Gianluca Trifiro

Summary

Affiliation: University of Messina
Country: Italy

Publications

  1. ncbi Adverse drug events in emergency department population: a prospective Italian study
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Messina, Italy
    Pharmacoepidemiol Drug Saf 14:333-40. 2005
  2. ncbi Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999-2002
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98100 Messina, Italy
    Eur J Clin Pharmacol 61:47-53. 2005
  3. doi Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Parkinsonism Relat Disord 14:420-5. 2008
  4. ncbi All-cause mortality associated with atypical and typical antipsychotics in demented outpatients
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Italy
    Pharmacoepidemiol Drug Saf 16:538-44. 2007
  5. ncbi Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
    Pharmacoepidemiol Drug Saf 16:552-9. 2007
  6. doi Prescribing pattern of antipsychotic drugs in the Italian general population 2000-2005: a focus on elderly with dementia
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Int Clin Psychopharmacol 25:22-8. 2010
  7. pmc Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011
    Domenico Italiano
    Department of Clinical and Experimental Medicine, University of Messina, Messina
    Br J Clin Pharmacol 79:1010-9. 2015
  8. doi Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009: a nationwide population-based study
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Ann Rheum Dis 72:694-700. 2013
  9. pmc Comparative Effectiveness of Biosimilar, Reference Product and Other Erythropoiesis-Stimulating Agents (ESAs) Still Covered by Patent in Chronic Kidney Disease and Cancer Patients: An Italian Population-Based Study
    Ylenia Ingrasciotta
    Unit of Clinical Pharmacology, A O U Policlinico G Martino, Messina, Italy
    PLoS ONE 11:e0155805. 2016
  10. doi The Management of Diabetes Mellitus in Patients with Chronic Kidney Disease: A Population-Based Study in Southern Italy
    Gianluca Trifiro
    Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Department of Clinical and Experimental Medicine, Policlinico Universitario G Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy
    Clin Drug Investig 36:203-12. 2016

Collaborators

Detail Information

Publications43

  1. ncbi Adverse drug events in emergency department population: a prospective Italian study
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Messina, Italy
    Pharmacoepidemiol Drug Saf 14:333-40. 2005
    ..We therefore carried out a study to determine ADE incidence and ADE-related hospital admissions among emergency department (ED) visits, and to identify the risk factors for serious ADE leading to ED visit...
  2. ncbi Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999-2002
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98100 Messina, Italy
    Eur J Clin Pharmacol 61:47-53. 2005
    ..To assess the antipsychotic use and the prevalence/incidence of antipsychotic drug users in Italy during the years 1999-2002. To estimate the persistence with antipsychotic medications, and to measure their off-label use...
  3. doi Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Parkinsonism Relat Disord 14:420-5. 2008
    ..A high proportion of APD users (15-20%) received only one prescription during the study period...
  4. ncbi All-cause mortality associated with atypical and typical antipsychotics in demented outpatients
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Italy
    Pharmacoepidemiol Drug Saf 16:538-44. 2007
    ..To estimate the association between use of typical and atypical antipsychotics and all-cause mortality in a population of demented outpatients...
  5. ncbi Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
    Pharmacoepidemiol Drug Saf 16:552-9. 2007
    ..To estimate 1-year prevalence, 1-year incidence and indication of use of antidepressant (AD) drug treatment in general practice of Southern Italy during the years 2003-2004...
  6. doi Prescribing pattern of antipsychotic drugs in the Italian general population 2000-2005: a focus on elderly with dementia
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Int Clin Psychopharmacol 25:22-8. 2010
    ..Similar trends were not observed in general population and elderly as a whole...
  7. pmc Indications of newer and older anti-epileptic drug use: findings from a southern Italian general practice setting from 2005-2011
    Domenico Italiano
    Department of Clinical and Experimental Medicine, University of Messina, Messina
    Br J Clin Pharmacol 79:1010-9. 2015
    ..The aim of the study was to analyze the prescribing pattern of both newer and older AEDs...
  8. doi Epidemiology of gout and hyperuricaemia in Italy during the years 2005-2009: a nationwide population-based study
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Ann Rheum Dis 72:694-700. 2013
    ..To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005-2009...
  9. pmc Comparative Effectiveness of Biosimilar, Reference Product and Other Erythropoiesis-Stimulating Agents (ESAs) Still Covered by Patent in Chronic Kidney Disease and Cancer Patients: An Italian Population-Based Study
    Ylenia Ingrasciotta
    Unit of Clinical Pharmacology, A O U Policlinico G Martino, Messina, Italy
    PLoS ONE 11:e0155805. 2016
    ..Since 2007 biosimilars of erythropoiesis-stimulating agents (ESAs) are available on the Italian market. Very limited post-marketing data exist on the comparative effectiveness of biosimilar and originator ESAs...
  10. doi The Management of Diabetes Mellitus in Patients with Chronic Kidney Disease: A Population-Based Study in Southern Italy
    Gianluca Trifiro
    Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Department of Clinical and Experimental Medicine, Policlinico Universitario G Martino, University of Messina, Via Consolare Valeria, 98125, Messina, Italy
    Clin Drug Investig 36:203-12. 2016
    ..Pharmacological management of DKD is challenging due to reduced renal excretion of some antidiabetic drugs. The aim of this population-based study was to explore antidiabetic drug use in DKD patients from Southern Italy...
  11. ncbi Statin-macrolide interaction risk: a population-based study throughout a general practice database
    Nadia Piacentini
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Eur J Clin Pharmacol 61:615-20. 2005
    ..e., macrolides). The aim of this study was to assess whether concurrent statin/macrolide prescriptions at high interaction risk are commonly written in a general practice setting...
  12. pmc Prescribing pattern of anti-epileptic drugs in an Italian setting of elderly outpatients: a population-based study during 2004-07
    Alessandro Oteri
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
    Br J Clin Pharmacol 70:514-22. 2010
    ....
  13. doi Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawal
    Marianna Alacqua
    University of Messina, Messina, Italy
    Arthritis Rheum 59:568-74. 2008
    ..The aim of the present study was to compare the trend of nonsteroidal antiinflammatory drug (NSAID) use and other analgesics in osteoarthritis (OA) treatment before and after rofecoxib withdrawal in Italian general practice...
  14. ncbi Use and tolerability of newer antipsychotics and antidepressants: a chart review in a paediatric setting
    Marianna Alacqua
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Pharm World Sci 30:44-50. 2008
    ..To analyse the prescribing pattern and the safety profile of different atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs) during the years 2002-2003 in paediatric setting...
  15. doi A nationwide prospective study on prescribing pattern of antidepressant drugs in Italian primary care
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
    Eur J Clin Pharmacol 69:227-36. 2013
    ..Our purpose was to explore antidepressant drug (AD) prescribing patterns in Italian primary care...
  16. ncbi The Effect of Safety Warnings on Antipsychotic Drug Prescribing in Elderly Persons with Dementia in the United Kingdom and Italy: A Population-Based Study
    Janet Sultana
    Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125, Messina, Sicily, Italy
    CNS Drugs 30:1097-1109. 2016
    ..e. the Medicines and Healthcare products Regulatory Agency in the UK and the Italian Drug Agency) regulatory agencies issued safety warnings against AP use in dementia in 2004 and 2009...
  17. doi How did the Introduction of Biosimilar Filgrastim Influence the Prescribing Pattern of Granulocyte Colony-Stimulating Factors? Results from a Multicentre, Population-Based Study, from Five Italian Centres in the Years 2009-2014
    Ilaria Marcianò
    Unit of Clinical Pharmacology, A O U Policlinico G Martino, Messina, Italy
    BioDrugs 30:295-306. 2016
    ..Granulocyte colony-stimulating factors (G-CSFs) are biological products for which the main indication of use is chemotherapy-induced neutropenia. Biosimilars of G-CSFs have been available in Europe since 2007...
  18. pmc Chronic kidney disease requiring healthcare services: a new approach to evaluate epidemiology of renal disease
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, University of Messina and Policlinico Universitario, Via Consolare Valeria, 98125 Messina, Italy
    Biomed Res Int 2014:268362. 2014
    ..The aim of this study was to evaluate the epidemiology of "medicalized" CKD, that is, CKD requiring healthcare services, in an outpatient setting...
  19. doi Drug interactions with levothyroxine therapy in patients with hypothyroidism: observational study in general practice
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Pharmacology Section, University of Messina, Messina, Italy
    Clin Drug Investig 35:187-95. 2015
    ....
  20. pmc Association of individual non-steroidal anti-inflammatory drugs and chronic kidney disease: a population-based case control study
    Ylenia Ingrasciotta
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    PLoS ONE 10:e0122899. 2015
    ..Non-steroidal anti-inflammatory agents (NSAIDs) are known to be associated with renal damage. No clear evidence exists regarding differential risk of chronic kidney disease (CKD), specifically, across various NSAIDs...
  21. doi Changes in the prescribing pattern of antidepressant drugs in elderly patients: an Italian, nationwide, population-based study
    Janet Sultana
    Department of Clinical and Experimental Medicine, Pharmacology Section, University of Messina, Via Consolare Valeria, 98125, Messina, Italy
    Eur J Clin Pharmacol 70:469-78. 2014
    ..The aim of this study was to analyze the trend in the use of ADs in the Italian elderly patients in the years 2003-2009, and specifically, to evaluate rates and predictors of AD treatment discontinuation in depressed older patients...
  22. pmc Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
    Br J Clin Pharmacol 62:582-90. 2006
    ....
  23. doi An overview of experimental and early investigational therapies for the treatment of polycystic kidney disease
    Domenico Santoro
    University of Messina, AOU G Martino PAD C, Department of Internal Medicine and Pharmacology, Via Consolare Valeria, 98100 Messina, Italy 39 090 2212331 39 090 2212331
    Expert Opin Investig Drugs 24:1199-218. 2015
    ..However, recent advances with ADPKD pathophysiology have stimulated research for new therapeutic strategies...
  24. pmc How Much Are Biosimilars Used in Clinical Practice? A Retrospective Italian Population-Based Study of Erythropoiesis-Stimulating Agents in the Years 2009-2013
    Ylenia Ingrasciotta
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    BioDrugs 29:275-84. 2015
    ..To explore the prescription patterns of erythropoiesis-stimulating agents (ESAs) in four large Italian geographic areas, where different health policy interventions to promote biosimilar use in routine care are undertaken...
  25. doi Acute cerebellar ataxia following meningococcal group C conjugate vaccination
    Paola Maria Cutroneo
    1Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    J Child Neurol 29:128-30. 2014
    ..Progressive clinical improvement was obtained after corticosteroid treatment. This case increases the small number of postvaccinal ataxias and contributes to further clarifying the complex pathogenesis of this disorder. ..
  26. doi Use of antipsychotics in elderly patients with dementia: do atypical and conventional agents have a similar safety profile?
    Gianluca Trifiro
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
    Pharmacol Res 59:1-12. 2009
    ..More effective interventions are necessary to improve postmarket drug safety in vulnerable populations...
  27. doi Drug safety information through the internet: the experience of an Italian website
    Giovanni Polimeni
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Centro Neurolesi Bonino Pulejo, Messina, Italy
    Drug Saf 32:245-53. 2009
    ..The site also contains specific sections dedicated to adverse reactions to herbal products and cosmetic preparations...
  28. ncbi The EU-ADR project: preliminary results and perspective
    Gianluca Trifiro
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Stud Health Technol Inform 148:43-9. 2009
    ..The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we describe the project framework and the preliminary results...
  29. doi Newer and older antiepileptic drug use in Southern Italy: a population-based study during the years 2003-2005
    Marianna Alacqua
    IRCCS Centro Neurolesi Bonino Pulejo, Via Palermo C da Casazza, Messina 98124, Italy
    Epilepsy Res 85:107-13. 2009
    ..To analyse the prescribing pattern of newer and older antiepileptic drugs (AEDs) during the years 2003-2005...
  30. doi The advent of biosimilars for the treatment of diabetes: current status and future directions
    Giovanni Polimeni
    Unit of Clinical Pharmacology, Sicilian Regional Centre of Pharmacovigilance, A U O Policlinico G Martino, Torre Biologica, Via Consolare Valeria, 98125, Gazzi, Messina, Italy
    Acta Diabetol 52:423-31. 2015
    ..This article discusses all the issues concerning biosimilar, especially biosimilar insulins. ..
  31. doi Erythropoiesis-stimulating agents: dose and mortality risk
    Guido Bellinghieri
    Department of Clinical and Experimental Medicine, University of Messina, Italy
    J Ren Nutr 25:164-8. 2015
    ..ESAs and Hb serum levels were inversely correlated with mortality. Together, these findings suggest that ESAs dosage and Hb level may play a role through an independent manner or an interactive effect that adversely affects mortality. ..
  32. doi Safety profile of biological medicines as compared with non-biologicals: an analysis of the italian spontaneous reporting system database
    Paola M Cutroneo
    Department of Clinical and Experimental Medicine, Unit of Clinical Pharmacology, University of Messina, Torre Biologica, Policlinico Universitario, Via Consolare Valeria, Gazzi, 98125, Messina, Italy
    Drug Saf 37:961-70. 2014
    ..In this context, a comparative safety evaluation of biologicals and biosimilars in clinical practice is warranted...
  33. doi Effects of L'Aquila earthquake on the prescribing pattern of antidepressant and antipsychotic drugs
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    Int J Clin Pharm 35:1053-62. 2013
    ..Moreover, it could be useful to both identify risk categories that require special assistance and assess possible drug abuse or misuse...
  34. doi Clinically significant drug interactions with newer antidepressants
    Edoardo Spina
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
    CNS Drugs 26:39-67. 2012
    ..Knowledge of the interaction potential of individual antidepressants is essential for safe prescribing and may help clinicians to predict and eventually avoid certain drug combinations...
  35. doi How much are biosimilars used in southern Italy?: a retrospective analysis of epoetin utilization in the local health unit of Messina in the years 2010-2011
    Chiara Loiacono
    Department of Clinical and Experimental Medicine and Pharmacology, Unit of Pharmacology, University of Messina, Messina, Italy
    BioDrugs 26:113-20. 2012
    ..Epoetins are one of the three biologics for which biosimilars are available in Italy. So far, there is a lack of Italian national/regional longitudinal data about epoetin use...
  36. doi Antidepressant use in the elderly: the role of pharmacodynamics and pharmacokinetics in drug safety
    Janet Sultana
    University of Messina, Policlinico Universitario G Martino, Department of Clinical and Experimental Medicine, Via Consolare Valeria, 98125 Messina, Italy
    Expert Opin Drug Metab Toxicol 11:883-92. 2015
    ..Antidepressants (ADs) are widely used among elderly persons, making AD-related safety an important issue...
  37. doi Monoclonal antibodies for renal diseases: current concepts and ongoing treatments
    Domenico Santoro
    University of Messina, Department of Internal Medicine and Pharmacology, AOU G Martino PAD C Via Consolare Valeria, 98100 Messina, Italy 39 090 2212331 39 090 2212331
    Expert Opin Biol Ther 15:1119-43. 2015
    ....
  38. doi Effectiveness of risk minimization measures for cabergoline-induced cardiac valve fibrosis in clinical practice in Italy
    Domenico Italiano
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    J Neural Transm (Vienna) 122:799-808. 2015
    ..However, only a small percentage of patients underwent serial echocardiography. Further efforts are needed to achieve better compliance with the prescribing guidelines for cabergoline treated patients in clinical practice...
  39. doi Expert opinion of nephrologists about the effectiveness of low-protein diet in different stages of chronic kidney disease (CKD)
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    Int J Food Sci Nutr 65:1027-32. 2014
    ..According to opinion of a large sample of Southern Italian nephrologists, low-protein diet may be more efficacious if started in CKD stage 3B than 4 and 5...
  40. doi Are the safety profiles of antipsychotic drugs used in dementia the same? An updated review of observational studies
    Gianluca Trifiro
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Messina, Policlinco Universitario, Via Consolare Valeria, 98125, Messina, Italy
    Drug Saf 37:501-20. 2014
    ..Robust evidence of such inter-drug variability could significantly improve patient safety as antipsychotics become more targeted to clinical risk factors...
  41. pmc The burden of nephrotoxic drug prescriptions in patients with chronic kidney disease: a retrospective population-based study in Southern Italy
    Ylenia Ingrasciotta
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy
    PLoS ONE 9:e89072. 2014
    ..The use of nephrotoxic drugs can further worsening renal function in chronic kidney disease (CKD) patients. It is therefore imperative to explore prescribing practices that can negatively affect CKD patients...
  42. doi Risk minimization activities of centrally authorized products in the EU: a descriptive study
    Inge M Zomerdijk
    Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Drug Saf 35:299-314. 2012
    ..This study describes the additional RMAs of centrally authorized medicinal products authorized between 1 January 1995 and 1 January 2010...
  43. doi Cerebellar stroke in elderly patient with basilar artery agenesia: a case report
    Rodolfo Savica
    Dipartimento di Scienze Neurologiche, Psichiatriche ed Anestesiologiche, A O U Policlinico G Martino, Universita di Messina, Messina, Italy
    J Stroke Cerebrovasc Dis 19:81-3. 2010
    ..Furthermore, the reverse dipping pattern together with the aging, hypertension, and diabetes had probably contributed to a hemodynamic malfunction of the cerebral vascular system...