A Signore

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc 99mTc-besilesomab (Scintimun) in peripheral osteomyelitis: comparison with 99mTc-labelled white blood cells
    Wolf S Richter
    Pharmtrace klinische Entwicklung GmbH, Alt Moabit 59 61, 10555 Berlin, Germany
    Eur J Nucl Med Mol Imaging 38:899-910. 2011
  2. ncbi request reprint Current status of PET imaging of differentiated thyroid cancer with second generation radiopharmaceuticals
    C Lauri
    Unit of Nuclear Medicine, Department of Medical Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
    Q J Nucl Med Mol Imaging 59:105-15. 2015
  3. ncbi request reprint Radiolabelled probes targeting infection and inflammation for personalized medicine
    Alberto Signore
    Nuclear Medicine Unit, Ospedale S Andrea, Via di Grottarossa 1035, 00189 Rome, Italy
    Curr Pharm Des 20:2338-45. 2014
  4. pmc Pharmacokinetic modelling of N-(4-[(18)F]fluorobenzoyl)interleukin-2 binding to activated lymphocytes in an xenograft model of inflammation
    Valentina Di Gialleonardo
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 39:1551-60. 2012
  5. pmc About inflammation and infection
    Alberto Signore
    Nuclear Medicine Unit, Department of Medical Surgical Sciences and of Translational Medicine, Sapienza University, Rome, Italy
    EJNMMI Res 3:8. 2013
  6. doi request reprint Imaging of β-cell mass and insulitis in insulin-dependent (Type 1) diabetes mellitus
    Valentina Di Gialleonardo
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 AB, Groningen, The Netherlands
    Endocr Rev 33:892-919. 2012
  7. ncbi request reprint Development and testing of a new disposable sterile device for labelling white blood cells
    A Signore
    Nuclear Medicine Unit, Faculty of Medicine and Psychology, La Sapienza University, Rome, Italy
    Q J Nucl Med Mol Imaging 56:400-8. 2012
  8. pmc Synthesis and optimization of the labeling procedure of 99mTc-HYNIC-interleukin-2 for in vivo imaging of activated T lymphocytes
    Calogero D'Alessandria
    Nuclear Medicine Unit, 2nd Faculty of Medicine, University Sapienza, Rome, Italy
    Mol Imaging Biol 12:539-46. 2010
  9. pmc Molecular imaging in atherosclerosis
    Andor W J M Glaudemans
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:2381-97. 2010
  10. pmc Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine
    Erik F J de Vries
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:842-8. 2010

Collaborators

Detail Information

Publications72

  1. pmc 99mTc-besilesomab (Scintimun) in peripheral osteomyelitis: comparison with 99mTc-labelled white blood cells
    Wolf S Richter
    Pharmtrace klinische Entwicklung GmbH, Alt Moabit 59 61, 10555 Berlin, Germany
    Eur J Nucl Med Mol Imaging 38:899-910. 2011
    ....
  2. ncbi request reprint Current status of PET imaging of differentiated thyroid cancer with second generation radiopharmaceuticals
    C Lauri
    Unit of Nuclear Medicine, Department of Medical Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
    Q J Nucl Med Mol Imaging 59:105-15. 2015
    ..Discussion is focused on the utility of ¹²⁴I-PET/CT, but we also mention the pathways explored by ⁶⁸Gallium-somatostatin analogues, ¹⁸F-FLT and ¹¹C-MET and their applications in this clinical setting...
  3. ncbi request reprint Radiolabelled probes targeting infection and inflammation for personalized medicine
    Alberto Signore
    Nuclear Medicine Unit, Ospedale S Andrea, Via di Grottarossa 1035, 00189 Rome, Italy
    Curr Pharm Des 20:2338-45. 2014
    ..Several advances have been observed in this field, and they seem to be very promising for a tailored medicine. ..
  4. pmc Pharmacokinetic modelling of N-(4-[(18)F]fluorobenzoyl)interleukin-2 binding to activated lymphocytes in an xenograft model of inflammation
    Valentina Di Gialleonardo
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 39:1551-60. 2012
    ..We now validated whether [(18)F]FB-IL2 can be used to quantify activated human peripheral blood mononuclear cells (hPBMC) in rats by pharmacokinetic modelling...
  5. pmc About inflammation and infection
    Alberto Signore
    Nuclear Medicine Unit, Department of Medical Surgical Sciences and of Translational Medicine, Sapienza University, Rome, Italy
    EJNMMI Res 3:8. 2013
    ..The most common nuclear medicine techniques and interpretation criteria to differentiate inflammation between infection are also briefly mentioned...
  6. doi request reprint Imaging of β-cell mass and insulitis in insulin-dependent (Type 1) diabetes mellitus
    Valentina Di Gialleonardo
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 AB, Groningen, The Netherlands
    Endocr Rev 33:892-919. 2012
    ..Several approaches and radiopharmaceuticals for imaging β-cells and lymphocytic insulitis are reviewed in detail...
  7. ncbi request reprint Development and testing of a new disposable sterile device for labelling white blood cells
    A Signore
    Nuclear Medicine Unit, Faculty of Medicine and Psychology, La Sapienza University, Rome, Italy
    Q J Nucl Med Mol Imaging 56:400-8. 2012
    ..Leukokit® was also tested in an international multi-centre study for easiness of WBC purification and labelling...
  8. pmc Synthesis and optimization of the labeling procedure of 99mTc-HYNIC-interleukin-2 for in vivo imaging of activated T lymphocytes
    Calogero D'Alessandria
    Nuclear Medicine Unit, 2nd Faculty of Medicine, University Sapienza, Rome, Italy
    Mol Imaging Biol 12:539-46. 2010
    ..However, both radiopharmaceuticals had some specific disadvantages, such as cost and time of synthesis...
  9. pmc Molecular imaging in atherosclerosis
    Andor W J M Glaudemans
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:2381-97. 2010
    ..Nevertheless, we expect such a tracer to be developed in the next few years and maybe, theoretically, it could even be used for targeted therapy (in the form of a beta-emitter) to combat cardiovascular disease...
  10. pmc Guidelines for the labelling of leucocytes with (99m)Tc-HMPAO. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine
    Erik F J de Vries
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:842-8. 2010
    ..This protocol includes quality control and safety procedures and is in accordance with current European Union regulations and International Atomic Energy Agency recommendations...
  11. pmc Guidelines for the labelling of leucocytes with (111)In-oxine. Inflammation/Infection Taskgroup of the European Association of Nuclear Medicine
    Manel Roca
    Radiopharmacy Unit, Nuclear Medicine Department, Hospital Universitario de Bellvitge, Barcelona, Spain
    Eur J Nucl Med Mol Imaging 37:835-41. 2010
    ..This protocol includes quality control and safety procedures and is in accordance with current European Union regulations and International Atomic Energy Agency recommendations...
  12. pmc Can we produce an image of bacteria with radiopharmaceuticals?
    A Signore
    Eur J Nucl Med Mol Imaging 35:1051-5. 2008
  13. doi request reprint The molecular imaging approach to image infections and inflammation by nuclear medicine techniques
    Alberto Signore
    Medicina Nucleare, 2nd Faculty of Medicine, Ospedale S Andrea, University of Rome Sapienza, Via di Grottarossa 1035, 00189 Rome, Italy
    Ann Nucl Med 25:681-700. 2011
    ..We also describe the clinical indications of all available radiopharmaceuticals in the light of the newly available guidelines...
  14. ncbi request reprint Targeting T and B lymphocytes with radiolabelled antibodies for diagnostic and therapeutic applications
    G Malviya
    Nuclear Medicine Unit, Second Faculty of Medicine and Surgery, La Sapienza University, Rome, Italy
    Q J Nucl Med Mol Imaging 54:654-76. 2010
    ..In this review article, we will discuss different possible targets for T and B cells and their radiolabelled mAbs for molecular imaging and radioimmunotherapy...
  15. doi request reprint Can sequential 18F-FDG PET/CT replace WBC imaging in the diabetic foot?
    Demetrio Familiari
    Nuclear Medicine Unit, Second Faculty of Medicine, Sapienza University of Rome, Rome, Italy
    J Nucl Med 52:1012-9. 2011
    ..Our aim was to evaluate the role of sequential (18)F-FDG PET/CT in patients with a high suspicion of osteomyelitis to define objective interpretation criteria to be compared with WBC scintigraphy...
  16. ncbi request reprint 99mTc-interleukin-2 scintigraphy as a potential tool for evaluating tumor-infiltrating lymphocytes in melanoma lesions: a validation study
    Alberto Signore
    Nuclear Medicine Unit, Departments of Clinical Sciences and Radiological Sciences, Second Faculty of Medicine, University La Sapienza, Rome, Italy
    J Nucl Med 45:1647-52. 2004
    ....
  17. ncbi request reprint Scientific production and impact of nuclear medicine in Europe: how do we publish?
    Alberto Signore
    Nuclear Medicine, Department of Clinical Sciences, 2nd Faculty of Medicine, University La Sapienza, 00161 Rome, Italy
    Eur J Nucl Med Mol Imaging 31:882-6. 2004
    ..Articles concerning the use of nuclear medicine in oncology account for more than one-quarter of all published nuclear medicine papers...
  18. ncbi request reprint The developing role of cytokines for imaging inflammation and infection
    A Signore
    Nu M E D Group, Servizio Speciale di Medicina Nucleare, Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy
    Cytokine 12:1445-54. 2000
    ..So far, IL-1, IL-1ra, IL-2, IL-6, IL-8, IL-10, IL-12 p40, G-CSF, IFN-gamma and EGF have been radiolabelled for in vivo targetting of different leukocyte subsets with promising results for their clinical use...
  19. ncbi request reprint Highlights of the annual congress of the European Association of Nuclear Medicine, Amsterdam 2003
    Alberto Signore
    Nuclear Medicine, Department of Clinical Sciences, 2nd Faculty of Medicine, University La Sapienza, 00161, Rome, Italy
    Eur J Nucl Med Mol Imaging 31:439-58. 2004
  20. ncbi request reprint Peptide radiopharmaceuticals for diagnosis and therapy
    A Signore
    Nuclear Medicine, Policlinico Umberto I, University La Sapienza, Rome, Italy
    Eur J Nucl Med 28:1555-65. 2001
    ..A new classification is also proposed for peptides targeting tumour cells based on the biological function of target receptors. These tailored radiopharmaceuticals are the basis of the new era of "molecular nuclear medicine"...
  21. ncbi request reprint Reduced cumulative incidence of diabetes but not insulitis following administration of chimeric human IL-15-murine IgG2b in NOD mice
    A Signore
    Department of Clinical Sciences, University La Sapienza, Rome, Italy
    Diabetes Metab Res Rev 19:464-8. 2003
    ..The rationale for the use of IL-15-IgG2b recombinant cytokine is related to its long half-life (28 +/- 4 h)...
  22. ncbi request reprint Radiolabelled lymphokines and growth factors for in vivo imaging of inflammation, infection and cancer
    Alberto Signore
    Nuclear Medicine Unit, Department of Clinical Sciences, University La Sapienza, Via del Policlinico 155, 00161, Roma, Italy
    Trends Immunol 24:395-402. 2003
    ..These studies will generate a deeper knowledge of the molecular mechanism of tumor metastasis and lead to new therapies in nuclear medicine...
  23. ncbi request reprint Targeting cytokine/chemokine receptors: a challenge for molecular nuclear medicine
    A Signore
    Nuclear Medicine Unit, Department of Clinical Sciences, Policlinico Umberto I, University La Sapienza, Via del Policlinico 155, 00161 Roma, Italy
    Eur J Nucl Med Mol Imaging 30:149-56. 2003
    ..In this paper we describe the characteristics of cytokines and chemokines, focussing on their role as radiopharmaceuticals for the imaging of cancer cells in vivo, a new challenge for molecular nuclear medicine...
  24. pmc Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies
    G Malviya
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 37:386-98. 2010
    ..This article reviews the use of radiolabelled mAbs in the study of RA with particular emphasis on the use of different radiolabelled monoclonal antibodies for therapy decision-making and follow-up...
  25. ncbi request reprint Receptor binding ligands to image infection
    M Chianelli
    Department of Diagnostics, Regina Apostolorum Hospital, Albano, Rome, Italy
    Curr Pharm Des 14:3316-25. 2008
    ..However, at present we still need to investigate many basic aspects to better understand the mechanisms of binding and accumulation of this class of radiopharmaceuticals to bacteria...
  26. ncbi request reprint Clinical indications to the use of (99m)Tc-EDDA/HYNIC-TOC to detect somatostatin receptor-positive neuroendocrine tumors
    M G Parisella
    Department of Nuclear Medicine, S Andrea Hospital, Second Faculty of Medicine, Sapienza University, Roma, Italy
    Q J Nucl Med Mol Imaging 56:90-8. 2012
    ..In patients with only biochemical suspicion of NET and in those with negative markers, this scintigraphy does not significantly modify the clinical management...
  27. ncbi request reprint The developing role of peptide radiopharmaceuticals in the study of chronic inflammation: new techniques for novel therapeutic options
    M Chianelli
    Nuclear Medicine Unit, Diagnostic Department, Regina Apostolorum Hospital, Via San Francesco d Assisi, 00041 Albano Laziale, Rome, Italy
    Q J Nucl Med 47:256-69. 2003
    ..This manuscript reviews the radiopharmaceuticals available or recently developed for imaging chronic inflammatory diseases and their use for therapy decision making and follow-up...
  28. pmc (99m)Tc-labeled rituximab for imaging B lymphocyte infiltration in inflammatory autoimmune disease patients
    G Malviya
    Nuclear Medicine Department, Faculty of Medicine and Surgery, Sapienza University of Rome, Via di Grottarossa 1035, 00189, Rome, Italy
    Mol Imaging Biol 14:637-46. 2012
    ....
  29. ncbi request reprint Radiolabelled peptides and monoclonal antibodies for therapy decision making in inflammatory diseases
    G Malviya
    Department of Nuclear Medicine and Molecular Imaging, University Medical Centre Groningen, University of Groningen, The Netherlands
    Curr Pharm Des 14:2401-14. 2008
    ..In this review article we describe the characteristics of peptides, cytokines and monoclonal antibodies with a particular emphasis on their role in therapy decision making and follow up in different inflammatory diseases...
  30. ncbi request reprint Receptor targeting agents for imaging inflammation/infection: where are we now?
    A Signore
    Department of Nuclear Medicine, 2nd Faculty of Medicine, La Sapienza University of Rome, Rome, Italy
    Q J Nucl Med Mol Imaging 50:236-42. 2006
    ..Such mapping represents the future of nuclear medicine imaging, as it aids in diagnosing the type of inflammation, in therapy decision-making, in selecting suitable candidates for therapy, and in evaluating treatment efficacy...
  31. ncbi request reprint Pancreatic scintigraphy with 99mTc-interleukin-2 at diagnosis of type 1 diabetes and after 1 year of nicotinamide therapy
    M Chianelli
    Nuclear Medicine Unit, Regina Apostolorum Hospital, Albano Laziale, Italy
    Diabetes Metab Res Rev 24:115-22. 2008
    ..To evaluate the clinical utility of pancreatic scintigraphy with 99mTc-interleukin-2 to identify Type 1 diabetic patients with pancreatic inflammation at diagnosis...
  32. ncbi request reprint CD95 and CD95-ligand expression in endocrine pancreas of NOD, NOR and BALB/c mice
    A Signore
    Nu M E D Group, Clinica Medica II, University La Sapienza, Rome, Italy
    Diabetologia 40:1476-9. 1997
    ..We demonstrate that alpha cells in the islets of Langherans constitutively express CD95L forming a natural shield around beta cells...
  33. ncbi request reprint 123I-Interleukin-2: biochemical characterization and in vivo use for imaging autoimmune diseases
    A Signore
    Dipartimento di Scienze Cliniche, Universita La Sapienza, 00161 Rome, Italy
    Nucl Med Commun 24:305-16. 2003
    ..I-IL2 scintigraphy may be useful for studying autoimmune phenomena and in diagnostic protocols to evaluate the presence of other tissue involvement in patients with an organ-specific autoimmune disease...
  34. ncbi request reprint Relevance of 99mTc-HYNIC-tir-octreotide scintigraphy in a patient affected by sarcoidosis with lung and joints involvement and secondary Sjogren's syndrome treated with infliximab: case report
    A Migliore
    UOS of Rheumatology, Fatebenefratelli, S Pietro Hospital, Rome, Italy
    Eur Rev Med Pharmacol Sci 12:127-30. 2008
    ..99mTc-HYNIC-TOC scintigraphy was useful in diagnosis, choice of treatment and follow-up...
  35. doi request reprint Role of scintigraphy with ⁹⁹mTc-infliximab in predicting the response of intraarticular infliximab treatment in patients with refractory monoarthritis
    F Conti
    Rheumatology Unit, Faculty of Medicine and Dentistry, Sapienza University of Rome, Rome, Italy
    Eur J Nucl Med Mol Imaging 39:1339-47. 2012
    ....
  36. ncbi request reprint New radiopharmaceuticals for imaging rheumatoid arthritis
    M Chianelli
    Department of Nuclear Medicine, Regina Apostolorum Hospital, Albano, Rome, Italy
    Q J Nucl Med Mol Imaging 50:217-25. 2006
    ..Currently available radiopharmaceuticals for imaging RA, with a special emphasis on recently developed agents and their use in therapy decision-making and follow-up are the focus of this article...
  37. doi request reprint Radiolabelled white blood cell scintigraphy in the work-up of dermal filler complications
    F R Grippaudo
    Plastic Surgery, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
    Eur J Nucl Med Mol Imaging 40:418-25. 2013
    ..We compared several qualitative and quantitative interpretation criteria and the results obtained with MRI and high-frequency US (HFUS)...
  38. ncbi request reprint An in vitro study to compare 99mTc-stannous colloids and 99mTc-HMPAO for labelling human leukocytes
    G Capriotti
    Nuclear Medicine Unit, 2nd Faculty of Medicine, La Sapienza University, Rome, Italy
    Q J Nucl Med Mol Imaging 48:229-36. 2004
    ....
  39. ncbi request reprint Fas and Fas ligand-mediated apoptosis and its role in autoimmune diabetes
    A Signore
    Clinica Medica II, University La Sapienza, Rome, Italy
    Diabetes Metab Rev 14:197-206. 1998
    ....
  40. ncbi request reprint Use of a 99mTc labeled anti-TNFalpha monoclonal antibody in Crohn's disease: in vitro and in vivo studies
    G Malviya
    Nuclear Medicine Unit, II Faculty of Medicine, La Sapienza University of Rome, Rome, Italy
    Q J Nucl Med Mol Imaging 51:334-42. 2007
    ..The aim of this study was to detect the presence of TNFalpha within the gut mucosa in patients with active CD by using (99m)Tc-labelled chimeric human/mouse monoclonal antibody anti-TNFalpha (Infliximab, Remicade)...
  41. doi request reprint Low-activity (2.0 GBq; 54 mCi) radioiodine post-surgical remnant ablation in thyroid cancer: comparison between hormone withdrawal and use of rhTSH in low-risk patients
    M Chianelli
    Nuclear Medicine Unit, Department of Diagnostics, Regina Apostolorum Hospital, Albano, Rome, Italy
    Eur J Endocrinol 160:431-6. 2009
    ..a) To compare the efficacy of low-activity (2 GBq; 54 mCi) (131)I ablation using l-thyroxine withdrawal or rhTSH stimulation, and (b) to assess the influence of thyroid remnants volume on the ablation rate...
  42. ncbi request reprint New approaches to image thyroid cancer cells and microenvironment
    F Galli
    Nuclear Medicine Unit, Department of Medical Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy
    Q J Nucl Med Mol Imaging 59:184-96. 2015
    ..In the present review we present the state of novel approaches to image thyroid cancer and its microenvironment, focusing on RAI-refractory thyroid cancer as a real clinical problem to be solved. ..
  43. doi request reprint High sensitive thyroglobulin assay on thyroxine therapy: can it avoid stimulation test in low and high risk differentiated thyroid carcinoma patients?
    P Trimboli
    Section of Endocrinology and Diabetology, Ospedale Israelitico, Rome, Italy
    Horm Metab Res 45:664-8. 2013
    ..23 ng/ml by our high sensitive assay should be considered disease free and they can avoid Tg stimulation test. High sensitive Tg assays should be used to better manage DTC patients. ..
  44. ncbi request reprint Sensitivity of [99mTc]methoxyisobutylisonitrile scan in patients with metastatic differentiated thyroid cancer
    G Ronga
    Nuclear Medicine Unit, Department of Clinical Sciences, La Sapienza University of Rome, Rome, Italy
    Q J Nucl Med Mol Imaging 51:364-71. 2007
    ....
  45. ncbi request reprint Diagnosis and followup of Takayasu's arteritis by scintigraphy with radiolabelled interleukin 2
    Piernatale Lucia
    Department of Clinical Sciences and Department of Radiological Sciences, University La Sapienza, Roma, Italy
    J Rheumatol 31:1225-7. 2004
  46. ncbi request reprint 99mTc-interleukin-2 and (99m)Tc-HMPAO granulocyte scintigraphy in patients with inactive Crohn's disease
    Alessio Annovazzi
    Nuclear Medicine Unit, Department of Clinical Sciences, Policlinico Umberto I, University La Sapienza, Rome, Italy
    Eur J Nucl Med Mol Imaging 30:374-82. 2003
    ..013). These results indicate that (99m)Tc-IL2 scintigraphy can be useful in selecting CD patients in clinical remission who could benefit from preventive therapy to avoid disease relapse...
  47. ncbi request reprint Synthesis of 99mTc-HYNIC-interleukin-12, a new specific radiopharmaceutical for imaging T lymphocytes
    Alessio Annovazzi
    Nuclear Medicine, Ospedale S Andrea, 2nd Faculty of Medicine La Sapienza, Via di Grottarossa 1035, 00189 Roma, Italy
    Eur J Nucl Med Mol Imaging 33:474-82. 2006
    ..The aims of the present study were to label IL12 with (99m)Tc, to evaluate its ability to bind to activated T lymphocytes in vitro and to study its biodistribution in normal mice and mice affected by autoimmune colitis...
  48. ncbi request reprint 99mTc-EDDA/HYNIC-TOC in the management of medullary thyroid carcinoma
    Maria Parisella
    Nuclear Medicine and Internal Medicine, Department of Clinical Sciences, University La Sapienza, Rome, Italy
    Cancer Biother Radiopharm 19:211-7. 2004
    ....
  49. ncbi request reprint Nuclear medicine imaging of diabetic foot infection: results of meta-analysis
    Gabriela Capriotti
    Nuclear Medicine, II Faculty of Medicine, University of Rome La Sapienza, Rome, Italy
    Nucl Med Commun 27:757-64. 2006
    ..The aim of this study was to develop a practical guideline to describe the radiopharmaceuticals to be used for different clinical conditions and different aims in diabetic foot infection...
  50. ncbi request reprint 99mTc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques
    Alessio Annovazzi
    Nuclear Medicine, 2nd Faculty of Medicine, University La Sapienza, Rome, Italy
    Eur J Nucl Med Mol Imaging 33:117-26. 2006
    ....
  51. ncbi request reprint Radioiodinated recombinant human TSH: a novel radiopharmaceutical for thyroid cancer metastases detection
    Frederica Corsetti
    University La Sapienza, Rome, Rome, Italy
    Cancer Biother Radiopharm 19:57-63. 2004
    ..Moreover, WBS displays poor sensitivity in poorly differentiated tumors due to a loss of iodine uptake capacity...
  52. doi request reprint Prognostic value of FDG uptake by the bone marrow in squamous cell carcinoma of the head and neck
    Francesco Cicone
    Department of Nuclear Medicine, 2nd Faculty of Medicine, University La Sapienza, Rome, Italy
    Nucl Med Commun 29:431-5. 2008
    ....
  53. ncbi request reprint Biological imaging for the diagnosis of inflammatory conditions
    Alberto Signore
    Department of Clinical Sciences, Nuclear Medicine, 2nd Faculty of Medicine, University of Rome, La Sapienza, Rome, Italy
    BioDrugs 16:241-59. 2002
    ..Recent advances in the diagnosis of inflammatory processes have led to the development of specific radiopharmaceuticals that are intended to allow specific stage-related diagnosis...
  54. ncbi request reprint Nuclear medicine imaging of inflammatory/infective disorders of the abdomen
    Alessio Annovazzi
    Nuclear Medicine, II Faculty of Medicine, University La Sapienza, Rome, Italy
    Nucl Med Commun 26:657-64. 2005
    ..A guideline for the optimal radiopharmaceutical(s) to be used in each clinical condition and for different aims is provided...
  55. doi request reprint Prognostic value of CD25 expression on lymphocytes and tumor cells in squamous-cell carcinoma of the head and neck
    David Loose
    Department of Head and Neck Surgery, University Hospital Ghent, Ghent, Belgium
    Cancer Biother Radiopharm 23:25-33. 2008
    ..Contrarywise, the CD25 expression on SCCHN tumor cells is not associated with a prognosis in SCCHN patients, and its role and meaning remains to be elucidated...
  56. ncbi request reprint Early prediction of endocrine therapy effect in advanced breast cancer patients using 99mTc-depreotide scintigraphy
    Bieke Van Den Bossche
    Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    J Nucl Med 47:6-13. 2006
    ..In vivo imaging of this molecular event by means of sequential (99m)Tc-depreotide scintigraphy could enable selection of breast cancer patients susceptible to endocrine therapy...
  57. ncbi request reprint Receptor-mediated tumor targeting with radiolabeled peptides: there is more to it than somatostatin analogs
    Giuliano Mariani
    University of Pisa Medical School Pisa, Italy
    J Nucl Med 47:1904-7. 2006
  58. ncbi request reprint Discordant findings between Tc-99m HMPAO mixed leukocytes and Tc-99m-labeled monoclonal antibody fragments (via LeukoScan) in a patient with pulmonary aspergillosis
    Ingeborg Goethals
    Division of Nuclear Medicine, University Hospital Ghent, Ghent, Belgium
    Clin Nucl Med 27:596. 2002
  59. ncbi request reprint False-negative Tc-99m MIBI scintigraphy in histopathologically proved recurrent high-grade oligodendroglioma
    Ingeborg Goethals
    Division of Nuclear Medicine, Ghent University Hospital, Belgium
    Clin Nucl Med 28:299-301. 2003
    ..However, the authors' results suggest that still other mechanisms may be involved in Tc-99m MIBI accumulation, which may account for false-negative imaging in brain tumors...
  60. ncbi request reprint Nuclear medicine imaging for prediction or early assessment of response to chemotherapy in patients suffering from breast carcinoma
    P van de Wiele
    Division of Nuclear Medicine, University Hospital Ghent, Belgium
    Breast Cancer Res Treat 72:279-86. 2002
    ....
  61. ncbi request reprint Tumour angiogenesis pathways: related clinical issues and implications for nuclear medicine imaging
    Christophe Van de Wiele
    Division of Nuclear Medicine P7, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
    Eur J Nucl Med Mol Imaging 29:699-709. 2002
    ....
  62. pmc Assessment of cancer-associated biomarkers by positron emission tomography: advances and challenges
    T Lee Collier
    PETNET Pharmaceuticals, North Wales, PA, USA
    Dis Markers 18:211-47. 2002
    ..The use of PET imaging in drug development, including the monitoring of cancer chemotherapy, also is discussed...
  63. ncbi request reprint Peptide receptor imaging: advances in the diagnosis of pulmonary diseases
    Christophe Van de Wiele
    Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Am J Respir Med 1:177-83. 2002
    ....
  64. ncbi request reprint Radiolabeled annexin-V for monitoring treatment response in oncology
    Christophe Van de Wiele
    Department of Head and Neck Surgery, University Hospital Ghent, Ghent, Belgium
    Cancer Biother Radiopharm 19:189-94. 2004
    ....
  65. ncbi request reprint The 17th International IRIST Congress Proceedings
    Christophe Van de Wiele
    Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Cancer Biother Radiopharm 19:716-9. 2004
    ..This report summarizes the 17th International IRIST Congress...
  66. ncbi request reprint In vivo apoptosis detection with radioiodinated Annexin V in LoVo tumour-bearing mice following Tipifarnib (Zarnestra, R115777) farnesyltransferase inhibitor therapy
    Bart Cornelissen
    Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Nucl Med Biol 32:233-9. 2005
    ..Subsequently, such patients would greatly benefit from a noninvasive and fast therapy evaluation...
  67. ncbi request reprint High plasma levels of human chromogranin A and adrenomedullin in patients with pheochromocytoma
    Dario Cotesta
    Department of Clinical Sciences, University of Rome La Sapienza, Rome, Italy
    Tumori 91:53-8. 2005
    ..The aim of our study was to investigate the plasma chromogranin A (CgA) and adrenomedullin (AM) levels in patients with pheochromocytomas...
  68. ncbi request reprint Nuclear medicine imaging of bone infections
    Napoleone Prandini
    Struttura Complessa di Medicina Nucleare, Azienda Ospedaliero Universitaria, Ferrara, Italy
    Nucl Med Commun 27:633-44. 2006
    ..Guidelines for the choice of the optimal radiopharmaceuticals to be used in each clinical condition and for different aims is provided...
  69. ncbi request reprint Somatostatin receptor scintigraphy using 99mTc-EDDA/HYNIC-TOC in patients with medullary thyroid carcinoma
    Rafał Czepczyński
    Department of Endocrinology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60 355 Poznan, Poland
    Eur J Nucl Med Mol Imaging 34:1635-45. 2007
    ....
  70. ncbi request reprint (123)I-Interleukin-2 uptake in squamous cell carcinoma of the head and neck carcinoma
    David Loose
    Department of Head and Neck Surgery, Ghent University Hospital, Ghent, Belgium
    Eur J Nucl Med Mol Imaging 35:281-6. 2008
    ....