloxacin
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, I 35131 Padova
    Chem Biodivers 1:782-801. 2004
    ....
  11. doi request reprint The phototoxicity of fluvastatin, an HMG-CoA reductase inhibitor, is mediated by the formation of a benzocarbazole-like photoproduct
    Giampietro Viola
    Laboratory of Oncohematology, Department of Pediatrics, University of Padova, 35128 Padova, Italy
    Toxicol Sci 118:236-50. 2010
    ..On the basis of our results, the phototoxicity of fluvastatin may be mediated by the formation of benzocarbazole-like photoproduct that acts as strong photosensitizer...
  12. ncbi request reprint Induction of gamma-globin mRNA, erythroid differentiation and apoptosis in UVA-irradiated human erythroid cells in the presence of furocumarin derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Biochem Pharmacol 75:810-25. 2008
    ..Altogether, these data suggest that psoralen derivatives warrant further evaluation as potential therapeutic drugs in beta-thalassemia and sickle cell anemia...
  13. doi request reprint Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition
    Giampietro Viola
    Dipartimento di Scienze Farmaceutiche, University of Padova, Padua, Italy
    Cancer Chemother Pharmacol 64:1235-51. 2009
    ....
  14. ncbi request reprint Indolo[2,3-b]-quinolizinium bromide: an efficient intercalator with DNA-photodamaging properties
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Chembiochem 3:550-8. 2002
    ..The kinetics of strand degradation under aerobic and anaerobic conditions suggest that a Type I reaction occurs, that is, radical-mediated DNA damage...
  15. doi request reprint Furocoumarins photolysis products induce differentiation of human erythroid cells
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, University of Padova, 35131 Padova, Italy
    J Photochem Photobiol B 92:24-8. 2008
    ..Altogether, these data suggest that photoproducts of psoralen warrant further evaluation as potential therapeutic drugs in beta-thalassaemia and sickle cell anaemia...
  16. ncbi request reprint Naphthoquinolizinium derivatives as a novel platform for DNA-binding and DNA-photodamaging chromophores
    Giampietro Viola
    Department of Pharmaceutical Sciences, Via Marzolo 5, University of Padova, Italy
    Photochem Photobiol Sci 1:882-9. 2002
    ..Moreover, efficient DNA damage was observed on UV-A irradiation in the presence of the quinolizinium salts. Primer extension analysis indicates that the photocleavage takes place preferentially at guanine-rich regions...
  17. ncbi request reprint Photosensitization of DNA strand breaks by three phenothiazine derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, via Marzolo 5 Padova, Italy
    Chem Res Toxicol 16:644-51. 2003
    ....
  18. ncbi request reprint Central role of mitochondria and p53 in PUVA-induced apoptosis in human keratinocytes cell line NCTC-2544
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Toxicol Appl Pharmacol 227:84-96. 2008
    ..Thus these results strongly indicate the necessity of p53 activation and the induction of the apoptotic machinery downstream of mitochondria...
  19. ncbi request reprint Photophysical properties and photobiological behavior of amodiaquine, primaquine and chloroquine
    Giampietro Viola
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Padova, Italy
    Photochem Photobiol 83:1415-27. 2007
    ..The photodamages produced by the drugs were also evaluated on proteins, lipids and DNA. The combined approaches were useful in understanding the mechanism of phototoxicity induced by these antimalarial drugs...
  20. ncbi request reprint Differential response of linear and angular psoralens in PUVA-induced apoptosis in HL-60 cells
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padua, Via Marzolo 5, 35131 Padua, Italy
    Photochem Photobiol Sci 3:237-9. 2004
    ..Treatment of cells with UVA radiation in combination with linear psoralens induces a cell-cycle block and subsequent apoptosis, whereas angular derivatives produce apoptosis without affecting the cellular cycle...
  21. pmc Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44121 Ferrara, Italy
    J Med Chem 56:2606-18. 2013
    ..Compound 4i significantly inhibited in vivo the growth of a syngeneic hepatocellular carcinoma in Balb/c mice...
  22. pmc Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Ferrara, Italy
    J Med Chem 53:4248-58. 2010
    ..Compound 4l was also shown to have potential antivascular activity, since it induced endothelial cell shape change in vitro and disrupted the sprouting of endothelial cells in the chick aortic ring assay...
  23. pmc Synthesis and in vitro evaluation of 3h-pyrrolo[3,2-f]-quinolin-9-one derivatives that show potent and selective anti-leukemic activity
    Maria Grazia Ferlin
    Department of Pharmaceutical Sciences, University of Padova, Italy
    ChemMedChem 5:1373-85. 2010
    ..This effect was associated with apoptosis, mitochondrial depolarization, generation of reactive oxygen species, activation of caspase-3, and cleavage of the enzyme poly(ADP-ribose) polymerase...
  24. pmc One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44121 Ferrara, Italy
    Eur J Med Chem 46:6015-24. 2011
    ..This indicated that 3f is a promising new antimitotic agent with encouraging preclinical potential...
  25. pmc Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44100 Ferrara, Italy
    J Med Chem 54:5144-53. 2011
    ..Preliminary results suggest that, in addition to cell death by apoptosis, cells were also killed via mitotic catastrophe as an alternative cell death mechanism...
  26. doi request reprint Differentiation and apoptosis in UVA-irradiated cells treated with furocoumarin derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1171:334-44. 2009
    ..Also, preclinical data demonstrate a possible use of these molecules for the treatment of beta-thalassemia and other hematological disorders...
  27. pmc Symmetrical alpha-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44100 Ferrara, Italy
    Bioorg Med Chem Lett 20:2733-9. 2010
    ..Moreover, compound 4b induced apoptosis through the mitochondrial pathway and activated caspase-3 in a concentration-dependent manner...
  28. pmc Synthesis and biological evaluation of 2-(3',4',5'-trimethoxybenzoyl)-3-aryl/arylaminobenzo[b]thiophene derivatives as a novel class of antiproliferative agents
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    Eur J Med Chem 45:5781-91. 2010
    ..Moreover, 4e perturbed mitochondrial membrane potential and caused activation of caspase-3 and cleavage of poly(ADP-rybose)polymerase (PARP), events that are involved in 4e-induced apoptosis...
  29. pmc Hybrid alpha-bromoacryloylamido chalcones. Design, synthesis and biological evaluation
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44100 Ferrara, Italy
    Bioorg Med Chem Lett 19:2022-8. 2009
    ..Moreover, compound 1k induced apoptosis through the mitochondrial pathway and activated caspase-3...
  30. doi request reprint TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis
    Elena Porcù
    Laboratorio di Oncoematologia, Dipartimento di Salute della Donna e del Bambino, Universita di Padova, Via Giustiniani 3, 35128 Padua, Italy
    Angiogenesis 16:647-62. 2013
    ..In a mice allogenic tumor model, immunohistochemical staining of tumors with anti-CD31 antibody showed that TR-644 significantly reduced the number of vessel, after 24 h from the administration of a single dose (30 mg/Kg)...
  31. pmc Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Via Fossato di Mortara 17 19, Universita di Ferrara, 44121 Ferrara, Italy
    Bioorg Med Chem 20:7083-94. 2012
    ..Moreover, the most active compound 3e induced apoptosis through the activation of caspase-2, -3 and -8, but 3e did not cause mitochondrial depolarization...
  32. ncbi request reprint 1-Thioangelicin: crystal structure, computer-aided studies and photobiological activity
    Daniela Vedaldi
    Department of Pharmaceutical Sciences, University of Pada Via F Marzolo 5, Padua 35131, Italy
    Farmaco 59:125-32. 2004
    ..Antiproliferative activity has been assessed on Balb/c 3T3 cultured cells...
  33. doi request reprint Design, synthesis, and structure-activity relationships of azolylmethylpyrroloquinolines as nonsteroidal aromatase inhibitors
    Maria Grazia Ferlin
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy
    J Med Chem 56:7536-51. 2013
    ....
  34. pmc Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44100 Ferrara, Italy
    J Med Chem 55:475-88. 2012
    ..Furthermore, compound 4l significantly reduced in vivo the growth of the HT-29 xenograft in a nude mouse model, suggesting that 4l is a promising new antimitotic agent with clinical potential...
  35. pmc The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation
    Elena Porcù
    Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia Pediatrica, Universita di Padova, 35128 Padova, Italy
    Sci Rep 6:27886. 2016
    ..Altogether, our results indicate that TR-764 is a novel TBA with strong potential as both antivascular and antitumor molecule that could improve the common anticancer therapies, by overcoming hypoxia-induced resistance mechanisms. ..
  36. doi request reprint Vascular disrupting activity of combretastatin analogues
    Elena Porcù
    Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Universita di Padova, 35131 Padova, Italy
    Vascul Pharmacol 83:78-89. 2016
    ..p. injection (30mg/kg), showed a stronger reduction of microvascular density. Altogether our results identified these derivatives as potential new vascular disrupting agents candidates. ..
  37. doi request reprint Natural daucane esters induces apoptosis in leukaemic cells through ROS production
    Stefano Dall'acqua
    Dipartimento di Scienze del Farmaco, Universita di Padova, Padova, Italy Electronic address
    Phytochemistry 108:147-56. 2014
    ..Taken together our results showed for the first time that daucane esters induces apoptotic cell death through a ROS-mediated mechanism in human leukemia cells. ..
  38. doi request reprint Natural daucane sesquiterpenes with antiproliferative and proapoptotic activity against human tumor cells
    Stefano Dall'acqua
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Padova, Italy
    Bioorg Med Chem 19:5876-85. 2011
    ..Our findings suggest the potential role of daucane derivatives as models for the development of proapoptotic compounds...
  39. doi request reprint Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma
    Francesca Pistollato
    Hemato Oncology Laboratory, Department of Pediatrics, University of Padova, Via Giustiniani 3, Padova 35128, Italy
    Biochem Pharmacol 80:1517-27. 2010
    ..2-DG inhibits anaerobic glycolysis altering GBM cell phenotype by forcing tumor cells into mitochondrial metabolism and by inducing differentiation...
  40. pmc Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity
    Davide Carta
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy
    J Med Chem 58:7991-8010. 2015
    ..Our data indicate that the excellent antiproliferative profile of 5f may be derived from its interactions with multiple cellular targets. ..
  41. pmc Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, 44121 Ferrara, Italy
    J Med Chem 58:3209-22. 2015
    ..Compound 3g had in vivo antitumor activity in a murine model comparable to the activity obtained with combretastatin A-4 phosphate. ..
  42. ncbi request reprint Two new sesquiterpene lactones from the leaves of Laurus nobilis
    Stefano Dall'acqua
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Viale S Ignacio 13, 09124 Cagliari, Italy
    Chem Pharm Bull (Tokyo) 54:1187-9. 2006
    ..The structures of the new compounds were identified by 1D and 2D NMR experiments, as well as high resolution mass spectrometry. The cytotoxic activity was also evaluated against three different tumor cell lines of human origin...
  43. doi request reprint Glioblastoma cancer stem cells: role of the microenvironment and therapeutic targeting
    Luca Persano
    Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
    Biochem Pharmacol 85:612-22. 2013
    ....
  44. ncbi request reprint Relationship between the structure and the DNA binding properties of diazoniapolycyclic duplex- and triplex-DNA binders: efficiency, selectivity, and binding mode
    Serena Basili
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, I 35131 Padova, Italy
    Biochemistry 46:12721-36. 2007
    ..Moreover, the diazoniapentaphene and diazoniaanthra[1,2-a]anthracene derivatives represent the first examples of triplex-DNA binders that do not require additional aminoalkyl side chains for efficient triplex stabilization...
  45. doi request reprint Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents
    Davide Carta
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131, Padova, Italy
    Eur J Med Chem . 2016
    ....
  46. doi request reprint FOXO3a and Posttranslational Modifications Mediate Glucocorticoid Sensitivity in B-ALL
    Francesca Consolaro
    Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine ICTEM, London, United Kingdom Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, University of Padova, Padova, Italy
    Mol Cancer Res 13:1578-90. 2015
    ..These posttranslational events can be exploited as biomarkers for B-ALL diagnosis and as drug targets for B-ALL treatment, particularly for overcoming the glucocorticoid resistance...
  47. pmc 2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization
    Romeo Romagnoli
    Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, Ferrara, Italy
    J Med Chem 52:5551-5. 2009
    ..Tumor cell exposure to several of these compounds led to the arrest of HeLa cells in the G2/M phase of the cell cycle and induction of apoptosis...
  48. ncbi request reprint In vitro phototoxic properties of new 6-desfluoro and 6-fluoro-8-methylquinolones
    G Miolo
    Department of Pharmaceutical Sciences, University of Padova and Center for Chemical Investigation of Drugs associated to the National Institute for the Chemistry of Biological Systems CNR, Via Marzolo 5, Padova, Italy
    Toxicol In Vitro 16:683-93. 2002
    ..Preliminary experiments on pBR322 DNA show that these derivatives do not photocleave DNA, differently from the two photogenotoxic fluoroquinolones, ciprofloxacin and lomefloxacin, used as reference compounds...
  49. ncbi request reprint Cytotoxic constituents from Anagyris foetida leaves
    G Innocenti
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    Fitoterapia 77:595-7. 2006
    ..In vitro cytotoxicity of compounds 1-3 was also evaluated...
  50. ncbi request reprint Photobiological studies of new cyclopentene-psoralens
    L Dalla Via
    Department of Pharmaceutical Sciences, University of Padova, Padua, Italy
    Farmaco 53:638-44. 1998
    ..These differences in behaviour between 4 and 7 are probably due to the molecular curvature resulting from the introduction of the cyclopentane ring...
  51. doi request reprint Recent advances in vascular disrupting agents in cancer therapy
    Elena Porcù
    Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia Pediatrica, Universita di Padova, Italy
    Future Med Chem 6:1485-98. 2014
    ..Several resistance mechanisms occur, such as the resistance of the tumor rim cells, while promising results have been described in combination with other chemotherapeutics. ..
  52. pmc A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents
    Roberta Bortolozzi
    Department of Women s and Children s Health, Oncohematology Laboratory, University of Padova, Padova, Italy These authors contributed equally to this work
    Oncotarget 5:5978-91. 2014
    ..Importantly, we showed that the combination of CP with some chemotherapeutic drugs displayed a good synergy that strongly affected the survival of both RS4;11 and SEM cells. ..
  53. ncbi request reprint Cytotoxic constituents of roots of Chaerophyllum hirsutum
    Stefano Dall'acqua
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Nat Prod 67:1588-90. 2004
    ..Several of the isolated compounds were tested for their cytotoxic activity against the HL-60, HT-1080, LoVo, and LoVo/Doxo cell lines...
  54. pmc FOXM1 is overexpressed in B-acute lymphoblastic leukemia (B-ALL) and its inhibition sensitizes B-ALL cells to chemotherapeutic drugs
    Francesca Consolaro
    Department of Woman s and Child s Health, Oncohematology Laboratory, University of Padova, Padova, Italy
    Int J Oncol 47:1230-40. 2015
    ..Therefore our results suggest that FOXM1 is highly expressed in both patients and B-ALL cell lines, and that targeting FOXM1 could be an attractive strategy for leukemia therapy and for overcoming drug resistance...
  55. pmc Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluation
    Elena Porcù
    Department of Woman s and Child s Health, Laboratory of Oncohematology, University of Padova, Via Giustiniani 2, Padova 35128, Italy
    Eur J Med Chem 84:476-90. 2014
    ..In addition, these compounds significantly reduced the expression of the anti-apoptotic proteins Mcl-1 and Bcl-2. ..
  56. doi request reprint Selective ratiometric detection of H2O2 in water and in living cells with boronobenzo[b]quinolizinium derivatives
    Roberta Bortolozzi
    Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, University of Padova, Via Giustiniani 2, I 35128 Padova, Italy
    Chem Commun (Camb) 50:8242-5. 2014
    ....
  57. doi request reprint 9-(4-Dimethylaminophenyl)benzo[b]quinolizinium: A Near-Infrared Fluorophore for the Multicolor Analysis of Proteins and Nucleic Acids in Living Cells
    Roberta Bortolozzi
    Author names in alphabetical order Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, University of Padova, Via Giustiniani 3, I 35128 Padova Italy
    Chemistry 19:8736-41. 2013
    ..It is demonstrated that this chemosensor also allows the fluorimetric multicolor analysis of different components in living cells. ..
  58. doi request reprint Targeting BAG-1: a novel strategy to increase drug efficacy in acute myeloid leukemia
    Sanja Aveic
    Women and Child Health Department, Hematology Oncology Laboratory Istituto di Ricerca Pediatrica IRP, University of Padova, Padova, Italy Electronic address
    Exp Hematol 43:180-190.e6. 2015
    ....
  59. ncbi request reprint Induction of DNA-double-strand breaks by auger electrons from 99mTc complexes with DNA-binding ligands
    Pascal Häfliger
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chembiochem 6:414-21. 2005
    ..These results indicate that the Auger electron emitter 99mTc can induce dsb in DNA when decaying in its direct vicinity and this implies potential for systemic radiotherapy with 99mTc complexes...
  60. ncbi request reprint Excited-state properties and in vitro phototoxicity studies of three phenothiazine derivatives
    Fausto Elisei
    Department of Chemistry, University of Perugia, Italy
    Photochem Photobiol 75:11-21. 2002
    ..In particular, the photophysical properties of the compounds under investigation and the results of the study on their phototoxicity are in agreement with a mechanism that involves the radical cation of the drugs as a main intermediate...
  61. ncbi request reprint DNA cleavage induced by photoexcited antimalarial drugs: a photophysical and photobiological study
    Gian Gaetano Aloisi
    Department of Chemistry and CEMIN Centro di Eccellenza sui Materiali Innovativi Nanostrutturati, University of Perugia, Perugia, Italy
    Photochem Photobiol 83:664-74. 2007
    ..Moreover the singlet and triplet states and radical cations of the drugs are quenched by 2'-deoxyguanosine monophosphate. The absorbances of these transients decrease with increasing DNA concentration...
  62. ncbi request reprint Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity
    Paola Barraja
    Dipartimento Farmacochimico, Tossicologico e Biologico Università degli Studi, Via Archirafi 32, 90123 Palermo, Italy
    Bioorg Med Chem Lett 13:2809-11. 2003
    ..Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position...
  63. doi request reprint On the reactivity of 6-acetyl-7-(2-dimethylaminovinyl)pyrazolo[1,5-a]pyrimidines with 1,3- and 1,4-bisnucleophiles
    Stefano Chimichi
    Dipartimento di Chimica Organica U Schiff and Laboratorio di Progettazione, Sintesi e Studio di Eterocicli Biologicamente Attivi HeteroBioLab, University of Florence, I 50019 Sesto F no Firenze, Italy
    Org Biomol Chem 6:739-44. 2008
    ..A convenient procedure leading to new pyrazolo[1,5-a]quinazolines is described; a modest bioactivity of these compounds against two human tumor cell lines was also ascertained...
  64. ncbi request reprint Comparative studies on the DNA-binding properties of linear and angular dibenzoquinolizinium ions
    Heiko Ihmels
    Organic Chemistry II, University of Siegen, Adolf Reichwein Str 2, 57068 Siegen, Germany
    J Org Chem 71:8401-11. 2006
    ..Moreover, the comparison between 5a and 6 demonstrates the significant influence of the shape of the pi system on the duplex- and triplex-stabilizing properties of the dibenzoquinolizinium ions...
  65. doi request reprint Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I
    Patrizia Diana
    Dipartimento Farmacochimico Tossicologico e Biologico, Universita degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy
    J Med Chem 51:2387-99. 2008
    ..Moreover, 4c induced a clear increase in the mitotic index, inhibited microtubule assembly in vitro, and interestingly also acted as a topoisomerase I inhibitor...
  66. ncbi request reprint Pyrrolo[2,3-h]quinolinones: a new ring system with potent photoantiproliferative activity
    Paola Barraja
    Dipartimento Farmacochimico, Tossicologico e Biologico Università degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy
    Bioorg Med Chem 14:8712-28. 2006
    ..On the contrary, they induce significative photodamage to lipids and proteins...
  67. ncbi request reprint Intercalation of organic dye molecules into double-stranded DNA. Part 2: the annelated quinolizinium ion as a structural motif in DNA intercalators
    Heiko Ihmels
    Institute of Organic Chemistry, University of Siegen, Siegen, Germany
    Photochem Photobiol 81:1107-15. 2005
    ..In addition, studies on the biological activities of annelated quinolizinium derivatives, such as topoisomerase poisoning or cell toxicity, are highlighted...
  68. ncbi request reprint Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones
    Paola Barraja
    Dipartimento Farmacochimico, Tossicologico e Biologico, Università degli Studi di Palermo Via Archirafi 32, 90123 Palermo, Italy
    Bioorg Med Chem Lett 15:2291-4. 2005
    ..The compound bearing a methyl substituent at the pyrrole nitrogen resulted as the most interesting showing IC50 in the nanomolar range...
  69. ncbi request reprint Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions
    Gian Gaetano Aloisi
    Laboratorio di Chimica Fisica, Dipartimento di Chimica, Universita di Perugia, Perugia, Italy
    Photochem Photobiol 79:248-58. 2004
    ..The combined approaches were proven to be useful for understanding the mechanism of phototoxicity induced by the antimalarial drugs...
  70. ncbi request reprint 9-donor-substituted acridizinium salts: versatile environment-sensitive fluorophores for the detection of biomacromolecules
    Anton Granzhan
    University of Siegen, Organic Chemistry II, Adolf Reichwein Strasse 2, D 57068 Siegen, Germany
    J Am Chem Soc 129:1254-67. 2007
    ..In each case, the emission enhancement is supposed to result from the hindrance of the torsional relaxation in the corresponding binding site of the biomacromolecule, which in turn suppresses the excited-state deactivation pathway...
  71. ncbi request reprint Pyrazolyl-diamine ligands that bear anthracenyl moieties and their rhenium(I) tricarbonyl complexes: synthesis, characterisation and DNA-binding properties
    Rute F Vitor
    Departamento de Quimica, ITN, Estrada Nacional 10, 2686 953 Sacavem Codex, Portugal
    Chembiochem 9:131-42. 2008
    ....
  72. ncbi request reprint 6-Aminoacridizinium bromide: a fluorescence probe which lights up in AT-rich regions of DNA
    Heiko Ihmels
    Institute of Organic Chemistry, University of Wurzburg, Am Hubland, Wurzburg, Germany
    Org Biomol Chem 1:2999-3001. 2003
    ..The title compound exhibits a selective enhancement of its fluorescence intensity in the presence of AT-rich DNA...
  73. ncbi request reprint Cell-specific and nuclear targeting with [M(CO)(3)](+) (M=(99m)Tc, Re)-based complexes conjugated to acridine orange and bombesin
    Nikos Agorastos
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Chemistry 13:3842-52. 2007
    ..Whereas no internalization was found with B16F1 cells, fluorescence microscopy on PC3 cells bearing the BBN receptor showed high and rapid uptake by receptor-mediated endocytosis into the cytoplasm, but not into the nucleus...