Leonardo Pantoni

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. doi request reprint Cognitive decline and dementia related to cerebrovascular diseases: some evidence and concepts
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Cerebrovasc Dis 27:191-6. 2009
  2. doi request reprint Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3-negative patients
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 74:57-63. 2010
  3. doi request reprint Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Lancet Neurol 9:689-701. 2010
  4. doi request reprint Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    J Neurol 260:1014-21. 2013
  5. ncbi request reprint Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
  6. ncbi request reprint Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, Hopital Lariboisiere, Paris, France
    Cerebrovasc Dis 21:315-22. 2006
  7. ncbi request reprint Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
  8. doi request reprint First report of a pathogenic mutation on exon 24 of the NOTCH3 gene in a CADASIL family
    Raffaella Valenti
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    J Neurol 258:1632-6. 2011
  9. pmc Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
    BMJ 339:b2477. 2009
  10. doi request reprint Cerebral hemorrhages in CADASIL: report of four cases and a brief review
    Valentina Rinnoci
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    J Neurol Sci 330:45-51. 2013

Collaborators

Detail Information

Publications47

  1. doi request reprint Cognitive decline and dementia related to cerebrovascular diseases: some evidence and concepts
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Cerebrovasc Dis 27:191-6. 2009
    ..Despite impressive epidemiological data, the actual burden of CVDs in terms of cognitive decline is still incompletely appreciated by physicians and health regulators...
  2. doi request reprint Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3-negative patients
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 74:57-63. 2010
    ..To report the characteristics of patients suspected to have cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) but in whom no NOTCH3 gene pathogenic mutation was found...
  3. doi request reprint Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Lancet Neurol 9:689-701. 2010
    ..Small vessel disease should be a main target for preventive and treatment strategies, but all types of presentation and complications should be taken into account...
  4. doi request reprint Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    J Neurol 260:1014-21. 2013
    ..In our cohort of non-disabled elders, severe WMC were associated with the presence and the occurrence of neurological signs, independently of other vascular brain lesions, confirming that these lesions have clinical relevance...
  5. ncbi request reprint Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population...
  6. ncbi request reprint Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, Hopital Lariboisiere, Paris, France
    Cerebrovasc Dis 21:315-22. 2006
    ..We sought whether such a trend existed in the association of vascular risk factors or comorbidities with the severity of ARWMC aiming particularly at further elucidating the relative roles of hypertension and stroke in this regard...
  7. ncbi request reprint Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    ..To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients...
  8. doi request reprint First report of a pathogenic mutation on exon 24 of the NOTCH3 gene in a CADASIL family
    Raffaella Valenti
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    J Neurol 258:1632-6. 2011
    ..This report underlines that when CADASIL is suspected the genetic analysis should be performed on all the NOTCH3 exons coding for EGF-like repeats including exon 24 and confirms that CADASIL may have heterogeneous phenotypes...
  9. pmc Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
    BMJ 339:b2477. 2009
    ..To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes...
  10. doi request reprint Cerebral hemorrhages in CADASIL: report of four cases and a brief review
    Valentina Rinnoci
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    J Neurol Sci 330:45-51. 2013
    ..Strokes are typically ischemic, while hemorrhagic events have been only sporadically described. However, cerebral microbleeds have been found in 31-69% of CADASIL patients...
  11. doi request reprint The VAS-COG clinic: an out-patient service for patients with cognitive and behavioral consequences of cerebrovascular diseases
    Laura Ciolli
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    Neurol Sci 33:1277-83. 2012
    ..The VAS-COG clinic may represent a model in this regard and might be important for improving the care of patients and offering counseling to their families. The efficacy of this service needs, however, to be proved by successive work...
  12. doi request reprint Urinary complaints in nondisabled elderly people with age-related white matter changes: the Leukoaraiosis And DISability (LADIS) Study
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 56:1638-43. 2008
    ..To investigate, in a cohort of nondisabled elderly people, the association between urinary complaints and severity of age-related white matter changes (ARWMC)...
  13. doi request reprint White matter microstructural damage in small vessel disease is associated with Montreal cognitive assessment but not with mini mental state examination performances: vascular mild cognitive impairment Tuscany study
    Marco Pasi
    From the Department of NEUROFARBA, Neuroscience Section, University of Florence, Italy M P, E S, A P, L C, A D B, S M, S N, F P, R V, D I Mario Serio Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy A G, M M Medical Physics Section, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Italy N T Department of Electrical, Electronic, and Information Engineering Guglielmo Marconi, University of Bologna, Cesena, Italy S D and Stroke Unit and Neurology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy L P
    Stroke 46:262-4. 2015
    ..We investigated if diffusion tensor imaging-derived indices are more strongly associated with performances on MoCA or on the widely used mini mental state examination in patients with mild cognitive impairment and small vessel disease...
  14. ncbi request reprint A pathogenic mutation on exon 21 of the NOTCH3 gene causing CADASIL in an octogenarian paucisymptomatic patient
    Francesca Pescini
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Neurol Sci 267:170-3. 2008
    ..The newly reported mutation might sustain a milder expressivity of the disease...
  15. doi request reprint Familial cerebral cavernous malformation: report of a further Italian family
    Serena Nannucci
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Neurol Sci 30:143-7. 2009
    ..This report underlines that a familial form of CCM could be suspected when a patient presents with multiple CCMs; neurologists and neurosurgeons should be aware that genetic testing for these forms is available...
  16. doi request reprint The Florence VAS-COG clinic: a model for the care of patients with cognitive and behavioral disturbances consequent to cerebrovascular diseases
    Anna Poggesi
    NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy
    J Alzheimers Dis 42:S453-61. 2014
    ..In this paper, we report on the general organization of such a service (the Florence VAS-COG Clinic) after 9 years of activity, updating a previous work related to the first 5 years...
  17. doi request reprint Neurological abnormalities predict disability: the LADIS (Leukoaraiosis And DISability) study
    Anna Poggesi
    Neuroscience Section, NEUROFARBA Department, University of Florence, Florence, Italy
    J Neurol 261:1160-9. 2014
    ..Systematically checking for neurological examination abnormalities in older patients may be cost-effective in identifying those at risk of functional decline...
  18. doi request reprint Predictive value of MoCA in the acute phase of stroke on the diagnosis of mid-term cognitive impairment
    Emilia Salvadori
    NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy
    J Neurol 260:2220-7. 2013
    ..3 % negative predictive value. In a sample of mild stroke patients, MoCA seems to be a good predictor of mid-term PSCI, making it a possible candidate for a brief cognitive screening in the acute stroke setting...
  19. doi request reprint Facial affect recognition in CADASIL patients
    Raffaella Valenti
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Clin Neuropsychol 28:65-71. 2013
    ..This effect was not mediated by depression, cognitive impairment, and MMSE score. Facial affect recognition is reduced in the CADASIL patients and this impairment might represent an early manifestation of the disease...
  20. doi request reprint The Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Scale: a screening tool to select patients for NOTCH3 gene analysis
    Francesca Pescini
    Department of Neurological and Psychiatric Sciences, University of Florence, and Department of Radiology, Neuroradiology Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy
    Stroke 43:2871-6. 2012
    ..We aimed at developing the CADASIL scale, a screening tool to be applied in the clinical setting...
  21. ncbi request reprint The relation between white-matter lesions and cognition
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Curr Opin Neurol 20:390-7. 2007
    ..To summarize recent findings and developments in the field of the relation between white-matter lesions and cognition...
  22. pmc Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience
    Ida Donnini
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, Florence, Italy
    J Headache Pain 13:299-302. 2012
    ..Based on these data, a randomized controlled trial seems worthy to be carried out to test the efficacy and safety of this drug...
  23. doi request reprint Factors predicting the Montreal cognitive assessment (MoCA) applicability and performances in a stroke unit
    Marco Pasi
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    J Neurol 260:1518-26. 2013
    ..MoCA seems to reveal some degree of cognitive deficit even in patients with mild stroke...
  24. doi request reprint Bone marrow-derived progenitor cells in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Francesca Pescini
    Department of Neurological and Psychiatric Sciences, Thrombosis Center, University of Florence, Florence, Italy
    Stroke 41:218-23. 2010
    ..No data are available about these cells in CADASIL. Our objective in this study was to evaluate endothelial progenitor cells and CPCs role in CADASIL...
  25. ncbi request reprint Postmortem examination of vascular lesions in cognitive impairment: a survey among neuropathological services
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 37:1005-9. 2006
    ..We aimed at surveying the postmortem neuropathological procedures used in different centers in examining brain lesions of presumable or possible vascular origin in cognitively impaired patients...
  26. ncbi request reprint Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neuroepidemiology 24:51-62. 2005
    ..The study results may also help to standardize, on an international basis, tools and criteria to identify early stages of disability...
  27. doi request reprint Post-stroke dementia and cognitive impairment
    Marco Pasi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Front Neurol Neurosci 30:65-9. 2012
    ..The detection of cognitive impairment in the acute phase of stroke can offer valid information to the clinician on whether to set an early cognitive rehabilitation and to plan a more focused follow-up...
  28. pmc Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes: A Study of Clinical, Neuroimaging, and Biological Markers-The VMCI-Tuscany Study: Rationale, Design, and Methodology
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    Int J Alzheimers Dis 2012:608013. 2012
    ..This paper summarizes the main aims and methodological aspects of this multicenter, ongoing, observational study enrolling patients affected by VMCI with SVD...
  29. ncbi request reprint [New evidence in the field of white matter changes]
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    No To Shinkei 58:298-302. 2006
  30. doi request reprint Development and psychometric properties of a neuropsychological battery for mild cognitive impairment with small vessel disease: the VMCI-Tuscany Study
    Emilia Salvadori
    NEUROFARBA Department, Neuroscience Section, University of Florence, Tuscany, Italy
    J Alzheimers Dis 43:1313-23. 2015
    ..Vascular cognitive impairment may have a selective neuropsychological profile. We developed a battery for assessing mild cognitive impairment (MCI) in patients with small vessel disease (SVD), its applicability, and psychometric properties...
  31. doi request reprint The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study
    Mario Mascalchi
    Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Hum Brain Mapp 35:819-30. 2014
    ....
  32. ncbi request reprint Pathophysiology of cerebral small vessels in vascular cognitive impairment
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Int Psychogeriatr 15:59-65. 2003
    ..Modern magnetic resonance techniques such as diffusion, perfusion, and spectroscopy may allow the in vivo study of the pathophysiology of small-vessel diseases and the consequences on the brain parenchyma...
  33. ncbi request reprint Vascular mild cognitive impairment: concept, definition, and directions for future studies
    Arturo Consoli
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Aging Clin Exp Res 24:113-6. 2012
    ..Longitudinal studies on the natural history of vascular MCI, with investigation of the factors responsible for the transition to dementia, are worthy of being planned and carried out...
  34. ncbi request reprint Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models
    Cristina Sarti
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol Sci 203:263-6. 2002
    ..We propose this model to investigate subcortical vascular dementia...
  35. doi request reprint The use of CT in dementia
    Marco Pasi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Int Psychogeriatr 23:S6-12. 2011
    ....
  36. doi request reprint Investigations in primary care
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Front Neurol Neurosci 24:66-78. 2009
    ....
  37. doi request reprint Impact of cerebral white matter changes on functionality in older adults: An overview of the LADIS Study results and future directions
    Leonardo Pantoni
    NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy
    Geriatr Gerontol Int 15:10-6. 2015
    ..We also discuss some therapeutic perspectives regarding the beneficial impact of physical activity on the risk of vascular cognitive impairment in patients with WMC. Geriatr Gerontol Int 2015; 15 (Suppl. 1): 10-16. ..
  38. doi request reprint Inherited leukoencephalopathies with clinical onset in middle and old age
    Serena Nannucci
    NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy
    J Neurol Sci 347:1-13. 2014
    ....
  39. ncbi request reprint Visual rating scales for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 33:2827-33. 2002
    ..We aimed to compare 6 widely used rating scales for leukoaraiosis and to calculate conversion coefficients of the score of 1 scale in the score of a second scale...
  40. ncbi request reprint Pathological lesions in vascular dementia
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Ann N Y Acad Sci 977:279-91. 2002
    ..An ongoing survey aimed at collecting information about the procedures used in different pathological laboratories in the assessment of lesions possibly associated with dementia is finally presented...
  41. ncbi request reprint Efficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trial
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 35, 50134 Florence, Italy
    Stroke 36:619-24. 2005
    ..Evidence of drug efficacy in vascular dementia (VaD) is scanty. Therapeutic trials should address VaD subtypes. We studied the efficacy and safety of the calcium antagonist nimodipine in subcortical VaD...
  42. ncbi request reprint Not-so-silent infarcts
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Lancet Neurol 2:335. 2003
  43. doi request reprint Effects of sapropterin on endothelium-dependent vasodilation in patients with CADASIL: a randomized controlled trial
    Renata De Maria
    From the CNR Institute of Clinical Physiology, Cardiothoracic and Vascular Department, Niguarda Ca Granda Hospital, Milan, Italy R D M, J C, M P, O P CNR Institute of Translational Pharmacology, Rome, Italy M F Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy F T, C M, C T Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy A Federico, M T D, M L S NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy D I, R V Department of Epidemiology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy A T, C P Department of Neuroscience, Mental Health and Sensory Organs NESMOS and Center for Experimental Neurological Therapies, Sant Andrea Hospital, University of Rome La Sapienza, Rome, Italy S R, F O Neurovascular Treatment Unit, University of Zagreb
    Stroke 45:2959-66. 2014
    ..We assessed whether supplementation with sapropterin, a synthetic tetrahydrobiopterin analog, improves endothelium-dependent vasodilation in CADASIL patients...
  44. doi request reprint Thrombolysis in acute stroke patients with cerebral small vessel disease
    Leonardo Pantoni
    Stroke Unit and Neurology, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Cerebrovasc Dis 37:5-13. 2014
    ..Intracerebral hemorrhage (ICH) remains the most devastating and unpredictable complication related to thrombolysis, and neuroimaging evidence of SVD is nowadays recognized as one of the risk factors for thrombolysis-related ICH...
  45. ncbi request reprint The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat
    Alessia Melani
    Department of Preclinical and Clinical Pharmacology, University of Florence, V le Pieraccini 6, 50139, Florence, Italy
    Brain Res 959:243-50. 2003
    ..Furthermore, this study, for the first time, proposes that turning behavior after permanent intraluminal MCAo, be used as a precocious index of neurological deficit and neuronal damage...
  46. ncbi request reprint Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat
    Cristina Sarti
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
    Behav Brain Res 136:13-20. 2002
    ..We investigated whether rats subjected to bilateral common carotid artery occlusion (bCCA-o) developed focal neurological deficits, gait dysfunction, and working memory alterations...
  47. ncbi request reprint Treatment of vascular dementia: evidence from trials with non-cholinergic drugs
    Leonardo Pantoni
    Azienda Ospedaliera Careggi and University of Florence, Florence, Italy
    J Neurol Sci 226:67-70. 2004
    ..This selective focus seems to be better suited for disclosing specific treatments in the field of VaD...