M Palumbo

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. pmc Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage
    Sara N Richter
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    Nucleic Acids Res 34:1982-91. 2006
  2. pmc Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases
    Sara N Richter
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    Nucleic Acids Res 35:6075-85. 2007
  3. pmc Effects of magnesium and related divalent metal ions in topoisomerase structure and function
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Nucleic Acids Res 37:702-11. 2009
  4. ncbi request reprint Anticancer agents: towards the future
    Manlio Palumbo
    Department of Pharmaceutical Sciences, Via Marzolo, 5, 35131 Padova, Italy
    Curr Med Chem Anticancer Agents 4:425-7. 2004
  5. ncbi request reprint Quantitation of camptothecin and related compounds
    M Palumbo
    Department of Pharmaceutical Sciences, University of Padova, Italy
    J Chromatogr B Biomed Sci Appl 764:121-40. 2001
  6. ncbi request reprint Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex
    Manlio Palumbo
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padua, Italy
    Biochim Biophys Acta 1587:145-54. 2002
  7. pmc Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB
    C Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, Padova 35131, Italy
    Antimicrob Agents Chemother 54:213-20. 2010
  8. pmc The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage
    B Gatto
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Nucleic Acids Res 29:4224-30. 2001
  9. ncbi request reprint Nucleic acid aptamers based on the G-quadruplex structure: therapeutic and diagnostic potential
    B Gatto
    University of Padova, Department of Pharmaceutical Sciences, Via Marzolo, 5 35131 Padova, Italy
    Curr Med Chem 16:1248-65. 2009
  10. ncbi request reprint Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions
    C Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, Padova, 35100, Italy
    J Mol Biol 311:195-203. 2001

Collaborators

Detail Information

Publications59

  1. pmc Clerocidin interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to induce selective irreversible DNA damage
    Sara N Richter
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    Nucleic Acids Res 34:1982-91. 2006
    ..The unique ability to form exclusively irreversible DNA breaks suggests topoisomerase IV may be a key intracellular target of CL in bacteria...
  2. pmc Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases
    Sara N Richter
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    Nucleic Acids Res 35:6075-85. 2007
    ....
  3. pmc Effects of magnesium and related divalent metal ions in topoisomerase structure and function
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Nucleic Acids Res 37:702-11. 2009
    ..A general two-metal ion mechanism is widely accepted to account for the biophysical and biochemical data thus far available...
  4. ncbi request reprint Anticancer agents: towards the future
    Manlio Palumbo
    Department of Pharmaceutical Sciences, Via Marzolo, 5, 35131 Padova, Italy
    Curr Med Chem Anticancer Agents 4:425-7. 2004
    ..This paper discusses recent advances and perspectives in the field of selective drug recognition considering the key targets tyrosine kinases, DNA-topoisomerases and telomerase...
  5. ncbi request reprint Quantitation of camptothecin and related compounds
    M Palumbo
    Department of Pharmaceutical Sciences, University of Padova, Italy
    J Chromatogr B Biomed Sci Appl 764:121-40. 2001
    ..Hence, the conditions of extraction, pre-treatment and quantitative analysis are to be carefully calibrated in order to provide meaningful results...
  6. ncbi request reprint Sequence-specific interactions of drugs interfering with the topoisomerase-DNA cleavage complex
    Manlio Palumbo
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padua, Italy
    Biochim Biophys Acta 1587:145-54. 2002
    ....
  7. pmc Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB
    C Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, Padova 35131, Italy
    Antimicrob Agents Chemother 54:213-20. 2010
    ..Stabilization of the A subunit appears to be considerably more effective than stabilization of the B subunit. Our data suggest that these two distinct sites could cooperate in the reconstituted enzyme...
  8. pmc The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage
    B Gatto
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Nucleic Acids Res 29:4224-30. 2001
    ....
  9. ncbi request reprint Nucleic acid aptamers based on the G-quadruplex structure: therapeutic and diagnostic potential
    B Gatto
    University of Padova, Department of Pharmaceutical Sciences, Via Marzolo, 5 35131 Padova, Italy
    Curr Med Chem 16:1248-65. 2009
    ....
  10. ncbi request reprint Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions
    C Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, Padova, 35100, Italy
    J Mol Biol 311:195-203. 2001
    ..The results obtained in the presence of ciprofloxacin additionally suggest that the Mg(2+)-mediated quinolone binding to the enzyme might be involved in the mechanism of action of this family of drugs...
  11. ncbi request reprint Anthracyclines: recent developments in their separation and quantitation
    G Zagotto
    Department of Pharmaceutical Sciences, University of Padova, Italy
    J Chromatogr B Biomed Sci Appl 764:161-71. 2001
    ..This review describes the most recent developments in the separation and quantitation of the above clinically useful drugs, together with their principal metabolites. Some less widely used derivatives will also be considered...
  12. ncbi request reprint Novel pyrrolo[3,2-f]quinolines: synthesis and antiproliferative activity
    M G Ferlin
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Bioorg Med Chem 9:1843-8. 2001
    ..Comparison with previously investigated regioisomers shows modulation of activity dictated by the position and conformational freedom of side-chain groups...
  13. ncbi request reprint In vitro selection of DNA aptamers that bind L-tyrosinamide
    E Vianini
    Department of Pharmaceutical Sciences, University of Padova, via 5, 35131 Padova, Marzolo, Italy
    Bioorg Med Chem 9:2543-8. 2001
    ..The identified aptamer sequence will constitute the basis for further in vitro evolution protocols and structure-based drug design...
  14. ncbi request reprint New 1,4-anthracene-9,10-dione derivatives as potential anticancer agents
    G Zagotto
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Italy
    Farmaco 55:1-5. 2000
    ..Molecular modeling studies have been performed to compare the test drugs in terms of steric overlapping...
  15. ncbi request reprint Interaction model for anthracycline activity against DNA topoisomerase II
    Stefano Moro
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, Padova, Italy
    Biochemistry 43:7503-13. 2004
    ..The findings may explain several established structure-activity relationships of antitumor anthracyclines and may thus provide a framework for further developments of effective Top2 poisons...
  16. doi request reprint 2-Phenylquinolones as inhibitors of the HIV-1 Tat-TAR interaction
    Barbara Gatto
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    ChemMedChem 4:935-8. 2009
    ....
  17. ncbi request reprint Antiviral 6-amino-quinolones: molecular basis for potency and selectivity
    Sara N Richter
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Bioorg Med Chem Lett 15:4247-51. 2005
    ..Interestingly, the basicity of the above substituent modulates chelation of the quinolone template to magnesium ions, which, in turn, critically affects the potency and target selectivity in the antiviral quinolone family...
  18. ncbi request reprint Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and human Cathepsin G
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Biochem Pharmacol 71:287-93. 2006
    ..A non-linear relationship was found between degree of sulfation and binding affinity or enzyme inhibition properties, showing a composite correlation between heparin charge density and interference with EL/CatG activity...
  19. ncbi request reprint Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5 35131 Padova, Italy
    Bioorg Med Chem 15:555-62. 2007
    ..Besides the presence of a planar seven-condensed ring system, the introduction of a cyclic amine in the side chains critically affects the selectivity window...
  20. doi request reprint Rational design, synthesis, and DNA binding properties of novel sequence-selective peptidyl congeners of ametantrone
    Alessandra Gianoncelli
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    ChemMedChem 5:1080-91. 2010
    ....
  21. doi request reprint Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting
    Sara N Richter
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Via Gabelli 63, 35121 Padova, Italy
    Bioorg Med Chem Lett 20:1202-4. 2010
    ..The activity against the former was in part due to enhanced drug entry. In addition, SD8 appears to share chromosome- and plasmid-mediated resistance mechanisms with fluoroquinolones...
  22. pmc The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein
    Arianna Loregian
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy
    Antimicrob Agents Chemother 54:1930-40. 2010
    ..Finally, WC5 combined with ganciclovir in checkerboard experiments exhibited highly synergistic activity. These findings suggest that WC5 deserves further investigation as a candidate anti-HCMV drug with a novel mechanism of action...
  23. doi request reprint In front of and behind the replication fork: bacterial type IIA topoisomerases
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131, Padua, Italy
    Cell Mol Life Sci 67:2001-24. 2010
    ....
  24. ncbi request reprint Effects of calcium ions on the interactions between antithrombin and factor Xa mediated by variously sulfated, semisynthetic low-molecular-weight heparins
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Italy
    Semin Thromb Hemost 28:355-60. 2002
    ..These results help in assessing proper structure-activity relationships for glycosaminoglycans, a multitarget family of biologically active compounds...
  25. ncbi request reprint The quinolone family: from antibacterial to anticancer agents
    Claudia Sissi
    Dept of Pharmaceutical Sciences, V Marzolo 5, 35100 Padova, Italy
    Curr Med Chem Anticancer Agents 3:439-50. 2003
    ..Moreover, quinolones link antibacterial and anticancer chemotherapy together and provide an opportunity to clarify drug mechanism across divergent species...
  26. ncbi request reprint Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy
    Biochem Pharmacol 67:631-42. 2004
    ..The difference appears to account for the divergent anticancer potential exhibited by different aza-AP regioisomers and suggests a specific molecular recognition of the cleavage complex by the studied drugs...
  27. ncbi request reprint Modulation of antithrombin-protease interactions by semisynthetic low-molecular-weight heparins with different sulfation patterns
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Padova, Italy
    Semin Thromb Hemost 29:661-70. 2003
    ..These results indicate that chemical modification of the heparin sulfation pattern can be used to modulate binding specificity and activity toward its biological targets...
  28. ncbi request reprint The effects of metal ions on the structure and stability of the DNA gyrase B protein
    C Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy
    J Mol Biol 353:1152-60. 2005
    ....
  29. pmc Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative
    Sara Richter
    Department of Pharmaceutical Sciences, University of Padua, 35131 Padua, Italy
    Antimicrob Agents Chemother 48:1895-9. 2004
    ..Furthermore, WM5 disrupts the natural protein-nucleic acid complex with a 50% inhibitory concentration in the low micromolar range in both in vitro and in vivo assays...
  30. ncbi request reprint Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin
    Teresa Pecere
    Department of Histology, Microbiology and Medical Biotechnology, University of Padova, Padua, Italy
    Int J Cancer 106:836-47. 2003
    ..Due to its high accumulation in neuroectodermal tumor cells AE could also kill tumor cells harboring p53 mutant genes. This property would further contribute to AE specific anti-tumor activity and might be exploitable in the clinic...
  31. ncbi request reprint Antiviral properties of quinolone-based drugs
    Sara Richter
    Department of Pharmaceutical Science, University of Padova, Italy
    Curr Drug Targets Infect Disord 4:111-6. 2004
    ..The information gained so far will be useful for future rational drug design aimed at developing new compounds with optimized antiviral activity...
  32. ncbi request reprint Topoisomerase I, II alpha and II beta mRNA expression in peripheral blood mononuclear cells of patients with solid tumor: preliminary results
    G Cartei
    UOC Medical Oncology, 1 Floor, National Cancer Institute IOV IRCSS, University of Padova, Padova, Italy
    Ann Oncol 17:v25-28. 2006
    ..Anti-topoisomerase (TPs-inhibitors) drugs exist and are largely used in chemotherapy, however, most often blindly of the cancer TPs status...
  33. pmc Concerted bis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA
    Sara N Richter
    Department of Pharmaceutical Sciences, University of Padova, 35131 Padova, Italy
    Nucleic Acids Res 32:5658-67. 2004
    ..These results provide helpful hints to explain the reversible/irreversible nature of topoisomerase II mediated DNA damage produced by CL at C/G steps...
  34. doi request reprint Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences
    Claudia Pivetta
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5 35131 Padova, Italy
    Bioorg Med Chem 16:9331-9. 2008
    ....
  35. doi request reprint Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation
    Giuseppe Zagotto
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 51:5566-74. 2008
    ..These results are of help in the rational design of more efficient G-quadruplex stabilizers, possibly endowed with cancer cell-selective antiproliferative effects...
  36. ncbi request reprint Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives
    Giuseppe Zagotto
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy
    Bioorg Med Chem 16:354-61. 2008
    ..A more extended planar surface would allow more efficient stacking interactions with the quadruplex structure, hence more effective telomerase inhibition...
  37. ncbi request reprint Alternative approaches to the discovery and development of telomerase-targeted anticancer drugs
    Sara Richter
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5 35131 Padova, Italy
    Mini Rev Med Chem 3:37-49. 2003
    ....
  38. pmc Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action
    Sara Richter
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Nucleic Acids Res 31:5149-56. 2003
    ..Its oxidation state seems crucial to modulate the rates of reactivity by finely tuning the strain applied on the oxirane ring...
  39. ncbi request reprint Effects of sulfation on antithrombin-thrombin/factor Xa interactions in semisynthetic low molecular weight heparins
    C Sissi
    Department of Pharmaceutical Sciences, University of Padua, Padua, Italy
    Semin Thromb Hemost 27:483-7. 2001
    ..These results indicate that chemical modification of the sulfation pattern of LMW heparin can be used to efficiently modulate binding affinity and activity toward biological targets...
  40. ncbi request reprint In vitro basis for schedule-dependent interaction between gemcitabine and topoisomerase-targeted drugs in the treatment of colorectal cancer
    S N Richter
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Italy
    Ann Oncol 17:v20-24. 2006
    ..While combination of gemcitabine with anti-topoisomerase poisons is routinely used in oncology, little is known on the biological interactions between these drugs...
  41. doi request reprint Reactivity of clerocidin towards adenine: implications for base-modulated DNA damage
    Sara N Richter
    Department of Histology, Microbiology and Medicinal Biotechnologies, University of Padova, 35131 Padova, Italy
    Org Biomol Chem 7:976-85. 2009
    ..Finally, molecular modelling analysis gave useful indications to solve the apparent contradiction between direct and topoisomerase II-mediated covalent clerocidin reactivity with deoxyadenosine...
  42. ncbi request reprint Antitumor potential of aza-bioisosterism in anthracenedione-based drugs
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy
    Curr Top Med Chem 4:219-30. 2004
    ..In particular, a 2-aza-anthracene-9,10-dione and a 9-aza-anthrapyrazole derivative are presently undergoing advanced clinical trials and appear to be promising in view of their approval as anticancer drugs...
  43. doi request reprint DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action
    Claudia Sissi
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo, 5, 35131 Padova, Italy
    Biochemistry 47:8538-45. 2008
    ..An effectual role for DNA recruiting the second catalytic metal ion is envisaged...
  44. ncbi request reprint Dissecting reactivity of clerocidin toward common buffer systems by means of selected drug analogues
    Sara N Richter
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Chem Res Toxicol 18:35-40. 2005
    ..On the contrary, as true for almost any structure bearing potentially reactive functionalities, any solid prediction should be based on a deeper understanding of the mutual influence of vicinal groups...
  45. ncbi request reprint Effects of common buffer systems on drug activity: the case of clerocidin
    Sara Richter
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
    Chem Res Toxicol 17:492-501. 2004
    ....
  46. doi request reprint Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents
    Marco Di Antonio
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo, 5, 35131 Padova, Italy
    J Am Chem Soc 131:13132-41. 2009
    ..By dissecting reversible recognition and alkylation events, we found that the reversible process is a prerequisite to DNA alkylation, which in turn reinforces the G-quadruplex structural rearrangement...
  47. ncbi request reprint BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photocytotoxic agents
    Filippo Doria
    Dipartimento di Chimica Organica, Universita di Pavia, Italy
    J Med Chem 50:6570-9. 2007
    ....
  48. ncbi request reprint Bipyridyl ligands as photoactivatable mono- and bis-alkylating agents capable of DNA cross-linking
    Daniela Verga
    Dipartimento di Chimica Organica, Universita di Pavia, V le Taramelli 10, 27100 Pavia, Italy
    Org Biomol Chem 5:233-5. 2007
    ..The photoactivation of 6,6'-bis-CH2X-[2,2']bipyridinyl-5,5'-diol ligands as mono and bis-alkylating agents has been investigated, detecting transient heterocyclic quinone methides...
  49. ncbi request reprint Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges
    Giovanni Capranico
    Department of Biochemistry G Moruzzi, Alma Mater Studiorum University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Curr Med Chem Anticancer Agents 4:335-45. 2004
    ..Moreover, we will review novel and diverse approaches relevant to the development of new topoisomerase-related therapeutics...
  50. pmc Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage
    Xiao Su Pan
    Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St George s, University of London, Cranmer Terrace, London, SW17 0RE, UK
    Nucleic Acids Res 36:5516-29. 2008
    ..The results suggest a novel mechanism of enzyme inhibition in which the -1 nt at the gyrase-DNA gate exhibit different CL reactivities to produce both irreversible and reversible DNA damage...
  51. ncbi request reprint 2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: novel, potent, cytotoxic, and DNA-binding agents
    Ippolito Antonini
    Department of Chemical Sciences, University of Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 45:696-702. 2002
    ..The 2,6-di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones (4) constitute a new class of potent, cytotoxic DNA-binding agents not cross-resistant with doxorubicin...
  52. ncbi request reprint Design, synthesis, and biological properties of new bis(acridine-4-carboxamides) as anticancer agents
    Ippolito Antonini
    Department of Chemical Sciences, University of Camerino, Via S Agostino 1, 62032 Camerino, Italy
    J Med Chem 46:3109-15. 2003
    ..Some highly DNA-affinic and potent cytotoxic compounds, 9b,f and 13b,c, have been selected for the National Cancer Institute (NCI) screening on 60 human tumor cell lines and identified as new leads in the antitumor strategies...
  53. ncbi request reprint Intralesional topotecan in advanced ovarian cancer: a clinical report, based on a preclinical study
    Maria Ornella Nicoletto
    Medical Oncology Department, Hospital of Padava, Padova, Italy
    Oncol Rep 9:1351-4. 2002
    ....
  54. pmc New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action
    Cristina Parolin
    Department of Histology, Microbiology and Medical Biotechnologies, Section of Microbiology and Virology, University of Padua, Italy
    Antimicrob Agents Chemother 47:889-96. 2003
    ..6 nM). These data indicate that WM5 is a promising lead compound for the development of a new class of HIV-1 transcription inhibitors characterized by recognition of viral RNA target(s)...
  55. ncbi request reprint Binol quinone methides as bisalkylating and DNA cross-linking agents
    Sara N Richter
    Dipartimento di Chimica Organica, Universita di Pavia, Via le Taramelli 10, 27100 Pavia, Italy
    J Am Chem Soc 126:13973-9. 2004
    ....
  56. ncbi request reprint Toward efficient Zn(II)-based artificial nucleases
    Elisa Boseggia
    Dipartimento di Scienze Chimiche e Istituto CNR Tecnologia delle Membrane Sezione di Padova, Universita di Padova, Via Marzolo 1, I 35131 Padua, Italy
    J Am Chem Soc 126:4543-9. 2004
    ..In the case of too-short spacers, the advantages due to the increased DNA affinity are canceled due to the incorrect positioning of the reactive group, thus leading to cleavage inhibition...
  57. ncbi request reprint Structure modifications of 6-aminoquinolones with potent anti-HIV activity
    Oriana Tabarrini
    Dipartimento di Chimica e Tecnologia del Farmaco, Universita di Perugia, Via del Liceo 1, 06123 Perugia, Italy
    J Med Chem 47:5567-78. 2004
    ..Time-of-addition experiments clearly confirm that the new, potent 6-aminoquinolones interact at a postintegration step in the replication cycle of HIV...
  58. ncbi request reprint Efficient plasmid DNA cleavage by a mononuclear copper(II) complex
    Claudia Sissi
    Dipartimento di Scienze Chimiche e Istituto CNR Tecnologia delle Membrane Sezione di Padova, Universita di Padova, Via Marzolo 1, I 35131 Padova, Italy
    Inorg Chem 44:2310-7. 2005
    ..A concurrent oxidative mechanism becomes competitive upon addition of reductants or in the presence of high levels of molecular oxygen: under such conditions, in fact, a remarkable increase in the rate of DNA cleavage is observed...
  59. doi request reprint Tuning the activity of Zn(II) complexes in DNA cleavage: clues for design of new efficient metallo-hydrolases
    Carla Bazzicalupi
    Dipartimento di Chimica, Universita degli Studi di Firenze, Via della Lastruccia 3, 50019, Sesto Fiorentino, Firenze, Italy
    Inorg Chem 47:5473-84. 2008
    ....