Paola Romagnani

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi From basic science to clinical practice: use of cytokines and chemokines as therapeutic targets in renal diseases
    Paola Romagnani
    Interdepartmental Laboratory of Cellular and Molecular Nephrology, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Nephrol 18:229-33. 2005
  2. doi Parietal epithelial cells: their role in health and disease
    Paola Romagnani
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Contrib Nephrol 169:23-36. 2011
  3. doi Of mice and men: the riddle of tubular regeneration
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    J Pathol 229:641-4. 2013
  4. doi Renal progenitors: an evolutionary conserved strategy for kidney regeneration
    Paola Romagnani
    Pediatric Nephrology Unit, Meyer Children s Hospital, University of Florence, Viale Pieraccini 24, 50139 Florence, Italy
    Nat Rev Nephrol 9:137-46. 2013
  5. doi Renal progenitors in non-diabetic and diabetic nephropathies
    Paola Romagnani
    Center of Excellence for Molecular and Clinical Studies on Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Trends Endocrinol Metab 24:13-20. 2013
  6. ncbi CXC chemokines: the regulatory link between inflammation and angiogenesis
    Paola Romagnani
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Trends Immunol 25:201-9. 2004
  7. ncbi Nephrotic syndrome and renal failure after allogeneic stem cell transplantation: novel molecular diagnostic tools for a challenging differential diagnosis
    Paola Romagnani
    Department of Clinical Pathophysiology, Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Italy
    Am J Kidney Dis 46:550-6. 2005
  8. ncbi Pharmacological modulation of stem cell function
    P Romagnani
    Excellence Center for Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    Curr Med Chem 14:1129-39. 2007
  9. pmc Toward the identification of a "renopoietic system"?
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Stem Cells 27:2247-53. 2009
  10. ncbi Peripheral blood as a source of stem cells for regenerative medicine
    Paola Romagnani
    University of Florence, Center for Research, Transfer and High Education DENOthe, Viale Pieraccini 6, Florence 50139, Italy
    Expert Opin Biol Ther 6:193-202. 2006

Detail Information

Publications79

  1. ncbi From basic science to clinical practice: use of cytokines and chemokines as therapeutic targets in renal diseases
    Paola Romagnani
    Interdepartmental Laboratory of Cellular and Molecular Nephrology, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    J Nephrol 18:229-33. 2005
    ....
  2. doi Parietal epithelial cells: their role in health and disease
    Paola Romagnani
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Contrib Nephrol 169:23-36. 2011
    ....
  3. doi Of mice and men: the riddle of tubular regeneration
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    J Pathol 229:641-4. 2013
    ..However, beyond the controversial results obtained from humans and rodents, identification of tubular progenitors in humans can move the field forward and provide a novel perspective for understanding tubular regeneration...
  4. doi Renal progenitors: an evolutionary conserved strategy for kidney regeneration
    Paola Romagnani
    Pediatric Nephrology Unit, Meyer Children s Hospital, University of Florence, Viale Pieraccini 24, 50139 Florence, Italy
    Nat Rev Nephrol 9:137-46. 2013
    ..Understanding the mechanisms that drive renal progenitor growth and differentiation represent the key step for modulating this potential for therapeutic purposes...
  5. doi Renal progenitors in non-diabetic and diabetic nephropathies
    Paola Romagnani
    Center of Excellence for Molecular and Clinical Studies on Chronic, Degenerative and Neoplastic Diseases to Develop Novel Therapies, University of Florence, Florence, Italy
    Trends Endocrinol Metab 24:13-20. 2013
    ..Renal progenitors may represent a novel target in diabetic nephropathy and other kidney disorders...
  6. ncbi CXC chemokines: the regulatory link between inflammation and angiogenesis
    Paola Romagnani
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Trends Immunol 25:201-9. 2004
  7. ncbi Nephrotic syndrome and renal failure after allogeneic stem cell transplantation: novel molecular diagnostic tools for a challenging differential diagnosis
    Paola Romagnani
    Department of Clinical Pathophysiology, Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Italy
    Am J Kidney Dis 46:550-6. 2005
    ....
  8. ncbi Pharmacological modulation of stem cell function
    P Romagnani
    Excellence Center for Research, Transfer and High Education, DENOthe, University of Florence, Florence, Italy
    Curr Med Chem 14:1129-39. 2007
    ....
  9. pmc Toward the identification of a "renopoietic system"?
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Stem Cells 27:2247-53. 2009
    ..Knowledge of renal progenitor cell biology may enable a better comprehension of the mechanisms of renal repair as well as more effective targeted therapies for acute and chronic kidney diseases...
  10. ncbi Peripheral blood as a source of stem cells for regenerative medicine
    Paola Romagnani
    University of Florence, Center for Research, Transfer and High Education DENOthe, Viale Pieraccini 6, Florence 50139, Italy
    Expert Opin Biol Ther 6:193-202. 2006
    ..This review analyses the different subsets of SCs described in PB, the different hypotheses suggested to explain their origin, and the possible mechanisms that provide the basis for their biological potential...
  11. doi Kidney regeneration: any prospects?
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, and Meyer Children s Hospital, Nephrology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Contrib Nephrol 170:228-36. 2011
    ....
  12. pmc Possible mechanisms of kidney repair
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Fibrogenesis Tissue Repair 2:3. 2009
    ....
  13. pmc Regeneration of glomerular podocytes by human renal progenitors
    Elisa Ronconi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139, Firenze, Italy
    J Am Soc Nephrol 20:322-32. 2009
    ....
  14. ncbi Regenerative potential of embryonic renal multipotent progenitors in acute renal failure
    Elena Lazzeri
    Excellence Center for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
    J Am Soc Nephrol 18:3128-38. 2007
    ..The ability of these cells to repair renal damage, together with their apparent lack of tumorigenicity, suggests their potential in the treatment of renal failure...
  15. pmc Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells
    Benedetta Mazzinghi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50121 Florence, Italy
    J Exp Med 205:479-90. 2008
    ....
  16. pmc Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders
    Laura Lasagni
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    Stem Cells 28:1674-85. 2010
    ..Taken altogether, these results suggest that the severity of glomerular disorders depends on the Notch-regulated balance between podocyte death and regeneration provided by renal progenitors...
  17. ncbi High CXCL10 expression in rejected kidneys and predictive role of pretransplant serum CXCL10 for acute rejection and chronic allograft nephropathy
    Elena Lazzeri
    Center for Research, Transfer and High Education MCINDENT, Florence, Italy
    Transplantation 79:1215-20. 2005
    ..Several experimental models have shown that CXCL10 is required for initiation and development of graft failure caused by both acute and chronic rejection...
  18. ncbi Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling
    Francesco Liotta
    Excellence Center of the University of Florence De Novo Therapy, Florence, Italy
    Stem Cells 26:279-89. 2008
    ....
  19. ncbi CXCR3-mediated opposite effects of CXCL10 and CXCL4 on TH1 or TH2 cytokine production
    Paola Romagnani
    Center for Research, Transfer, and High Education DENOthe, University of Florence, Italy
    J Allergy Clin Immunol 116:1372-9. 2005
    ..Two variants of the CXCR3 receptor exist, one (CXCR3-A) reactive with CXCL9, CXCL10, and CXCL11 and the other (CXCR3-B) also reactive with CXCL4. Both variants are contemporarily expressed by human T cells...
  20. doi Characterization of renal progenitors committed toward tubular lineage and their regenerative potential in renal tubular injury
    Maria Lucia Angelotti
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy
    Stem Cells 30:1714-25. 2012
    ..These data suggest that CD133+CD24+CD106- cells represent tubular-committed progenitors that display resistance to apoptotic stimuli and exert regenerative potential for injured tubular tissue...
  21. doi Comparison between VDR analogs and current immunosuppressive drugs in relation to CXCL10 secretion by human renal tubular cells
    Costanza Sagrinati
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Transpl Int 23:914-23. 2010
    ..Our data suggest that BXL-01-0029 could potentially be a dose-reducing agent for conventional immunosuppressors in kidney rejection management...
  22. pmc An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4
    Laura Lasagni
    Department of Clinical Pathophysiology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Exp Med 197:1537-49. 2003
    ....
  23. pmc Phenotypic and functional features of human Th17 cells
    Francesco Annunziato
    Center for Research, Transfer and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders DENOThe, University of Florence, Florence 50134, Italy
    J Exp Med 204:1849-61. 2007
    ....
  24. ncbi PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion
    Laura Lasagni
    Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, Florence, Italy
    Blood 109:4127-34. 2007
    ..These results demonstrate that CXCL4 and CXCL4L1 exhibit a distinct subcellular localization and are secreted in a differentially regulated manner, suggesting distinct roles in inflammatory or homeostatic processes...
  25. ncbi CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors
    Paola Romagnani
    Center for Research, Transfer and High Education DENOthe, University of Florence, Italy
    Circ Res 97:314-22. 2005
    ....
  26. doi The role of endothelial progenitor cells in acute kidney injury
    Francesca Becherucci
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Blood Purif 27:261-70. 2009
    ..The loss of endothelial cell function may represent an important therapeutic target, in which EPCs may show potential importance in ameliorating the acute and chronic effects of ischemic AKI...
  27. ncbi Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys
    Costanza Sagrinati
    Interdepartmental Laboratory of Cellular and Molecular Nephrology, University of Florence, Viale Pieraccini 6, 50139, Firenze, Italy
    J Am Soc Nephrol 17:2443-56. 2006
    ....
  28. ncbi High pretransplant serum levels of CXCL10/IP-10 are related to increased risk of renal allograft failure
    Mario Rotondi
    Department of Clinical Pathophysiology, University of Florence, Italy
    Am J Transplant 4:1466-74. 2004
    ..787). Thus, measurement of pretransplant serum CXCL10 levels might represent a clinically useful parameter to identify subjects who are at high risk of severe rejection and graft failure...
  29. doi Predictive role of pretransplant serum CXCL10 for cardiac acute rejection
    Clara Crescioli
    Excellence Center for Research, Transfer and High Education DENOthe, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Transplantation 87:249-55. 2009
    ..In the present study, we investigated whether pretransplant CXCL10 serum level may be a predictive noninvasive biomarker in heart transplant (HTx) recipients, as well...
  30. pmc Expression of IP-10/CXCL10 and MIG/CXCL9 in the thyroid and increased levels of IP-10/CXCL10 in the serum of patients with recent-onset Graves' disease
    Paola Romagnani
    Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Am J Pathol 161:195-206. 2002
    ..They also suggest that the production of these chemokines by resident follicular epithelial cells may contribute to the recruitment of CXCR3-expressing type 1 T-helper cells in the initial phases of GD...
  31. doi High pretransplant serum levels of CXCL9 are associated with increased risk of acute rejection and graft failure in kidney graft recipients
    Mario Rotondi
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Transpl Int 23:465-75. 2010
    ..These findings might be used for the individualization of immunosuppressive therapies...
  32. doi Activation of p38(MAPK) mediates the angiostatic effect of the chemokine receptor CXCR3-B
    Ilaria Petrai
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni 85, I 50134 Florence, Italy
    Int J Biochem Cell Biol 40:1764-74. 2008
    ..In conclusion, the p38(MAPK) pathway is a downstream effector of CXCR3-B implicated in the angiostatic action of this chemokine receptor...
  33. ncbi A young woman with oedema
    Elena Lazzeri
    Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence
    Intern Emerg Med 1:209-15. 2006
  34. doi Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma
    Francesco Liotta
    Excellence Center for Research, Transfer, and High Education DENOthe, Department of Urology, University of Florence, Florence, Italy
    BJU Int 107:1500-6. 2011
    ..To verify in vitro the inhibitory activity of tumour isolated Tregs on the effector T cells and, finally, to assess the prognostic role of Treg frequency determination...
  35. doi Stem-cell approaches for kidney repair: choosing the right cells
    Costanza Sagrinati
    Excellence Center for Research, Transfer and High Education DENOthe De Novo Therapies, University of Florence, V le Morgagni 85, 50134, Florence, Italy
    Trends Mol Med 14:277-85. 2008
    ..However, BMSCs also represent an attractive alternative, especially for the treatment of patients affected by acute renal failure...
  36. pmc Resistin as an intrahepatic cytokine: overexpression during chronic injury and induction of proinflammatory actions in hepatic stellate cells
    Cristiana Bertolani
    Dipartimento di Medicina Interna, University of Florence, Viale Morgagni, 85, I 50134 Florence, Italy, and the Liver Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Am J Pathol 169:2042-53. 2006
    ....
  37. ncbi Thymic regulatory T cells
    Enrico Maggi
    Center of Research, Transfer, High Education MCIDNENT, University of Florence, Firenze, Italy
    Autoimmun Rev 4:579-86. 2005
    ..The result that Th1 cells are highly susceptible to the suppressive activity of Treg thymocytes is consistent with the important role of these cells in protecting against the Th1-mediated immune response to autoantigens...
  38. ncbi Role of chemokines in endocrine autoimmune diseases
    Mario Rotondi
    Excellence Center for Research, Transfer and High Education De Novo Therapies, University of Florence, 50121 Florence, Italy
    Endocr Rev 28:492-520. 2007
    ....
  39. ncbi Functional features of human CD25+ regulatory thymocytes
    Francesco Liotta
    Center for Research, Transfer, High Education MCIDNENT, University of Florence, Italy
    Microbes Infect 7:1017-22. 2005
    ..This review discusses the phenotype and the functional features of the human naturally occurring CD25+ regulatory thymocytes...
  40. ncbi The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C
    Andrea Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Florence, Italy
    Gastroenterology 125:1060-76. 2003
    ..We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also studied...
  41. ncbi IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxide
    Paola Romagnani
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
    J Am Soc Nephrol 13:53-64. 2002
    ..These data also indicate that the production of IP-10 and Mig by human mesangial cells can be downregulated by NO donors through cGMP-independent inhibition of NF-kappaB activation...
  42. ncbi Elevated serum interferon-gamma-inducible chemokine-10/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines
    Mario Rotondi
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, V le Pieraccini 6, 50139 Firenze, Italy
    J Clin Endocrinol Metab 90:2357-63. 2005
    ..Taken together, these data suggest a potential role of hZFC, through the production of CXCL10, in regulating the recruitment of specific subsets of activated lymphocytes in autoimmune AD...
  43. doi Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
    Fabio Cianchi
    Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy
    Clin Cancer Res 14:7691-700. 2008
    ....
  44. doi Regeneration and the kidney
    Elena Lazzeri
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    Curr Opin Nephrol Hypertens 19:248-53. 2010
    ..In this review, we highlight the burst of recent knowledge leading to discovery of regenerative mechanisms also in adult kidneys...
  45. pmc Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced
    Laura Lasagni
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy Electronic address
    Stem Cell Reports 5:248-63. 2015
    ..These results establish renal progenitors as critical determinants of glomerular disease outcome and a pharmacological enhancement of their differentiation as a possible therapeutic strategy...
  46. ncbi Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines
    Lorenzo Cosmi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Blood 103:3117-21. 2004
    ....
  47. doi Lessons from genetics: is it time to revise the therapeutic approach to children with steroid-resistant nephrotic syndrome?
    Francesca Becherucci
    Nephrology and Dialysis Unit, Meyer Children s Hospital, Florence, Italy
    J Nephrol 29:543-50. 2016
    ....
  48. doi Next generation sequencing and functional analysis of patient urine renal progenitor-derived podocytes to unravel the diagnosis underlying refractory lupus nephritis
    Paola Romagnani
    Department of Biomedical Experimental and Clinical Sciences Mario Serio, Florence, Italy Nephrology and Dialysis Unit, Meyer Children s University Hospital, Florence, Italy
    Nephrol Dial Transplant 31:1541-5. 2016
    ..Thus, lupus podocytopathy can be confirmed as a cause of RLN by functional genetics on patient-derived podocytes. ..
  49. doi Glomerular epithelial stem cells: the good, the bad, and the ugly
    Laura Lasagni
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    J Am Soc Nephrol 21:1612-9. 2010
    ..Better understanding of the mechanisms that regulate growth and differentiation of glomerular epithelial stem cells may provide new clues for prevention and treatment of glomerulosclerosis...
  50. doi Glomerular regeneration: when can the kidney regenerate from injury and what turns failure into success?
    Anna Peired
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    Nephron Exp Nephrol 126:70. 2014
    ..The problem with glomerular regeneration is centered around the podocyte, a highly specialized cell that is the critical constituent of the glomerular filtration barrier...
  51. doi Renal progenitors and childhood: from development to disorders
    Francesca Becherucci
    Pediatric Nephrology and Dialysis Unit, Meyer Children s University Hospital, Florence, Italy
    Pediatr Nephrol 29:711-9. 2014
    ..In this review, we summarize the evidence on the existence of renal progenitors in fetal and adult kidneys and discuss their role in physiology as well as in the pathogenesis of renal disorders with a particular focus on childhood age. ..
  52. doi CXCL10: a candidate biomarker in transplantation
    Paola Romagnani
    Excellence Center for Research, Transfer and High Education DENOthe, University of Florence, 50139 Florence, Italy
    Clin Chim Acta 413:1364-73. 2012
    ....
  53. pmc How much can the tubule regenerate and who does it? An open question
    Duccio Lombardi
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    Nephrol Dial Transplant 31:1243-50. 2016
    ....
  54. pmc Renal Cancer Stem Cells: Characterization and Targeted Therapies
    Anna Julie Peired
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, 50139 Florence, Italy Department of Biomedical, Experimental and Clinical Sciences, University of Florence, 50139 Florence, Italy
    Stem Cells Int 2016:8342625. 2016
    ..In conclusion, CSCs are an important player in carcinogenesis and represent a valid target for therapy in RCC patients. ..
  55. ncbi Biologic modulation in renal regeneration
    Benedetta Mazzinghi
    a Nephrology Unit, Meyer Children s University Hospital, Florence, Italy
    Expert Opin Biol Ther 16:1403-1415. 2016
    ..Following the discovery of renal progenitors, the investigation of new therapeutic approaches to promote the kidney regenerative capacity has received increasing research attention...
  56. pmc Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence
    Anna Julie Peired
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, Florence, Italy Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
    Stem Cells Int 2016:4798639. 2016
    ..The data obtained from these clinical trials will provide further insight into safety, feasibility, and efficacy of MSC-based therapy in renal pathologies and allow the design of consensus protocol for clinical purpose...
  57. doi Stem cell therapy for kidney disease
    Elena Lazzeri
    a University of Florence Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, Florence, Italy 390552758342
    Expert Opin Biol Ther 15:1455-68. 2015
    ..With the emergence of stem cells as potential therapeutic agents, attempts in using them to significantly reduce the burden of these diseases have increased...
  58. doi A road to chronic kidney disease: toward glomerulosclerosis via dendrin
    Francesca Becherucci
    Nephrology and Dialysis Unit, Meyer Children s Hospital, Florence, Italy
    Am J Pathol 185:2072-5. 2015
    ..This commentary highlights the article by Weins et al that describes a potential mechanism to delay the onset and progression of end-stage kidney disease. ..
  59. doi Retinoids and glomerular regeneration
    Elena Lazzeri
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO THERAPIES, University of Florence, Florence, Italy Electronic address
    Semin Nephrol 34:429-36. 2014
    ..A more complete understanding of retinoid-dependent renal progenitor differentiation into podocytes should reward us with new insights into the mechanisms of progression toward glomerulosclerosis. ..
  60. doi Basic research: Podocyte progenitors and ectopic podocytes
    Laura Lasagni
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Viale Morgagni 85, Florence 50134, Italy
    Nat Rev Nephrol 9:715-6. 2013
    ..New research demonstrates that these populations represent podocyte progenitors and ectopic podocytes—distinct cell types with different clinical implications...
  61. doi What can tubular progenitor cultures teach us about kidney regeneration?
    Paola Romagnani
    Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, Florence, Italy
    Kidney Int 83:351-3. 2013
    ..Toll-like receptor-mediated activation now appears as a previously unknown mechanism of progenitor-mediated tubular regeneration, implying that proinflammatory factors activate regenerative processes in the kidney...
  62. pmc Chronic kidney disease in children
    Francesca Becherucci
    Nephrology and Dialysis Unit, Meyer Children s Hospital, Florence, Italy
    Clin Kidney J 9:583-91. 2016
    ..In addition, we will discuss factors related to CKD that start during childhood and require appropriate treatments in order to optimize health outcomes and transition to nephrologist management in adult life. ..
  63. doi Glomerular parietal epithelial cells in kidney physiology, pathology, and repair
    Stuart J Shankland
    aDivision of Nephrology, University of Washington Medical Center, Seattle, Washington, USA bDivision of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen Innenstadt, Munich, Germany cExcellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies DENOTHE, University of Florence, Florence, Italy
    Curr Opin Nephrol Hypertens 22:302-9. 2013
    ..The rationale is that PECs have been largely ignored until the recent availability of cell lineage tracing studies, human and murine PEC culture systems, and potential therapeutic interventions of PECs...
  64. ncbi Renal cell carcinoma metastatic to the breast and breast cancer metastatic to the kidney: two rare solitary metastases
    Mauro Gacci
    Department of Urology, University of Florence, Florence, Italy
    Breast J 11:351-2. 2005
  65. ncbi Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    Lorenzo Cosmi
    Dipartimento di Medicina Interna, Viale Morgagni 85, Firenze 50134, Italy
    Blood 102:4107-14. 2003
    ..These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells...
  66. ncbi Interferon-gamma-inducible alpha-chemokine CXCL10 involvement in Graves' ophthalmopathy: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Rome 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:614-20. 2006
    ..Human thyrocytes in primary culture produce large amounts of CXCL10 when stimulated by interferon-gamma (IFNgamma) and TNFalpha...
  67. ncbi Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
    ....
  68. pmc Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
    Francesco Annunziato
    Department of Internal Medicine, University Florence, Italy
    J Exp Med 196:379-87. 2002
    ....
  69. ncbi CXCR3 and its binding chemokines in myeloma cells: expression of isoforms and potential relationships with myeloma cell proliferation and survival
    Nicola Giuliani
    Hematology and CTMO, University of Parma, Italy
    Haematologica 91:1489-97. 2006
    ..Recent data suggest that CXCR3-binding chemokines may also regulate proliferation and survival in endothelial cells through the interaction with two distinct isoforms of CXCR3 (CXCR3-A and CXCR3-B)...
  70. ncbi Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Cytokine 34:32-8. 2006
    ....
  71. ncbi Increase of interferon-gamma inducible alpha chemokine CXCL10 but not beta chemokine CCL2 serum levels in chronic autoimmune thyroiditis
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Eur J Endocrinol 152:171-7. 2005
    ..To measure serum levels of CXCL10 and CCL2 prototype chemokines of the two major subclass (CXC and CC) in patients with newly diagnosed chronic autoimmune thyroiditis (AT), and relate the findings to the clinical phenotype...
  72. ncbi Role for interferon-gamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    Mauro Krampera
    Department of Clinical and Experimental Medicine, University of Verona, Italy
    Stem Cells 24:386-98. 2006
    ..These findings suggest that the beneficial effect on graft-versus-host disease induced by in vivo coinfusion with the graft of MSCs may be due to the activation of the immunomodulatory properties of MSCs by T cell- derived IFN-gamma...
  73. ncbi High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and National Research Center, Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 89:5496-9. 2004
    ..We conclude that circulating CXCL10 is increased in patients with AT and is associated with hypothyroidism. CXCL10 may be regarded as a marker of a more aggressive thyroiditis leading to thyroid destruction...
  74. ncbi Age-dependent changes in CXC chemokine ligand 10 serum levels in euthyroid subjects
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, University of Pisa School of Medicine, Italy
    J Interferon Cytokine Res 25:547-52. 2005
    ..Results of this study, performed in healthy subjects on an age gradient, demonstrate an increase in serum CXCL10 with advancing age overall in females, supporting the hypothesis of enhanced Th1 immune responses in aging...
  75. ncbi Serum CXCL10 levels and occurrence of thyroid dysfunction in patients treated with interferon-alpha therapy for hepatitis C virus-related hepatitis
    Mario Rotondi
    Unit of Internal Medicine and Endocrinology Fondazione Salvatore Maugeri IRCCS and Chair of Endocrinology, University of Pavia, Pavia, Italy
    Eur J Endocrinol 156:409-14. 2007
    ..CXC chemokine ligand 10 (CXCL10) is a chemokine known to play a role in both thyroid autoimmune disease and hepatitis C virus (HCV) hepatitis...
  76. ncbi Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Eur J Endocrinol 154:651-8. 2006
    ..Longitudinal assessment of sCXCL10 in autoimmune hypo- or hyperthyroidism has not yet been performed...
  77. ncbi Increase of interferon-gamma-inducible CXC chemokine CXCL10 serum levels in patients with active Graves' disease, and modulation by methimazole therapy
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Clin Endocrinol (Oxf) 64:189-95. 2006
    ....
  78. ncbi Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1485-90. 2007
    ..Forty healthy subjects and 40 patients with autoimmune thyroiditis served as control groups...
  79. ncbi Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients
    Caroline Schmidt-Lucke
    Department of Internal Medicine III, Division of Cardiology, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Am J Physiol Heart Circ Physiol 292:H2425-31. 2007
    ..Recruitment of T(reg) into the cardiac allograft during transcoronary passage may induce graft tolerance during subclinical inflammation potentially influencing allograft vasculopathy...