Alberto Sulli

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. doi request reprint Coexistence of osteopoikilosis with seronegative spondyloarthritis and Raynaud's phenomenon: first case report with evaluation of the nailfold capillary bed and literature review
    B Ruaro
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy
    Reumatismo 64:335-9. 2012
  2. ncbi request reprint [Nailfold videocapillaroscopy in systemic sclerosis: diagnostic and follow-up parameters and correlation with both specific serum autoantibodies and subsets of skin involvement]
    A Sulli
    Divisione di Reumatologia, Dipartimento di Medicina Interna, Universita degli Studi di Genova, Genoa
    Reumatismo 56:36-45. 2004
  3. ncbi request reprint Blunted coronary flow reserve in systemic sclerosis
    A Sulli
    Division of Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Rheumatology (Oxford) 43:505-9. 2004
  4. ncbi request reprint Glucocorticoid effects on adrenal steroids and cytokine responsiveness in polymyalgia rheumatica and elderly onset rheumatoid arthritis
    Alberto Sulli
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, San Martino Hospital, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Ann N Y Acad Sci 1069:307-14. 2006
  5. doi request reprint Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes
    Paola Montagna
    Research Laboratories and Clinical Academic Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:30-5. 2010
  6. ncbi request reprint Identification and quantification of selected inflammatory genes modulated by leflunomide and prednisone treatment in early rheumatoid arthritis patients
    Maurizio Cutolo
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 29:72-9. 2011
  7. ncbi request reprint Antiproliferative-antiinflammatory effects of methotrexate and sex hormones on cultured differentiating myeloid monocytic cells (THP-1)
    Maurizio Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:232-7. 2002
  8. doi request reprint Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients
    Maurizio Cutolo
    Research Laboratories and Clinical Academic Unit of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    J Autoimmun 32:254-60. 2009
  9. doi request reprint Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:15-21. 2010
  10. pmc CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 16132 Genova, Italy
    Arthritis Res Ther 11:R176. 2009

Collaborators

Detail Information

Publications66

  1. doi request reprint Coexistence of osteopoikilosis with seronegative spondyloarthritis and Raynaud's phenomenon: first case report with evaluation of the nailfold capillary bed and literature review
    B Ruaro
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy
    Reumatismo 64:335-9. 2012
    ..To the best of our knowledge, this is the first case of OPK studied by videocapillaroscopy, demonstrating the absence of specific microvascular abnormalities of nailfold capillaries...
  2. ncbi request reprint [Nailfold videocapillaroscopy in systemic sclerosis: diagnostic and follow-up parameters and correlation with both specific serum autoantibodies and subsets of skin involvement]
    A Sulli
    Divisione di Reumatologia, Dipartimento di Medicina Interna, Universita degli Studi di Genova, Genoa
    Reumatismo 56:36-45. 2004
    ..The presence of the different subsets of skin involvement (limSS and difSS), as well as the role of some specific serum autoantibodies in the expression of the NVC parameters were investigated...
  3. ncbi request reprint Blunted coronary flow reserve in systemic sclerosis
    A Sulli
    Division of Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Rheumatology (Oxford) 43:505-9. 2004
    ..The possible correlations between the CFR values and the duration of the disease, specific autoantibodies and cutaneous involvement subsets were investigated...
  4. ncbi request reprint Glucocorticoid effects on adrenal steroids and cytokine responsiveness in polymyalgia rheumatica and elderly onset rheumatoid arthritis
    Alberto Sulli
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, San Martino Hospital, University of Genova, Viale Benedetto XV, 6 16132 Genova, Italy
    Ann N Y Acad Sci 1069:307-14. 2006
    ..Interestingly, in PMR and EORA/PMR patients, GC treatment was found to downregulate PRG serum levels...
  5. doi request reprint Estrogens interfere with leflunomide modulation of cytokine production by human activated monocytes
    Paola Montagna
    Research Laboratories and Clinical Academic Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:30-5. 2010
    ..001 vs. E2). E2 seems to contrast the LEF-M activity. These results might support a more efficient therapeutical effect of LEF in male with respect to female RA patients...
  6. ncbi request reprint Identification and quantification of selected inflammatory genes modulated by leflunomide and prednisone treatment in early rheumatoid arthritis patients
    Maurizio Cutolo
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 29:72-9. 2011
    ....
  7. ncbi request reprint Antiproliferative-antiinflammatory effects of methotrexate and sex hormones on cultured differentiating myeloid monocytic cells (THP-1)
    Maurizio Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:232-7. 2002
    ..Therefore, the enhancing antiinflammatory effects exerted by androgens might represent a further explanation for the reduced frequency of inflammatory diseases in male subjects...
  8. doi request reprint Sex hormones modulate the effects of Leflunomide on cytokine production by cultures of differentiated monocyte/macrophages and synovial macrophages from rheumatoid arthritis patients
    Maurizio Cutolo
    Research Laboratories and Clinical Academic Unit of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    J Autoimmun 32:254-60. 2009
    ..05 and p < 0.001). E2 seems to contrast, but T seems to synergize the LEF-M activity. Results might support a stronger therapeutical efficacy, at least for LEF, in male RA patients, as already reported by clinical evidences...
  9. doi request reprint Inflammatory gene profile in early rheumatoid arthritis and modulation by leflunomide and prednisone treatment
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:15-21. 2010
    ..The results suggest that the combination of PN and LEF seems to play a synergistic effect by modulating some inflammatory genes in early RA...
  10. pmc CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 16132 Genova, Italy
    Arthritis Res Ther 11:R176. 2009
    ..In addition, the anti-inflammatory effects of CTLA4-Ig on co-cultures of RA SM and M with activated T cells were tested...
  11. doi request reprint Effects of estrogens on extracellular matrix synthesis in cultures of human normal and scleroderma skin fibroblasts
    Stefano Soldano
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1193:25-9. 2010
    ..This study seems to support important modulatory effects of E2 in the fibrotic progression of the SSc process via ER interactions...
  12. ncbi request reprint Anti-TNF and sex hormones
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine University of Genova, Viale Benedetto XV6, 16132, Genova, Italy
    Ann N Y Acad Sci 1069:391-400. 2006
    ..In patients with at least long-standing RA, this indicates that alterations of serum sex hormones and altered activity of respective converting enzymes are imprinted for a long-lasting period over at least 12 weeks...
  13. ncbi request reprint Circadian rhythms: glucocorticoids and arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV6, 16132 Genova, Italy
    Ann N Y Acad Sci 1069:289-99. 2006
    ..In conclusion, the right timing (early morning) for the glucocorticoid therapy in arthritis is fundamental and well justified by the circadian rhythms of the inflammatory mechanisms...
  14. pmc Sex hormone modulation of cell growth and apoptosis of the human monocytic/macrophage cell line
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Arthritis Res Ther 7:R1124-32. 2005
    ..Androgens were found to increase the apoptosis, and oestrogens showed a protective trend on cell death--both acting as modulators of the NF-kappaB complex...
  15. doi request reprint Raynaud's phenomenon and plasma endothelin: correlations with capillaroscopic patterns in systemic sclerosis
    Alberto Sulli
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy
    J Rheumatol 36:1235-9. 2009
    ....
  16. doi request reprint Peripheral blood perfusion correlates with microvascular abnormalities in systemic sclerosis: a laser-Doppler and nailfold videocapillaroscopy study
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, No 6, 16132 Genova, Italy
    J Rheumatol 37:1174-80. 2010
    ..The effects on FBP of intravenous (IV) treatment with the prostacyclin analog iloprost were also investigated...
  17. ncbi request reprint Bone metabolism changes during anti-TNF-alpha therapy in patients with active rheumatoid arthritis
    Bruno Seriolo
    Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1069:420-7. 2006
    ..e., TNF-alpha) cytokine effects on bone metabolism...
  18. ncbi request reprint Synovial fluid estrogens in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Bebedetto XV, 6, Genova 16132, Italy
    Autoimmun Rev 3:193-8. 2004
    ..e. SF in RA) of 16alpha-hydroxyestrone or 2-hydroxyestrogens...
  19. doi request reprint Vitamin D, steroid hormones, and autoimmunity
    Maurizio Cutolo
    Research Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1317:39-46. 2014
    ..Finally, 1,25(OH)2 D3 seems to reduce aromatase activity and limit the negative effects related to increased peripheral estrogen metabolism (cell proliferation, B cell overactivity). ..
  20. doi request reprint Timing of transition between capillaroscopic patterns in systemic sclerosis
    Alberto Sulli
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Arthritis Rheum 64:821-5. 2012
    ..To investigate the timing of transition through different patterns of nailfold microvascular damage in patients with systemic sclerosis (SSc)...
  21. ncbi request reprint Effects of combined treatments with CTLA4-IG (abatacept), dexamethasone and methotrexate on cultured human macrophages
    Maurizio Cutolo
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Italy
    Clin Exp Rheumatol 34:500-6. 2016
    ..To evaluate the anti-inflammatory effect of CTLA4-Ig (abatacept) and dexamethasone (DEX) monotreatment versus their combination and adding methotrexate (MTX) on cultured human macrophages...
  22. pmc Alternatively Activated (M2) Macrophage Phenotype Is Inducible by Endothelin-1 in Cultured Human Macrophages
    Stefano Soldano
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
    PLoS ONE 11:e0166433. 2016
    ..The study investigated the possible role of ET-1 in inducing the transition from cultured human macrophages into M2 cells...
  23. ncbi request reprint CTLA4-Ig/CD86 interactions in cultured human endothelial cells: effects on VEGFR-2 and ICAM1 expression
    Maurizio Cutolo
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 33:250-4. 2015
    ..Therefore, the effects of CTLA4-Ig/CD86 interaction on VEGFR-2 (vascular endothelial growth factor receptor 2) and ICAM1 expression, were evaluated in cultured ECs...
  24. doi request reprint Effects of macitentan and its active metabolite on cultured human systemic sclerosis and control skin fibroblasts
    Maurizio Cutolo
    From Research Laboratory and Academic Division of Clinical Rheumatology, Research Laboratory of Nephrology, Department of Internal Medicine, and the Department of Health Science, Unit of Dermatology, University of Genoa, Genoa, Italy and the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium M Cutolo, MD, Full Professor, Director P Montagna, BS, PhD R Brizzolara, BS, PhD E Alessandri, MD A Sulli, MD, Assistant Professor C Pizzorni, MD, Assistant Professor S Soldano, BS, PhD, Research Laboratory and Academic Division of Clinical Rheumatology B Villaggio, BS, Research Laboratory of Nephrology, Department of Internal Medicine P P Tavilla, MD, Department of Health Science, Unit of Dermatology, University of Genoa V Smith, MD, PhD, Department of Rheumatology, Ghent University Hospital
    J Rheumatol 42:456-63. 2015
    ....
  25. ncbi request reprint Intracellular NF-kB-decrease and IKB╬▒ increase in human macrophages following CTLA4-Ig treatment
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 31:943-6. 2013
    ..We investigated cytokine production and NF-kB expression following CTLA4-Ig (abatacept) treatment of cultured human macrophages...
  26. doi request reprint Longterm treatment with endothelin receptor antagonist bosentan and iloprost improves fingertip blood perfusion in systemic sclerosis
    Maurizio Cutolo
    From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    J Rheumatol 41:881-6. 2014
    ..To evaluate the longterm effects of endothelin-1 (ET-1) antagonism on peripheral blood perfusion (PBP) in patients with systemic sclerosis (SSc)...
  27. ncbi request reprint Efficacy of the switch to modified-release prednisone in rheumatoid arthritis patients treated with standard glucocorticoids
    Maurizio Cutolo
    Department of Internal Medicine, University of Genova, Genova, Italy
    Clin Exp Rheumatol 31:498-505. 2013
    ..Modified-release (MR) prednisone taken at bedtime (released 2am) is more effective than immediate-release (IR) GC taken in the morning...
  28. doi request reprint Longterm effects of endothelin receptor antagonism on microvascular damage evaluated by nailfold capillaroscopic analysis in systemic sclerosis
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 40:40-5. 2013
    ..Using nailfold videocapillaroscopy (NVC), we evaluated longterm effects of ET-1 antagonist treatment on nailfold microvascular damage in patients with SSc, over a 3-year followup period...
  29. doi request reprint Use of glucocorticoids and risk of infections
    Maurizio Cutolo
    Research Laboratory and Academic Clinical Unit of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Autoimmun Rev 8:153-5. 2008
    ..Consequently, the use of the lowest possible GC dose, at the night time and even for the shortest possible time, should decrease dramatically the risk of infections...
  30. ncbi request reprint Estrogens and autoimmune diseases
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Ann N Y Acad Sci 1089:538-47. 2006
    ..e., TNF-alpha, Il-1, IL-12). In this respect, it is interesting that male patients with RA seem to profit more from anti-TNFalpha strategies than do female patients...
  31. doi request reprint Capillaroscopy
    Maurizio Cutolo
    Research Laboratories and Clinical Academic Unit of Rheumatology, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 22:1093-108. 2008
    ..Several other NVC patterns have also been identified, such as in dermatomyosistis, systemic lupus eythaematosus, mixed connective tissue disease and antiphospholipid syndrome...
  32. ncbi request reprint Sex hormones and rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV 6, 16132 Genova, Italy
    Autoimmun Rev 1:284-9. 2002
    ..Local increased estrogen concentrations and decreased androgen levels have been observed in RA synovial fluids and seem to play a more important role in the immune/inflammatory local response...
  33. ncbi request reprint Effects of anti-TNF-alpha treatment on lipid profile in patients with active rheumatoid arthritis
    Bruno Seriolo
    Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1069:414-9. 2006
    ..01], respectively). TG and Lp(a) levels, as well as the atherogenic index were not significantly changed. Interestingly, variations in disease activity were significantly and inversely correlated with HDL cholesterol levels...
  34. doi request reprint Progression of nailfold microvascular damage and antinuclear antibody pattern in systemic sclerosis
    Alberto Sulli
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 40:634-9. 2013
    ..Patients with SSc were followed prospectively to monitor progression of microvascular damage...
  35. doi request reprint Estrogen metabolism and autoimmunity
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Dept Internal Medicine, University of Genova Italy, Viale Benedetto XV, 6 16132 Genova, Italy
    Autoimmun Rev 11:A460-4. 2012
    ..g. macrophages and fibroblasts) represents a common pathway that characterizes a similar final immune reactivity in both male and female patients...
  36. ncbi request reprint Modulation of cell growth and apoptosis by sex hormones in cultured monocytic THP-1 cells
    Maurizio Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:204-10. 2002
    ..In conclusion, these results support the possibility of sex hormone modulation of apoptosis in macrophage-like cells, with interesting therapeutic perspectives in rheumatoid arthritis...
  37. ncbi request reprint Serum osteocalcin levels in premenopausal rheumatoid arthritis patients
    Bruno Seriolo
    Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:502-7. 2002
    ..This study suggests that generalized bone loss occurs in active RA and is characterized by an evident bone resorption correlated with the high levels of inflammation...
  38. doi request reprint Brachial artery endothelial-dependent flow-mediated dilation identifies early-stage endothelial dysfunction in systemic sclerosis and correlates with nailfold microvascular impairment
    Daniela Rollando
    Academic Unit of Cardiovascular Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Rheumatol 37:1168-73. 2010
    ..Evidence has shown that vascular impairment in SSc may be a sign of endothelial dysfunction involving both microvascular and macrovascular systems, although the pathological mechanisms of the dysfunction are poorly understood...
  39. ncbi request reprint Effects of Longterm Treatment with Bosentan and Iloprost on Nailfold Absolute Capillary Number, Fingertip Blood Perfusion, and Clinical Status in Systemic Sclerosis
    Amelia Chiara Trombetta
    From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium
    J Rheumatol 43:2033-2041. 2016
    ..Observed values were correlated with clinical outcomes...
  40. ncbi request reprint Primary Raynaud's phenomenon and nailfold videocapillaroscopy: age-related changes in capillary morphology
    Carmen Pizzorni
    Research Laboratories and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A O U San Martino, University of Genova, Viale Benedetto XV, No 6, 16132, Genoa, Italy
    Clin Rheumatol . 2016
    ..0001). In conclusion, our study detected different age-related morphological capillary changes mainly in younger patients with PRP, as well as statistically significant correlations between the presence of different capillary variables...
  41. doi request reprint Quantitative Alterations of Capillary Diameter Have a Predictive Value for Development of the Capillaroscopic Systemic Sclerosis Pattern
    Amelia Chiara Trombetta
    From the Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy Department of Rheumatology, Ghent University Hospital, Ghent University, Ghent, Belgium A C Trombetta, MD, PhD, Trainee in Clinical and Experimental Immunology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa V Smith, MD, Associate Professor of Rheumatology, Department of Rheumatology, Ghent University Hospital, Ghent University C Pizzorni, MD, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa M Meroni, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa S Paolino, PhD, Assistant Professor of Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa C Cariti, MD, Trainee in Rheumatology, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa B Ruaro, MD
    J Rheumatol 43:599-606. 2016
    ....
  42. doi request reprint Nailfold capillaroscopy for prediction of novel future severe organ involvement in systemic sclerosis
    Vanessa Smith
    From the Department of Rheumatology, Ghent University Hospital, Ghent, Belgium Department of Internal Medicine and Medical Specialities, University Sapienza, Rome Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy Department of Internal Medicine, Biostatistics Unit, Department of Public Health, Ghent University, and Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium
    J Rheumatol 40:2023-8. 2013
    ..Assessment of associations of nailfold videocapillaroscopy (NVC) scleroderma (systemic sclerosis; SSc) ("early," "active," and "late") with novel future severe clinical involvement in 2 independent cohorts...
  43. doi request reprint How to perform and interpret capillaroscopy
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine DIMI, University of Genova, Viale Benedetto XV, No 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 27:237-48. 2013
    ..In other connective tissue diseases (CTDs) prospective clinical studies resulting in indices which can predict future clinical complications have not been published, as yet...
  44. ncbi request reprint Androgens and estrogens modulate the immune and inflammatory responses in rheumatoid arthritis
    Maurizio Cutolo
    Laboratory and Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy
    Ann N Y Acad Sci 966:131-42. 2002
    ....
  45. doi request reprint Assessing microvascular changes in systemic sclerosis diagnosis and management
    Maurizio Cutolo
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, 6 16132 Genova, Italy
    Nat Rev Rheumatol 6:578-87. 2010
    ....
  46. ncbi request reprint Serum prolactin concentrations in male patients with rheumatoid arthritis
    Bruno Seriolo
    Division of Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, 16132 Genova, Italy
    Ann N Y Acad Sci 966:258-62. 2002
    ..The serum PRL concentration was found to be increased in relation to the duration and the activity of the disease. Serum PRL levels do not seem to have any relationship with the BMD, at least in RA...
  47. ncbi request reprint Role of estrogens in inflammatory response: expression of estrogen receptors in peritoneal fluid macrophages from endometriosis
    Silvia Capellino
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, San Martino Hospital, University of Genoa, Italy
    Ann N Y Acad Sci 1069:263-7. 2006
    ..Therefore, estrogens seem to play an important role in the immune response, independently from the pathology...
  48. ncbi request reprint The contribution of capillaroscopy to the differential diagnosis of connective autoimmune diseases
    Maurizio Cutolo
    Internal Medicine and Rheumatology, Research Laboratory and Clinical Academic Unit of Rheumatology, University of Genova, Italy
    Best Pract Res Clin Rheumatol 21:1093-108. 2007
    ..In systemic sclerosis, the recognition of clear and different NVC morphological patterns ("early", "active", "late") should suggest including this analysis in the classification criteria of the disease...
  49. ncbi request reprint Nocturnal hormones and clinical rhythms in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Immunology and Endocrinology, University of Genoa, Viale Benedetto XV, 16132 Genoa I, Italy
    Ann N Y Acad Sci 1051:372-81. 2005
    ....
  50. doi request reprint Nailfold capillaroscopic parameters and skin telangiectasia patterns in patients with systemic sclerosis
    Carmen Pizzorni
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS AOU San Martino IST Genova, Italy
    Microvasc Res . 2016
    ..To correlate nailfold capillaroscopic parameters with the presence of skin telangiectases (TAs) in systemic sclerosis patients (SSc)...
  51. doi request reprint Short-term follow-up of digital ulcers by laser speckle contrast analysis in systemic sclerosis patients
    Barbara Ruaro
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS A O U San Martino IST, University of Genova, Genoa, Italy
    Microvasc Res 101:82-5. 2015
    ..To monitor in systemic sclerosis (SSc) the evolution of digital ulcer (DU) status by analysing blood perfusion (BP) using laser speckle contrast analysis (LASCA)...
  52. pmc Methods for the morphological and functional evaluation of microvascular damage in systemic sclerosis
    Barbara Ruaro
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
    Korean J Intern Med 30:1-5. 2015
    ..These two methods are also used to identify changes in digital blood perfusion after the infusion of vasodilators. ..
  53. doi request reprint Laser speckle contrast analysis: a new method to evaluate peripheral blood perfusion in systemic sclerosis patients
    Barbara Ruaro
    Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
    Ann Rheum Dis 73:1181-5. 2014
    ..Correlations between LASCA and single laser Doppler flowmetry (LDF) analysis were also checked...
  54. doi request reprint CTLA-4 blockade in the treatment of rheumatoid arthritis: an update
    Maurizio Cutolo
    a Research Laboratories and Academic Division of Clinical Rheumatology, Postgraduate School of Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy
    Expert Rev Clin Immunol 12:417-25. 2016
    ....
  55. ncbi request reprint Early Diagnostic and Predictive Value of Capillaroscopy in Systemic Sclerosis
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova Italy
    Curr Rheumatol Rev 9:249-53. 2013
    ..NVC is a safe and reliable tool for the early diagnosis of SSc and the different NVC scleroderma patterns have a predictive value for the clinical complications of the disease. ..
  56. doi request reprint Vitamin D endocrine system involvement in autoimmune rheumatic diseases
    Maurizio Cutolo
    Research Laboratories and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Italy
    Autoimmun Rev 11:84-7. 2011
    ..Recently, the onset of symptoms of early arthritis during winter or spring have been associated with greater radiographic evidence of disease progression at 12 months possibly are also related to seasonal lower vitamin D serum levels...
  57. ncbi request reprint Steroid hormones and disease activity during pregnancy in systemic lupus erythematosus
    Andrea Doria
    Division of Rheumatology, University of Padova, Padua, Italy
    Arthritis Rheum 47:202-9. 2002
    ..Moreover, to investigate whether, during gestation, there is any relationship between steroid concentration and SLE activity...
  58. ncbi request reprint Capillaroscopy
    Maurizio Cutolo
    Research Laboratory and Division of Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Best Pract Res Clin Rheumatol 19:437-52. 2005
    ..Other major NVC patterns have been described in the field of rheumatic diseases. Interestingly, correlations are evident between the NVC and the clinical symptoms, severity of the disease and the laboratory findings...
  59. doi request reprint Estrogen's effects in chronic autoimmune/inflammatory diseases and progression to cancer
    Maurizio Cutolo
    Department of Internal Medicine, Research Laboratories and Academic Division of Clinical Rheumatology, University of Genova Italy, Viale Benedetto XV, 6, 16132 Genova, Italy
    Expert Rev Clin Immunol 10:31-9. 2014
    ....
  60. doi request reprint Therapy. Optimized treatment algorithms for digital vasculopathy in SSc
    Maurizio Cutolo
    Research Laboratories and Academic Division of Clinical Rheumatology, Director Postgraduate School on Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, 6, 16132 Genova, Italy
    Nat Rev Rheumatol 11:569-71. 2015
    ..Integrated therapeutic approaches and monitoring systems that offer improved modalities of care feature in the new best practice recommendations for the treatment of digital vasculopathy in SSc...
  61. doi request reprint Circadian use of glucocorticoids in rheumatoid arthritis
    Maurizio Cutolo
    Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Neuroimmunomodulation 22:33-9. 2015
    ....
  62. ncbi request reprint Adrenal gland hypofunction in active polymyalgia rheumatica. effect of glucocorticoid treatment on adrenal hormones and interleukin 6
    Maurizio Cutolo
    Department of Internal Medicine and Medical Specialities, University of Genova, Italy
    J Rheumatol 29:748-56. 2002
    ....
  63. ncbi request reprint Melatonin in rheumatoid arthritis: synovial macrophages show melatonin receptors
    Georges J M Maestroni
    Centre for Experimental Pathology, Istituto Cantonale di Patologia, Locarno, Switzerland
    Ann N Y Acad Sci 966:271-5. 2002
    ..Furthermore, melatonin is present in the synovial fluid of RA patients and synovial macrophages express a specific binding site. We suggest that melatonin may exert a disease-promoting role in RA...
  64. ncbi request reprint Identification of transition from primary Raynaud's phenomenon to secondary Raynaud's phenomenon by nailfold videocapillaroscopy: comment on the article by Hirschl et al
    Maurizio Cutolo
    Arthritis Rheum 56:2102-3; author reply 2103-4. 2007
  65. ncbi request reprint Pregnancy, cytokines, and disease activity in systemic lupus erythematosus
    Andrea Doria
    University of Padova, Padova, Italy
    Arthritis Rheum 51:989-95. 2004
    ..To evaluate levels of selected cytokines and soluble receptors involved in the humoral immune response during pregnancy in systemic lupus erythematosus (SLE) patients...