Genomes and Genes
Affiliation: University of Turin
Publications107 found, 100 shown here
- History of biasPaolo Vineis
University of Torino, ISI Foundation, Torino
Soz Praventivmed 47:156-61. 2002..The subsequent period--until now--has been characterised by more formal and systematic definitions...
- Cancer as an evolutionary process at the cell level: an epidemiological perspectivePaolo Vineis
Department of Biomedical Sciences and Human Oncology, University of Torino, Via Santena 7, 10126 Torino, Italy and ISI Foundation, Torino, Italy
Carcinogenesis 24:1-6. 2003....
- The relationship between polymorphisms of xenobiotic metabolizing enzymes and susceptibility to cancerPaolo Vineis
Dipartimento di Scienze Biomediche e Oncologia Umana, Unit of Cancer Epidemiology, University of Torino and ISI Foundation, Via Santena 7, 10126 Torino, Italy
Toxicology 181:457-62. 2002..In addition, a theoretical approach to the problem of gene-environment interactions at low levels of exposure is offered...
- The randomized controlled trial in studies using biomarkersPaolo Vineis
Dipartimento di Scienze Biomediche e Oncologia Umana, Via Santena 7, University of Torino, Torino, Italy
Biomarkers 8:13-32. 2003..This review summarizes the main issues that should be addressed in a protocol, and illustrates these with an example...
- Delayed infection, late tonsillectomy or adenoidectomy and adult leukaemia: a case-control studyP Vineis
Servizio di Epidemiologia dei Tumori, Ospedale S Giovanni Battista e Università di Torino, Italy
Br J Cancer 88:47-9. 2003..2, 95% confidence interval 1.1-16.2). We propose that late infection is a proliferative stimulus for B-cells...
- Outdoor air pollution and lung cancer: recent epidemiologic evidencePaolo Vineis
Department of Biomedical Sciences and Human Oncology, University of Turin and CPO Piemonte, Turin, Italy
Int J Cancer 111:647-52. 2004
- CYP1A1 T3801 C polymorphism and lung cancer: a pooled analysis of 2451 cases and 3358 controlsPaolo Vineis
Universita degli Studi di Torino, Torino, Italy
Int J Cancer 104:650-7. 2003..The analyses were more inconsistent and failed to reach statistical significance in Asians. This observation might be due to design specificities or unknown effect modifiers in the Asian studies...
- Causality in epidemiologyPaolo Vineis
Unit of Clinical Epidemiology, Ospedale S Giovanni Battista, Torino
Soz Praventivmed 48:80-7. 2003..Epidemiology makes use more often of study designs that simulate experimentation, than of surveys in the general population...
- Dose-response relationship in tobacco-related cancers of bladder and lung: a biochemical interpretationPaolo Vineis
Department of Biomedical Sciences and Human Oncology, University of Torino and ISI Foundation, Torino, Italy
Int J Cancer 108:2-7. 2004
- Evidence-based medicine and ethics: a practical approachP Vineis
University of Torino and ISI Foundation, Torino
J Med Ethics 30:126-30. 2004..Physicians and patients should accept the irreducible fuzziness of many of the concepts they use when dealing with health and disease...
- Tobacco and cancer: recent epidemiological evidenceP Vineis
Unit of Cancer Epidemiology, University of Torino, CPO Piemonte, via Santena 7 10126 Torino, Torino, Italy
J Natl Cancer Inst 96:99-106. 2004
- Diet, genetic susceptibility and carcinogenesisP Vineis
Unit of Cancer Epidemiology, University of Torino and CPO Piemonte, Torino, Italy
Public Health Nutr 4:485-91. 2001..The present contribution is a short review of the relevant literature, with particular emphasis on some polymorphisms involved in dietary exposures. In addition, the practical implications of genetic testing in this field are discussed...
- Haematopoietic cancer and medical history: a multicentre case control studyP Vineis
Unit of Cancer Epidemiology, Ospedale S Giovanni, Torino, Italy
J Epidemiol Community Health 54:431-6. 2000..Other associations (diabetes, tonsillectomy, autoimmune diseases) have been inconsistently reported...
- Delayed infection, family size and malignant lymphomasP Vineis
Servizio di Epidemiologia dei Tumori, Ospedale S Giovanni Battista e Università di Torino, Via Santena 7, I 10123 Torino, Italy
J Epidemiol Community Health 54:907-11. 2000..It is suggested that delayed infection could explain NHL trends, through an impairment of the Th1/Th2 lymphocyte patterns...
- DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysisFabrizio Veglia
Life Sciences and Epidemiology Unit, ISI Foundation, Torino 10133, Italy
Carcinogenesis 29:932-6. 2008..The results of our pooled and meta-analyses suggest that bulky DNA adducts are associated with lung cancer arising in current smokers after a follow-up of several years...
- Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancerCarlotta Sacerdote
Unità di epidemiologia dei tumori, Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino and CPO Piemonte, Torino, Italy
Mutagenesis 22:281-5. 2007..This study found a reduced risk associated with fruit and vegetable intake. No interaction was observed between fruit and vegetable consumption and DNA repair gene polymorphisms...
- Polymorphisms in the XRCC1 gene modify survival of bladder cancer patients treated with chemotherapyCarlotta Sacerdote
HuGeF Human Genetics Foundation, Torino, Italy
Int J Cancer 133:2004-9. 2013..This finding may have clinical implications for the choice of therapy. ..
- Association between total number of deaths, diabetes mellitus, incident cancers, and haplotypes in chromosomal region 8q24 in a prospective studySimonetta Guarrera
Department of Genetics, Biology and Biochemistry, Universityof Torino, Torino, Italy
Am J Epidemiol 175:479-87. 2012..This observation can shed light on the mechanisms underlying reported associations between 8q24 variants and disparate chronic diseases...
- ERCC1 haplotypes modify bladder cancer risk: a case-control studyFulvio Ricceri
Unit of Epidemiology and Life Sciences, ISI Foundation, Turin, Italy
DNA Repair (Amst) 9:191-200. 2010..A detailed characterization of DNA repair genetic variation is warranted and might ultimately help to identify multiple susceptibility variants that could be responsible for joint effects on the risk...
- Lactase persistence and bitter taste response: instrumental variables and mendelian randomization in epidemiologic studies of dietary factors and cancer riskCarlotta Sacerdote
Centre for cancer Epidemiology and Prevention CPO Piemonte, Turin, Italy
Am J Epidemiol 166:576-81. 2007..These results suggest that the LCT and TAS2R38 variants are good candidates for Mendelian randomization studies of cancer and other health outcomes...
- Persistent infection by HCV and EBV in peripheral blood mononuclear cells and risk of non-Hodgkin's lymphomaLorenzo Richiardi
Cancer Epidemiology Unit, CeRMS and CPO Piemonte, University of Turin, Via Santena 7, 10129 Turin, Italy
Cancer Epidemiol 34:709-12. 2010..These null results, although based on a relatively small sample size, suggest that persistent EBV and HCV infection in the PBMC is not a stronger predictor of NHL risk than serological evidence of infection...
- Expression of DNA repair and metabolic genes in response to a flavonoid-rich dietSimonetta Guarrera
Institute for Scientific Interchange Foundation, Section of Life Sciences, Viale Settimio Severo 65, Torino, Italy
Br J Nutr 98:525-33. 2007..Larger studies are needed to clarify the possible effects of flavonoids in vivo; our preliminary results could help to better plan new studies on gene expression and diet...
- Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysisPaolo Vineis
Epidemiology Department, Univerisitá degli Studi di Torino, 10126 Torino, Italy
Carcinogenesis 28:1902-5. 2007..People with rare combinations of common gene variants have a high risk of cancer and can be assimilated to subjects with highly penetrant mutations...
- Occupational exposures, environmental tobacco smoke, and lung cancerFabrizio Veglia
Institute for Scientific Interchange ISI Foundation, Turin, Italy
Epidemiology 18:769-75. 2007..We have studied the association between 52 high-risk job titles and lung cancer incidence in a large prospective study, with more than 200,000 participants followed for more than 6 years and 809 incident cases of lung cancer...
- H2AX phosphorylation level in peripheral blood mononuclear cells as an event-free survival predictor for bladder cancerValentina Turinetto
Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy
Mol Carcinog 55:1833-1842. 2016..01), suggesting a protective effect of basal DSB signaling. Our data suggest that γ-H2AX can be considered as a potential molecular biomarker to identify patients with a higher risk of BC recurrence. © 2015 Wiley Periodicals, Inc...
- Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjectsFulvio Ricceri
Human Genetics Foundation previously at ISI Foundation, Turin, Italy
Cancer Epidemiol Biomarkers Prev 19:3174-81. 2010..Factors that have been reported to be related to DNA adduct levels include smoking, diet, body mass index (BMI), genetic polymorphisms, the season of collection of biologic material, and air pollutants...
- Differentially methylated microRNAs in prediagnostic samples of subjects who developed breast cancer in the European Prospective Investigation into Nutrition and Cancer (EPIC-Italy) cohortFrancesca Cordero
Department of Computer Science, University of Torino, Corso Svizzera 185, 10149 Turin, Italy
Carcinogenesis 36:1144-53. 2015..Assuming that altered methylation of miRNAs detectable in blood may be present before diagnosis, it may represent a biomarker for early detection or risk of cancer and may help to understand the cascade of events preceding tumour onset. ..
- Shorter leukocyte telomere length is independently associated with poor survival in patients with bladder cancerAlessia Russo
Genomic Variation in Human Population and Complex Diseases Unit, Human Genetics Foundation, Turin, Italy Department of Medical Sciences, University of Turin, Turin, Italy
Cancer Epidemiol Biomarkers Prev 23:2439-46. 2014..Therefore, we investigated the impact of TL on bladder cancer survival...
- Is there evidence of involvement of DNA repair polymorphisms in human cancer?Fulvio Ricceri
Human Genetics Foundation, Torino, Italy
Mutat Res 736:117-21. 2012....
- Bulky DNA adducts and risk of cancer: a meta-analysisFabrizio Veglia
Section of Life Sciences, ISI Foundation, 10133 Torino, Italy
Cancer Epidemiol Biomarkers Prev 12:157-60. 2003..This conclusion also suggests that similar (aromatic) compounds may be involved in the etiology of both types of cancer...
- Detection of multiple mutations in urinary exfoliated cells from male bladder cancer patients at diagnosis and during follow-upRossana Critelli
Molecular and Genetic Epidemiology Unit, Human Genetics Foundation, Turin, Italy
Oncotarget . 2016..80 (95% CI: 0.71-0.89).Mutations in urine of BC patients may represent reliable biomarkers. In particular, TERT and FGFR3 mutations have a good accuracy of recurrence prediction...
- Risk of second primary malignancies in women with breast cancer: Results from the European prospective investigation into cancer and nutrition (EPIC)Fulvio Ricceri
Unit of Cancer Epidemiology CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy
Int J Cancer 137:940-8. 2015..We describe in a large cohort of women with breast cancer a 30% excess of second primaries. Among risk factors for breast cancer, a history of full-term pregnancy was inversely associated with the risk of second primary cancer. ..
- Seasonality modifies methylation profiles in healthy peopleFulvio Ricceri
Unit of Cancer Epidemiology CERMS, Department of Medical Sciences, University of Turin and Città della Salute e della Scienza Hospital, Turin, Italy Department of Mathematics, University of Turin, Turin, Italy
PLoS ONE 9:e106846. 2014..04 or 0.05 depending on the CpG island involved) in autumn and winter compared with spring and summer. Seasonality seems to be a modifier of methylation levels and this observation should be taken into account in future analyses. ..
- Lower educational level is a predictor of incident type 2 diabetes in European countries: the EPIC-InterAct studyCarlotta Sacerdote
Center for Cancer Prevention, CPO Piemonte, Torino, Italy
Int J Epidemiol 41:1162-73. 2012..Age-, gender- and country-specific relative indices of inequality (RII) were used as the measure of educational level and RII tertiles were analysed...
- Randomized controlled trial: effect of nutritional counselling in general practiceCarlotta Sacerdote
CPO Piemonte, Torino, Italy
Int J Epidemiol 35:409-15. 2006..To investigate the effectiveness of a non-structured 15-min educational intervention by general practitioners (GPs) on modifications of daily diet among healthy adults...
- Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cellsFederica Saletta
Section of Life Sciences, ISI Foundation, Turin, Italy
Cancer Res 67:7088-94. 2007....
- XRCC3 and XPD/ERCC2 single nucleotide polymorphisms and the risk of cancer: a HuGE reviewMaurizio Manuguerra
Section of Epidemiology, ISI Foundation, Torino, Italy
Am J Epidemiol 164:297-302. 2006....
- Exposure to solvents and risk of non-Hodgkin lymphoma: clues on putative mechanismsPaolo Vineis
University of Turin, Turin, Italy
Cancer Epidemiol Biomarkers Prev 16:381-4. 2007..Both hypotheses (i.e., the interaction with autoimmune diseases and with familial predisposition) indirectly suggest that an immunologic mechanism could be involved in lymphomagenesis from solvents...
- Occult HCV infection: an unexpected finding in a population unselected for hepatic diseaseLaura De Marco
Unit of Cancer Epidemiology, C E R M S, University of Turin, Turin, Italy
PLoS ONE 4:e8128. 2009..Abnormal values of liver enzymes and presence of replicative HCV-RNA in peripheral blood mononuclear cells are also observed. Aim of the study was to evaluate occult HCV occurrence in a population unselected for hepatic disease...
- Appropriateness of early breast cancer management in relation to patient and hospital characteristics: a population based study in Northern ItalyR Rosato
Department of Psychology, University of Torino, Torino, Italy
Breast Cancer Res Treat 117:349-56. 2009..Social and geographical factors, in addition to hospital specialization, should be considered to reduce inappropriateness of care for breast cancer...
- DNA repair polymorphisms and cancer risk in non-smokers in a cohort studyG Matullo
ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
Carcinogenesis 27:997-1007. 2006..Further investigations of the combined effects of polymorphisms within these DNA repair genes, smoking and other risk factors may help to clarify the influence of genetic variation in the carcinogenic process...
- DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control studyG Matullo
Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Turin, Italy
Int J Cancer 92:562-7. 2001..Our results suggest that bladder-cancer risk can be genetically modulated by XRCC3, which may repair DNA cross-link lesions produced by aromatic amines and other environmental chemicals...
- Aromatic amines and cancerP Vineis
Unit of Cancer Epidemiology, Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
Cancer Causes Control 8:346-55. 1997..The consistent observation of a difference between men and women in bladder cancer risk, after allowing for known risk factors, suggests consideration of gender-related biological determinants for future investigation...
- Current smoking, occupation, N-acetyltransferase-2 and bladder cancer: a pooled analysis of genotype-based studiesP Vineis
CPO Piemonte at the University of Torino, Torino, Italy
Cancer Epidemiol Biomarkers Prev 10:1249-52. 2001..Our observation suggests that NAT2 is not a risk factors per se but modulates the effect of carcinogens contained in tobacco smoke (probably arylamines) or associated with occupational exposures...
- [The physicians' view on the utility and impact of oncological guidelines in clinical practice. A survey of Piedmont physicians]Carlotta Sacerdote
SCDU Epidemiologia dei Tumori, AO S G Battista, CPO Piemonte, Torino
Epidemiol Prev 31:34-8. 2007..To determine whether the guidelines (LGR) prepared in Piedmont for the treatment of colorectal and breast cancer reached the targetphysician population and how they were been perceived by physicians...
- Determinants of exposure to environmental tobacco smoke in 21,588 Italian non-smokersFabrizio Veglia
Institute for Scientific Interchange Foundation, Turin, Italy
Tumori 89:665-8. 2003..Exposure is likely to be uneven in the population. Knowledge of its distribution is important for a better planning of preventive activities...
- Individual susceptibility to carcinogensPaolo Vineis
Unit of Cancer Epidemiology, Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
Oncogene 23:6477-83. 2004..Such susceptibility genes are of considerable scientific interest, but do not confer high enough risks to be clinically relevant...
- Environment, population, and biology: a short history of modern epidemiologyAlessandra Parodi
History of Medicine, University of Torino, Italy
Perspect Biol Med 49:357-68. 2006..The tension between mechanistic and population-based studies is still present within epidemiology and is in fact essential for the success of the discipline...
- Compliance with clinical practice guidelines for breast cancer treatment: a population-based study of quality-of-care indicators in ItalyCarlotta Sacerdote
Cancer Epidemiology Unit, San Giovanni Battista Hospital, CPO Piemonte and University of Turin, Turin, Italy
BMC Health Serv Res 13:28. 2013..The aim of this population-based study was to evaluate the impact of regional guidelines (Piedmont guidelines, PGL) for breast cancer diagnosis and treatment on quality-of-care indicators in the Northwestern Italian region of Piedmont...
- Dietary habits, internal migration and social class in a sample of a northern Italian populationP Vineis
Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
Tumori 78:235-8. 1992..47 in men and 0.56 in women. Important gradients by social class were also suggested for several nutrients...
- Epigenetics and epidemiology: models of study and examplesKarin van Veldhoven
HuGeF Foundation, Turin, Italy
Cancer Treat Res 159:241-55. 2014..Here we present an example of how the "meet-in-the-middle" approach can be used to address the role of endocrine disruptors, by reviewing the relevant literature. ..
- Modelling patterns of clearance of HPV-16 infection and vaccination efficacyIacopo Baussano
SCDU di Epidemiologia dei Tumori, Servizio di Statistica Medica, CPO Piemonte, Novara, Italy
Vaccine 29:1270-7. 2011....
- Genetic testing for salePaolo Vineis
University of Torino, Dipartimento di Scienze Biomediche e Oncologia Umana, Torino, Italy
Epidemiology 15:3-5. 2004
- Selection and validation of biomarkers for chemoprevention: the contribution of epidemiologyP Vineis
University of Torino, Italy
IARC Sci Publ 154:57-68. 2001..Finally, we suggest a theory of causality based on the work of Wesley Salmon and the concept of 'propagating mark', which is particularly attractive for molecular epidemiologists...
- EPO or not-EPO? An evidence based informed consentE Mezza
Department of Internal Medicine, University of Torino, Torino, Italy
Int J Artif Organs 27:320-9. 2004..Informed consent is crucial in therapeutic choices; however, the forms presented to patients are often locally developed and information may not be homogeneous...
- Quality of systematic reviews used in guidelines for oncology practiceF Vigna-Taglianti
Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
Ann Oncol 17:691-701. 2006..Systematic reviews are an important tool for developing clinical recommendations. Those of high quality assure a good level of confidence on the strength of the recommendations...
- Prevention of exposure of young children to parental tobacco smoke: effectiveness of an educational programP Vineis
Unit of Cancer Epidemiology, Ospedale Maggiore di S. Giovanni Battista, Torino, Italy
Tumori 79:183-6. 1993..CONCLUSIONS: Educational interventions against smoking should be planned taking into account the difference in efficacy according to social class...
- XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjectsG Matullo
Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126, Torino, ISI Foundation, Institute for Scientific Interchange, Villa Gualino, 10133, Torino, Italy
Carcinogenesis 22:1437-45. 2001..These data show that all the analysed polymorphisms could result in deficient DNA repair and suggest a need for further investigation into the possible interactions between these polymorphisms, smoking and other risk factors...
- Asbestos exposure, physical activity and colon cancer: a case-control studyP Vineis
Dipartimento di Scienze Biomediche e Oncologia Umana, Main Hospital and University of Torino, Italy
Tumori 79:301-3. 1993..8, 95% c.i. 1.05-21.5), in particular pipe fitters and boilermakers (3 cases and 1 control; OR = 10.7; 1.07-103)...
- Haemoglobin adducts formed by aromatic amines in smokers: sources of inter-individual variabilityG Ronco
Unit of Epidemiology, Local Health Administration TO I, Torino, Italy
Br J Cancer 61:534-7. 1990..This interpretation is consistent with recent animal experiments suggesting that there are different enzyme systems for the two classes of compounds...
- Inter-observer variability in the interpretation of mammogramsP Vineis
Servizio di Epidemiologia dei Tumori, , Torino, Italia
Tumori 74:275-9. 1988..82 (median 0.60) for parenchymal patterns; 0.33-0.67 (0.48) for diagnosis in five categories; and 0.22-0.57 (0.38) for indications for further diagnostic tests. These values are comparable with those reported from other investigations...
- DNA adducts and the protective role of fruits and vegetablesP Vineis
University of Torino, Italy
IARC Sci Publ 156:469-74. 2002
- CDH1 gene polymorphisms, smoking, Helicobacter pylori infection and the risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)Mazda Jenab
International Agency for Research on Cancer IARC WHO, Lyon, France
Eur J Cancer 44:774-80. 2008..However, three CDH1 polymorphisms in the same haplotype block, including the CDH1-160C/A, interacted with smoking to increase GC risk in smokers but not in never smokers. These findings should be confirmed in larger independent studies...
- Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE reviewLawrence S Engel
Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Am J Epidemiol 156:95-109. 2002..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...
- Disease proportions attributable to environmentRodolfo Saracci
Imperial College London, St, Mary s Campus, Norfolk Place W2 1PG, London, UK
Environ Health 6:38. 2007..The latter aspect is not just a semantic question but carries implications for the focus of preventive actions, whether centred on the material and social environment or on single individuals...
- Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)Julie A Britton
Department of Epidemiology and Public Health, Imperial College London, Room 151, St Mary s Campus, Norfolk Place W2 1PG, London, UK
Haematologica 93:1666-77. 2008..It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma...
- Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) StudyHubert W Vesper
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Agric Food Chem 56:6046-53. 2008..In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered...
- The microenvironments of multistage carcinogenesisEzio Laconi
Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Patologia Sperimentale, Universita di Cagliari, 09125 Cagliari, Italy
Semin Cancer Biol 18:322-9. 2008..A deeper understanding of the role(s) of tissue and tumor microenvironments in the pathogenesis of cancer is essential to design more effective strategies for the management of this disease...
- Intake of vegetables, legumes, and fruit, and risk for all-cause, cardiovascular, and cancer mortality in a European diabetic populationUte Nöthlings
Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, 14558 Germany
J Nutr 138:775-81. 2008....
- Plasma carotenoids, retinol, and tocopherols and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition studyTimothy J Key
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 86:672-81. 2007..Previous studies suggest that high plasma concentrations of carotenoids, retinol, or tocopherols may reduce the risk of prostate cancer...
- Assessment of cumulative evidence on genetic associations: interim guidelinesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
Int J Epidemiol 37:120-32. 2008..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
- The association of gastric cancer risk with plasma folate, cobalamin, and methylenetetrahydrofolate reductase polymorphisms in the European Prospective Investigation into Cancer and NutritionStein Emil Vollset
LOCUS for Homocysteine and Related Vitamins, Institute of Medicine, University of Bergen, Bergen, Norway
Cancer Epidemiol Biomarkers Prev 16:2416-24. 2007..However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer...
- A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25Rayjean J Hung
International Agency for Research on Cancer IARC, Lyon 69008, France
Nature 452:633-7. 2008..Our results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets...
- Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and NutritionRuth C Travis
Cancer Research UK Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Int J Cancer 121:1331-8. 2007....
- Air pollution and cancer: biomarker studies in human populationsPaolo Vineis
Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, Norfolk Place, London, UK
Carcinogenesis 26:1846-55. 2005....
- Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)Rudolf Kaaks
Nutrition and Hormones Group, International Agency for Research on Cancer IARC WHO, Lyon, France
J Natl Cancer Inst 97:755-65. 2005..We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk...
- Gene-environment interactions: how many false positives?Giuseppe Matullo
J Natl Cancer Inst 97:550-1. 2005
- CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactionsPaolo Vineis
Imperial College London, London, UK
Biomarkers 9:298-305. 2004..7 (95% CI = 0.5-15.3). An association between lung cancer and the homozygous CYP1A1*2A genotype is confirmed. An apparent and biologically plausible interaction is suggested between this genotype and GSTM1...
- Measuring DNA repair capacity: small stepsMarianne Berwick
J Natl Cancer Inst 97:84-5. 2005
- A self-fulfilling prophecy: are we underestimating the role of the environment in gene-environment interaction research?Paolo Vineis
Department of Epidemiology and Public Health, Imperial College London, UK
Int J Epidemiol 33:945-6. 2004
- Randomized controlled trial of dietary intervention: association between level of urinary phenolics and anti-mutagenicityChristian Malaveille
International Agency for Research on Cancer, Lyon, France
Mutat Res 561:83-90. 2004..A strong correlation was found between urinary phenolics and anti-mutagenicity in all the groups involved in the trial. Such correlation was not explained by dietary variables...
- Association of metabolic gene polymorphisms with tobacco consumption in healthy controlsKim M Smits
University Maastricht, Maastricht, The Netherlands
Int J Cancer 110:266-70. 2004..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...
- Applying new biotechnologies to the study of occupational cancer--a workshop summaryMark Toraason
National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Environ Health Perspect 112:413-6. 2004..The workshop focused on identifying and interpreting markers for early biologic effect and inherited modifiers of risk...
- Non-Hodgkin's lymphoma and type of tobacco smokeEmanuele Stagnaro
Department of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy
Cancer Epidemiol Biomarkers Prev 13:431-7. 2004..This investigation sought to evaluate the association between NHL and type of tobacco smoked (blond, black, or mixed), focusing on the Working Formulation (WF) subgroups...
- A molecular epidemiology project on diet and cancer: the EPIC-Italy Prospective Study. Design and baseline characteristics of participantsDomenico Palli
UO Epidemiologia Molecolare e Nutrizionale, Centro per lo Studio e la Prevenzione Oncologica CSPO, Istituto scientifico della Regione Toscana, Florence, Italy
Tumori 89:586-93. 2003..Baseline characteristics of participants are briefly described...
- Occupation and bladder cancer among men in Western EuropeManolis Kogevinas
Respiratory and Environmental Health Research Unit, IMIM, Barcelona, Spain
Cancer Causes Control 14:907-14. 2003..We examined which occupations and industries are currently at high risk for bladder cancer in men...
- The effects of diet on DNA bulky adduct levels are strongly modified by GSTM1 genotype: a study on 634 subjectsDomenico Palli
Molecular and Nutritional Epidemiology Unit and Cancer Risk Factor Branch, Molecular Biology Laboratory CSPO, Scientific Institute of Tuscany, Florence, Italy
Carcinogenesis 25:577-84. 2004..Our results suggest that the role of a diet rich in antioxidants in preventing or reducing DNA adduct formation is restricted to subjects lacking the detoxifying activity of GSTM1 isoenzyme (approximately 50% of the general population)...
- Non-Hodgkin's lymphoma, leukemia, and exposures in agriculture: results from the Italian multicenter case-control studyLucia Miligi
Environmental and Occupational Epidemiology Unit, Center for Study and Prevention of Cancer, Florence, Italy
Am J Ind Med 44:627-36. 2003..The etiology of non-Hodgkin's lymphoma (NHL) and leukemia is still largely unknown, but exposure to chemicals, in particular pesticides, has been suggested to be a risk factor...
- Combination of DNA repair gene single nucleotide polymorphisms and increased levels of DNA adducts in a population-based studyGiuseppe Matullo
Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Italy
Cancer Epidemiol Biomarkers Prev 12:674-7. 2003..18-21.45; five alleles, adjusted OR = 7.65, 95% CI = 0.94-62.2]. Our study suggests that the combined effect of multiple variant alleles may be more important than the investigation of single SNP in modulating DNA repair capacity...
- DNA adducts and lung cancer risk: a prospective studyMarco Peluso
Cancer Risk Factor Branch, CSPO Scientific Institute of Tuscany Region, Florence, Italy
Cancer Res 65:8042-8. 2005..Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O3 indicates a possible role for photochemical smog in determining DNA damage...
- 4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition prospective studyLuisa Airoldi
Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
Cancer Epidemiol Biomarkers Prev 14:2118-24. 2005..The most important finding of this prospective study is that, at least in women, 4-ABP-Hb adducts may help identify subjects at high risk of cancers related to environmental tobacco smoke exposure...
- Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)Jakob Linseisen
Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany
Int J Cancer 121:1103-14. 2007..In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers...
- Haplotype-based analysis of common variation in the acetyl-coA carboxylase alpha gene and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and NutritionOlga M Sinilnikova
IARC, Lyon, France
Cancer Epidemiol Biomarkers Prev 16:409-15. 2007..However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis...
- Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective studyPaolo Vineis
Imperial College London, London UK
Environ Health 6:7. 2007..It is therefore useful to estimate the burden of disease associated with indoor and outdoor air pollution...
- Immunotoxic effects of chemicals: A matrix for occupational and environmental epidemiological studiesAngela Veraldi
Centre for Study and Cancer Prevention, Unit of Environmental and Occupational Epidemiology, Florence, Italy
Am J Ind Med 49:1046-55. 2006..Many biological and chemical agents have the capacity to alter the way the immune system functions in human and animals. This study evaluates the immunotoxicity of 20 substances used widely in work environments...
- Alcohol consumption and risk of leukemia: A multicenter case-control studyGiuseppe Gorini
Istituto Toscano Tumori, Environmental and Occupational Epidemiology Unit, Centre for Study and Prevention of Cancer CSPO, Via di S Salvi, 12 50135 Florence, Italy
Leuk Res 31:379-86. 2007....
- Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition CohortKaren Steindorf
Unit of Environmental Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Int J Cancer 119:2389-97. 2006..It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors...
- Tobacco smoke and bladder cancer--in the European Prospective Investigation into Cancer and NutritionBine Kjøller Bjerregaard
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Int J Cancer 119:2412-6. 2006....
- Causal models in epidemiology: past inheritance and genetic futurePaolo Vineis
Division of Epidemiology, Public Health and Primary Care, Imperial College London, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
Environ Health 5:21. 2006..4. At the population level, there is additional uncertainty in quantifying interaction and assigning etiologic fractions to different necessary causes because of ignorance about the components of the sufficient cause...
- TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective studyEmmanuelle Gormally
IARC, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
Cancer Res 66:6871-6. 2006..TP53 mutation may be associated with environmental exposures. These observations have implications for monitoring early steps of carcinogenesis...
- Randomized controlled trial: effects of diet on DNA damage in heavy smokersGlenn Talaska
Department of Environmental Health, University of Cincinnati, OH, USA
Mutagenesis 21:179-83. 2006..Smoking is the most important single preventable cause of cancer; at the present stage of knowledge it is totally unlikely that certain dietary habits can seriously counteract the effects of tobacco smoking...