Anna Sparatore

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint N-homolupinanoyl and N-(omega-lupinylthio)alkanoyl derivatives of some tricyclic systems as ligands for muscarinic M1 and M2 receptor subtypes
    Bruno Tasso
    Dipartimento di Scienze Farmaceutiche, University of Genoa, Viale Benedetto XV, 3, I 16132 Genova, Italy
    Farmaco 58:669-76. 2003
  2. pmc ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function
    Xiao Qing Tang
    Department of Physiology, Medical College, University of South China, Hengyang, 421001, Hunan, P, R, China
    Med Gas Res 1:20. 2011
  3. ncbi request reprint Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors
    A Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Italy
    Farmaco 54:248-54. 1999
  4. doi request reprint Pharmacological profile of a novel H(2)S-releasing aspirin
    Anna Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milano, Italy
    Free Radic Biol Med 46:586-92. 2009
  5. ncbi request reprint [4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs)
    Anna Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Viale Abruzzi 42, I 20131 Milan
    Chem Biodivers 3:385-95. 2006
  6. ncbi request reprint 4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity
    Anna Sparatore
    Institute of Medicinal Chemistry, University of Milan, Viale Abruzzi, 42, 20131 Milan, Italy
    Bioorg Med Chem 13:5338-45. 2005
  7. doi request reprint Therapeutic potential of new hydrogen sulfide-releasing hybrids
    Anna Sparatore
    Department of Pharmaceutical Science Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli, 25 20133 Milano, Italy
    Expert Rev Clin Pharmacol 4:109-21. 2011
  8. ncbi request reprint 2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine
    A Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica, University of Milan, Viale Abruzzi, 42 I 20131 Milan, Italy
    Farmaco 56:169-74. 2001
  9. ncbi request reprint Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline
    Anna Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    Bioorg Med Chem Lett 18:3737-40. 2008
  10. ncbi request reprint High antiplasmodial activity of novel plasmepsins I and II inhibitors
    Mario dell'Agli
    Department of Pharmacological Sciences, School of Pharmacy, University of Milan, Milan 20100, Italy
    J Med Chem 49:7440-9. 2006

Collaborators

Detail Information

Publications22

  1. ncbi request reprint N-homolupinanoyl and N-(omega-lupinylthio)alkanoyl derivatives of some tricyclic systems as ligands for muscarinic M1 and M2 receptor subtypes
    Bruno Tasso
    Dipartimento di Scienze Farmaceutiche, University of Genoa, Viale Benedetto XV, 3, I 16132 Genova, Italy
    Farmaco 58:669-76. 2003
    ..However, only moderate selectivity for one or the other subtype was seen...
  2. pmc ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function
    Xiao Qing Tang
    Department of Physiology, Medical College, University of South China, Hengyang, 421001, Hunan, P, R, China
    Med Gas Res 1:20. 2011
    ..abstract:..
  3. ncbi request reprint Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors
    A Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Italy
    Farmaco 54:248-54. 1999
    ..The compound with the highest affinity for 5-HT4 receptor was tested for the enhancement of intestinal transit rate but was inactive at the oral dose of 100 mg/kg...
  4. doi request reprint Pharmacological profile of a novel H(2)S-releasing aspirin
    Anna Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milano, Italy
    Free Radic Biol Med 46:586-92. 2009
    ....
  5. ncbi request reprint [4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs)
    Anna Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Viale Abruzzi 42, I 20131 Milan
    Chem Biodivers 3:385-95. 2006
    ..Thus, compounds 1 and 5 represent interesting starting point for preparing novel agents for the treatment of dyslipidemia or of dyslipidemic type-2 diabetes...
  6. ncbi request reprint 4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity
    Anna Sparatore
    Institute of Medicinal Chemistry, University of Milan, Viale Abruzzi, 42, 20131 Milan, Italy
    Bioorg Med Chem 13:5338-45. 2005
    ..All compounds but one exerted significant antimalarial activity. Some of the quinolizidine derivatives were from 5 to 10 times more active than chloroquine on the CQ-resistant strain. No toxicity against mammalian cells was observed...
  7. doi request reprint Therapeutic potential of new hydrogen sulfide-releasing hybrids
    Anna Sparatore
    Department of Pharmaceutical Science Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli, 25 20133 Milano, Italy
    Expert Rev Clin Pharmacol 4:109-21. 2011
    ..Finally the mechanism(s) of action of glutathione-dependent and independent, and of gas (H(2)S) release (spontaneous or enzymatic) and its implications for clinical pharmacology perspectives will be also discussed...
  8. ncbi request reprint 2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine
    A Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica, University of Milan, Viale Abruzzi, 42 I 20131 Milan, Italy
    Farmaco 56:169-74. 2001
    ..With the exception of two, all the prepared esters exhibited good affinity to muscarinic receptors (on a non-selective basis), with pKi in the range 6.67-7.68...
  9. ncbi request reprint Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline
    Anna Sparatore
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    Bioorg Med Chem Lett 18:3737-40. 2008
    ..Preliminary studies of the acute toxicity and of the metabolism of the most active compound MG3 indicate a promising profile as a new antimalarial drug candidate...
  10. ncbi request reprint High antiplasmodial activity of novel plasmepsins I and II inhibitors
    Mario dell'Agli
    Department of Pharmacological Sciences, School of Pharmacy, University of Milan, Milan 20100, Italy
    J Med Chem 49:7440-9. 2006
    ..The most promising compounds (2, 6, 10) were not cytotoxic against human fibroblasts at 100 microM and were highly selective for PLMs vs human cathepsin D...
  11. doi request reprint Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline
    Chiara Rusconi
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
    Bioorg Med Chem 20:5980-5. 2012
    ..These results confirm that the racemate (±)-AM1 could be considered as a potential antimalarial agent, ensuring a decrease of costs of synthesis compared to (-)-AM1...
  12. ncbi request reprint Atovaquone-statine "double-drugs" with high antiplasmodial activity
    Sergio Romeo
    Institute of Medicinal Chemistry Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    ChemMedChem 3:418-20. 2008
  13. doi request reprint Novel amodiaquine congeners as potent antimalarial agents
    Manolo Casagrande
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    Bioorg Med Chem 16:6813-23. 2008
    ..Among these compounds, two quinolizidinylmethylamino derivatives (6f and 7f) displayed high activity against both CQ-S and CQ-R strains...
  14. doi request reprint Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline
    Manolo Casagrande
    Dipartimento Scienze Farmaceutiche, Universita degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy
    Bioorg Med Chem 20:5965-79. 2012
    ..These results confirm that the presence of an heteroaryl moiety in the side chain of 7-chloro-4-aminoquinoline is useful for the design and development of new powerful antimalarial agents...
  15. doi request reprint Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on pathological cardiovascular alterations induced by glutathione depletion in rats
    Giuseppe Rossoni
    Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Eur J Pharmacol 648:139-45. 2010
    ..This implies that H₂S released by both ACS14 and ACS21 was involved in protecting the heart from ischemia/reperfusion, and significantly limited vascular endothelial dysfunction in aortic tissue and the related hypertension...
  16. doi request reprint Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines
    Manolo Casagrande
    Dipartimento di Scienze Farmaceutiche Pietro Pratesi, Universita degli Studi di Milano, Via Mangiagalli, 25, 20133 Milan, Italy
    Bioorg Med Chem 18:6625-33. 2010
    ..The antimalarial activity of this new class of compounds seems to be related to the inhibition of heme detoxification process of parasites, as in the case of chloroquine...
  17. doi request reprint New aryldithiolethione derivatives as potent histone deacetylase inhibitors
    Valerio Tazzari
    Sulfidris s r l, Viale Gran Sasso 17, 20131 Milan, Italy
    Bioorg Med Chem 18:4187-94. 2010
    ..The HDAC inhibitory activity comparable to that of SAHA and the inhibition of A549 cell proliferation suggest that these compounds are worthy of further studies as potential anticancer agents...
  18. pmc Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes
    Fausta Omodeo-Salè
    Dipartimento di Scienze Molecolari Applicate ai Biosistemi DISMAB, Facolta di Farmacia, Universita degli Studi di Milano, Milan, Italy
    Antimicrob Agents Chemother 53:4339-44. 2009
    ....
  19. ncbi request reprint New prostaglandin derivative for glaucoma treatment
    Elena Perrino
    Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
    Bioorg Med Chem Lett 19:1639-42. 2009
    ..This is the first time that an application of a hydrogen sulphide-releasing molecule is reported for the treatment of ocular diseases...
  20. ncbi request reprint Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'
    Sergio Romeo
    Institute of Medicinal Chemistry, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
    Bioorg Med Chem Lett 14:2931-4. 2004
    ..59 to 400 nM and the best IC50 value for inhibition of Plasmodium falciparum growth in vitro was 0.4 microM, which represent a remarkable improvement compared to other statine-based PLMII inhibitors...
  21. doi request reprint New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity
    Elena Perrino
    Sulfidris s r l, Viale Gran Sasso 17, 20131 Milan, Italy
    Bioorg Med Chem Lett 18:1893-7. 2008
    ..This is the first time that HDAC inhibitory activity is described for dithiolethiones and thiosulfonates...
  22. ncbi request reprint Novel sigma binding site ligands as inhibitors of cell proliferation in breast cancer
    Federica Barbieri
    Laboratory of Pharmacology and Neuroscience, National Institute for Cancer Research, Largo R Benzi 10, 16132, Genoa, Italy
    Oncol Res 13:455-61. 2003
    ..The data from the current study show that these novel sigma receptor ligands exhibit interesting cytotoxic activity and suggest their potential for development as antitumor agents...