L Trusolino

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    L Trusolino
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Torino, Candiolo, Italy
    Cell 107:643-54. 2001
  2. ncbi request reprint Scatter-factor and semaphorin receptors: cell signalling for invasive growth
    Livio Trusolino
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    Nat Rev Cancer 2:289-300. 2002
  3. doi request reprint The Met tyrosine kinase receptor in development and cancer
    Alessandra Gentile
    Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo Torino, Italy
    Cancer Metastasis Rev 27:85-94. 2008
  4. ncbi request reprint HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
    L Trusolino
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 14:1629-40. 2000
  5. ncbi request reprint Interactions between scatter factors and their receptors: hints for therapeutic applications
    L Trusolino
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, University of Torino School of Medicine, 10060 Candiolo, Torino
    FASEB J 12:1267-80. 1998
  6. doi request reprint Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer
    S Gastaldi
    Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
    Oncogene 32:1428-40. 2013
  7. ncbi request reprint Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth
    E Medico
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo To, Italy
    Cancer Res 61:5861-8. 2001
  8. ncbi request reprint Scatter factor-dependent branching morphogenesis: structural and histological features
    P Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino, Italy
    Eur J Histochem 51:79-92. 2007
  9. pmc Invasive growth: from development to metastasis
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo Torino, Italy
    J Clin Invest 109:857-62. 2002
  10. doi request reprint Drug development of MET inhibitors: targeting oncogene addiction and expedience
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, Candiolo, Turin 10060, Italy
    Nat Rev Drug Discov 7:504-16. 2008

Collaborators

Detail Information

Publications16

  1. ncbi request reprint A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
    L Trusolino
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Torino, Candiolo, Italy
    Cell 107:643-54. 2001
    ..Such findings invoke an unexpected role for alpha6beta4 in cancer invasion as a functional amplifier of biochemical outputs rather than a mechanical adhesive device...
  2. ncbi request reprint Scatter-factor and semaphorin receptors: cell signalling for invasive growth
    Livio Trusolino
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    Nat Rev Cancer 2:289-300. 2002
    ..What are the differences between physiological and pathological activation of these signalling molecules, and can we exploit them therapeutically to prevent metastasis?..
  3. doi request reprint The Met tyrosine kinase receptor in development and cancer
    Alessandra Gentile
    Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo Torino, Italy
    Cancer Metastasis Rev 27:85-94. 2008
    ..Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met...
  4. ncbi request reprint HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
    L Trusolino
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 14:1629-40. 2000
    ..These data suggest that HGF/SF promotes cell adhesion and invasiveness by increasing the avidity of integrins for their specific ligands...
  5. ncbi request reprint Interactions between scatter factors and their receptors: hints for therapeutic applications
    L Trusolino
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, University of Torino School of Medicine, 10060 Candiolo, Torino
    FASEB J 12:1267-80. 1998
    ..This review is focused on how, and to what extent, scatter factors can behave 'well' or 'badly' according to their molecular structure, the way they are activated, and the way they interact with cell surface receptors and coreceptors...
  6. doi request reprint Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer
    S Gastaldi
    Laboratory of Molecular Pharmacology, Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
    Oncogene 32:1428-40. 2013
    ....
  7. ncbi request reprint Osteopontin is an autocrine mediator of hepatocyte growth factor-induced invasive growth
    E Medico
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo To, Italy
    Cancer Res 61:5861-8. 2001
    ....
  8. ncbi request reprint Scatter factor-dependent branching morphogenesis: structural and histological features
    P Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino, Italy
    Eur J Histochem 51:79-92. 2007
    ....
  9. pmc Invasive growth: from development to metastasis
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo Torino, Italy
    J Clin Invest 109:857-62. 2002
  10. doi request reprint Drug development of MET inhibitors: targeting oncogene addiction and expedience
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, Candiolo, Turin 10060, Italy
    Nat Rev Drug Discov 7:504-16. 2008
    ..Here we discuss recent progress in the development of molecules that inhibit MET function and consider their application in a subset of human tumours that are potentially responsive to MET-targeted therapies...
  11. pmc Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth
    Andrea Bertotti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    J Cell Biol 175:993-1003. 2006
    ..These results unravel a novel pathway whereby beta4 directs tyrosine kinase-based signals toward adhesion-unrelated outcomes...
  12. pmc Negative feedback regulation of Met-dependent invasive growth by Notch
    M Cristina Stella
    Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, IV Floor, Str Prov 142, km 3, 95, 10060 Candiolo, Torino, Italy
    Mol Cell Biol 25:3982-96. 2005
    ..These results unravel an in-built mechanism of negative feedback regulation in which Met activation leads to transcriptional induction of Notch function, which in turn limits HGF activity through repression of the Met oncogene...
  13. ncbi request reprint Interactions between growth factor receptors and adhesion molecules: breaking the rules
    Paolo M Comoglio
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142, 10060 Candiolo Torino, Italy
    Curr Opin Cell Biol 15:565-71. 2003
    ....
  14. ncbi request reprint Role of the MET/HGF receptor in proliferation and invasive behavior of osteosarcoma
    Nadia Coltella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment IRCC, Strada Provinciale 142, Km 3 95, 10060 Candiolo To, Italy
    FASEB J 17:1162-4. 2003
    ..These data show that HGF activates both the mitogen and motogen machinery in osteosarcoma cells and suggest that HGF might promote their malignant behavior by concomitant activation of different pathways and biological functions...
  15. ncbi request reprint Cancer: the matrix is now in control
    Paolo M Comoglio
    Nat Med 11:1156-9. 2005
  16. ncbi request reprint Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis
    Andrea Bertotti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino School of Medicine, Candiolo Torino, Italy
    Cancer Res 65:10674-9. 2005
    ....