Lorella Pasquinucci

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. doi request reprint The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:66-70. 2012
  2. ncbi request reprint New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands
    L Pasquinucci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Pharmazie 62:813-24. 2007
  3. doi request reprint Evaluation of N-substitution in 6,7-benzomorphan compounds
    Lorella Pasquinucci
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 18:4975-82. 2010
  4. doi request reprint Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:957-61. 2012
  5. doi request reprint The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Neuropharmacology 71:70-82. 2013
  6. doi request reprint Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties
    Agostino Marrazzo
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    J Med Chem 54:3669-73. 2011
  7. doi request reprint Evaluation of N-substituent structural variations in opioid receptor profile of LP1
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 24:2832-42. 2016
  8. doi request reprint The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation
    Carmela Parenti
    Pharmacology and Toxicology Section, Department of Drug Sciences, University of Catania, 95125, Catania, Italy
    Inflamm Res 63:231-7. 2014
  9. ncbi request reprint Multitarget opioid/non-opioid ligands in pain treatment: new players in an old game II
    Rita Turnaturi
    Department of Drug Sciences Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Curr Med Chem . 2016
  10. doi request reprint Multitarget opioid ligands in pain relief: New players in an old game
    Rita Turnaturi
    Department of Drug Sciences Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy Electronic address
    Eur J Med Chem 108:211-28. 2016

Collaborators

Detail Information

Publications17

  1. doi request reprint The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:66-70. 2012
    ..The aim of this work was to evaluate and compare the induction of tolerance to antinociceptive effects from treatment with LP1 and morphine...
  2. ncbi request reprint New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands
    L Pasquinucci
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Pharmazie 62:813-24. 2007
    ..Evaluation of docking simulations of compounds 9 and 28 into the KOP and MOP receptor displayed selective ligand interactions with the important amino acid residues Tyr320 (TMVII) and Trp318 (TMVII), respectively...
  3. doi request reprint Evaluation of N-substitution in 6,7-benzomorphan compounds
    Lorella Pasquinucci
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 18:4975-82. 2010
    ..LP1, possessing a mu/delta agonist profile, could represent a lead in further developing benzomorphan-based ligands with potent in vivo analgesic activity and a reduced tendency to induce side effects...
  4. doi request reprint Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:957-61. 2012
    ..The aim of this work was to determine whether the antinociceptive effect produced by LP1 was central or peripheral and to assess which opioid receptor subtypes are involved in its effects...
  5. doi request reprint The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Neuropharmacology 71:70-82. 2013
    ..Our studies seem to support that multitarget ligand approach should be useful for persistent pain conditions in which mechanical allodynia and thermal hyperalgesia are significant components of the nociceptive response...
  6. doi request reprint Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties
    Agostino Marrazzo
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    J Med Chem 54:3669-73. 2011
    ..The σ(2) ligand (-)-9 displayed agonist properties in an in vitro isolated organ bath assay and antiproliferative effects on LNCaP and PC3 prostate cancer cell lines...
  7. doi request reprint Evaluation of N-substituent structural variations in opioid receptor profile of LP1
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 24:2832-42. 2016
    ..Therefore, compound 9 could represent a potential lead to further develop antagonists as valid therapeutic agents and useful pharmacological tools to study opioid receptor function. ..
  8. doi request reprint The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation
    Carmela Parenti
    Pharmacology and Toxicology Section, Department of Drug Sciences, University of Catania, 95125, Catania, Italy
    Inflamm Res 63:231-7. 2014
    ..Here, we investigated the effect of σ1 blockade in an inflammatory pain model...
  9. ncbi request reprint Multitarget opioid/non-opioid ligands in pain treatment: new players in an old game II
    Rita Turnaturi
    Department of Drug Sciences Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Curr Med Chem . 2016
    ..Here, we deal with multitarget ligands with opioid-non opioid mechanism of action as potential drug candidates for the management of different pain states...
  10. doi request reprint Multitarget opioid ligands in pain relief: New players in an old game
    Rita Turnaturi
    Department of Drug Sciences Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy Electronic address
    Eur J Med Chem 108:211-28. 2016
    ..Moreover, the potential of these compounds, both as analgesic drugs and pharmacological tools to explore heteromer receptors, has been stressed. ..
  11. doi request reprint Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells
    Agostino Marrazzo
    Department of Pharmaceutical Sciences, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Eur J Med Chem 46:433-8. 2011
    ..MRJF4 was also used in combination with σ(1) agonist (+)-pentazocine and σ(2) antagonist AC927 in order to evaluate the role of σ receptor subtypes in prostate cancer cell death...
  12. ncbi request reprint Specific kappa opioid receptor agonists
    G Ronsisvalle
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Farmaco 56:121-5. 2001
    ..The representative ligands provide insights to binding modes of benzomorphan derivatives to the kappa opioid receptor...
  13. ncbi request reprint Nonpeptide analogues of dynorphin A(1-8): design, synthesis, and pharmacological evaluation of kappa-selective agonists
    G Ronsisvalle
    Department of Pharmaceutical Sciences, University of Catania, Viale Andrea Doria, 6 Città Universitaria, 95125 Catania, Italy
    J Med Chem 43:2992-3004. 2000
    ..88 and 1.1 mg/kg, respectively), fully prevented by nor-BNI. Thus, these novel analogues open an exciting avenue for the design of peptidomimetics of dynorphin A(1-8)...
  14. ncbi request reprint Substituted 1-phenyl-2-cyclopropylmethylamines with high affinity and selectivity for sigma sites
    G Ronsisvalle
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Bioorg Med Chem 8:1503-13. 2000
    ..Moreover, modifications of carboxyl groups provided compounds with the highest affinities in the series. In particular, compound 25 with reverse-type ester showed a Ki of 0.6 and 4.05 nM for sigma1 and sigma2 binding sites, respectively...
  15. doi request reprint New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation
    Emanuela Arena
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 24:3149-56. 2016
    ..In particular, our data suggest that new very selective compounds 7 and 12 could be promising tools to investigate the disorders in which σ1 receptor dysfunction and oxidative stress are contemporarily involved. ..
  16. doi request reprint An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain
    Simone Ronsisvalle
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy Electronic address
    Bioorg Med Chem 24:5280-5290. 2016
    ..Molecular modeling studies, conducted on 5 and on several reference compounds, allowed us to propose possible residues in the MOR ligand binding domain essential for their interactions with 'orthosteric' and 'allosteric' binding sites...
  17. ncbi request reprint Synthesis and pharmacological evaluation of potent and enantioselective sigma 1, and sigma 2 ligands
    A Marrazzo
    Department of Pharmaceutical Sciences, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
    Farmaco 56:181-9. 2001
    ..In fact, the (-)-10 enantiomer showed a preference for sigma 1 whereas (+)-10 showed a preference for sigma 2...