A Naldini

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Cutting edge: IL-1beta mediates the proangiogenic activity of osteopontin-activated human monocytes
    Antonella Naldini
    Unit of Neuroimmunophysiology, Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    J Immunol 177:4267-70. 2006
  2. ncbi request reprint Downregulation of hypoxia-related responses by novel antitumor histone deacetylase inhibitors in MDAMB231 breast cancer cells
    Antonella Naldini
    Department of Physiology, University of Siena, Siena, Italy
    Anticancer Agents Med Chem 12:407-13. 2012
  3. ncbi request reprint Role of inflammatory mediators in angiogenesis
    Antonella Naldini
    Department of Physiology, University of Siena, 53100 Siena, Italy
    Curr Drug Targets Inflamm Allergy 4:3-8. 2005
  4. ncbi request reprint Thrombin-mediated IL-10 up-regulation involves protease-activated receptor (PAR)-1 expression in human mononuclear leukocytes
    Antonella Naldini
    University of Siena, Via Aldo Moro, 53100, Siena, Italy
    J Leukoc Biol 78:736-44. 2005
  5. ncbi request reprint Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells
    A Naldini
    Institute of General Physiology, University of Siena, Italy
    J Cell Physiol 173:335-42. 1997
  6. ncbi request reprint A ribonuclease protection assay-based approach for analysis of angiogenic gene expression in archival tissues
    Antonella Naldini
    Department of Physiology, University of Siena, Italy
    Diagn Mol Pathol 16:147-52. 2007
  7. doi request reprint The effects of autologous platelet gel on inflammatory cytokine response in human peripheral blood mononuclear cells
    Antonella Naldini
    Department of Physiology, University of Siena, Italy
    Platelets 19:268-74. 2008
  8. doi request reprint Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Eur J Cancer 45:454-60. 2009
  9. doi request reprint The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    J Leukoc Biol 87:365-9. 2010
  10. doi request reprint Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Eur J Cancer 46:3400-8. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Cutting edge: IL-1beta mediates the proangiogenic activity of osteopontin-activated human monocytes
    Antonella Naldini
    Unit of Neuroimmunophysiology, Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    J Immunol 177:4267-70. 2006
    ..In conclusion, OPN-activated monocytes may contribute to the onset of angiogenesis through a mechanism mediated by IL-1beta...
  2. ncbi request reprint Downregulation of hypoxia-related responses by novel antitumor histone deacetylase inhibitors in MDAMB231 breast cancer cells
    Antonella Naldini
    Department of Physiology, University of Siena, Siena, Italy
    Anticancer Agents Med Chem 12:407-13. 2012
    ....
  3. ncbi request reprint Role of inflammatory mediators in angiogenesis
    Antonella Naldini
    Department of Physiology, University of Siena, 53100 Siena, Italy
    Curr Drug Targets Inflamm Allergy 4:3-8. 2005
    ..We will try to provide a rationale for the use of both cytokines and cytokine blockades as novel potential pharmaceutical targets to modulate angiogenesis in chronic inflammation as well as in cancer...
  4. ncbi request reprint Thrombin-mediated IL-10 up-regulation involves protease-activated receptor (PAR)-1 expression in human mononuclear leukocytes
    Antonella Naldini
    University of Siena, Via Aldo Moro, 53100, Siena, Italy
    J Leukoc Biol 78:736-44. 2005
    ..Our results may also contribute to better design therapeutic strategies to treat several disorders, characterized by the presence of inflammatory as well as coagulant responses...
  5. ncbi request reprint Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells
    A Naldini
    Institute of General Physiology, University of Siena, Italy
    J Cell Physiol 173:335-42. 1997
    ..Furthermore, these results suggest a differential pattern of cytokine production in vivo in hypoxic tissues...
  6. ncbi request reprint A ribonuclease protection assay-based approach for analysis of angiogenic gene expression in archival tissues
    Antonella Naldini
    Department of Physiology, University of Siena, Italy
    Diagn Mol Pathol 16:147-52. 2007
    ..In conclusion, our study provides evidence that ribonuclease protection assay on archival specimens would be highly valuable for retrospective studies, for diagnosis or prognosis...
  7. doi request reprint The effects of autologous platelet gel on inflammatory cytokine response in human peripheral blood mononuclear cells
    Antonella Naldini
    Department of Physiology, University of Siena, Italy
    Platelets 19:268-74. 2008
    ..In conclusion, PG treatment reveals a unique capacity of articulating a pro-inflammatory and pro-angiogenic cytokine profile in human PBMC, which may partially explain the clinical success of PG application in a wide range of diseases...
  8. doi request reprint Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Eur J Cancer 45:454-60. 2009
    ..The overall results identify for the first time a functional role for PAR-1 in the cellular responses of breast cancer to a hypoxic microenvironment...
  9. doi request reprint The adaptor protein p66Shc is a positive regulator in the angiogenic response induced by hypoxic T cells
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    J Leukoc Biol 87:365-9. 2010
    ..In conclusion, hypoxic T cells may contribute to the onset of angiogenesis through a novel VEGF-mediated mechanism, where p66Shc acts as a positive regulator...
  10. doi request reprint Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Eur J Cancer 46:3400-8. 2010
    ..The overall results may have important implications in those therapeutic approaches aimed to inhibit IL-1-mediated activities in tumour cells, specifically in breast cancer...
  11. doi request reprint Hypoxia affects dendritic cell survival: role of the hypoxia-inducible factor-1α and lipopolysaccharide
    Antonella Naldini
    Unit of Neuroimmunophysiology, Department of Physiology, University of Siena, Siena, Italy
    J Cell Physiol 227:587-95. 2012
    ..Our results may contribute to further understand the physiology of DC and the molecular mechanisms involved in the survival of DC, with important implications in the regulation of the immune response...
  12. doi request reprint Identification of thrombin-like activity in ovarian cancer associated ascites and modulation of multiple cytokine networks
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Thromb Haemost 106:705-11. 2011
    ....
  13. ncbi request reprint The thrombin peptide, TP508, enhances cytokine release and activates signaling events
    Antonella Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Peptides 25:1917-26. 2004
    ..These data support the hypothesis that TP508 may accelerate tissue repair through the activation of the inflammatory response...
  14. ncbi request reprint Hypoxia modulates cyclin and cytokine expression and inhibits peripheral mononuclear cell proliferation
    A Naldini
    Institute of General Physiology, University of Siena, Siena, Italy
    J Cell Physiol 181:448-54. 1999
    ..This should be important in local hypoxia, usually associated with necrotic areas, in inflammation, and infections, where T lymphocyte capability of producing stimulatory cytokines is desirable...
  15. ncbi request reprint Hypoxia induces the expression and release of interleukin 1 receptor antagonist in mitogen-activated mononuclear cells
    A Naldini
    Institute of General Physiology, University of Siena, Siena, Italy
    Cytokine 13:334-41. 2001
    ..These results suggest that activated mononuclear cells tend to respond to hypoxic stress by modulating the expression of IL-1Ra and IL-1-related molecules and their release in the surrounding microenvironment...
  16. ncbi request reprint Thrombin regulates the expression of proangiogenic cytokines via proteolytic activation of protease-activated receptor-1
    A Naldini
    Institute of General Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Gen Pharmacol 35:255-9. 2000
    ..These results confirm that thrombin is a strong activator of monocytes and could be involved in angiogenesis by inducing cytokines that could enhance the angiogenic process in tissue repair...
  17. pmc Inhibition of interleukin-12 expression by alpha-thrombin in human peripheral blood mononuclear cells: a potential mechanism for modulating Th1/Th2 responses
    A Naldini
    Department of Physiology, University of Siena, Via Aldo Moro, 53100 Siena, Italy
    Br J Pharmacol 140:980-6. 2003
    ..In conclusion, the observation that thrombin significantly affects the production of IL-12, as well as of IL-10, implies a concerted role orchestrated by thrombin in PBMC that could be crucial to effective immunity and inflammation...
  18. ncbi request reprint Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation
    A Naldini
    University of Siena, Institute of General Physiology, Italy
    J Cell Physiol 177:76-84. 1998
    ..That thrombin stimulates cytokine production and proliferation in populations of differentiated monocytes suggests that thrombin may be an important regulator of inflammation and wound healing...
  19. ncbi request reprint Human alpha-thrombin stimulates proliferation of interferon-gamma differentiated, growth-arrested U937 cells, overcoming differentiation-related changes in expression of p21CIP1/WAF1 and cyclin D1
    Antonella Naldini
    Institute of General Physiology, University of Siena, Siena, Italy
    J Cell Physiol 191:290-7. 2002
    ..These results may help explain how thrombin can overcome growth arrest in normal tissue to initiate tissue repair and why thrombin and thrombin-like enzymes may contribute to unrestricted proliferation observed in certain malignancies...
  20. ncbi request reprint Thrombin enhancement of interleukin-1 expression in mononuclear cells: involvement of proteinase-activated receptor-1
    Antonella Naldini
    Department of Physiology, University of Siena, Siena, Italy
    Cytokine 20:191-9. 2002
    ....
  21. ncbi request reprint Regulation of angiogenesis by Th1- and Th2-type cytokines
    A Naldini
    Department of Physiology, University of Siena, 53100 Siena, Italy
    Curr Pharm Des 9:511-9. 2003
    ....
  22. ncbi request reprint Interleukin 10 production in patients undergoing cardiopulmonary bypass: evidence of inhibition of Th-1-type responses
    A Naldini
    Institute of General Physiology, University of Siena, Italy
    Cytokine 11:74-9. 1999
    ..The release of different patterns of cytokines observed after CPB may be helpful in understanding and preventing the development of infectious and immune complications in surgical procedure employing CPB...
  23. ncbi request reprint p66Shc is involved in promoting HIF-1alpha accumulation and cell death in hypoxic T cells
    Fabio Carraro
    Department of Physiology, University of Siena, Siena, Italy
    J Cell Physiol 211:439-47. 2007
    ..Thus, p66Shc may play an important role in downstream hypoxic signaling, involving HIF-1alpha protein accumulation and cell death in T lymphocytes...
  24. pmc p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells
    Sonia Pacini
    Department of Evolutionary Biology, University of Siena, 53100 Siena, Italy
    Mol Cell Biol 24:1747-57. 2004
    ..The data highlight a novel interplay between p66Shc and p52Shc in the control of T-cell fate...
  25. ncbi request reprint Thrombin inhibits IFN-gamma production in human peripheral blood mononuclear cells by promoting a Th2 profile
    Antonella Naldini
    Department of Physiology, University of Siena, 53100 Siena, Italy
    J Interferon Cytokine Res 26:793-9. 2006
    ....
  26. ncbi request reprint Pyrazolo[3,4-d]pyrimidines endowed with antiproliferative activity on ductal infiltrating carcinoma cells
    Fabio Carraro
    Dipartimento di Fisiologia, Unità di Fisiologia Cellulare e Molecolare, Universita degli Studi di Siena, Via Aldo Moro, I 53100 Siena, Italy
    J Med Chem 47:1595-8. 2004
    ..The ability of such compounds to significantly reduce 8701-BC cell proliferation suggests that this scaffold could be a promising lead for the development of antitumoral agents able to block Src phosphorylation of breast cancer cells...
  27. ncbi request reprint Role of the hypoxic microenvironment in the antitumor activity of tyrosine kinase inhibitors
    I Filippi
    Unit of Neuroimmunophysiology, Department of Physiology, University of Siena, Siena, Italy
    Curr Med Chem 18:2885-92. 2011
    ..For all these reasons it is important to identify new TKIs which are also active in hypoxia, the real tumor microenvironment, as possible alternative therapy...
  28. ncbi request reprint Pyrazolo[3,4-d]pyrimidines as potent antiproliferative and proapoptotic agents toward A431 and 8701-BC cells in culture via inhibition of c-Src phosphorylation
    Fabio Carraro
    Dipartimento di Fisiologia, Sezione di Neuroimmunofisiologia, Universita degli Studi di Siena, Via Aldo Moro, I 53100, Siena, Italy
    J Med Chem 49:1549-61. 2006
    ..Moreover, molecular modeling simulations have been performed to hypothesize the way, at the molecular level, by which the inhibitors were able to act as antiproliferative agents...
  29. ncbi request reprint Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs
    Eleonora Cavarra
    Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Via Aldo Moro, Siena, Italy I 53100
    Am J Physiol Lung Cell Mol Physiol 287:L1186-92. 2004
    ..The difference we observed in the cytokine receptor profile may offer an additional explanation for the different fibrogenic response of the two mouse strains to bleomycin...
  30. ncbi request reprint Inhibition of Bcr-Abl phosphorylation and induction of apoptosis by pyrazolo[3,4-d]pyrimidines in human leukemia cells
    Fabrizio Manetti
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, 53100 Siena, Italy
    ChemMedChem 2:343-53. 2007
    ..Finally, molecular modeling simulations were also performed to hypothesize the binding mode of the compounds into the Abl binding site...
  31. doi request reprint Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines
    Fabrizio Manetti
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, I 53100, Siena, Italy
    J Med Chem 51:1252-9. 2008
    ..Insertion of halogen substituents with various substitution patterns, suggested by simulations, led to a significant improvement of leukemia cell growth inhibition and to an increase up to 1 order of magnitude of the affinity toward Abl...
  32. doi request reprint 3D QSAR models built on structure-based alignments of Abl tyrosine kinase inhibitors
    Federico Falchi
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Alcide de Gasperi 2, 53100 Siena, Italy
    ChemMedChem 4:976-87. 2009
    ..Additional biological assays confirmed the important role of the selected compounds as inhibitors of cell proliferation in leukemia cells...
  33. ncbi request reprint Inducible nitric oxide synthase activity correlates with lymphangiogenesis and vascular endothelial growth factor-C expression in head and neck squamous cell carcinoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    J Pathol 208:439-45. 2006
    ..Taken together, our results indicate that iNOS activity may promote lymphangiogenesis and spread to lymph nodes in HNSCC, with the possible involvement of VEGF-C...
  34. ncbi request reprint Osteopontin (Eta-1) and fibroblast growth factor-2 cross-talk in angiogenesis
    Daria Leali
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    J Immunol 171:1085-93. 2003
    ..OPN-mediated recruitment of proangiogenic monocytes may represent a mechanism of amplification of FGF2-induced neovascularization during inflammation, wound healing, and tumor growth...
  35. ncbi request reprint Expression of protease-activated receptors 1 and 2 in melanocytic nevi and malignant melanoma
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Hum Pathol 36:676-85. 2005
    ..Conversely, the significance of PAR-2 up-regulation in both benign and malignant melanocytic lesions requires further research...
  36. ncbi request reprint Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism
    Claudia Di Serio
    Department of Critical Care Medicine and Surgery, University of Firenze, Firenze, Italy
    Basic Clin Pharmacol Toxicol 101:63-9. 2007
    ..These data suggest that, in view of the development of PAR1-selective antagonists as therapeutic agents, effects potentially unrelated to PAR1 inhibition should be carefully scrutinized...