Flavia Mulè

Summary

Affiliation: University of Palermo
Country: Italy

Publications

  1. ncbi request reprint Myogenic NOS and endogenous NO production are defective in colon from dystrophic (mdx) mice
    F Mule
    Dipartimento Farmaco Biologico, Universita della Calabria, 87036 Arcavacata di Rende CS, Italy
    Am J Physiol Gastrointest Liver Physiol 281:G1264-70. 2001
  2. doi request reprint Gastric emptying, small intestinal transit and fecal output in dystrophic (mdx) mice
    Flavia Mulè
    Laboratorio di Fisiologia generale, Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    J Physiol Sci 60:75-9. 2010
  3. ncbi request reprint Involvement of CB1 and CB2 receptors in the modulation of cholinergic neurotransmission in mouse gastric preparations
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Viale delle Scienze, Universita di Palermo, 90128 Palermo, Italy
    Pharmacol Res 56:185-92. 2007
  4. ncbi request reprint Role for NK(1) and NK(2) receptors in the motor activity in mouse colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Eur J Pharmacol 570:196-202. 2007
  5. ncbi request reprint Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, 90128 Palermo, Italia
    Pharmacol Res 56:132-9. 2007
  6. ncbi request reprint Altered tachykinergic influence on gastric mechanical activity in mdx mice
    F Mule
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Palermo, Italy
    Neurogastroenterol Motil 18:844-52. 2006
  7. ncbi request reprint Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice
    F Mule
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Palermo, Italy
    Neurogastroenterol Motil 18:446-54. 2006
  8. pmc Role of NK1 and NK2 receptors in mouse gastric mechanical activity
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Br J Pharmacol 147:430-6. 2006
  9. ncbi request reprint Evidence for the presence of P2y and P2x receptors with different functions in mouse stomach
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Italy
    Eur J Pharmacol 513:135-40. 2005
  10. ncbi request reprint Spontaneous mechanical activity and evoked responses in isolated gastric preparations from normal and dystrophic (mdx) mice
    F Mule
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Italia
    Neurogastroenterol Motil 14:667-75. 2002

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Myogenic NOS and endogenous NO production are defective in colon from dystrophic (mdx) mice
    F Mule
    Dipartimento Farmaco Biologico, Universita della Calabria, 87036 Arcavacata di Rende CS, Italy
    Am J Physiol Gastrointest Liver Physiol 281:G1264-70. 2001
    ..This mechanism appears to be defective in mdx mice...
  2. doi request reprint Gastric emptying, small intestinal transit and fecal output in dystrophic (mdx) mice
    Flavia Mulè
    Laboratorio di Fisiologia generale, Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    J Physiol Sci 60:75-9. 2010
    ..The present results provide evidence for motor intestinal alterations in mdx mice in in vivo conditions...
  3. ncbi request reprint Involvement of CB1 and CB2 receptors in the modulation of cholinergic neurotransmission in mouse gastric preparations
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Viale delle Scienze, Universita di Palermo, 90128 Palermo, Italy
    Pharmacol Res 56:185-92. 2007
    ..In addition, this study provides experimental evidence that also the activation of CB2 receptors is able to reduce cholinergic neurotransmission in the mouse stomach...
  4. ncbi request reprint Role for NK(1) and NK(2) receptors in the motor activity in mouse colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Eur J Pharmacol 570:196-202. 2007
    ..NK(1) receptors appear to be located on cholinergic and on nitrergic neurons as well as on smooth muscle cells, whereas NK(2) receptors seem to be present exclusively on smooth muscle cells...
  5. ncbi request reprint Evidence for a modulatory role of cannabinoids on the excitatory NANC neurotransmission in mouse colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, 90128 Palermo, Italia
    Pharmacol Res 56:132-9. 2007
    ..However, endogenous ligands do not seem to modulate tonically the NANC transmission in mouse colon...
  6. ncbi request reprint Altered tachykinergic influence on gastric mechanical activity in mdx mice
    F Mule
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Palermo, Italy
    Neurogastroenterol Motil 18:844-52. 2006
    ..The hypo-responsiveness to NK2 receptors could depend on the reduced expression of these receptors...
  7. ncbi request reprint Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice
    F Mule
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Palermo, Italy
    Neurogastroenterol Motil 18:446-54. 2006
    ..iNOS mRNA was expressed only in mdx stomach. The results suggest that in mdx gastric preparations, iNOS is functionally expressed, being involved in the slow relaxation induced by VIP...
  8. pmc Role of NK1 and NK2 receptors in mouse gastric mechanical activity
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Br J Pharmacol 147:430-6. 2006
    ..6. These results suggest that, in mouse stomach, NK1 receptors, causing relaxant responses, are present on nitrergic inhibitory myenteric neurons, whereas NK2 receptors, mediating contractile responses, are present at muscular level...
  9. ncbi request reprint Evidence for the presence of P2y and P2x receptors with different functions in mouse stomach
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Italy
    Eur J Pharmacol 513:135-40. 2005
    ..Our results suggest that in mouse stomach are present muscular P2Y receptors, subserving relaxation, and neuronal presynaptic P2X receptors, mediating contraction...
  10. ncbi request reprint Spontaneous mechanical activity and evoked responses in isolated gastric preparations from normal and dystrophic (mdx) mice
    F Mule
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Italia
    Neurogastroenterol Motil 14:667-75. 2002
    ..No significant difference was found in evoked responses. The enteric neurotransmission is preserved in mdx gastric preparations, although alterations in the ongoing production of nitric oxide are present...
  11. ncbi request reprint Signal transduction pathways involved in the mechanical responses to protease-activated receptors in rat colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Palermo, Italy
    J Pharmacol Exp Ther 303:1265-72. 2002
    ..Indeed, tyrosine kinase and L-type Ca2+ channels would act sequentially. The influx of Ca2+ in turn would cause release of Ca2+ from sarcoplasmic reticulum...
  12. pmc Involvement of nitric oxide and tachykinins in the effects induced by protease-activated receptors in rat colon longitudinal muscle
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Italy
    Br J Pharmacol 139:598-604. 2003
    ..These actions may contribute to motility disturbances during intestinal trauma and inflammation...
  13. pmc NANC inhibitory neurotransmission in mouse isolated stomach: involvement of nitric oxide, ATP and vasoactive intestinal polypeptide
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Università di Palermo 90128, Palermo, Italia
    Br J Pharmacol 140:431-7. 2003
    ..VIP is responsible for the slow relaxation evoked by high frequencies of stimulation. The different neurotransmitters appear to work in parallel, although NO could serve also as a neuromodulator that facilitates release of VIP...
  14. pmc Evidence for the presence of functional protease activated receptor 4 (PAR4) in the rat colon
    F Mule
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Gut 53:229-34. 2004
    ..The aims of this study were: (i) to examine expression of PAR(4) in rat proximal colon; (ii) to determine the mechanical effects induced by PAR(4) activation in longitudinal muscle; and (iii) to characterise the underlying mechanisms...
  15. pmc Dual effect mediated by protease-activated receptors on the mechanical activity of rat colon
    Flavia Mulè
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Italy
    Br J Pharmacol 136:367-74. 2002
    ..PARs mediate changes of the mechanical activity of longitudinal and circular muscle which might explain the alterations of colonic motility observed during inflammatory conditions...
  16. ncbi request reprint Inhibitory influence of chromogranin A N-terminal fragment (vasostatin-1) on the spontaneous contractions of rat proximal colon
    Antonella Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale Università di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Regul Pept 130:42-7. 2005
    ..1 microM) or tetrodotoxin (TTX) (1 microM). The results suggest that VS-1 plays an inhibitory modulatory role on spontaneous contractions rat colon circular muscle, through mechanisms involving in part neural release of nitric oxide...
  17. ncbi request reprint Mechanisms underlying the inhibitory effects induced by pituitary adenylate cyclase-activating peptide in mouse ileum
    Maria Grazia Zizzo
    Dipartimento di Medicina Sperimentale Viale delle Scienze, 90128 Palermo, Italia
    Eur J Pharmacol 521:133-8. 2005
    ....
  18. doi request reprint Arginine vasopressin, via activation of post-junctional V1 receptors, induces contractile effects in mouse distal colon
    Mariangela Mastropaolo
    Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, I 90128 Palermo, Italy
    Regul Pept 187:29-34. 2013
    ..No modulation has been observed on the contractility of the circular muscle...
  19. ncbi request reprint Mechanisms underlying the nitric oxide inhibitory effects in mouse ileal longitudinal muscle
    Maria Grazia Zizzo
    Diparttimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, Palermo, Italia
    Can J Physiol Pharmacol 83:805-10. 2005
    ....
  20. doi request reprint Activation of P2Y receptors by ATP and by its analogue, ADPbetaS, triggers two calcium signal pathways in the longitudinal muscle of mouse distal colon
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, Palermo, Italy
    Eur J Pharmacol 595:84-9. 2008
    ..In the longitudinal muscle of mouse distal colon, ATP and ADPbetaS induce muscular contraction via a P2Y receptor, coupled to differential signal pathways leading to intracellular calcium increase...
  21. doi request reprint Glucagon-like peptide-2 relaxes mouse stomach through vasoactive intestinal peptide release
    Antonella Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Am J Physiol Gastrointest Liver Physiol 296:G678-84. 2009
    ..The effect appears to be mediated by prejunctional neural release of VIP and confined to fundic region...
  22. pmc Inhibitory responses to exogenous adenosine in murine proximal and distal colon
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Br J Pharmacol 148:956-63. 2006
    ..In the distal colon, adenosine activates both A(1) and A(2B) receptors, the latter located on enteric inhibitory neurons releasing NO...
  23. ncbi request reprint Neurotransmitters involved in the fast inhibitory junction potentials in mouse distal colon
    Rosa Serio
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Eur J Pharmacol 460:183-90. 2003
    ..A neuromodulator role of PACAP in the inhibitory pathway is supposed...
  24. doi request reprint Role of cholinergic neurons in the motor effects of glucagon-like peptide-2 in mouse colon
    Antonella Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Palermo, Italy
    Am J Physiol Gastrointest Liver Physiol 299:G1038-44. 2010
    ..The effect is mediated by G(i) protein...
  25. doi request reprint Functional evidence for different roles of GABAA and GABAB receptors in modulating mouse gastric tone
    Alessandra Rotondo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Neuropharmacology 58:1033-7. 2010
    ....
  26. doi request reprint Gastric relaxation induced by apigenin and quercetin: analysis of the mechanism of action
    Alessandra Rotondo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, Viale delle Scienze, Palermo, Italy
    Life Sci 85:85-90. 2009
    ..Recently, flavonoids have been shown to cause murine gastric relaxation. In the present study we examined the mechanism of action underlying gastric relaxation induced by apigenin and quercetin in isolated mouse stomach...
  27. ncbi request reprint Mechanisms underlying hyperpolarization evoked by P2Y receptor activation in mouse distal colon
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo Laboratorio di Fisiologia generale Università di Palermo Viale delle Scienze, 90128 Palermo, Italy
    Eur J Pharmacol 544:174-80. 2006
    ..In conclusion, in murine colon, apamin-sensitive hyperpolarization induced by activation of P2Y receptors is mainly mediated by release of Ca2+ from intracellular ryanodine-dependent stores via a mechanism involving adenylyl cyclase...
  28. doi request reprint Inhibitory effects of indicaxanthin on mouse ileal contractility: analysis of the mechanism of action
    Sara Baldassano
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, 90128 Palermo, Italy
    Eur J Pharmacol 658:200-5. 2011
    ....
  29. doi request reprint Tetrodotoxin-dependent effects of menthol on mouse gastric motor function
    Antonella Amato
    Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Universita di Palermo, 90128 Palermo, Italy
    Eur J Pharmacol 718:131-7. 2013
    ..The latter effect appears due, almost in part, to neural mechanisms, with involvement of α-adrenoceptors leading to reduction of tonic ongoing release of acetylcholine...
  30. ncbi request reprint Interplay between PACAP and NO in mouse ileum
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Neuropharmacology 46:449-55. 2004
    ..In turn, NO would stimulate the release of PACAP from inhibitory neurones...
  31. ncbi request reprint Nitric oxide induces muscular relaxation via cyclic GMP-dependent and -independent mechanisms in the longitudinal muscle of the mouse duodenum
    Rosa Serio
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, 90128 Palermo, Italy
    Nitric Oxide 8:48-52. 2003
    ....
  32. pmc Tachykinergic neurotransmission is enhanced in duodenum from dystrophic (mdx) mice
    Maria Grazia Zizzo
    Laboratorio di Fisiologia generale, Dipartimento di Medicina Sperimentale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italia
    Br J Pharmacol 145:334-41. 2005
    ..In mdx mice, the impairment of NO function leads to an increase in the nerve-evoked contractions...
  33. doi request reprint Glucagon-like peptide-1 relaxes gastric antrum through nitric oxide in mice
    Alessandra Rotondo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, 90128 Palermo, Italy
    Peptides 32:60-4. 2011
    ..These results suggest that exogenous GLP-1 is able to reduce mouse gastric motility by acting peripherally in the antral region, through neural NO release...
  34. ncbi request reprint Relaxation induced by N-terminal fragments of chromogranin A in mouse gastric preparations
    Antonella Amato
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita di Palermo, 90128 Palermo, Italy
    Regul Pept 139:90-5. 2007
    ..The relaxation is mediated in part by neural mechanisms through NO production and in part by non-neural mechanisms involving the opening of small conductance Ca(2+)-dependent K(+) channels...
  35. doi request reprint Can guanine-based purines be considered modulators of intestinal motility in rodents?
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Eur J Pharmacol 650:350-5. 2011
    ..Guanine-based purines appear to interfere with prejunctional acethylcoline release. Their effects are dependent by their cellular uptake, and independent by adenine-based purine receptors...
  36. doi request reprint Exogenous glucagon-like peptide 1 reduces contractions in human colon circular muscle
    Antonella Amato
    Laboratorio di Fisiologia generale, Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche STEBICEF, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy Mediterranean Institute for Transplantation and Advanced Specialized Therapies ISMETT, Palermo, Italy
    J Endocrinol 221:29-37. 2014
    ..In conclusion, the results of this study suggest that GLP1R is expressed in the human colon and, once activated by exogenous GLP1, mediates an inhibitory effect on large intestine motility through NO neural release...
  37. doi request reprint Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet
    Sara Baldassano
    Laboratorio di Fisiologia generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari STEMBIO, Universita di Palermo, 90128 Palermo, Italy
    J Endocrinol 217:11-20. 2013
    ..This study provides the first experimental evidence for a role of endogenous GLP2 in the intestinal adaptation to HFD in obese mice and for a dysregulation of the GLP2/GLP2R system after a prolonged HFD...
  38. pmc Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum
    Maria Grazia Zizzo
    Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari STEMBIO, Laboratorio di Fisiologia generale, Universita di Palermo, Palermo, Italy
    Purinergic Signal 8:275-85. 2012
    ..Indeed, the presence of atypical UTP-sensitive receptors leading to muscular contraction is suggested. All uracil-sensitive receptors are linked to the PLC pathway...
  39. doi request reprint A1 receptors mediate adenosine inhibitory effects in mouse ileum via activation of potassium channels
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Viale delle Scienze, Palermo I 90128, Italy
    Life Sci 84:772-8. 2009
    ....
  40. ncbi request reprint Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: role of GABA(A) and GABA(C) receptors
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    Neuropharmacology 52:1685-90. 2007
    ....
  41. doi request reprint D1 receptors play a major role in the dopamine modulation of mouse ileum contractility
    Maria Grazia Zizzo
    Dipartimento di Biologia Cellulare e dello Sviluppo, Laboratorio di Fisiologia generale, Viale delle Scienze, I 90128 Palermo, Universita di Palermo, Italy
    Pharmacol Res 61:371-8. 2010
    ..This study would provide new insight on the pharmacology of the modulation of the gastrointestinal contractility by dopamine...
  42. doi request reprint GLP-2 as Beneficial Factor in the Glucose Homeostasis in Mice Fed a High Fat Diet
    Sara Baldassano
    Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche STEBICEF, Universita di Palermo, Palermo, Italy
    J Cell Physiol 230:3029-36. 2015
    ..The present study suggests that endogenous GLP-2 may act as a protective factor against the dysregulation of the glucose metabolism that occurs in HFD mice, because GLP-2 (3-33) worsens glucose metabolism disorders...
  43. doi request reprint Gastric relaxation induced by glucagon-like peptide-2 in mice fed a high-fat diet or fasted
    Alessandra Rotondo
    Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari STEMBIO, Universita di Palermo, 90128 Palermo, Italy
    Peptides 32:1587-92. 2011
    ..The changes in the GLP-2R expression are associated with modifications of GLP-2 gastric relaxant efficacy. This could represent an adaptive response to reduced or increased nutrient intake...
  44. doi request reprint Postnatal development of the dopaminergic signaling involved in the modulation of intestinal motility in mice
    Maria Grazia Zizzo
    Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Laboratorio di Fisiologia generale, Palermo, Universita di Palermo, Palermo, Italia
    Pediatr Res 80:440-7. 2016
    ..Since antidopaminergic drugs are pharmacological agents employed in the management of gastrointestinal motor disorders at all ages, we investigated whether the enteric dopaminergic system may undergo developmental changes after birth...
  45. ncbi request reprint Influence of endogenous glucagon-like peptide-2 on lipid disorders in mice fed a high-fat diet
    Sara Baldassano
    a Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche STEBICEF, Universita di Palermo, Italy
    Endocr Res 41:317-324. 2016
    ..The purpose of the present study was to investigate the influence of endogenous glucagon-like peptide-2 (GLP-2) on lipid profile in mice fed a standard diet (STD) or a high-fat diet (HFD)...
  46. pmc Guanosine negatively modulates the gastric motor function in mouse
    Maria Grazia Zizzo
    Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Universita di Palermo, Viale delle Scienze, 90128, Palermo, Italy
    Purinergic Signal 9:655-61. 2013
    ..The latter is dependent by its cellular uptake and involves adenylyl cyclase activation and increase in cAMP intracellular levels, while it is independent on neural action potentials, adenosine receptors, and K(+) channel activation. ..
  47. doi request reprint Food intake in lean and obese mice after peripheral administration of glucagon-like peptide 2
    Sara Baldassano
    Laboratorio di Fisiologia generale, Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari STEMBIO, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy
    J Endocrinol 213:277-84. 2012
    ..Gly2]GLP2 decreased the gastric emptying rate. Results suggest that GLP2 can reduce food intake in mice in the short term, likely acting at a peripheral level. DIO mice are less sensitive to the anorectic effect of the peptide...
  48. pmc Biological and biophysics aspects of metformin-induced effects: cortex mitochondrial dysfunction and promotion of toxic amyloid pre-fibrillar aggregates
    Pasquale Picone
    Istituto di Biomedicina e Immunologia Molecolare, CNR, Palermo, Italy
    Aging (Albany NY) 8:1718-34. 2016
    ..These findings indicate that metformin induces different adverse effects, leading to an overall increase of the risk of AD onset. ..
  49. doi request reprint GLP2: an underestimated signal for improving glycaemic control and insulin sensitivity
    Antonella Amato
    Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche STEBICEF Università di Palermo, Palermo, Italy
    J Endocrinol 229:R57-66. 2016
    ....
  50. ncbi request reprint Glucagon-like peptide-2 treatment improves glucose dysmetabolism in mice fed a high-fat diet
    Sara Baldassano
    Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche STEBICEF, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128, Palermo, Italy
    Endocrine 54:648-656. 2016
    ..The mechanisms underlying the beneficial impact of GLP-2 on glucose metabolism remain to be established...
  51. doi request reprint Influence of glucagon-like peptide 2 on energy homeostasis
    Sara Baldassano
    Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche STEBICEF, Universita di Palermo, 90128, Italy
    Peptides 86:1-5. 2016
    ..GLP-2 could be considered an hormone causing positive energy balance, which, however has the role to mitigate the metabolic dysfunctions associated with hyper-adiposity...
  52. doi request reprint Neuronostatin: peripheral site of action in mouse stomach
    Antonella Amato
    Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari STEMBIO, Universita di Palermo, 90128 Palermo, Italy
    Peptides 64:8-13. 2015
    ..This indirectly action could cause reduction of food intake in the short term. ..
  53. doi request reprint Involvement of cholinergic nicotinic receptors in the menthol-induced gastric relaxation
    Antonella Amato
    Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Universita di Palermo, 90128 Palermo, Italy Electronic address
    Eur J Pharmacol 745:129-34. 2014
    ....
  54. doi request reprint Effects of menthol on circular smooth muscle of human colon: analysis of the mechanism of action
    Antonella Amato
    Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche STEBICEF, Laboratorio di Fisiologia generale, Universita di Palermo, Viale delle Scienze, 90128 Palermo, Italy Electronic address
    Eur J Pharmacol 740:295-301. 2014
    ....