Cristina Marzano

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies
    Paola Fossa
    Dipartimento di Scienze Farmaceutiche, Universita di Genova, Viale Benedetto XV 3, 16132 Genoa, Italy
    Bioorg Med Chem 10:743-51. 2002
  2. ncbi request reprint DNA damage and biological effects induced by photosensitization with new N(1)-unsubstituted furo[2,3-h]quinolin-2(1H)-ones
    Cristina Marzano
    Department of Pharmaceutical Sciences, University of Padua, Via Francesco Marzolo 5, I 35131 Padova, Italy
    Bioorg Med Chem 10:2835-44. 2002
  3. ncbi request reprint Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 49:7317-24. 2006
  4. doi request reprint Homoleptic phosphino copper(I) complexes with in vitro and in vivo dual cytotoxic and anti-angiogenic activity
    V Gandin
    Dipartimento di Scienze del Farmaco, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    Metallomics 7:1497-507. 2015
  5. ncbi request reprint Copper complexes as anticancer agents
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Padova, Italy
    Anticancer Agents Med Chem 9:185-211. 2009
  6. doi request reprint In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 51:798-808. 2008
  7. ncbi request reprint New copper(I) phosphane complexes of dihydridobis(3-nitro-1,2,4-triazolyl)borate ligand showing cytotoxic activity
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Inorg Biochem 100:299-304. 2006
  8. ncbi request reprint Antitumor activity of a new platinum(II) complex with low nephrotoxicity and genotoxicity
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131, Italy
    Chem Biol Interact 148:37-48. 2004
  9. ncbi request reprint Cytotoxicity and DNA damage induced by a new platinum(II) complex with pyridine and dithiocarbamate
    Cristina Marzano
    Department of Pharmaceutical Chemistry, University of Padova, Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del C N R, Via Marzolo 5, Padova, Italy
    Chem Biol Interact 140:215-29. 2002
  10. ncbi request reprint Can a mixed damage interfere with DNA-protein cross-links repair?
    C Marzano
    Department of Pharmaceutical Sciences of Padova University, Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del C N R, Italy
    J Cell Mol Med 5:171-7. 2001

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Novel angular furo and thieno-quinolinones: synthesis and preliminary photobiological studies
    Paola Fossa
    Dipartimento di Scienze Farmaceutiche, Universita di Genova, Viale Benedetto XV 3, 16132 Genoa, Italy
    Bioorg Med Chem 10:743-51. 2002
    ..On the basis of these results, the unsubstituted thieno[2,3h]quinoline 2(1H)one seems to be the most interesting potential drug for PUVA photochemotherapy and photopheresis...
  2. ncbi request reprint DNA damage and biological effects induced by photosensitization with new N(1)-unsubstituted furo[2,3-h]quinolin-2(1H)-ones
    Cristina Marzano
    Department of Pharmaceutical Sciences, University of Padua, Via Francesco Marzolo 5, I 35131 Padova, Italy
    Bioorg Med Chem 10:2835-44. 2002
    ..For all these features, 3b seemed to be a new promising potential drug for PUVA therapy and photopheresis...
  3. ncbi request reprint Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 49:7317-24. 2006
    ..We hypothesize that the cytotoxic activity of the new copper(I) complex may be correlated to its ability to trigger paraptosis, a nonapoptotic mechanism of cell death...
  4. doi request reprint Homoleptic phosphino copper(I) complexes with in vitro and in vivo dual cytotoxic and anti-angiogenic activity
    V Gandin
    Dipartimento di Scienze del Farmaco, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    Metallomics 7:1497-507. 2015
    ..In vivo studies on the antitumor efficacy and ability to inhibit angiogenesis confirmed the dual cytotoxic and anti-angiogenic properties of Cu(i) derivatives. ..
  5. ncbi request reprint Copper complexes as anticancer agents
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Padova, Italy
    Anticancer Agents Med Chem 9:185-211. 2009
    ..This overview, collecting the most significant strategies adopted in the last ten years to design promising anticancer copper(I,II) compounds, would be a help to the researchers working in this field...
  6. doi request reprint In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 51:798-808. 2008
    ....
  7. ncbi request reprint New copper(I) phosphane complexes of dihydridobis(3-nitro-1,2,4-triazolyl)borate ligand showing cytotoxic activity
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Inorg Biochem 100:299-304. 2006
    ..It is worth noting that all three tested Cu(I) complexes appear to be particularly effective against A549 carcinoma cells that are resistant to cisplatin treatment...
  8. ncbi request reprint Antitumor activity of a new platinum(II) complex with low nephrotoxicity and genotoxicity
    Cristina Marzano
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131, Italy
    Chem Biol Interact 148:37-48. 2004
    ..In summary, [Pt(ESDT)(Py)Cl] may be considered as a new platinum(II) complex with remarkable antitumor activity and low nephrotoxicity and genotoxicity compared with cisplatin...
  9. ncbi request reprint Cytotoxicity and DNA damage induced by a new platinum(II) complex with pyridine and dithiocarbamate
    Cristina Marzano
    Department of Pharmaceutical Chemistry, University of Padova, Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del C N R, Via Marzolo 5, Padova, Italy
    Chem Biol Interact 140:215-29. 2002
    ....
  10. ncbi request reprint Can a mixed damage interfere with DNA-protein cross-links repair?
    C Marzano
    Department of Pharmaceutical Sciences of Padova University, Centro di Studio sulla Chimica del Farmaco e dei Prodotti Biologicamente Attivi del C N R, Italy
    J Cell Mol Med 5:171-7. 2001
    ..TMP and 8-MOP induced chromosomal aberrations in CHO cells to the same extent, while FQ appeared to be more active. Our data suggest that the ISC induced by TMP could trap enzymes involved in DPC repair...
  11. ncbi request reprint 1,4,8-trimethylfuro[2,3-H]quinolin-2(1H)-one, a new furocoumarin bioisoster
    Cristina Marzano
    Department of Pharmaceutical Sciences of Padova University, Via Marzolo 5, 35131, Padova, Italy
    Eur J Med Chem 39:411-9. 2004
    ..Moreover, compound 5a generated reactive oxygen species to a considerable extent. For these features, compound 5a appears to be a new photosensitizing agent whose special activity deserves to be deeply investigated...
  12. doi request reprint Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications
    Maria Pia Rigobello
    Department of Biological Chemistry, University of Padova, Padova, Italy
    Free Radic Biol Med 50:1620-9. 2011
    ....
  13. doi request reprint Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines
    Alessandro Zanella
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35131, Padova, Italy
    Invest New Drugs 29:1213-23. 2011
    ..These data were correlated with changes in mitochondrial membrane potential and production of reactive oxygen species (ROS) in drug-treated 2008 cells...
  14. ncbi request reprint Mechanism of action of 4-hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one, a very active angular furocoumarin-like sensitizer
    Cristina Marzano
    Department of Pharmaceutical Science, Padova University, Padova, Italy
    Photochem Photobiol 81:1371-9. 2005
    ....
  15. doi request reprint Novel mixed-ligand copper(I) complexes: role of diimine ligands on cytotoxicity and genotoxicity
    Valentina Gandin
    Dipartimento di Scienze del Farmaco, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 56:7416-30. 2013
    ....
  16. ncbi request reprint 4-Hydroxymethyl- and 4-methoxymethylfuro[2,3-h]quinolin-2(1H)-ones: synthesis and biological properties
    Adriana Chilin
    Department of Pharmaceutical Sciences, University of Padova, Via Francesco Marzolo 5, I 35131, Padova, Italy
    Bioorg Med Chem 11:1311-8. 2003
    ..For all these features, HOFQ and the other analogues appeared very promising photochemotherapeutic agents, whose mechanism of action will be further investigated...
  17. doi request reprint Synthesis and in vitro antitumor activity of water soluble sulfonate- and ester-functionalized silver(I) N-heterocyclic carbene complexes
    Valentina Gandin
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy Electronic address
    J Inorg Biochem 129:135-44. 2013
    ..The inhibition of this selenoenzyme determined an alteration of the cellular redox environment thus leading to the induction of the apoptotic cell death through the activation of the ASK-1 pathway. ..
  18. pmc A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling
    Valentina Gandin
    Department of Pharmaceutical Sciences, University of Padova, Padova, Italy
    J Cell Mol Med 16:142-51. 2012
    ..These data, providing a mechanistic characterization of CP-induced cancer cell death, shed light on the signaling pathways involved in paraptosis thus offering a new tool to overcome apoptosis-resistance in colon cancer cells...
  19. doi request reprint Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
    Valentina Gandin
    Dipartimento di Scienze Farmaceutiche, Universita di Padova, Via Marzolo 5, 35121 Padova, Italy
    Biochem Pharmacol 79:90-101. 2010
    ..Pharmacodynamic studies in human ovarian cancer cells allowed for the correlation of intracellular drug accumulation with TrxR inhibition that leads to the induction of apoptosis via the mitochondrial pathway...
  20. doi request reprint In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxiliary monodentate phosphine ligands
    Valentina Gandin
    Dipartimento di Scienze del Farmaco, Universita di Padova, Via Marzolo 5, 35131 Padova, Italy
    J Med Chem 57:4745-60. 2014
    ..Finally, the antitumor efficacy of complex 1 was validated in the murine Lewis Lung Carcinoma (LLC) model. ..
  21. doi request reprint Chemistry and biological activity of platinum amidine complexes
    Rino A Michelin
    Department of Chemical Processes of Engineering, Padova University, Via F Marzolo 9, 35131 Padova, Italy
    ChemMedChem 6:1172-83. 2011
    ....
  22. ncbi request reprint T4 phage photoinactivation by linear furocoumarins and angular furoquinolinones
    Frazia Bettio
    Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131, Padova, Italy
    ChemMedChem 1:525-7. 2006
  23. doi request reprint Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity
    Cristina Marzano
    Department of Pharmaceutical Sciences, University of Padova, Italy
    J Inorg Biochem 103:1113-9. 2009
    ..Complexes 2 and 3 exhibited a biological activity comparable to that of cisplatin...
  24. doi request reprint Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift
    Maria Pia Rigobello
    Dipartimento di Chimica Biologica, Universita di Padova, 35121 Padova, Italy
    Free Radic Biol Med 47:710-21. 2009
    ..Investigation of TrxR activity and expression levels as well as the cellular redox state demonstrated the involvement of TrxR inhibition and redox changes in selenite and auranofin combined action...
  25. doi request reprint Gold(III)-dithiocarbamato anticancer agents: activity, toxicology and histopathological studies in rodents
    Cristina Marzano
    Department of Pharmaceutical Sciences, University of Padova, Padova, Italy
    Int J Cancer 129:487-96. 2011
    ..Altogether, these results confirm the reliability of our drug design strategy and support the validation of this gold(III)-dithiocarbamato derivative as a suitable candidate for clinical trials...
  26. pmc A novel copper(I) complex induces ER-stress-mediated apoptosis and sensitizes B-acute lymphoblastic leukemia cells to chemotherapeutic agents
    Roberta Bortolozzi
    Department of Women s and Children s Health, Oncohematology Laboratory, University of Padova, Padova, Italy These authors contributed equally to this work
    Oncotarget 5:5978-91. 2014
    ..Importantly, we showed that the combination of CP with some chemotherapeutic drugs displayed a good synergy that strongly affected the survival of both RS4;11 and SEM cells. ..
  27. doi request reprint Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine
    Diego Montagner
    Dipartimento di Scienze Chimiche, Universita di Padova, Padova, Italy
    J Inorg Biochem 105:919-26. 2011
    ..Interestingly, whereas the Pt(II) nucleoside complexes (1-4) did not show appreciable cytotoxicity, the corresponding amidine derivatives (7a, 7b, 8a, 8b, 5b, and 6b) exhibited a significant in vitro antitumor activity...
  28. doi request reprint Novel ametantrone-amsacrine related hybrids as topoisomerase IIβ poisons and cytotoxic agents
    Giuseppe Zagotto
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
    Arch Pharm (Weinheim) 347:728-37. 2014
    ..Among the compounds tested, 10, 11, and 19 appear to be promising for further development. ..
  29. doi request reprint trans,cis,cis-bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a prodrug candidate for the treatment of oxaliplatin-refractory colorectal cancer
    Valentina Gandin
    Dipartimento di Scienze del Farmaco, Universita di Padova, Via Marzolo 5, 35131 Padova Italy
    ChemMedChem 9:1299-305. 2014
    ..This result is likely related to the high lipophilicity shown by the title compound that favors its cellular accumulation by passive diffusion. ..
  30. ncbi request reprint Pyran derivatives. Part XXI. Antiproliferative and cytotoxic properties of novel N-substituted 4-aminocoumarins, their benzo-fused derivatives, and some related 2-aminochromones
    Mario Di Braccio
    Dipartimento di Scienze Farmaceutiche dell Università, Viale Benedetto XV 3, 16132 Genova, Italy
    Farmaco 58:1083-97. 2003
    ..74-13.8 microM), whereas only four compounds 5-8 exhibited a comparable cytotoxic activity (IC(50) range: 4.95-12.9 microM)...