A Pessina

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi The key role of adult stem cells: therapeutic perspectives
    Augusto Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Italy
    Curr Med Res Opin 22:2287-300. 2006
  2. ncbi Prevalidation of the rat CFU-GM assay for in vitro toxicology applications
    Augusto Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Italy
    Altern Lab Anim 38:105-17. 2010
  3. ncbi Mesenchymal stromal cells uptake and release paclitaxel without reducing its anticancer activity
    Massimo Mariotti
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Anticancer Agents Med Chem 15:400-5. 2015
  4. doi Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice
    Augusto Pessina
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
    Br J Haematol 160:766-78. 2013
  5. pmc Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy
    Laura de Girolamo
    Laboratorio di Biotecnologie applicate all Ortopedia, IRCCS Istituto Ortopedico Galeazzi, Milano, Italy
    Curr Pharm Des 19:2459-73. 2013
  6. ncbi Human skin-derived fibroblasts acquire in vitro anti-tumor potential after priming with Paclitaxel
    Augusto Pessina
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Anticancer Agents Med Chem 13:523-30. 2013
  7. pmc Mesenchymal stromal cells primed with paclitaxel provide a new approach for cancer therapy
    Augusto Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Milan, Italy
    PLoS ONE 6:e28321. 2011
  8. ncbi Mitochondrial function, apoptosis and cell cycle delay in the WEHI-3B leukaemia cell line and its variant Ciprofloxacin-resistant WEHI-3B/CPX
    A Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Milan, Italy
    Cell Prolif 40:568-79. 2007
  9. ncbi Microbiological risk assessment in stem cell manipulation
    Augusto Pessina
    Department of Public Health Microbiology Virology, University of Milan, Italy
    Crit Rev Microbiol 34:1-12. 2008
  10. doi Application of human CFU-Mk assay to predict potential thrombocytotoxicity of drugs
    A Pessina
    Department of Public Health Microbiology Virology, Faculty of Medicine, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Toxicol In Vitro 23:194-200. 2009

Collaborators

Detail Information

Publications32

  1. ncbi The key role of adult stem cells: therapeutic perspectives
    Augusto Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Italy
    Curr Med Res Opin 22:2287-300. 2006
    ..Adult stem cells are involved in regenerating tissues for renewal and damage repair...
  2. ncbi Prevalidation of the rat CFU-GM assay for in vitro toxicology applications
    Augusto Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Italy
    Altern Lab Anim 38:105-17. 2010
    ....
  3. ncbi Mesenchymal stromal cells uptake and release paclitaxel without reducing its anticancer activity
    Massimo Mariotti
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Anticancer Agents Med Chem 15:400-5. 2015
    ....
  4. doi Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice
    Augusto Pessina
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
    Br J Haematol 160:766-78. 2013
    ..Once the effectiveness of hMSCsPTX on established cancers in mice is proven, this procedure could be proposed for leukaemia therapy in humans...
  5. pmc Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy
    Laura de Girolamo
    Laboratorio di Biotecnologie applicate all Ortopedia, IRCCS Istituto Ortopedico Galeazzi, Milano, Italy
    Curr Pharm Des 19:2459-73. 2013
    ..The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects...
  6. ncbi Human skin-derived fibroblasts acquire in vitro anti-tumor potential after priming with Paclitaxel
    Augusto Pessina
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Anticancer Agents Med Chem 13:523-30. 2013
    ..Since hSDFs can be easily isolated from skin biopsies without any particular pain and discomfort to donor patients, we conclude that hSDFs may represent a valid cell type option for carrying and delivering anti-cancer drugs...
  7. pmc Mesenchymal stromal cells primed with paclitaxel provide a new approach for cancer therapy
    Augusto Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Milan, Italy
    PLoS ONE 6:e28321. 2011
    ....
  8. ncbi Mitochondrial function, apoptosis and cell cycle delay in the WEHI-3B leukaemia cell line and its variant Ciprofloxacin-resistant WEHI-3B/CPX
    A Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Milan, Italy
    Cell Prolif 40:568-79. 2007
    ..The susceptibility of two cell lines, WEHI-3B myelomonocytic leukaemia and its variant Ciprofloxacin-resistant WEHI-3B/CPX to undergo apoptosis induced by Ciprofloxacin was studied and compared...
  9. ncbi Microbiological risk assessment in stem cell manipulation
    Augusto Pessina
    Department of Public Health Microbiology Virology, University of Milan, Italy
    Crit Rev Microbiol 34:1-12. 2008
    ....
  10. doi Application of human CFU-Mk assay to predict potential thrombocytotoxicity of drugs
    A Pessina
    Department of Public Health Microbiology Virology, Faculty of Medicine, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Toxicol In Vitro 23:194-200. 2009
    ..When the C max is higher than IC90 and/or IC50, thrombocytopenia can occur due to direct toxicity of chemicals on CFU-Mk progenitors...
  11. doi Assessment of human herpesvirus-6 infection in mesenchymal stromal cells ex vivo expanded for clinical use
    A Pessina
    Department of Public Health Microbiology Virology, University of Milan, Italy
    Transpl Infect Dis 11:491-6. 2009
    ....
  12. ncbi Refinement and optimisation of the rat CFU-GM assay to incorporate the use of cryopreserved bone-marrow cells for in vitro toxicology applications
    Augusto Pessina
    Department of Public Health, Microbiology, Virology, University of Milan, Italy
    Altern Lab Anim 37:417-25. 2009
    ..This SOP dramatically reduces the number of rats used and increases the homogeneity of the data obtained...
  13. doi CD45+/CD133+ positive cells expanded from umbilical cord blood expressing PDX-1 and markers of pluripotency
    Augusto Pessina
    Department of Public Health, Microbiology and Virology, University of Milan, Milan, Italy
    Cell Biol Int 34:783-90. 2010
    ....
  14. ncbi Bcl-2 down modulation in WEHI-3B/CTRES cells resistant to Cholera Toxin (CT)-induced apoptosis
    Augusto Pessina
    Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Cell Res 16:306-12. 2006
    ....
  15. ncbi In vitro toxicity of clozapine, olanzapine, and quetiapine on granulocyte-macrophage progenitors (GM-CFU)
    A Pessina
    Institute of Microbiology, University of Milan, Italy
    Pharmacopsychiatry 39:20-2. 2006
    ....
  16. ncbi Hematotoxicity testing by cell clonogenic assay in drug development and preclinical trials
    Augusto Pessina
    Institute of Microbiology, University of Milan, Italy
    Curr Pharm Des 11:1055-65. 2005
    ....
  17. doi A mesenchymal stromal cell line resistant to paclitaxel that spontaneously differentiates into osteoblast-like cells
    Augusto Pessina
    Department of Public Health Microbiology Virology, University of Milan, Via Pascal 36, 20133, Milan, Italy
    Cell Biol Toxicol 27:169-80. 2011
    ..Taken together, our results indicated that SR-4987 line is a very interesting cell model useful to investigate both drug sensitivity resistance and physiopathological aspects related to mesenchymal cell function...
  18. ncbi In vitro sensitivity of human gastric cancer cells (HGC-27) to Helicobacter pylori cytotoxin
    A Pessina
    Institute of Microbiology, University of Milan, Italy
    Scand J Gastroenterol 38:1228-34. 2003
    ..The vacuolizing activity of this toxin is related to alteration of endo-lysosomic function and pore formation into plasmatic membrane...
  19. ncbi Pancreas developing markers expressed on human mononucleated umbilical cord blood cells
    A Pessina
    Institute of Microbiology, University of Milan, Italy
    Biochem Biophys Res Commun 323:315-22. 2004
    ..Our data demonstrate that UCB contains a cell population having a phenotype very similar to endocrine cell precursors in transition to beta cells...
  20. ncbi A methylcellulose microculture assay for the in vitro assessment of drug toxicity on granulocyte/macrophage progenitors (CFU-GM)
    Augusto Pessina
    Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Altern Lab Anim 32:17-23. 2004
    ....
  21. ncbi Prevalidation of a model for predicting acute neutropenia by colony forming unit granulocyte/macrophage (CFU-GM) assay
    A Pessina
    Institute of Microbiology, Via Pascal 36, 20133, Milan, Italy
    Toxicol In Vitro 15:729-40. 2001
    ..On the basis of these results, we proposed a formal Phase II validation study using the Test A SOP for 16-18 additional xenobiotics that represent the spectrum of haematotoxic potential...
  22. ncbi High sensitivity of human epidermal keratinocytes (HaCaT) to topoisomerase inhibitors
    A Pessina
    Institute of Microbiology, University of Milan, Italy
    Cell Prolif 34:243-52. 2001
    ....
  23. ncbi Role of SR-4987 stromal cells in the modulation of doxorubicin toxicity to in vitro granulocyte-macrophage progenitors (CFU-GM)
    A Pessina
    Cell Culture Laboratory, Institute of Medical Microbiology, University of Milan, Italy
    Life Sci 65:513-23. 1999
    ....
  24. ncbi Altered DNA-cleavage activity of topoisomerase II from WEHI-3B leukemia cells with specific resistance to ciprofloxacin
    A Pessina
    Institute of Microbiology, Faculty of Medicine, University of Milan, 20133 Milan, Italy
    Anticancer Drugs 12:441-51. 2001
    ..It could be consequent to a decreased binding affinity of CPX for the topoisomerase II--DNA complex or to a decreased affinity or specificity of topoisomerase II for its DNA cleavage sites...
  25. ncbi Application of the CFU-GM assay to predict acute drug-induced neutropenia: an international blind trial to validate a prediction model for the maximum tolerated dose (MTD) of myelosuppressive xenobiotics
    A Pessina
    Institute of Microbiology, Milan, Italy
    Toxicol Sci 75:355-67. 2003
    ....
  26. doi Human skin-derived fibroblasts used as a 'Trojan horse' for drug delivery
    V Coccè
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy
    Clin Exp Dermatol 41:417-24. 2016
    ..As human stromal dermal fibroblasts (hSDFs) represent an interesting alternative to hMSCs, being easy to isolate, they could be an ideal candidate for this kind of procedure...
  27. ncbi Adipose tissue-derived stromal cells primed in vitro with paclitaxel acquire anti-tumor activity
    A Bonomi
    Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy
    Int J Immunopathol Pharmacol 26:33-41. 2013
    ..For this reason, this source of stromal cells represents an important alternative to BM-MSCs in developing new tools for carrying and delivering anti-cancer drugs into tumor microenvironments...
  28. ncbi Secretion of basic fibroblast growth factor (FGF-2) by WEHI-3B myelomonocytic leukemia cells
    Augusto Pessina
    Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Growth Factors 20:121-9. 2002
    ....
  29. ncbi Selection of a WEHI-3B leukemia cell subclone resistant to inhibition by cholera toxin
    Augusto Pessina
    Institute of Microbiology, University of Milan, Italy
    Mol Cell Biochem 233:19-26. 2002
    ..Our study describes the first cell line resistant to CT originated from a susceptible parental strain and provides a new interesting cell model for studying the cAMP dependent mechanisms involved in cell growth regulation...
  30. ncbi In vitro tests for haematotoxicity: prediction of drug-induced myelosuppression by the CFU-GM assay
    Augusto Pessina
    Institute of Microbiology, University of Milan, Via Pascal 36, 20133 Milan, Italy
    Altern Lab Anim 30:75-9. 2002
    ....
  31. ncbi Outer membrane permeability of Serratia marcescens to meropenem and imipenem
    A Raimondi
    Institute of Medical Microbiology, University of Milan, Italy
    J Chemother 6:363-7. 1994
    ....
  32. ncbi Different biological conditions influencing bacterial adherence assay
    A Pessina
    Institute of Medical Microbiology, University of Milan, Italy
    J Chemother 7:8-11. 1995
    ..Our observations indicate that the different methods used make it impracticable to compare many data from the literature and suggest the need to search for more homogeneity in this type of assay...