Saverio Francesco Retta

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1
    Saverio Francesco Retta
    Department of Genetic, Biology and Biochemistry, University of Torino and Experimental Medicine Research Centre, San Giovanni Battista Hospital, Via Santena 5 bis, 10126 Turin, Italy
    Gene 325:63-78. 2004
  2. pmc Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin
    Saverio Francesco Retta
    Department of Clinical and Biological Sciences, School of Medicine and Surgery, University of Torino, Regione Gonzole 10, 10043 Orbassano, Torino, Italy CCM Italia Research Network 1 Electronic address
    Int J Biochem Cell Biol 81:254-270. 2016
  3. ncbi request reprint Cerebral cavernous malformation (CCM) disease: from monogenic forms to genetic susceptibility factors
    E Trapani
    Department of Clinical and Biological Sciences, University of Torino, Orbassano, Torino, Italy
    J Neurosurg Sci 59:201-9. 2015
  4. pmc Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?
    Luca Goitre
    Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Italy
    J Signal Transduct 2012:807682. 2012
  5. pmc Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1
    Paolo Guazzi
    Department of Biotechnologies, Chemistry and Pharmacy, University of Siena, Siena, Italy
    PLoS ONE 7:e44705. 2012
  6. ncbi request reprint Rap1: a turnabout for the crosstalk between cadherins and integrins
    Saverio Francesco Retta
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, I 10126 Torino, Italy
    Eur J Cell Biol 85:283-93. 2006
  7. doi request reprint Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis
    Floriana Francalanci
    Molecular Biotechnology Centre, Department of Genetics, Biology and Biochemistry, Via Nizza 52, 10126 Torino, Italy
    Exp Cell Res 315:285-303. 2009
  8. ncbi request reprint E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function
    Fiorella Balzac
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, Torino, 10126, Italy
    J Cell Sci 118:4765-83. 2005
  9. pmc KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun
    Luca Goitre
    Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano Torino, Italy
    Free Radic Biol Med 68:134-47. 2014
  10. pmc KRIT1 regulates the homeostasis of intracellular reactive oxygen species
    Luca Goitre
    Molecular Biotechnology Centre, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    PLoS ONE 5:e11786. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1
    Saverio Francesco Retta
    Department of Genetic, Biology and Biochemistry, University of Torino and Experimental Medicine Research Centre, San Giovanni Battista Hospital, Via Santena 5 bis, 10126 Turin, Italy
    Gene 325:63-78. 2004
    ..Our results indicate that maintenance of a proper ratio between Krit1A and Krit1B could be functionally relevant and suggest that the novel Krit1B isoform might expand our understanding of the role of Krit1 in CCM1 pathogenesis...
  2. pmc Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin
    Saverio Francesco Retta
    Department of Clinical and Biological Sciences, School of Medicine and Surgery, University of Torino, Regione Gonzole 10, 10043 Orbassano, Torino, Italy CCM Italia Research Network 1 Electronic address
    Int J Biochem Cell Biol 81:254-270. 2016
    ....
  3. ncbi request reprint Cerebral cavernous malformation (CCM) disease: from monogenic forms to genetic susceptibility factors
    E Trapani
    Department of Clinical and Biological Sciences, University of Torino, Orbassano, Torino, Italy
    J Neurosurg Sci 59:201-9. 2015
    ....
  4. pmc Molecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?
    Luca Goitre
    Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano, Italy
    J Signal Transduct 2012:807682. 2012
    ....
  5. pmc Identification of the Kelch family protein Nd1-L as a novel molecular interactor of KRIT1
    Paolo Guazzi
    Department of Biotechnologies, Chemistry and Pharmacy, University of Siena, Siena, Italy
    PLoS ONE 7:e44705. 2012
    ....
  6. ncbi request reprint Rap1: a turnabout for the crosstalk between cadherins and integrins
    Saverio Francesco Retta
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, I 10126 Torino, Italy
    Eur J Cell Biol 85:283-93. 2006
    ..In particular, it highlights some of the novel results recently obtained that raise the possibility of a pivotal role for Rap1 in the functional crosstalk between cadherins and integrins, suggesting interesting new regulatory mechanisms...
  7. doi request reprint Structural and functional differences between KRIT1A and KRIT1B isoforms: a framework for understanding CCM pathogenesis
    Floriana Francalanci
    Molecular Biotechnology Centre, Department of Genetics, Biology and Biochemistry, Via Nizza 52, 10126 Torino, Italy
    Exp Cell Res 315:285-303. 2009
    ....
  8. ncbi request reprint E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function
    Fiorella Balzac
    Department of Genetics, Biology and Biochemistry, University of Torino, Via Santena 5 bis, Torino, 10126, Italy
    J Cell Sci 118:4765-83. 2005
    ..Our findings provide the first evidence of an E-cadherin-modulated endosomal signaling pathway involving Rap1, and suggest that cadherins may have a novel modulatory role in integrin adhesive functions by fine-tuning Rap1 activation...
  9. pmc KRIT1 loss of function causes a ROS-dependent upregulation of c-Jun
    Luca Goitre
    Department of Clinical and Biological Sciences, University of Torino, 10043 Orbassano Torino, Italy
    Free Radic Biol Med 68:134-47. 2014
    ..Taken together with the reported role of c-Jun in vascular dysfunctions triggered by oxidative stress, our findings shed new light on the molecular mechanisms underlying KRIT1 function and CCM pathogenesis. ..
  10. pmc KRIT1 regulates the homeostasis of intracellular reactive oxygen species
    Luca Goitre
    Molecular Biotechnology Centre, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    PLoS ONE 5:e11786. 2010
    ....
  11. pmc The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading
    Simona Degani
    Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy
    J Cell Biol 156:377-87. 2002
    ..Together, these data show for the first time that ICAP-1 regulates Rho family GTPases during integrin-mediated cell matrix adhesion, acting as guanine dissociation inhibitor...
  12. pmc miR-21 coordinates tumor growth and modulates KRIT1 levels
    Francesca Orso
    Molecular Biotechnology Center, University of Torino, Torino, Italy
    Biochem Biophys Res Commun 438:90-6. 2013
    ..Our findings suggest that miR-21 promotes tumor cell growth, at least in part, by down-modulating the potential tumor suppressor KRIT1. ..
  13. pmc The Interplay between ROS and Ras GTPases: Physiological and Pathological Implications
    Elisa Ferro
    Department of Biotechnology, University of Siena, Via Fiorentina 1, 53100 Siena, Italy
    J Signal Transduct 2012:365769. 2012
    ..Here we discuss current understanding concerning mechanisms and physiopathological implications of the interplay between GTPases and redox agents...
  14. doi request reprint Ras GTPases are both regulators and effectors of redox agents
    Elisa Ferro
    Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, Siena, Italy
    Methods Mol Biol 1120:55-74. 2014
    ....
  15. doi request reprint The Ras superfamily of small GTPases: the unlocked secrets
    Luca Goitre
    Department of Clinical and Biological Sciences, University of Torino, Torino, Italy
    Methods Mol Biol 1120:1-18. 2014
    ..In this review we provide a general overview of the major milestones that eventually allowed to unlock the secret treasure chest of this large and important superfamily of proteins...
  16. doi request reprint Fluorescence microscopy study of Rap1 subcellular localization
    Luca Goitre
    Department of Clinical and Biological Sciences, University of Torino, Torino, Italy
    Methods Mol Biol 1120:197-205. 2014
    ..Thus, Rap1 was proposed as a fundamental regulator of the cross talk between cadherins and integrins. We provide microscopic techniques to study subcellular localization of Rap1 protein in the crosstalk between integrins and cadherins. ..
  17. doi request reprint Combined pulldown and time-lapse microscopy studies for determining the role of Rap1 in the crosstalk between integrins and cadherins
    Luca Goitre
    Department of Clinical and Biological Sciences, University of Torino, Torino, Italy
    Methods Mol Biol 1120:177-95. 2014
    ..Considering the importance of the molecular signalling triggered by Rap1, here we provide protocols to study this small GTPase in signalling pathways involving cadherins and integrins. ..
  18. doi request reprint Production of novel antioxidative phenolic amides through heterologous expression of the plant's chlorogenic acid biosynthesis genes in yeast
    Andrea Moglia
    DIVAPRA, Plant Genetics and Breeding, University of Torino, Via L da Vinci 44, 10095 Grugliasco TO, Italy
    Metab Eng 12:223-32. 2010
    ..When applied to mouse fibroblasts, N-(E)-p-coumaroyl-3-hydroxyanthranilic acid induced a reduction of intracellular reactive oxygen species, indicating a potential therapeutic value for this novel compound...
  19. ncbi request reprint Inhibition of PI3K induces Rac activation and membrane ruffling in proto-Dbl expressing cells
    Cristina Vanni
    Laboratorio di Biologia Molecolare, Istituto G Gaslini, Genova, Italy
    Cell Cycle 5:2657-65. 2006
    ..Our results suggest that proto-Dbl activates distinct downstream effectors to induce morphological changes and cell transformation...
  20. ncbi request reprint Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines
    Laura Moro
    Dipartimento di Scienze Mediche, Universita del Piemonte Orientale, Novara 28100, Italy
    J Biol Chem 277:9405-14. 2002
    ..Therefore these data indicate that integrin-mediated adhesion induces assembly of a macromolecular complex containing c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosine residues...
  21. ncbi request reprint Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha
    Daniel Bouvard
    Laboratoire d Etude de la Différenciation et de l Adhérence Cellulaires, Unité Mixte de Recherche UJF CNRS 5538, Institut Albert Bonniot, Faculte de Medecine de Grenoble, La Tronche F38706 cedex, France
    J Biol Chem 278:6567-74. 2003
    ..Altogether, these results suggest that ICAP-1 alpha plays a key role in cell adhesion by acting as a negative regulator of beta(1) integrin avidity...