Affiliation: University of Rome La Sapienza
- Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort studyLuisa Pastò
Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
BMC Neurol 12:165. 2012..The objective of this study was to assess the impact of epidural analgesia (EA) and caesarean delivery (CD) on the risk of post-partum relapses and disability in women with MS...
- Corticosteroids treatmentCarlo Pozzilli
Department of Neurological Sciences, La Sapienza University, V le Università 30, 00185 Rome, Italy
J Neurol Sci 223:47-51. 2004..Finally the association between methylprednisolone and interferon beta (IFNbeta) leads the recovery of active lesions at greater extent and reduces the formation of neutralizing antibodies (NABs) against IFNbeta in patients with RRMS...
- A longitudinal fMRI study on motor activity in patients with multiple sclerosisPatrizia Pantano
Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
Brain 128:2146-53. 2005..The tendency towards a normalization of brain functional activity is hampered in older patients and in those developing relapses or new irreversible brain damage...
- Contribution of corticospinal tract damage to cortical motor reorganization after a single clinical attack of multiple sclerosisPatrizia Pantano
Section of Neuroradiology, Department of Neurological Sciences, University of Rome, La Sapienza, I 00185 Rome, Italy
Neuroimage 17:1837-43. 2002..Furthermore, the significant correlation between the time since clinical onset and activation in motor areas suggests that cortical reorganization develops gradually in concomitance with the subclinical accumulation of tissue damage...
- Predictors of long-term clinical response to interferon beta therapy in relapsing multiple sclerosisValentina Tomassini
Dept of Neurological Sciences, La Sapienza University, Viale dell Universita, 30, 00185 Rome, Italy
J Neurol 253:287-93. 2006....
- Gray- and white-matter changes 1 year after first clinical episode of multiple sclerosis: MR imagingEytan Raz
Department of Neurological Sciences, Sapienza University of Rome, Viale dell Universita 30, 00185 Rome, Italy
Radiology 257:448-54. 2010..To assess, by means of magnetic resonance (MR) imaging, the longitudinal changes in white matter (WM) and gray matter (GM) in a cohort of patients with clinically isolated syndrome (CIS) who were followed up for 1 year...
- Effect of corpus callosum damage on ipsilateral motor activation in patients with multiple sclerosis: a functional and anatomical studyDelia Lenzi
Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
Hum Brain Mapp 28:636-44. 2007..Duration of TCI was negatively correlated with activation in the iM1. Our data suggest that functional changes in iM1 in patients with MS during a motor task partially represents a consequence of loss of transcallosal inhibitory fibers...
- fMRI evidence of brain reorganization during attention and memory tasks in multiple sclerosisCaterina Mainero
Section of Clinical Neurology, Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
Neuroimage 21:858-67. 2004..Functional changes in specific brain areas increase with increasing tissue damage suggesting that they may also represent adaptive mechanisms that reflect underlying neural disorganization or disinhibition, possibly associated with MS...
- Multiple sclerosis: white and gray matter damage associated with balance deficit detected at static posturographyLuca Prosperini
Department of Neurology and Psychiatry and Department of Psychology, Sapienza University, Viale dell Universita 30, 00185 Rome, Italy
Radiology 268:181-9. 2013....
- Cannabinoid-induced effects on the nociceptive system: a neurophysiological study in patients with secondary progressive multiple sclerosisAntonella Conte
Department of Neurological Sciences, University of Rome Sapienza, Viale dell Universita 30, 00185 Rome, Italy
Eur J Pain 13:472-7. 2009..In conclusion, the cannabinoid-induced changes in the RIII reflex threshold and area in patients with MS provide objective neurophysiological evidence that cannabinoids modulate the nociceptive system in patients with MS...
- Clinical markers of therapeutic response to disease modifying drugsCarlo Pozzilli
S Andrea Hospital, La Sapienza University, Via di Grottarossa, 1035, 00189, Rome, Italy
Neurol Sci 29:S211-3. 2008..Clinical parameters, such as relapse rate and disability progression assessing with EDSS scale, may represent two useful indicators of therapeutic response, but their value in predicting the long-term response to DMTs is weak...
- A longitudinal study of MR diffusion changes in normal appearing white matter of patients with early multiple sclerosisFrancesca Caramia
Department of Neurological Sciences, Neuroradiology, Rome, Italy
Magn Reson Imaging 20:383-8. 2002..The stage at which normal appearing white matter (NAWM) abnormalities first appear in multiple sclerosis (MS) is not clear. The aim of our study was to monitor water diffusion changes over time in NAWM of patients with early MS...
- Emerging oral drugs for multiple sclerosisClaudio Gasperini
S Camillo Forlanini Hospital, Department of Neuroscience, Viale dell Universita 30, 00185 Rome, Italy
Expert Opin Emerg Drugs 13:465-77. 2008....
- Clinically isolated syndrome suggestive of multiple sclerosis: voxelwise regional investigation of white and gray matterEytan Raz
Department of Neurological Sciences, Sapienza University of Rome, Viale dell Universita, 30, 00185 Rome, Italy
Radiology 254:227-34. 2010....
- Monthly corticosteroids decrease neutralizing antibodies to IFNbeta1 b: a randomized trial in multiple sclerosisCarlo Pozzilli
Department of Neurological Sciences, University La Sapienza, Rome, Italy
J Neurol 249:50-6. 2002..o49 for definition II, by the Wilcoxon-Gehan test). Methylprednisilone combined with IFNbeta-1 b reduces the incidence of neutralizing bodies to in terferon-beta during the first year of treatment in MS patients...
- Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 yearsFrancesca Bellomi
Department of Experimental Medicine and Pathology, Section of Virology, University La Sapienza, V le di Porta Tiburtina 28, 00185 Rome, Italy
J Neurol Sci 215:3-8. 2003..In conclusion, the data indicate that the disappearance of the anti-IFN antibodies from the serum while the patients are still undergoing IFN treatment depends on the titer of antibodies but not on the type of IFN administered...
- Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomised, double-blind, crossover trialValentina Tomassini
Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita 30, Rome 00185, Italy
J Neurol Sci 218:103-8. 2004..039). There were no significant effects for any of the secondary outcome variables. The results of this study show that ALCAR is better tolerated and more effective than amantadine for the treatment of MS-related fatigue...
- The use of ID migraine™ questionnaire in patients with multiple sclerosisVeronica Villani
Neurological Headache Centre, S Andrea Hospital, La Sapienza University, Rome, Italy
Neurol Sci 32:269-73. 2011..The use of the ID-M as a screening test is warranted not only in the epidemiological research, but also to ensure a better clinical management of patients with MS...
- Treating multiple sclerosis with fingolimod or intramuscular interferonCarlo Pozzilli
La Sapienza University, S Andrea Hospital, Multiple Sclerosis Centre, Department of Neurological Sciences, Viale dell Universita, 30, 00185 Rome, Italy
Expert Opin Pharmacother 11:1957-60. 2010..m. IFN-beta-1a, but it is still uncertain whether oral fingolimod could be used as first-line treatment, or as an alternative treatment for patients who have failed immunomodulating therapy...
- Cortical motor reorganization after a single clinical attack of multiple sclerosisPatrizia Pantano
Section of Neuroradiology, Department of Neurological Sciences, University of Rome La Sapienza, Italy
Brain 125:1607-15. 2002..The extent of these changes increased with the time elapsed since disease onset and the severity of brain damage...
- Sex hormones: a role in the control of multiple sclerosis?Valentina Tomassini
Department of Neurological Sciences, La Sapienza University, Rome, Italy
Expert Opin Pharmacother 7:857-68. 2006..A gender-based approach to multiple sclerosis could provide further benefits for its treatment and management...
- Supportive strategies to improve adherence to IFN β-1b in multiple sclerosis--results of the βPlus observational cohort studyCarlo Pozzilli
University Rome, Department of Neurological Sciences, La Sapienza University, S Andrea Hospital, Multiple Sclerosis Centre, Viale dell Universita 30, 00185 Rome, Italy
J Neurol Sci 307:120-6. 2011..Various strategies to improve adherence have been suggested including educative programs, injection devices and dedicated nurse assistance...
- Natalizumab treatment in multiple sclerosis: the experience of S. Andrea MS Centre in RomeL Prosperini
Multiple Sclerosis Centre, S Andrea Hospital, La Sapienza University, Via di Grottarossa 1035, 00189, Rome, Italy
Neurol Sci 31:303-7. 2011..Finally, the presence of antibodies anti-Natalizumab was strongly related to the occurrence of relapses (p = 0.002) and MRI activity (p < 0.001) even in the post-marketing experience...
- Primary headache and multiple sclerosis: preliminary results of a prospective studyVeronica Villani
Neurology Unit, S Andrea Hospital La Sapienza University, Via di Grottarossa 1035, 00189 Rome, Italy
Neurol Sci 29:S146-8. 2008..Investigating and treating HA in MS patients starting IFNb therapy may improve MS-specific medication compliance...
- Diffusion-weighted imaging tractography-based parcellation of the human lateral premotor cortex identifies dorsal and ventral subregions with anatomical and functional specializationsValentina Tomassini
Centre for Functional MRI of the Brain, University of Oxford, Oxford OX3 9DU, United Kingdom
J Neurosci 27:10259-69. 2007....
- Pharmacological methods to overcome IFN-beta antibody formation in the treatment of multiple sclerosisFrancesca Bagnato
Neuroimmunology Branch, National Institutes of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD, 20892 1400 USA
Expert Opin Investig Drugs 12:1153-63. 2003..Among those therapies, steroids meet the best criteria in terms of either safety or impact on the development of NAbs, at the present time...
- Real time PCR for detection of Chlamydophila pneumoniae in peripheral blood mononuclear cells of patients with multiple sclerosisRosa Sessa
J Neurol 254:1293-5. 2007
- Safety and tolerability in relapsing-remitting multiple sclerosis patients treated with high-dose subcutaneous interferon-beta by Rebiject autoinjection over a 1-year period: the CoSa studyAlessandra Lugaresi
Department of Oncology and Neuroscience, University G D Annunzio, Chieti, Italy
Clin Neuropharmacol 31:167-72. 2008..This study investigated the satisfaction of patients with relapsing-remitting MS treated with IFN-beta-1a (Rebif) by the autoinjection system, Rebiject...
- Computer-aided retraining of memory and attention in people with multiple sclerosis: a randomized, double-blind controlled trialAlessandra Solari
Laboratory of Epidemiology, National Neurological Institute C Besta, Via Celoria 11, 20133 Milan, Italy
J Neurol Sci 222:99-104. 2004..Computer-aided programs are used for retraining memory and attention, but data on the efficacy of these interventions are scarce...
- The distribution of magnetic resonance imaging response to interferonbeta-1b in multiple sclerosisMaria Pia Sormani
Neuroimaging Research Unit, Dept of Neurology, Scientific Institute and University Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, Italy
J Neurol 252:1455-8. 2005..This study might be regarded as a first step toward the definition of markers potentially useful to identify IFNbeta treatment responders and non-responders with regard to T2 lesion activity...
- The relationship between inflammation and atrophy in clinically isolated syndromes suggestive of multiple sclerosis: a monthly MRI study after triple-dose gadolinium-DTPAAndrea Paolillo
Dept of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
J Neurol 251:432-9. 2004..To examine the relationship between inflammation and brain atrophy in patients with a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS)...
- Epidemiology and current treatment of multiple sclerosis in Europe todayCarlo Pozzilli
Department of Neurological Science, University of Rome, La Sapienza, Italy
J Rehabil Res Dev 39:175-85. 2002..This article helps clinical researchers to understand better the differences in epidemiology and in the current treatment of MS in Europe...
- Brain reorganization during attention and memory tasks in multiple sclerosis: insights from functional MRI studiesCaterina Mainero
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, USA
J Neurol Sci 245:93-8. 2006....