D Ribatti

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. doi request reprint Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Peptides 29:1596-602. 2008
  2. pmc Angiogenesis and melanoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Cancers (Basel) 2:114-32. 2010
  3. ncbi request reprint Endogenous and exogenous fibroblast growth factor-2 modulate wound healing in the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, Bari, Italy
    Angiogenesis 3:89-95. 1999
  4. pmc The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Pharmaceuticals (Basel) 3:482-513. 2010
  5. pmc Tyrosine Kinase Inhibitors as Antiangiogenic Drugs in Multiple Myeloma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Pharmaceuticals (Basel) 3:1225-1231. 2010
  6. ncbi request reprint Inhibition of neuroblastoma-induced angiogenesis by fenretinide
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Int J Cancer 94:314-21. 2001
  7. doi request reprint Transgenic mouse models of angiogenesis and lymphangiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int Rev Cell Mol Biol 266:1-35. 2008
  8. pmc Miller's seminal studies on the role of thymus in immunity
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 144:371-5. 2006
  9. doi request reprint Erythropoietin and tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Stem Cells Dev 19:1-4. 2010
  10. ncbi request reprint The fundamental contribution of Jan C. Waldenström to the discovery and study of the so-called "Waldenström macroglobulinemia"
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, I 70124 Bari, Italy
    Leuk Res 31:435-8. 2007

Detail Information

Publications184 found, 100 shown here

  1. doi request reprint Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Peptides 29:1596-602. 2008
    ..Taken together, these findings indicate that leptin/Ob-R correlate with angiogenesis and tumor progression in patients with HCC and that an anti-leptin antibody exerts an angiostatic activity in HCC...
  2. pmc Angiogenesis and melanoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Cancers (Basel) 2:114-32. 2010
    ..This article summarizes the literature concerning the relationship between angiogenesis and human melanoma progression. The recent applications of antiangiogenic agents which interfere with melanoma progression are also described. ..
  3. ncbi request reprint Endogenous and exogenous fibroblast growth factor-2 modulate wound healing in the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, Bari, Italy
    Angiogenesis 3:89-95. 1999
    ....
  4. pmc The Chick Embryo Chorioallantoic Membrane as an In Vivo Assay to Study Antiangiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Pharmaceuticals (Basel) 3:482-513. 2010
    ..The fields of application of CAM in the study of antiangiogenesis, including our personal experience, are illustrated in this review article...
  5. pmc Tyrosine Kinase Inhibitors as Antiangiogenic Drugs in Multiple Myeloma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Pharmaceuticals (Basel) 3:1225-1231. 2010
    ..This review article is focused on the use of tyrosine kinase inhibitors as antiangiogenic molecules in the treatment of multiple myeloma...
  6. ncbi request reprint Inhibition of neuroblastoma-induced angiogenesis by fenretinide
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Int J Cancer 94:314-21. 2001
    ....
  7. doi request reprint Transgenic mouse models of angiogenesis and lymphangiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int Rev Cell Mol Biol 266:1-35. 2008
    ....
  8. pmc Miller's seminal studies on the role of thymus in immunity
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Immunol 144:371-5. 2006
    ..This review article summarizes the seminal work of the Australian scientist Francis Albert Pierre Miller concerning the description for the first time of the crucial role of the thymus for normal development of the immune system...
  9. doi request reprint Erythropoietin and tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Stem Cells Dev 19:1-4. 2010
    ....
  10. ncbi request reprint The fundamental contribution of Jan C. Waldenström to the discovery and study of the so-called "Waldenström macroglobulinemia"
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, I 70124 Bari, Italy
    Leuk Res 31:435-8. 2007
    ..This historical review article summarizes the fundamental contribution of Jan Costa Waldenström to the discovery and study of this lymphoproliferative disorder...
  11. ncbi request reprint Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Oncogene 25:4257-66. 2006
    ..The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed...
  12. pmc Genetic and epigenetic mechanisms in the early development of the vascular system
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    J Anat 208:139-52. 2006
    ....
  13. pmc Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygium
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Cell Mol Med 11:585-9. 2007
    ..These results suggest that the characteristic neovascularization observed in pterygium may be sustained, at least in part, by MC angiogenic mediators, in particular tryptase...
  14. pmc Angiogenesis in a human neuroblastoma xenograft model: mechanisms and inhibition by tumour-derived interferon-gamma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Br J Cancer 94:1845-52. 2006
    ..Once the dual origin of tumour vasculature is confirmed in NB patients, the xenograft model described here will prove useful in testing the efficacy of different antiangiogenic compounds...
  15. ncbi request reprint Development of the blood-brain barrier: a historical point of view
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, Bari, Italy
    Anat Rec B New Anat 289:3-8. 2006
    ..This review article summarizes the historical background underlying our current knowledge of the cellular and molecular mechanisms involved in the development and maintenance of the BBB...
  16. ncbi request reprint Novel therapeutic approaches targeting vascular endothelial growth factor and its receptors in haematological malignancies
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    Curr Cancer Drug Targets 5:573-8. 2005
    ..This review summarizes the literature on the use of these molecules in the treatment of hematological malignancies...
  17. ncbi request reprint Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Am J Obstet Gynecol 193:1961-5. 2005
    ..The aim of this study was to correlate the extent of angiogenesis with the number of MC expressing tryptase in human endometrial adenocarcinoma...
  18. ncbi request reprint Antiangiogenic strategies in neuroblastoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Cancer Treat Rev 31:27-34. 2005
    ..Here, we present an overview of recent advances in antiangiogenesis in neuroblastoma and describe the most important active substances, preclinical and clinical data, as well as future perspectives...
  19. ncbi request reprint The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Br J Haematol 128:303-9. 2005
    ..Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of several potential therapeutical implications, are discussed...
  20. ncbi request reprint Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Eur J Clin Invest 33:420-5. 2003
    ..Mast cell density (MCD) is highly correlated with the extent of both normal and pathological angiogenesis, such as that in chronic inflammatory diseases and tumours...
  21. ncbi request reprint Erythropoietin as an angiogenic factor
    D Ribatti
    Department of Human Anatomy, University of Bari Medical School, Bari, Italy
    Eur J Clin Invest 33:891-6. 2003
    ..New sites of Epo production have been found, such as the female reproductive organs and central nervous system. This review summarizes the involvement of Epo in the regulation of angiogenesis in both normal and pathological conditions...
  22. ncbi request reprint Angiogenesis in neuroblastoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Ann N Y Acad Sci 1028:133-42. 2004
    ..A major goal is the determination of whether inhibition of angiogenesis is a realistic way of inhibiting tumor cell dissemination and formation of metastasis in neuroblastoma...
  23. pmc In vivo time-course of the angiogenic response induced by multiple myeloma plasma cells in the chick embryo chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Anat 203:323-8. 2003
    ....
  24. ncbi request reprint The first evidence of the tumor-induced angiogenesis in vivo by using the chorioallantoic membrane assay dated 1913
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Leukemia 18:1350-1. 2004
  25. ncbi request reprint Hematopoietic cancer and angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Stem Cells Dev 13:484-95. 2004
    ....
  26. ncbi request reprint Angiogenesis and anti-angiogenesis in hematological malignancies
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    J Hematother Stem Cell Res 12:11-22. 2003
    ....
  27. ncbi request reprint Neovascularisation, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Eur J Cancer 39:666-74. 2003
    ..These results suggest that angiogenesis in human melanoma increases with tumour progression and that FGF-2 secreted by tumour cells and tryptase secreted by host MCs cooperate in its induction...
  28. ncbi request reprint Angiogenesis: basic and clinical aspects
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Ital J Anat Embryol 108:1-24. 2003
    ..Conversely, there are pathologic conditions in which preventing angiogenic processes could be useful in the treatment of a growing tumor or a chronic inflammatory process...
  29. ncbi request reprint Neridronate inhibits angiogenesis in vitro and in vivo
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Clin Rheumatol 26:1094-8. 2007
    ..Overall, these results suggest that anti-angiogenesis by neridronate could be used to treat a wide spectrum of angiogenesis-dependent diseases, including certain chronic inflammatory diseases and cancer...
  30. doi request reprint The embryonic origins of lymphatic vessels: an historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Br J Haematol 149:669-74. 2010
    ..More recent evidence has provided support for both hypotheses...
  31. pmc Mast cells and angiogenesis in gastric carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Exp Pathol 91:350-6. 2010
    ..Understanding the mechanisms of gastric cancer angiogenesis provides a basis for a rational approach to the development of an antiangiogenic therapy in patients with this malignancy...
  32. doi request reprint The controversial role of placental growth factor in tumor growth
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Cancer Lett 307:1-5. 2011
    ..Depending on the model, PlGF overexpression has been shown to result in tumor growth promotion or inhibition. This review article summarizes the most relevant literature data concerning this still unsolved important question...
  33. doi request reprint The role of pericytes in angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Dev Biol 55:261-8. 2011
    ..We will then consider the complex and multivarious contribution of pericytes to the different aspects of angiogenesis with particular emphasis on the potential role of these cells as targets in tumor therapy...
  34. doi request reprint Mast cells, angiogenesis and cancer
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare Bari, Italy
    Adv Exp Med Biol 716:270-88. 2011
    ..Data from experimental carcinogenesis and from different tumor settings in human pathology will be summarized. Information to be presented will suggest that MCs may serve as a novel therapeutic target for cancer treatment...
  35. ncbi request reprint From the discovery of Vascular Endothelial Growth Factor to the introduction of Avastin in clinical trials - an interview with Napoleone Ferrara
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Dev Biol 55:383-8. 2011
    ..Ferrara's work is revolutionizing quality of life for many of the estimated 1.2 million individuals in the US who have wet AMD. Upwards of a million AMD patients worldwide have already received anti-VEGF antibody therapy...
  36. doi request reprint Intussusceptive microvascular growth in tumors
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cancer Lett 316:126-31. 2012
    ..Interestingly, an angiogenic switch from sprouting to intussusceptive angiogenesis occurs after treatment with angiogenesis inhibitors and may be considered as a tumor-protective adaptative response...
  37. doi request reprint Chicken chorioallantoic membrane angiogenesis model
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Bari, Italy
    Methods Mol Biol 843:47-57. 2012
    ..The cells invade the epithelium and the mesenchymal connective tissue below, where they are found in the form of a dense bed of blood vessels, which is a target for intravasation...
  38. doi request reprint Morphological and molecular aspects of physiological vascular morphogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Angiogenesis 12:101-11. 2009
    ..This review article summarizes our knowledge concerning the principal factors involved in the regulation of vascular morphogenesis...
  39. ncbi request reprint Stephen Paget and the 'seed and soil' theory of metastatic dissemination
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare 11, Policlinico, I 70124, Bari, Italy
    Clin Exp Med 6:145-9. 2006
    ..The concept of his 'seed and soil' theory has been supported and confirmed by numerous publications. This review article summarises the most important literature data about this matter...
  40. ncbi request reprint The gelatin sponge-chorioallantoic membrane assay
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    Nat Protoc 1:85-91. 2006
    ..Nevertheless, the gelatin sponge-CAM assay is simple, inexpensive and suitable for large-scale screening...
  41. ncbi request reprint Tryptase- and leptin-positive mast cells correlate with vascular density in uterine leiomyomas
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Am J Obstet Gynecol 196:470.e1-7. 2007
    ..The aim of this study was to correlate the extent of angiogenesis with the number of MC expressing tryptase and leptin in human leiomyomas...
  42. ncbi request reprint The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and its role in haematological malignancies
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cytokine Growth Factor Rev 18:327-34. 2007
    ..This review describes its history, as well as its role in tumor angiogenesis associated with haematological malignancies, as traced by the main contributions to the international medical literature...
  43. ncbi request reprint Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 51:837-42. 2007
    ..The aim was to correlate the extent of angiogenesis with the number of mast cells reactive with tryptase in biopsy specimens of sentinel lymph nodes with and without micrometastases obtained from patients with breast cancer...
  44. ncbi request reprint Clodronate inhibits angiogenesis in vitro and in vivo
    D Ribatti
    Department of Human Anatomy and Histology, Policlinico, I 70124 Bari, Italy
    Oncol Rep 19:1109-12. 2008
    ..Overall, these results suggest that antiangiogenesis by clodronate can be used to treat a wide spectrum of angiogenesis-dependent diseases, including certain chronic inflammatory diseases and cancer...
  45. ncbi request reprint The chick embryo chorioallantoic membrane in the study of tumor angiogenesis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Rom J Morphol Embryol 49:131-5. 2008
    ..This article summarizes literature data about the use of the CAM in the study of tumor angiogenesis and particularly our experimental data concerning the study of angiogenesis in multiple myeloma and in neuroblastoma...
  46. doi request reprint The discovery of the placental growth factor and its role in angiogenesis: a historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124, Bari, Italy
    Angiogenesis 11:215-21. 2008
    ....
  47. doi request reprint Sidney Farber and the treatment of childhood acute lymphoblastic leukemia with a chemotherapeutic agent
    Domenico Ribatti
    Department of Basic Medical Sciences, University of Bari Medical School, Bari, Italy
    Pediatr Hematol Oncol 29:299-302. 2012
    ..In this historical note, the fundamental contribution of Sidney Farber to the treatment of ALL by using, for the first time, aminopterin-a chemotherapeutic agent-has been recognized...
  48. pmc Temporal expression of the matrix metalloproteinase MMP-2 correlates with fibronectin immunoreactivity during the development of the vascular system in the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    J Anat 195:39-44. 1999
    ..These results indicate that MMP-2 activity and fibronectin expression are 2 strictly related components of angiogenesis occurring in vivo...
  49. ncbi request reprint Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and anti-angiogenesis in vivo
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, Bari, Italy
    Anat Rec 264:317-24. 2001
    ....
  50. ncbi request reprint Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 correlate with progression in human neuroblastoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Italy
    Life Sci 68:1161-8. 2001
    ..These in situ data suggest that angiogenesis and degradation of extracellular matrix occur simultaneously with NB tumor progression...
  51. ncbi request reprint Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology University of Bari Medical School, Bari, Italy
    Int J Cancer 85:171-5. 2000
    ..These results suggest that angiogenesis in B-NHLs increases with their progression, and that MCs cooperate in its induction via the tryptase contained in their secretory granules...
  52. ncbi request reprint Aquaporin-1 expression in the chick embryo chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piaza Giulio Cesare, 11 Policlinico, I 70124 Bari, Italy
    Anat Rec 268:85-9. 2002
    ....
  53. ncbi request reprint Angiogenesis and anti-angiogenesis in neuroblastoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Eur J Cancer 38:750-7. 2002
    ..Accordingly, anti-angiogenic tumour therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block neuroblastoma progression are reviewed...
  54. ncbi request reprint Angiogenic activity of rat mast cells in the chick embryo chorioallantoic membrane is down-regulated by treatment with recombinant human alpha-2a interferon and partly mediated by fibroblast growth factor-2
    Domenico Ribatti
    Department of Human Anatomy and Histology, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    Haematologica 87:465-71. 2002
    ..We have previously demonstrated that isolated MC and their secretory granules, but not degranulated MC, induce an angiogenic response in the chick embryo chorioallantoic membrane (CAM) assay...
  55. ncbi request reprint Models for studying angiogenesis in vivo
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Int J Biol Markers 14:207-13. 1999
    ..In this review we describe and evaluate the methodology and specific features of some of the most frequently used in vivo assays...
  56. pmc The role of the vascular phase in solid tumor growth: a historical review
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Neoplasia 1:293-302. 1999
    ....
  57. ncbi request reprint Cell-mediated delivery of fibroblast growth factor-2 and vascular endothelial growth factor onto the chick chorioallantoic membrane: endothelial fenestration and angiogenesis
    D Ribatti
    Department of Human Anatomy, University of Bari Medical School, Bari, Italy
    J Vasc Res 38:389-97. 2001
    ..The gelatin sponge/CAM assay may constitute a new model to study the mechanisms leading to endothelial fenestration in tumor growth...
  58. ncbi request reprint The discovery of angiogenic factors: a historical review
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Gen Pharmacol 35:227-31. 2000
    ..Numerous inducers of angiogenesis have been identified and this review offers a historical account of the relevant literature concerning the discovery of the best-characterized angiogenic factors...
  59. ncbi request reprint Cross-talk between hematopoiesis and angiogenesis signaling pathways
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Curr Mol Med 2:537-43. 2002
    ....
  60. ncbi request reprint Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2
    D Ribatti
    Department of Human Anatomy and Histology, Piazza Giulio Cesare 11, Policlinico, I 70124 Bari, Italy
    Int J Mol Med 8:265-8. 2001
    ..Our study confirms that leptin is angiogenic in vivo and suggests that, at least in the chick CAM, its activity is in part mediated by the activation of endogenous FGF-2...
  61. doi request reprint Endogenous inhibitors of angiogenesis: a historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Leuk Res 33:638-44. 2009
    ..This review summarizes the present knowledge about endogenous inhibitors of angiogenesis...
  62. pmc William Harvey and the discovery of the circulation of the blood
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Angiogenes Res 1:3. 2009
    ..This Commentary emphasizes the fundamental contribution of William Harvey to the discovery of the circulation of the blood and his scientific and experimental approach to this matter...
  63. doi request reprint B16-F10 melanoma cells contribute to the new formation of blood vessels in the chick embryo chorioallantoic membrane through vasculogenic mimicry
    Domenico Ribatti
    Section of Human Anatomy and Histology, Department of Basic Medical Sciences, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Clin Exp Med 13:143-7. 2013
    ..Finally, we have shown that CAMs new-formed blood vessels are lined by both pigmented melanoma cells and cells immunoreactive to MART-1/Melan-A and PAS, suggesting the occurrence of a vasculogenic mimicry process...
  64. ncbi request reprint Antiangiogenic therapeutic approaches in multiple myeloma
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Bari, Italy
    Curr Cancer Drug Targets 12:768-75. 2012
    ..This review article summarizes the literature data concerning the employment of the most important antiangiogenic therapeutic agents actually used in preclinical models and clinical settings for the treatment of MM...
  65. doi request reprint Cancer stem cells and tumor angiogenesis
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cancer Lett 321:13-7. 2012
    ..In this context, the development of agents that eliminate or control CSC may be an effective strategy for cancer prevention...
  66. doi request reprint Angiogenic activity of classical hematopoietic cytokines
    Domenico Ribatti
    Department of Basic Medical Sciences, Section of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Leuk Res 36:537-43. 2012
    ..This review article summarizes the most important literature data concerning this inconvertible relationship...
  67. doi request reprint Mast cells, angiogenesis, and tumour growth
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, 70124 Bari, Italy
    Biochim Biophys Acta 1822:2-8. 2012
    ..This review will focus on the most recent acquisitions about this intriguing field of research. This article is part of a Special Issue entitled: Mast cells in inflammation...
  68. ncbi request reprint Inflammation and antiangiogenesis in cancer
    D Ribatti
    Department of Basic Medical Sciences, University of Bari Medical School, Policlinico, Bari, Italy
    Curr Med Chem 19:955-60. 2012
    ..In this review article, we will focus on some angiogenenic and anti-angiogenic molecules properties of immune cells that may be utilized for a potential parmacological use as anti-angiogenic agents in cancer...
  69. pmc VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex
    Vincenzo Benagiano
    Dipartimento Scienze Mediche di Base, Sezione di Anatomia e Istologia, Università Bari, Italy
    BMC Neurosci 12:118. 2011
    ....
  70. pmc Judah Folkman, a pioneer in the study of angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124, Bari, Italy
    Angiogenesis 11:3-10. 2008
    ..Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases...
  71. ncbi request reprint An experimental study in the chick embryo chorioallantoic membrane of the anti-angiogenic activity of cyclosporine in rheumatoid arthritis versus osteoarthritis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari, Medical School, Italy
    Inflamm Res 49:418-23. 2000
    ....
  72. ncbi request reprint Postnatal vasculogenesis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, I 70124, Bari, Italy
    Mech Dev 100:157-63. 2001
    ..The potential biomedical applications of endothelial precursor cells and the new opportunities for the development of new forms of tumor-targeted treatments are discussed...
  73. pmc Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 50:636-41. 2007
    ..The aim of this study was to correlate microvascular density and Epo/Epo-receptor (EpoR) expression in endothelial and tumour cells to the clinical stage of NB...
  74. doi request reprint Chick embryo chorioallantoic membrane as a useful tool to study angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    Int Rev Cell Mol Biol 270:181-224. 2008
    ..Finally, advantages and limitations of CAM as an experimental model to study angiogenesis and antiangiogenesis are discussed...
  75. pmc The role of microenvironment in tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, 70124, Bari, Italy
    Genes Nutr 3:29-34. 2008
    ..The encouraging results of pre-clinical and clinical trials in which tumors have been treated by targeting the tumor microenvironment are also discussed...
  76. doi request reprint Inflammatory angiogenesis in atherogenesis--a double-edged sword
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Ann Med 40:606-21. 2008
    ....
  77. ncbi request reprint Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development of the vascular system in the chick embryo bursa of Fabricius
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, I 70124 Bari, Italy
    Int J Mol Med 7:365-8. 2001
    ..These data support the view that VEGF acts as a paracrine stimulator of angiogenesis in the avian embryo and confirm the requirement of the endodermal layer for the normal formation of blood vessels by mesodermal cells...
  78. ncbi request reprint Mast cells and their secretory granules are angiogenic in the chick embryo chorioallantoic membrane
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 31:602-8. 2001
    ..Many data suggest that the density of mast cells is highly correlated with the extent of both normal and pathological angiogenesis...
  79. ncbi request reprint The contribution of Harold F. Dvorak to the study of tumor angiogenesis and stroma generation mechanisms
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Endothelium 14:131-5. 2007
    ..This work is again extremely significant for patients worldwide, as Dvorak's scientific research is leading his colleagues all over the world to examine how to treat a tumor through its blood supply...
  80. ncbi request reprint Mast cell contribution to angiogenesis related to tumour progression
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 34:1660-4. 2004
    ....
  81. ncbi request reprint The chick embryo chorioallantoic membrane as a model for in vivo research on anti-angiogenesis
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Curr Pharm Biotechnol 1:73-82. 2000
    ..Angiogenesis or anti-angiogenesis is evaluated quantitatively or semiquantitatively. The fields of application of CAM in the study of anti-angiogenesis, including our personal experience, are illustrated in this paper...
  82. ncbi request reprint Nonclassic endogenous novel [corrected] regulators of angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, School of Medicine, University of Bari, Bari, Italy
    Pharmacol Rev 59:185-205. 2007
    ..Investigations on "nonclassic" regulators of angiogenesis could open new perspectives in the therapy of diseases coupled to dysregulation of angiogenesis...
  83. doi request reprint Erythropoietin, the first century
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Bari, Italy
    Leuk Res 32:1169-72. 2008
  84. doi request reprint Hemangioblast does exist
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Leuk Res 32:850-4. 2008
  85. doi request reprint The seminal work of Werner Risau in the study of the development of the vascular system
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Dev Biol 54:567-72. 2010
    ..This review is dedicated to a retrospective analysis of the most important contributions of Risaus work in the field of angiogenesis during embryonic development and in post-natal life, in both physiological and pathological conditions...
  86. doi request reprint Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Dev Biol 55:99-102. 2011
    ....
  87. doi request reprint Novel angiogenesis inhibitors: addressing the issue of redundancy in the angiogenic signaling pathway
    Domenico Ribatti
    Dipartimento di Anatomia umana e Istologia, Universita degli Studi di Bari, Italy
    Cancer Treat Rev 37:344-52. 2011
    ..It would appear that the future of angiogenic inhibitors lies in the intelligent combination of multiple targeted agents with other angiogenic inhibitors, as well as more conventional therapies to maximise therapeutic effect...
  88. doi request reprint Tryptase-positive mast cells and CD8-positive T cells in human endometrial cancer
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Pathol Int 61:442-4. 2011
    ..These data suggest that inhibition of inflammation or manipulation of inflammatory resolution pathways may be a new therapeutic approach for the treatment of endometrial adenocarcinoma...
  89. pmc Erythropoietin is involved in angiogenesis in human primary melanoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Exp Pathol 91:495-9. 2010
    ..These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis...
  90. ncbi request reprint Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, Department of Biomedical Sciences and Human Oncology, University of Bari School of Medicine, Bari, Italy
    Blood 93:2627-36. 1999
    ..Taken together, these data demonstrate the ability of Epo to interact directly with endothelial cells and to elicit an angiogenic response in vitro and in vivo and thus act as a bona fide direct angiogenic factor...
  91. ncbi request reprint Macrophages and mast cells are involved in carotid plaque instability
    A Marzullo
    Department Pathology, University of Bari Medical School, Bari, Italy
    Rom J Morphol Embryol 52:981-4. 2011
    ....
  92. ncbi request reprint Human neuroblastoma cells produce extracellular matrix-degrading enzymes, induce endothelial cell proliferation and are angiogenic in vivo
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Int J Cancer 77:449-54. 1998
    ..Our data suggest that the 2 NB cell lines are angiogenic, to LAN-5 cells more than GI-LI-N ones. LAN-5 cells are indeed endowed with a more aggressive and invasive phenotype...
  93. ncbi request reprint Expression of tenascin is related to angiogenesis in pre-eclampsia
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Eur J Clin Invest 28:373-8. 1998
    ..In addition, pre-eclamptic and control samples were grafted onto the chick embryo chorioallantoic membrane (CAM) to study their possible angiogenic activity in vivo...
  94. ncbi request reprint Systemic sclerosis stimulates angiogenesis in the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Clin Rheumatol 17:115-20. 1998
    ..Moreover, the role played in the angiogenic response by the inflammatory cells forming the cellular infiltrate is suggested by this study...
  95. ncbi request reprint Localization of factor VIII-related antigen in the endothelium of the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Histochem Cell Biol 112:447-50. 1999
    ..The application of this antibody may be useful for quantifying neovascularization in response to various angiogenic stimuli applied to the CAM...
  96. doi request reprint Angiogenesis in asthma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 39:1815-21. 2009
    ..This review provides recent data showing the contribution of allergic inflammation in increased airway vascularity and potential therapeutical approaches in asthma treatment by acting on bronchial microvascular changes...
  97. doi request reprint The paracrine role of Tie-2-expressing monocytes in tumor angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare 11, Policlinico, Bari, Italy
    Stem Cells Dev 18:703-6. 2009
    ....
  98. ncbi request reprint The discovery of antiangiogenic molecules: a historical review
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Curr Pharm Des 15:345-52. 2009
    ..Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials...
  99. doi request reprint Co-localization of tryptase and cathepsin-G in mast cells in cutaneous mastocytosis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Cancer Lett 279:209-12. 2009
    ....
  100. doi request reprint Mast cells and angiogenesis in haematological malignancies
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11 Policlinico, 70124 Bari, Italy
    Leuk Res 33:876-9. 2009
    ....