Giuseppe Pelosi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Grading lung neuroendocrine tumors: Controversies in search of a solution
    Giuseppe Pelosi
    Department of Oncology and Hemato Oncology, Universita degli Studi di Milano, Milan, Italy
    Histol Histopathol 32:223-241. 2017
  2. doi request reprint Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian, 1, I 20133, Milan, Italy
    Virchows Arch 468:651-62. 2016
  3. doi request reprint Doing more with less: fluorescence in situ hybridization and gene sequencing assays can be reliably performed on archival stained tumor tissue sections
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via Giacomo Venezian, 1, 20133, Milano, Italy
    Virchows Arch 468:451-61. 2016
  4. doi request reprint Synergistic Activation upon MET and ALK Coamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy Department of Oncology and Hemato Oncology, Universita degli Studi, Milan, Italy Electronic address
    J Thorac Oncol 11:718-28. 2016
  5. doi request reprint What clinicians are asking pathologists when dealing with lung neuroendocrine neoplasms?
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian, 1, I 20133, Milan, Italy Department of Biomedical and Clinical Sciences Luigi Sacco, Universita degli Studi, Milan, Italy Electronic address
    Semin Diagn Pathol 32:469-79. 2015
  6. ncbi request reprint A modified vimentin histological score helps recognize pulmonary sarcomatoid carcinoma in small biopsy samples
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS National Cancer Institute, Milan, Italy
    Anticancer Res 32:1463-73. 2012
  7. doi request reprint Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS National Cancer Institute, Milan, Italy
    Lung Cancer 77:507-14. 2012
  8. doi request reprint ΔNp63 (p40) distribution inside lung cancer: a driver biomarker approach to tumor characterization
    Giuseppe Pelosi
    Dipartimento di Patologia Diagnostica e Laboratorio, Fondazione IRCCS Istituto Nazionale dei Tumori e Università degli Studi, Via G Venezian, 1, I 20133 Milan, Italy
    Int J Surg Pathol 21:229-39. 2013
  9. doi request reprint Unraveling tumor grading and genomic landscape in lung neuroendocrine tumors
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Endocr Pathol 25:151-64. 2014
  10. pmc Succinate dehydrogenase B subunit immunohistochemical expression predicts aggressiveness in well differentiated neuroendocrine tumors of the ileum
    Massimo Milione
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan I 20133, Italy
    Cancers (Basel) 4:808-20. 2012

Detail Information

Publications78

  1. doi request reprint Grading lung neuroendocrine tumors: Controversies in search of a solution
    Giuseppe Pelosi
    Department of Oncology and Hemato Oncology, Universita degli Studi di Milano, Milan, Italy
    Histol Histopathol 32:223-241. 2017
    ..In lung neuroendocrine tumors (NET), grading is tautologically included into the current 2015 WHO histologic classification. Little is known, however, about alternative grading systems in lung NET...
  2. doi request reprint Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian, 1, I 20133, Milan, Italy
    Virchows Arch 468:651-62. 2016
    ..This is consistent with diverse intra-tumor clonal evolution, which has potential implications for patient prognosis or development of secondary therapy resistance. ..
  3. doi request reprint Doing more with less: fluorescence in situ hybridization and gene sequencing assays can be reliably performed on archival stained tumor tissue sections
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via Giacomo Venezian, 1, 20133, Milano, Italy
    Virchows Arch 468:451-61. 2016
    ..0002). In conclusion, stained sections may be a valuable resource for FISH or sequencing analysis, but on cases expressing nuclear markers sequencing results need to be interpreted cautiously...
  4. doi request reprint Synergistic Activation upon MET and ALK Coamplification Sustains Targeted Therapy in Sarcomatoid Carcinoma, a Deadly Subtype of Lung Cancer
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan, Italy Department of Oncology and Hemato Oncology, Universita degli Studi, Milan, Italy Electronic address
    J Thorac Oncol 11:718-28. 2016
    ..Genetic alterations suitable for targeted therapy are poorly known issues in pulmonary sarcomatoid carcinoma (PSC), an uncommon and life-threatening family of non-small cell lung cancers...
  5. doi request reprint What clinicians are asking pathologists when dealing with lung neuroendocrine neoplasms?
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian, 1, I 20133, Milan, Italy Department of Biomedical and Clinical Sciences Luigi Sacco, Universita degli Studi, Milan, Italy Electronic address
    Semin Diagn Pathol 32:469-79. 2015
    ..Answers are still inconclusive, thus additional research is required to improve our understanding on lung NET. ..
  6. ncbi request reprint A modified vimentin histological score helps recognize pulmonary sarcomatoid carcinoma in small biopsy samples
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS National Cancer Institute, Milan, Italy
    Anticancer Res 32:1463-73. 2012
    ..As pulmonary sarcomatoid carcinomas (PSCs) are life-threatening tumors, an improvement in their recognition in small-sized tumor samples is clinically warranted...
  7. doi request reprint Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS National Cancer Institute, Milan, Italy
    Lung Cancer 77:507-14. 2012
    ..Genetic alterations for targeting therapy are largely unexplored issues in pulmonary sarcomatoid carcinoma (PSC), a life-threatening tumor subset...
  8. doi request reprint ΔNp63 (p40) distribution inside lung cancer: a driver biomarker approach to tumor characterization
    Giuseppe Pelosi
    Dipartimento di Patologia Diagnostica e Laboratorio, Fondazione IRCCS Istituto Nazionale dei Tumori e Università degli Studi, Via G Venezian, 1, I 20133 Milan, Italy
    Int J Surg Pathol 21:229-39. 2013
    ..The HS-guided assessment of p40 allowed an effective orientation among thoracic malignancies at the level of individual tumor patients thereby contributing to prospectively realize a driver, holistic approach to cancer characterization...
  9. doi request reprint Unraveling tumor grading and genomic landscape in lung neuroendocrine tumors
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Endocr Pathol 25:151-64. 2014
    ....
  10. pmc Succinate dehydrogenase B subunit immunohistochemical expression predicts aggressiveness in well differentiated neuroendocrine tumors of the ileum
    Massimo Milione
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan I 20133, Italy
    Cancers (Basel) 4:808-20. 2012
    ..7% in primary tumors. A correlation between SDHB expression loss, increased Ki-67 labeling index and biological aggressiveness was shown in advanced midgut neuroendocrine tumors, suggesting a role of tumor suppressor gene. ..
  11. ncbi request reprint Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Cancer 103:1154-64. 2005
    ..To the authors' knowledge, little is known regarding the role of E-cadherin/beta-catenin system dysregulation in pulmonary neuroendocrine tumors...
  12. doi request reprint Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    Virchows Arch 458:497-503. 2011
    ..This tumor had probably derived for clonal evolution of a p53-mutated common ancestor lesion...
  13. doi request reprint Lung cancer screening with low-dose computed tomography: a non-invasive diagnostic protocol for baseline lung nodules
    Giulia Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Lung Cancer 61:340-9. 2008
    ..We assessed the diagnostic utility of a non-invasive work-up protocol for nodules detected at baseline in volunteers enrolled in our single-centre screening trial, and followed for at least 1 year...
  14. ncbi request reprint Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung
    Giuseppe Pelosi
    Division of Pathology and Laboratory MedicineEuropean Institute of Oncology and National Cancer Institute, Milan, Italy
    Anticancer Res 30:4269-81. 2010
    ..Little is known about the dual role of RAS-association domain family 1 (RASSF1) gene at 3p21.3 in neuroendocrine tumors (NET) of the lung...
  15. ncbi request reprint Lack of prognostic implications of HER-2/neu abnormalities in 345 stage I non-small cell carcinomas (NSCLC) and 207 stage I-III neuroendocrine tumours (NET) of the lung
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Cancer 113:101-8. 2005
    ..Among neuroendocrine tumours, LCNEC show a slightly higher prevalence of either HER-2/neu gene amplification or protein overexpression...
  16. doi request reprint Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography
    Concetta De Cicco
    Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 86:1769-72. 2008
    ..Most are discovered on routine x-ray film and require further evaluation. Computed tomography (CT) is insufficient for a benign versus malignant diagnosis in about 30% of cases...
  17. ncbi request reprint A subset of high-grade pulmonary neuroendocrine carcinomas shows up-regulation of matrix metalloproteinase-7 associated with nuclear beta-catenin immunoreactivity, independent of EGFR and HER-2 gene amplification or expression
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Virchows Arch 447:969-77. 2005
    ..A minor subset of these tumors shows beta-catenin nuclear accumulation in association with increased expression of MMP-7, but not of cyclin D1, independent of EGFR and HER-2 gene amplification or expression...
  18. ncbi request reprint CD117 immunoreactivity in stage I adenocarcinoma and squamous cell carcinoma of the lung: relevance to prognosis in a subset of adenocarcinoma patients
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Mod Pathol 17:711-21. 2004
    ..Targeting the CD117 pathway could be a novel therapeutic strategy in a subset of pulmonary carcinomas...
  19. ncbi request reprint 3q26 Amplification and polysomy of chromosome 3 in squamous cell lesions of the lung: a fluorescence in situ hybridization study
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine and Cancer Genetic Unit, IFOM Foundation FIRC Institute of Molecular Oncology Foundation, Milan, Italy
    Clin Cancer Res 13:1995-2004. 2007
    ....
  20. doi request reprint Screening-detected lung cancers: is systematic nodal dissection always essential?
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 6:525-30. 2011
    ..To address whether systematic lymph node dissection is always necessary in early lung cancer, we identified factors predicting nodal involvement in a screening series and applied them to nonscreening-detected cancers...
  21. doi request reprint Immunhistochemistry by means of widely agreed-upon markers (cytokeratins 5/6 and 7, p63, thyroid transcription factor-1, and vimentin) on small biopsies of non-small cell lung cancer effectively parallels the corresponding profiling and eventual diagnoses
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 6:1039-49. 2011
    ..Little, however, is known about the likelihood of immunohistochemistry (IHC)-assessed small biopsies to effectively parallel profiling and, hence, eventual diagnoses of surgical specimens...
  22. doi request reprint ΔNp63 (p40) and thyroid transcription factor-1 immunoreactivity on small biopsies or cellblocks for typing non-small cell lung cancer: a novel two-hit, sparing-material approach
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS National Cancer Institute, Milan, Italy
    J Thorac Oncol 7:281-90. 2012
    ..As sparing material for molecular testing is mandatory, a minimalist immunohistochemistry (IHC)-based diagnostic approach is warranted by means of novel, reliable, and easy-to-assess biomarkers...
  23. ncbi request reprint K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Mod Pathol 17:538-46. 2004
    ....
  24. doi request reprint Randomized biomarker trial of anastrozole or low-dose tamoxifen or their combination in subjects with breast intraepithelial neoplasia
    Bernardo Bonanni
    Divisions of Cancer Prevention and Genetics, European Institute of Oncology, Milan, University of Milan School of Medicine, Milan, Italy
    Clin Cancer Res 15:7053-60. 2009
    ..The influence of CYP2D6 genotype on tamoxifen effects was also determined...
  25. ncbi request reprint Detecting cell-free circulating hTERT mRNA in the plasma may identify a subset of nonsmall cell lung cancer patients
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Virchows Arch 448:7-15. 2006
    ..It can be added to the panel of multiple genetic tracers to detect lung cancer in the plasma of patients, although, per se, it is not specific for this tumor...
  26. ncbi request reprint Randomized dose-ranging trial of tamoxifen at low doses in hormone replacement therapy users
    Andrea Decensi
    Division of Chemoprevention, European Institute of Oncology, Milan, Italy
    J Clin Oncol 25:4201-9. 2007
    ..We assessed the optimal biologic dose and schedule of tamoxifen in HRT users using surrogate end point biomarkers and menopausal symptoms...
  27. ncbi request reprint Prognostic role of lymph node involvement in lung metastasectomy
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 133:967-72. 2007
    ..We assessed the prognostic value of lymph node status in lung metastasectomy and the prevalence of unexpected mediastinal lymph node involvement after lymph node sampling or dissection...
  28. ncbi request reprint Adjuvant surgery after carboplatin and VP16 in resectable small cell lung cancer
    Giulia Veronesi
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 2:131-4. 2007
    ....
  29. doi request reprint Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    Lung Cancer 62:202-14. 2008
    ..Repeat cancers are potentially aggressive tumors. K-ras mutation analysis supports the impression that multifocal tumors at baseline are separate synchronous primaries...
  30. doi request reprint Difficulties encountered managing nodules detected during a computed tomography lung cancer screening program
    Giulia Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 136:611-7. 2008
    ..We evaluated the pitfalls, difficulties, and sources of mistakes in the management of lung nodules detected in volunteers in the Cosmos single-center screening trial...
  31. ncbi request reprint Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Institute of European Oncology and University of Milan School of Medicine, Italy
    Am J Surg Pathol 27:1203-15. 2003
    ....
  32. ncbi request reprint Detecting lung cancer in plasma with the use of multiple genetic markers
    Francesca Andriani
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 108:91-6. 2004
    ..2%) of stage I patients whose tumors had an alteration. These results provide the proof of principle that plasma DNA alterations are tumor-specific in most cases and support blood testing as a noninvasive strategy for early detection...
  33. doi request reprint Genetic alterations in combined neuroendocrine neoplasms of the lung
    Tiziana D'Adda
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Parma, Italy
    Mod Pathol 21:414-22. 2008
    ..The genetic differences observed provide the basis for the divergent differentiation and parallel the morphological differences in the two components of these combined neuroendocrine neoplasms...
  34. doi request reprint Screening with Low-Dose Computed Tomography Does Not Improve Survival of Small Cell Lung Cancer
    Mario Silva
    Section of Radiology, Department of Surgical Sciences, University Hospital of Parma, Parma, Italy Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Electronic address
    J Thorac Oncol 11:187-93. 2016
    ..The purpose of this study was to describe the outcome of SCLC in lung cancer screening trials and compare the frequency of SCLC in our cohort with that in the major lung cancer screening trials...
  35. ncbi request reprint Computer-assisted image analysis of breast fine needle aspiration in a randomized chemoprevention trial of fenretinide vs. placebo in HRT users
    Davide Serrano
    Division of Chemoprevention, European Institute of Oncology, Milan, Italy
    Breast 17:91-7. 2008
    ..Digital nuclear morphometric analysis can capture subtle differences along neoplastic progression. Studies showed different profiles from normal to cancer lesions. Our goal is to utilize this method as biomarker in chemoprevention trials...
  36. pmc Alterations of the Notch pathway in lung cancer
    Britta Westhoff
    IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
    Proc Natl Acad Sci U S A 106:22293-8. 2009
    ..Our results show that the deregulation of the Notch pathway is a relatively frequent event in NSCLCs and suggest that it might represent a possible target for molecular therapies in these tumors...
  37. doi request reprint A critical appraisal of the adjuvant chemotherapy guidelines for patients with completely resected T3N0 non-small-cell lung cancer
    Tommaso De Pas
    New Drugs Development and Clinical Pharmacology Unit, Department of Medicine, European Institute of Oncology, Milan, Italy
    Acta Oncol 49:480-4. 2010
    ..However, these two tumor subgroups should be considered as different entities. While the efficacy of adjuvant chemotherapy has been established in patients with T1-2N1 NSCLC, its benefit in patients with T3N0 tumor remains questionable...
  38. ncbi request reprint Prognostic implications of neuroendocrine differentiation and hormone production in patients with Stage I nonsmall cell lung carcinoma
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Cancer 97:2487-97. 2003
    ..However, little is known regarding the prevalence and clinical implications of NE differentiation in patients with Stage I NSCLC...
  39. ncbi request reprint Independent value of fascin immunoreactivity for predicting lymph node metastases in typical and atypical pulmonary carcinoids
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G Ripamonti, 435, I 20141 Milan, Italy
    Lung Cancer 42:203-13. 2003
    ..Targeting the fascin pathway could be a novel therapeutic strategy of pulmonary carcinoids...
  40. ncbi request reprint Malignancy-associated X chromosome allelic losses in foregut endocrine neoplasms: further evidence from lung tumors
    Tiziana D'Adda
    Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, University of Parma, Parma, Italy
    Mod Pathol 18:795-805. 2005
    ....
  41. doi request reprint Dissecting Pulmonary Large-Cell Carcinoma by Targeted Next Generation Sequencing of Several Cancer Genes Pushes Genotypic-Phenotypic Correlations to Emerge
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Department of Biomedical and Clinical Sciences Luigi Sacco, Universita degli Studi, Milan, Italy Department of Oncology, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy Pathologic Anatomy, Azienda Ospedaliero Universitaria, Policlinico di Modena, Modena, Italy Department of Oncology and Advanced Technology, Operative Unit of Pathologic Anatomy, IRCCS Azienda Arcispedale S Maria Nuova, Reggio Emilia, Italy Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy Department of Medical Oncology, and Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    J Thorac Oncol 10:1560-9. 2015
    ..Little is known about genotypic and phenotypic correlations in undifferentiated large-cell carcinoma (LCC) of the lung...
  42. doi request reprint In vitro and in silico studies of MDM2/MDMX isoforms predict Nutlin-3A sensitivity in well/de-differentiated liposarcomas
    Fabio Bozzi
    Laboratory of Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy
    Lab Invest 93:1232-40. 2013
    ..However, our findings predict heterogeneous responses depending on the relative expression of mdm2, mdm2-b, mdmx, and mdmx-s transcripts and proteins. ..
  43. ncbi request reprint Extended pneumonectomy with partial resection of the left atrium, without cardiopulmonary bypass, for lung cancer
    Lorenzo Spaggiari
    Department of Thoracic Surgery European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 79:234-40. 2005
    ..The present study analyzed a single center's experience with this extended surgery, highlighting the surgery's technical aspects, postoperative outcomes, and oncologic results...
  44. ncbi request reprint A primary pure yolk sac tumor of the lung exhibiting CDX-2 immunoreactivity and increased serum levels of alkaline phosphatase intestinal isoenzyme
    Giuseppe Pelosi
    Division of Pathology, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 14:247-51. 2006
    ..The pathologist should be aware of yolk sac tumor arising in the lung and that alkaline phosphatase intestinal isoform could become an additional serum marker for such a tumor...
  45. doi request reprint Localised thoracic sarcomas: outcome improvement over time at a single institution
    Leonardo Duranti
    Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, Italy
    Eur J Cancer 49:2689-97. 2013
    ..To assess changes in survival over time in patients affected by thoracic soft tissue sarcomas treated at a single institution...
  46. ncbi request reprint Primary thoracic synovial sarcoma: factors affecting long-term survival
    Domenico Galetta
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 134:808-9. 2007
  47. doi request reprint Ki-67 labeling index of neuroendocrine tumors of the lung has a high level of correspondence between biopsy samples and surgical specimens when strict counting guidelines are applied
    Alessandra Fabbri
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Virchows Arch . 2017
    ..Our results are important for clinical management of patients with metastases of a lung NET...
  48. doi request reprint Conversion to stem-cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells
    Francesca Andriani
    Tumor Genomics Unit, Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Mol Oncol 10:253-71. 2016
    ..These findings have implications for current endeavors to identify tumors with increased plasticity. ..
  49. ncbi request reprint p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas?
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    J Pathol 198:100-9. 2002
    ..Although p63 is likely to be involved in the development of pulmonary squamous cell carcinoma, it does not carry any prognostic implication for NSCLC patients...
  50. doi request reprint Brief report: activity of imatinib in a patient with platelet-derived-growth-factor receptor positive malignant solitary fibrous tumor of the pleura
    Tommaso De Pas
    New Drugs Development Unit, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 3:938-41. 2008
    ..Treatment with imatinib should be considered for patients with recurrent or unresectable MSFTs with PDGFR expression...
  51. ncbi request reprint Images in pathology: micronodular epithelial hyperplasia in ectopic thymus
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 14:73-4. 2006
  52. ncbi request reprint Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Am J Surg Pathol 30:375-87. 2006
    ....
  53. ncbi request reprint Role of positron emission tomography scanning in the management of lung nodules detected at baseline computed tomography screening
    Giulia Veronesi
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Ann Thorac Surg 84:959-65; discussion 965-6. 2007
    ..We present results using positron tomography scanning (CT-PET) to evaluate LD-CT-detected lung nodules during the first year of the Continuing Observation of Smoking Subjects (COSMOS) early detection trial for lung cancer...
  54. ncbi request reprint Decreased immunoreactivity of CD99 is an independent predictor of regional lymph node metastases in pulmonary carcinoid tumors
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 1:468-77. 2006
    ..Few data are available on the prevalence and clinicopathological meaning of CD99, the transmembrane product of the pseudoautosomal MIC2 gene, in pulmonary neuroendocrine tumors...
  55. doi request reprint Stopping Smoking Reduces Mortality in Low-Dose Computed Tomography Screening Participants
    Ugo Pastorino
    Thoracic Surgery Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milan, Italy Electronic address
    J Thorac Oncol 11:693-9. 2016
    ..In the present study, we tested the effect of stopping smoking on the overall mortality of participants undergoing repeated LDCT screening for many years...
  56. doi request reprint Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation
    Massimo Milione
    Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Histopathology 64:1014-26. 2014
    ..EWSR1-FEV translocation is exceedingly rare in Ewing sarcoma, as FEV expression is restricted to prostate, brain and serotonin neuroendocrine cells (NE) and related tumours...
  57. ncbi request reprint Absence of epidermal growth factor receptor gene mutations in patients with hormone refractory prostate cancer not responding to gefitinib
    Giuseppe Curigliano
    Division of Medical Oncology, Clinical Pharmacology and New Drugs Development Unit, European Institute of Oncology and University of Milan School of Medicine, Milano, Italy
    Prostate 67:603-4. 2007
    ..To our knowledge no data have been reported on EGFR gene mutations in hormone refractory prostate cancer (HRPC)...
  58. ncbi request reprint Effects of raloxifene on sex steroid hormones and C-telopeptide in postmenopausal women with primary breast cancer
    Harriet Johansson
    Division of Chemoprevention, European Institute of Oncology, Milan, Italy
    Breast Cancer Res Treat 98:167-72. 2006
    ..024) and E2 (p=0.01), and positively with DHEA-S (p=0.016) and CTX (p=0.040). Our results provide evidence for an early endocrine effect of raloxifene which further suggests a favorable impact on breast cancer prevention...
  59. doi request reprint Optimizing pemetrexed-gemcitabine combination in patients with advanced non-small cell lung cancer: a pharmacogenetic approach
    Tommaso M De Pas
    Unit of Medical Oncology of Respiratory Tract and Sarcomas, New Drugs Development Division, European Institute of Oncology, Milan, Italy
    J Thorac Oncol 6:768-73. 2011
    ..A pharmacogenetic approach was adopted to evaluate hENT1 and dCK expressions in humans and to identify the potential best time interval to administer gemcitabine after pemetrexed in patients with advanced NSCLC...
  60. ncbi request reprint Quantification of free circulating DNA as a diagnostic marker in lung cancer
    Gabriella Sozzi
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 21:3902-8. 2003
    ..This study was designed to assess the sensitivity and specificity of a quantitative molecular assay of circulating DNA to identify patients with lung cancer and monitor their disease...
  61. ncbi request reprint Superior vena cava replacement for lung cancer using a heterologous (bovine) prosthesis: preliminary results
    Lorenzo Spaggiari
    Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    J Thorac Cardiovasc Surg 131:490-1. 2006
  62. ncbi request reprint Preliminary results on safety and activity of a randomized, double-blind, 2 x 2 trial of low-dose tamoxifen and fenretinide for breast cancer prevention in premenopausal women
    Aliana Guerrieri-Gonzaga
    Division of Chemoprevention, European Institute of Oncology, Milan, Italy
    J Clin Oncol 24:129-35. 2006
    ....
  63. ncbi request reprint Images in pathology. Benign hyperplastic mesothelial cells in lymph node
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 15:297-9. 2007
  64. ncbi request reprint Video-assisted management of malignant pleural effusion in breast carcinoma
    Roberto Gasparri
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Cancer 106:271-6. 2006
    ..The results of video-thoracoscopic approach (VATS) chemical pleurodesis was analyzed in patients with recurrent pleural effusion from breast carcinoma...
  65. ncbi request reprint Typical and atypical pulmonary carcinoid tumor overdiagnosed as small-cell carcinoma on biopsy specimens: a major pitfall in the management of lung cancer patients
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Am J Surg Pathol 29:179-87. 2005
    ....
  66. doi request reprint Invited commentary
    Giuseppe Pelosi
    Istituto Europeo di Oncologia ed Università degli Studi di Milano, Via G Ripamonti, 435, Milan, Italy
    Ann Thorac Surg 86:1090-1. 2008
  67. doi request reprint Pulmonary resections: cytostructural effects of different-wavelength lasers versus electrocautery
    Paolo Scanagatta
    Fondazione IRCCS National Cancer Institute, Milan, Italy
    Tumori 98:90-3. 2012
    ..The aim of the present study was to evaluate the parenchymal damage caused by different surgical instruments: a new generation electrosurgical scalpel and two different-wavelength lasers...
  68. doi request reprint Large cell carcinoma of the lung: a tumor in search of an author. A clinically oriented critical reappraisal
    Giuseppe Pelosi
    Department of Pathology and Laboratory Medicine, Istituto Nazionale Tumori, Milan, Italy Department of Biomedical and Clinical Sciences Luigi Sacco, Universita degli Studi di Milano, Milan, Italy
    Lung Cancer 87:226-31. 2015
    ..In conclusion, most LCC/NSCLC-NOS may be eventually re-classified and addressed by exploiting IHC and/or molecular testing to satisfy the criteria of precision medicine (the right drug, to the right patient, at the right time). ..
  69. doi request reprint Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial
    Ugo Pastorino
    Unit of Thoracic Surgery, Foundation IRCCS National Cancer Institute of Milan, Via Venezian 1, Milan, Italy
    Eur J Cancer Prev 21:308-15. 2012
    ..There was no evidence of a protective effect of annual or biennial LDCT screening. Furthermore, a meta-analysis of the four published randomized trials showed similar overall mortality in the LDCT arms compared with the control arm...
  70. ncbi request reprint Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results
    Ugo Pastorino
    Division of Thoracic Surgery, Istituto Nazionale Tumori, Milan, Italy
    Lancet 362:593-7. 2003
    ..We investigated the efficacy of repeated yearly spiral CT and selective use of positron emission tomography (PET) in a large cohort of high-risk volunteers...
  71. doi request reprint The classification of lung carcinoma: time to change the morphology-based approach?
    Giuseppe Pelosi
    Divisione di Anatomia Patologica e Medicina di Laboratorio, European Institute of Oncology, Milan, Italy
    Int J Surg Pathol 18:161-72. 2010
    ....
  72. ncbi request reprint Treatment of pulmonary metastases from primary intraosseous odontogenic carcinoma
    Domenico Galetta
    Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy
    Lancet Oncol 7:272-3. 2006
  73. doi request reprint Osteopontin, E-cadherin, and β-catenin expression as prognostic biomarkers in patients with radically resected gastric cancer
    Maria Di Bartolomeo
    Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133, Milan, Italy
    Gastric Cancer 19:412-20. 2016
    ..Our results suggest that osteopontin overexpression is a valuable independent predictor of tumor recurrence and survival in patients with radically resected gastric cancer...
  74. doi request reprint Does immunohistochemistry affect response to therapy and survival of inoperable non-small cell lung carcinoma patients? A survey of 145 stage III-IV consecutive cases
    Giuseppe Pelosi
    1Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Int J Surg Pathol 22:136-48. 2014
    ..The terminology of "NSCLC-NOS, favor by IHC" is appropriate to alert clinicians toward more aggressive tumors. ..
  75. pmc FOLFOX-4 chemotherapy for patients with unresectable or relapsed peritoneal pseudomyxoma
    Filippo Pietrantonio
    Medical Oncology Department, Surgery Department, Pathology and Molecular Biology Department, Scientific Directorate, and Clinical Nutrition Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Oncologist 19:845-50. 2014
    ..The aim of our study was to assess the activity of chemotherapy with 5-fluorouracil and oxaliplatin (FOLFOX-4 regimen) in terms of response rate in this subset of patients...
  76. doi request reprint Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib
    Elena Conca
    Laboratory of Molecular Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Via Venezian 1, 20133 Milan, Italy
    Mol Oncol 7:756-62. 2013
    ....
  77. doi request reprint Intravascular papillary endothelial hyperplasia of the renal vein
    Giuseppe Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Milan, Italy
    Int J Surg Pathol 19:518-20. 2011
    ....
  78. pmc A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer
    Fabrizio Bianchi
    IFOM, the FIRC Institute for Molecular Oncology Foundation, at the IFOM IEO Campus, Milan, Italy
    EMBO Mol Med 3:495-503. 2011
    ..Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC...