Marina Saetta

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease
    Marina Saetta
    Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Padova, Padova, Italy
    Am J Respir Crit Care Med 165:1404-9. 2002
  2. ncbi request reprint Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression
    Simonetta Baraldo
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Via Giustiniani 3, Padova, Italy
    Chest 132:1733-40. 2007
  3. pmc Implementing lessons learned from previous bronchial biopsy trials in a new randomized controlled COPD biopsy trial with roflumilast
    Neil C Barnes
    GlaxoSmithKline, Stockley Park West, Uxbridge, Middlesex, UB11 1BT, UK and Barts and The London School of Medicine and Dentistry, London, UK
    BMC Pulm Med 14:9. 2014
  4. pmc Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema
    Fiorella Calabrese
    Institute of Pathology, University of Padua, Italy
    Respir Res 6:14. 2005
  5. ncbi request reprint Increased proportion of CD8+ T-lymphocytes in the paratracheal lymph nodes of smokers with mild COPD
    Marina Saetta
    Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Padova, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 20:28-32. 2003
  6. doi request reprint IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease
    Fiorella Calabrese
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padova, Padova, Italy
    Am J Respir Crit Care Med 178:894-901. 2008
  7. doi request reprint Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma
    Graziella Turato
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy
    Am J Respir Crit Care Med 178:476-82. 2008
  8. doi request reprint Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma
    Simonetta Baraldo
    Department of Cardiac, Thoracic and Vascular Sciences, Section of Respiratory Diseases, University of Padova, Padua, Italy
    J Allergy Clin Immunol 130:1307-14. 2012
  9. ncbi request reprint Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD
    Erica Bazzan
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova and Padova City Hospital, Padova, Italy
    Chest 143:98-106. 2013
  10. doi request reprint Mechanisms of decrease in fractional exhaled nitric oxide during acute bronchoconstriction
    Ilaria Cattoni
    Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
    Chest 143:1269-76. 2013

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease
    Marina Saetta
    Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Padova, Padova, Italy
    Am J Respir Crit Care Med 165:1404-9. 2002
    ..These findings suggest that the CXCR3/CXCL10 axis may be involved in the T cell recruitment that occurs in peripheral airways of smokers with COPD and that these T cells may have a type-1 profile...
  2. ncbi request reprint Matrix metalloproteinase-2 protein in lung periphery is related to COPD progression
    Simonetta Baraldo
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Via Giustiniani 3, Padova, Italy
    Chest 132:1733-40. 2007
    ..We performed this study to quantify the expression of MMP-2 in a population of COPD patients at different stages of severity...
  3. pmc Implementing lessons learned from previous bronchial biopsy trials in a new randomized controlled COPD biopsy trial with roflumilast
    Neil C Barnes
    GlaxoSmithKline, Stockley Park West, Uxbridge, Middlesex, UB11 1BT, UK and Barts and The London School of Medicine and Dentistry, London, UK
    BMC Pulm Med 14:9. 2014
    ..However, these anti-inflammatory effects are yet to be confirmed in another robust study directly assessing inflammatory markers in bronchial sub-mucosa...
  4. pmc Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema
    Fiorella Calabrese
    Institute of Pathology, University of Padua, Italy
    Respir Res 6:14. 2005
    ..Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema...
  5. ncbi request reprint Increased proportion of CD8+ T-lymphocytes in the paratracheal lymph nodes of smokers with mild COPD
    Marina Saetta
    Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Padova, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 20:28-32. 2003
    ..This finding suggests that, in COPD, the polarisation of the immune response may occur in the regional lymph nodes, possibly as a consequence of the presentation of an endogenous antigen that remains unknown...
  6. doi request reprint IL-32, a novel proinflammatory cytokine in chronic obstructive pulmonary disease
    Fiorella Calabrese
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padova, Padova, Italy
    Am J Respir Crit Care Med 178:894-901. 2008
    ..Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder of the lung, yet the mechanisms that regulate this immune-inflammatory response are not fully understood...
  7. doi request reprint Nonatopic children with multitrigger wheezing have airway pathology comparable to atopic asthma
    Graziella Turato
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy
    Am J Respir Crit Care Med 178:476-82. 2008
    ..Epidemiologic studies have shown that, in atopic children, wheezing is more likely to persist into adulthood, eventually becoming asthma, whereas it appears to resolve by adolescence in nonatopic children...
  8. doi request reprint Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma
    Simonetta Baraldo
    Department of Cardiac, Thoracic and Vascular Sciences, Section of Respiratory Diseases, University of Padova, Padua, Italy
    J Allergy Clin Immunol 130:1307-14. 2012
    ..Impaired immune response to viral infections in atopic asthmatic patients has been recently reported and debated. Whether this condition is present in childhood and whether it is affected by atopy per se deserves further investigation...
  9. ncbi request reprint Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD
    Erica Bazzan
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova and Padova City Hospital, Padova, Italy
    Chest 143:98-106. 2013
    ..Emerging evidence suggests that D6 might behave differently in human chronic inflammatory conditions. We, therefore, investigated the involvement of D6 in the immune responses in COPD, a chronic inflammatory condition of the lung...
  10. doi request reprint Mechanisms of decrease in fractional exhaled nitric oxide during acute bronchoconstriction
    Ilaria Cattoni
    Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
    Chest 143:1269-76. 2013
    ..Whether a lower Feno50 level during bronchoconstriction is only an artifact due to the strong flow dependence of this parameter is controversial...
  11. ncbi request reprint Airway inflammation in severe chronic obstructive pulmonary disease: relationship with lung function and radiologic emphysema
    Graziella Turato
    Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Padova, Italy
    Am J Respir Crit Care Med 166:105-10. 2002
    ....
  12. ncbi request reprint Epithelial damage and angiogenesis in the airways of children with asthma
    Angelo Barbato
    Divisione di Pneumologia, Dipartimento di Scienze Cardiologiche, Toraciche e Vascolari Università degli Studi di Padova, Via Giustiniani 3, Padova, Italy
    Am J Respir Crit Care Med 174:975-81. 2006
    ..Airway remodeling and inflammation are characteristic features of adult asthma that are still poorly investigated in childhood asthma...
  13. doi request reprint Mast cell infiltration discriminates between histopathological phenotypes of chronic obstructive pulmonary disease
    Andrea Ballarin
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy
    Am J Respir Crit Care Med 186:233-9. 2012
    ..We described before that smokers can develop either panlobular (PLE) or centrilobular emphysema (CLE). The latter has worse small airways remodeling and narrowing, which account for the airflow obstruction similar to asthma...
  14. doi request reprint Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up
    Marco Contoli
    Research Centre on Asthma and COPD, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    J Allergy Clin Immunol 125:830-7. 2010
    ..Both smokers and patients with asthma can experience fixed airflow obstruction, which is associated with distinctive patterns of airway pathology. The influence of fixed airflow obstruction on the prognosis of these patients is unknown...
  15. ncbi request reprint The Role of Lymphocytes in the Pathogenesis of Asthma and COPD
    Simonetta Baraldo
    Department of Cardiac, Thoracic and Vascular Sciences, Section of Respiratory Diseases, University of Padova 35128 Padua, Italy
    Curr Med Chem 14:2250-6. 2007
    ..In this review, we will discuss the current concepts on the recruitment, homing and activity of lymphocytes in these two respiratory diseases...
  16. pmc Immune Inflammation and Disease Progression in Idiopathic Pulmonary Fibrosis
    Elisabetta Balestro
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
    PLoS ONE 11:e0154516. 2016
    ..52, p = 0.005). In conclusion an innate and adaptive inflammation appears to be a prominent feature in the lung of patients with IPF and could contribute to determining of the rate of disease progression. ..
  17. doi request reprint Ceramide expression and cell homeostasis in chronic obstructive pulmonary disease
    Maria C Scarpa
    Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani 2, Padua, Italy
    Respiration 85:342-9. 2013
    ..Increased expression of ceramide has been detected in emphysema. Ceramide promotes autophagy and apoptosis, which concur with cellular homeostasis...
  18. doi request reprint Pathophysiology of the small airways in chronic obstructive pulmonary disease
    Simonetta Baraldo
    Department of Cardiac, Thoracic and Vascular Sciences, Respiratory Diseases Clinic, University of Padova, Padua, Italy
    Respiration 84:89-97. 2012
    ..We will start by describing the normal structure of the small airways, and then observe the main pathological alterations that accumulate in this site and how they parallel pulmonary function derangement...
  19. doi request reprint A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family
    Francesca Polverino
    Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova and Padova City Hospital, 35128 Padova, Italy
    Am J Respir Crit Care Med 182:1011-9. 2010
    ..Chronic obstructive pulmonary disease (COPD) is a disorder characterized by an abnormal inflammatory response that persists even after smoking cessation, yet the underlying mechanisms are not fully understood...
  20. doi request reprint Alpha-1 Antitrypsin Deficiency Today: New Insights in the Immunological Pathways
    Simonetta Baraldo
    Department of Cardiac, Thoracic and Vascular Sciences, University of Padova and Padova City Hospital, Padova, Italy
    Respiration 91:380-5. 2016
    ..Of importance, the potent immunoregulatory, tolerogenic role of AAT may support its therapeutic use in a number of diseases other than AATD, particularly in immune-related disorders. ..
  21. doi request reprint Alpha-1 Antitrypsin Deficiency: Beyond the Protease/Antiprotease Paradigm
    Manuel G Cosio
    1 Department of Cardiac, Thoracic, and Vascular Sciences, University of Padova, Padova, Italy and
    Ann Am Thorac Soc 13:S305-10. 2016
    ....
  22. doi request reprint Decreased maturation of dendritic cells in the central airways of COPD patients is associated with VEGF, TGF-β and vascularity
    Andrea Zanini
    Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
    Respiration 87:234-42. 2014
    ..Moreover, DCs can interact with angiogenic modulators, resulting in modification of their biology and participation in angiogenesis...
  23. ncbi request reprint Effect of inhalation of thermal water on airway inflammation in chronic obstructive pulmonary disease
    Manuela Pellegrini
    Department of Environmental Medicine and Public Health, University of Padova, Via Giustiniani, 2 35128 Padova PD, Italy
    Respir Med 99:748-54. 2005
    ..However, the short-term improvement in some components health-related quality of life was not related with changes in lung function or with the degree of airway inflammation...
  24. ncbi request reprint Endothelial cell activity in chronic obstructive pulmonary disease without severe pulmonary hypertension
    Giuseppe Cella
    Department of Medical and Surgical Sciences, University of Padova, Italy
    Clin Appl Thromb Hemost 11:435-40. 2005
    ....
  25. doi request reprint High viral frequency in children with gastroesophageal reflux-related chronic respiratory disorders
    Fiorella Calabrese
    Department of Medical Diagnostic Sciences and Special Therapies, University of Padua, Padua, Italy
    Pediatr Pulmonol 43:690-6. 2008
    ..It is not well established whether infective agents may be present in lung aspiration. The aim of the work was to investigate whether different infective agents could be found in children with GER-related CRDs...
  26. ncbi request reprint Up-regulated membrane and nuclear leukotriene B4 receptors in COPD
    Emanuela Marian
    Dipartimento di Medicina Ambientale e Sanità Pubblica, Universita degli Studi di Padova, Via Giustiniani, 2, 35128 Padova, Italy
    Chest 129:1523-30. 2006
    ..Proinflammatory LTB4 activities are mediated by BLT1, while the inactivation of LTB4 is promoted by PPARalpha...
  27. ncbi request reprint An asthmatic patient with progressive lung dysfunction: a case of misdiagnosis
    Fiorella Calabrese
    Department of Pathology, Padova Hospital, University of Padova, 35121 Padova, Italy
    Lancet 368:814. 2006
  28. doi request reprint Is chronic obstructive pulmonary disease a disease of aging?
    Manuel G Cosio
    Department of Cardiac, Thoracic and Vascular Sciences, Respiratory Disease Clinic, University of Padova, Padua, Italy
    Respiration 87:508-12. 2014
    ..In conclusion, we suggest that COPD could be considered a disease of the predisposed young individual that manifests clinically in old age because we live longer, with all of its consequences...
  29. ncbi request reprint Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone
    Alfredo Chetta
    Department of Clinical Sciences, Section of Respiratory Diseases, University of Parma, Parma, Italy
    Am J Respir Crit Care Med 167:751-7. 2003
    ..In conclusion, this study shows that in patients with mild to moderate asthma, high dose of inhaled FP given over 6 weeks can significantly affect airway remodeling by reducing both submucosal vascularity and basement membrane thickness...
  30. doi request reprint Noneosinophilic asthma in children: relation with airway remodelling
    S Baraldo
    Dept of Cardiac, Thoracic andVascular Sciences, University of Padua, Padua, Italy
    Eur Respir J 38:575-83. 2011
    ....
  31. ncbi request reprint [Current knowledge on pathogenesis and pathologic anatomy of chronic obstructive pulmonary disease]
    Graziella Turato
    Recenti Prog Med 93:249-56. 2002
    ..Finally we will address the effect of smoking cessation or anti-inflammatory treatment in an attempt to investigate the potential reversibility of the pathologic lesions characteristic of COPD...
  32. ncbi request reprint Pulmonary biomarkers in chronic obstructive pulmonary disease
    Peter J Barnes
    National Heart and Lung Institute, Imperial College London, London, UK
    Am J Respir Crit Care Med 174:6-14. 2006
    ..In the future, pulmonary biomarkers may be useful in predicting disease progression, indicating disease instability, and in predicting response to current therapies and novel therapies, many of which are now in development...
  33. pmc The laws of attraction: chemokines, neutrophils and eosinophils in severe exacerbations of asthma
    Graziella Turato
    Thorax 62:465-6. 2007
  34. ncbi request reprint [Pathology of chronic obstructive pulmonary disease]
    Graziella Turato
    Divisione di Pneumologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi, Padova
    Ann Ist Super Sanita 39:507-17. 2003
    ....
  35. ncbi request reprint Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease
    Leonardo M Fabbri
    Research Center on Asthma and COPD, University of Ferrara, Italy
    Am J Respir Crit Care Med 167:418-24. 2003
    ..In conclusion, despite similar fixed airflow obstruction, subjects with a history of asthma have distinct characteristics compared with subjects with a history of COPD and should be properly identified and treated...
  36. ncbi request reprint Airway inflammation in childhood asthma
    Angelo Barbato
    Department of Pediatrics, University of Modena and Reggio Emilia, Italy
    Am J Respir Crit Care Med 168:798-803. 2003
    ..Moreover, in children with asthma but not in children with atopy without asthma, there is a downregulation of TGFbeta-RII...
  37. ncbi request reprint Small airway morphology and lung function in the transition from normality to chronic airway obstruction
    Angelo Corsico
    Dipartimento di Medicina Interna, Universita di Genova, 16132 Genova, Italy
    J Appl Physiol 95:441-7; discussion 435. 2003
    ....
  38. ncbi request reprint Neutrophil chemokines in severe exacerbations of chronic obstructive pulmonary disease: fatal chemo-attraction?
    Marina Saetta
    Am J Respir Crit Care Med 168:911-3. 2003
  39. ncbi request reprint Low-volume ventilation causes peripheral airway injury and increased airway resistance in normal rabbits
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Universita di Milano, 20133 Milan, Italy
    J Appl Physiol (1985) 92:949-56. 2002
    ..This is probably due to cyclic opening and closing of peripheral airways on ZEEP...
  40. ncbi request reprint Dependence of lung injury on inflation rate during low-volume ventilation in normal open-chest rabbits
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Via Mangiagalli 32, 20133 Milan, Italy
    J Appl Physiol (1985) 97:260-8. 2004
    ....
  41. ncbi request reprint Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma
    Andrea Zanini
    Salvatore Maugeri Foundation, Division of Pneumology, IRCCS Rehabilitation Institute of Tradate, Tradate, Italy
    J Allergy Clin Immunol 120:329-33. 2007
    ..On the contrary, up to now, no study has addressed the role of chymase-positive mast cells (MC(TC)) in microvasculature changes...